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Research Studies is a monthly compilation of research articles funded by AHRQ or authored by AHRQ researchers and recently published in journals or newsletters.
Results1 to 25 of 551 Research Studies Displayed
Choi KR, Lotfizadah AD, Bhakta B
Concordance between patient-centered and adaptive behavior outcome measures after applied behavior analysis for autism.
In clinical trials, applied behavioral analysis (ABA) is an evidence-based approach to autism spectrum disorder that has been shown to improve child functional status. Setting and tracking individualized, patient-centered goals is a focus in ABA, yet there is little research on measuring progress on such goals. The purpose of this study was to observe and evaluate a clinical sample of children 3 to 16 years of age (N=154) receiving 24 months of ABA for autism spectrum disorder, and assess the concordance between patient-centered and standard outcome measures of treatment progress. The study found that there was limited concordance among measures at 12 and 24 months of ABA. The study also found that between 12 and 24 months of ABA, the percentage of children who achieved clinically meaningful gain on patient-centered goal measures increased, while the percentage of children who achieved clinically meaningful gains in adaptive behavior decreased. The study concluded that providers should have continuous dialogue with patients and caregivers to ensure that ASD programs and interventions progress toward meaningful goals and outcomes for patients and their caregivers.
Citation: Choi KR, Lotfizadah AD, Bhakta B . Concordance between patient-centered and adaptive behavior outcome measures after applied behavior analysis for autism. BMC Pediatr 2022 May 27;22(1):314. doi: 10.1186/s12887-022-03383-2..
Keywords: Patient-Centered Healthcare, Autism, Behavioral Health
McBain RK, Cantor JH, Kofner A
Brief report: Medicaid expansion and growth in the workforce for autism spectrum disorder.
This study examined the role that state Medicaid expansion has played in utilization of child psychiatrists, board-certified behavioral analysts (BCBAs) and pediatricians for children with autism spectrum disorder (ASD). Health workforce data from HRSA was used to examine workforce growth from 2008-2017. State Medicaid expansion was associated with a 9% increase in BCBAs per 100,000 children one year after enactment, and a 5% increase in child psychiatrists, but no association with growth in pediatrician utilization.
Citation: McBain RK, Cantor JH, Kofner A . Brief report: Medicaid expansion and growth in the workforce for autism spectrum disorder. J Autism Dev Disord 2022 Apr;52(4):1881-89. doi: 10.1007/s10803-021-05044-2..
Keywords: Children/Adolescents, Autism, Medicaid, Workforce, Behavioral Health
Parast L, Burkhart Q, Bardach NS
Development and testing of an emergency department quality measure for pediatric suicidal ideation and self-harm.
The authors sought to develop and test a new quality measure assessing timeliness of follow-up mental health care for youth presenting to the emergency department (ED) with suicidal ideation or self-harm. Using Medicaid administrative data, they concluded that this new ED quality measure may be useful for monitoring and improving the quality of care for this vulnerable population; however, they recommended future work in order to establish the measure's predictive validity using more prevalent outcomes such as recurrence of suicidal ideation or deliberate self-harm.
Citation: Parast L, Burkhart Q, Bardach NS . Development and testing of an emergency department quality measure for pediatric suicidal ideation and self-harm. Acad Pediatr 2022 Apr;22(3s):S92-s99. doi: 10.1016/j.acap.2021.03.005..
Keywords: Children/Adolescents, Emergency Department, Behavioral Health, Quality Measures, Quality Indicators (QIs), Quality of Care
Lin Y, Sharma B, Thompson HM
External validation of a machine learning classifier to identify unhealthy alcohol use in hospitalized patients.
This study’s objective was to validate a machine learning approach to alcohol screening using a natural language processing (NLP) classifier developed at an independent medical center. This retrospective cohort study took place at a midwestern US tertiary-care, urban medical center that has an inpatient structured universal screening model for unhealthy substance use and an active addiction consult service. The cohort included 57,605 unplanned admissions of adult patients between October 23, 2017 and December 31, 2019 with electronic health record (EHR) documentation of manual alcohol screening. The authors examined error in manual screening and reviewed discordance between the NLP classifier and AUDIT-derived reference. The classifier demonstrated adequate sensitivity and specificity for routine clinical use as an automated screening tool for identifying at-risk patients.
Citation: Lin Y, Sharma B, Thompson HM . External validation of a machine learning classifier to identify unhealthy alcohol use in hospitalized patients. Addiction 2022 Apr;117(4):925-33. doi: 10.1111/add.15730..
Keywords: Alcohol Use, Behavioral Health, Screening, Electronic Health Records (EHRs), Health Information Technology (HIT)
Scott K, Becker SJ, Helseth SA
Pharmacotherapy interventions for adolescent co-occurring substance use and mental health disorders: a systematic review.
This systematic literature review examined the impact of pharmacotherapy interventions on adolescents with substance use (SU) disorders and mental health issues. The authors included ten randomized controlled trials exploring seven pharmacotherapies in the final evaluation. All studies had low to moderate risk of bias. Four studies evaluated pharmacotherapy for co-occurring depression and SU, 3 evaluated ADHD and SU, and 3 evaluated bipolar disorder and SU. Five of the 10 studies included a behavioral intervention. They found no evidence that pharmacotherapy for co-occurring mental health diagnoses impacted SU.
Citation: Scott K, Becker SJ, Helseth SA . Pharmacotherapy interventions for adolescent co-occurring substance use and mental health disorders: a systematic review. Fam Pract 2022 Mar 24;39(2):301-10. doi: 10.1093/fampra/cmab096..
Keywords: Children/Adolescents, Substance Abuse, Behavioral Health, Medication
Tang LA, Jeffery AD, Leech AA
A comparison of methods to identify antenatal substance use within electronic health records.
This study described the development of a natural-language-processing-based algorithm for detecting antenatal substance use among individuals receiving perinatal care. Findings showed that the accuracy of antenatal substance use detection was improved with more stringent case definitions; however, the overall proportion of true cases confirmed by manual chart review decreased.
Citation: Tang LA, Jeffery AD, Leech AA . A comparison of methods to identify antenatal substance use within electronic health records. Am J Obstet Gynecol MFM 2022 Mar;4(2):100535. doi: 10.1016/j.ajogmf.2021.100535..
Keywords: Electronic Health Records (EHRs), Health Information Technology (HIT), Substance Abuse, Pregnancy, Women, Behavioral Health
Presskreischer R, Steinglass JE, Anderson KE
Eating disorders in the U.S. Medicare population.
This cross-sectional study explored the prevalence, sociodemographic and clinical characteristics, and health care spending for Medicare enrollees with eating disorders. A representative 20% sample of 2016 Medicare inpatient, outpatient, carrier, and home health fee-for-service claims and Medicare Advantage encounter records was used. The sample included almost 12 million Medicare enrollees of whom 0.15% had an eating disorder diagnosis. A greater proportion of individuals diagnosed with an eating disorder diagnosis were female, under age 65, and dually eligible for Medicaid due to disability or low-income qualification than those without a diagnosis. Individuals with eating disorders had higher rates of comorbid conditions, with the greatest differences in cardiac arrythmias, arthritis, and thyroid conditions. Spending was $29,456 for enrollees with eating disorders compared to $7,418 without.
Citation: Presskreischer R, Steinglass JE, Anderson KE . Eating disorders in the U.S. Medicare population. Int J Eat Disord 2022 Mar;55(3):362-71. doi: 10.1002/eat.23676..
Keywords: Behavioral Health, Medicare, Healthcare Costs
Auty SG, Griffith KN
Medicaid expansion and drug overdose mortality during the COVID-19 pandemic in the United States.
This study examined trends in overdose mortality nationally and by state Medicaid expansion status from 2013 to 2020. Using data from the CDC’s WONDER database, findings showed that the increase in drug or opioid overdose deaths experienced during the first year of the COVID-19 pandemic was similar in states with and without Medicaid expansion.
Citation: Auty SG, Griffith KN . Medicaid expansion and drug overdose mortality during the COVID-19 pandemic in the United States. Drug Alcohol Depend 2022 Mar 1;232:109340. doi: 10.1016/j.drugalcdep.2022.109340..
Keywords: COVID-19, Medicaid, Opioids, Substance Abuse, Behavioral Health, Mortality, Public Health
Wyse JJ, McGinnis KA, Edelman EJ
Twelve-month retention in opioid agonist treatment for opioid use disorder among patients with and without HIV.
Although opioid agonist therapy (OAT) is associated with positive health outcomes, including improved HIV management, long-term retention in OAT remains low among patients with opioid use disorder (OUD). The investigators concluded that history of homelessness was associated with a lower likelihood of retention. Predictors of retention were largely distinct between patients with HIV and patients without HIV. Findings highlighted the need for clinical, systems, and research initiatives to better understand and improve OAT retention.
Citation: Wyse JJ, McGinnis KA, Edelman EJ . Twelve-month retention in opioid agonist treatment for opioid use disorder among patients with and without HIV. AIDS Behav 2022 Mar;26(3):975-85. doi: 10.1007/s10461-021-03452-0..
Keywords: Opioids, Substance Abuse, Behavioral Health, Human Immunodeficiency Virus (HIV)
Caves Sivaraman JJ, Ranapurwala SI, Proescholdbell S
Suicide typologies among Medicaid beneficiaries, North Carolina 2014-2017.
Only ½ of suicide decedents are diagnosed with a mental health condition; population-based screening strategies are needed to help identify people who are at risk of suicide, and it may be necessary for providers to consider patient life circumstances that may place them at a higher risk. The purpose of this study was to identify suicide typologies among suicide decedents and describe the alignment between medical diagnoses and life circumstances. Decedent demographics, stressful life events, perceived and diagnosed/ health issues, suicidal behavior, and suicide method contributed to the typologies. In 2020 the researchers linked North Carolina Medicaid data with data from the North Carolina Violent Death reporting System (NC-VDRS) to analyze suicide decedents from 2014-2017, aged 25-54 years of age. Researchers analyzed 6 indicators of life circumstances from Medicaid claims and 12 indicators from the NC-VDRS and developed separate models for men and women. The study found that 88.3% of the suicide decedents were White, with a median age of 41 years, and more than 70% had experienced a health care visit in the 90 days prior to suicide. The study concluded that almost one-half of suicide decedents have a typology characterized by a low probability of diagnosis of mental health issues. The authors report that screenings for suicide could be improved by using improved indicators of lived experience and mental health.
Citation: Caves Sivaraman JJ, Ranapurwala SI, Proescholdbell S . Suicide typologies among Medicaid beneficiaries, North Carolina 2014-2017. BMC Psychiatry 2022 Feb 10;22(1):104. doi: 10.1186/s12888-022-03741-5..
Keywords: Medicaid, Behavioral Health
Wright JH, Owen J, Eells TD
Effect of computer-assisted cognitive behavior therapy vs usual care on depression among adults in primary care: a randomized clinical trial.
Computer-assisted cognitive behavior therapy (CCBT) has been proposed as a method for improving access to effective psychotherapy, reducing cost, and increasing the convenience and efficiency of treatment for depression. The purpose of this study was to evaluate whether clinician-supported CCBT is more effective than treatment as usual (TAU) in primary care patients with depression and to examine the feasibility and implementation of CCBT in a primary care population with substantial numbers of patients with low income, limited internet access, and low levels of educational attainment.
Citation: Wright JH, Owen J, Eells TD . Effect of computer-assisted cognitive behavior therapy vs usual care on depression among adults in primary care: a randomized clinical trial. JAMA Netw Open 2022 Feb;5(2):e2146716. doi: 10.1001/jamanetworkopen.2021.46716..
Keywords: Depression, Behavioral Health, Primary Care, Treatments, Comparative Effectiveness
Turvey CL, Fuhrmeister LA, Klein DM
Patient and provider experience of electronic patient portals and secure messaging in mental health treatment.
This study explored patient and provider experience of patient electronic access to the mental health treatment record and the use of secure messaging. Participants received online surveys with questions about their experiences. Researchers concluded that the implementation of electronic access to mental health notes requires a transition from viewing the medical record as the exclusive tool of providers to that of a collaborative tool for patients and providers to achieve treatment goals.
Citation: Turvey CL, Fuhrmeister LA, Klein DM . Patient and provider experience of electronic patient portals and secure messaging in mental health treatment. Telemed J E Health 2022 Feb;28(2):189-98. doi: 10.1089/tmj.2020.0395..
Keywords: Electronic Health Records (EHRs), Health Information Technology (HIT), Patient Experience, Behavioral Health, Patient and Family Engagement
Schoenfeld EM, Soares WE, Schaeffer EM
"This is part of emergency medicine now": a qualitative assessment of emergency clinicians' facilitators of and barriers to initiating buprenorphine.
Despite evidence demonstrating the safety and efficacy of buprenorphine for the treatment of emergency department (ED) patients with opioid use disorder (OUD), incorporation into clinical practice has been highly variable. In this study, the investigators explored barriers and facilitators to the prescription of buprenorphine, as perceived by practicing ED clinicians. The investigators concluded that while some participants were hesitant to adopt a "new" role in treating patients with medications for OUD, many already had.
Citation: Schoenfeld EM, Soares WE, Schaeffer EM . "This is part of emergency medicine now": a qualitative assessment of emergency clinicians' facilitators of and barriers to initiating buprenorphine. Acad Emerg Med 2022 Jan;29(1):28-40. doi: 10.1111/acem.14369..
Keywords: Emergency Department, Opioids, Medication, Substance Abuse, Behavioral Health
Carroll AR, Hall M, Brown CM
Association of race/ethnicity and social determinants with rehospitalization for mental health conditions at acute care children's hospitals.
This retrospective cohort study evaluated the associations of race/ethnicity and social determinants with 90-day rehospitalization of children with mental health conditions to acute non-psychiatric children’s hospitals. Children included were aged 5 to 18 years at 32 freestanding U.S. children’s hospitals from 2016-2018 using the Children’s Hospital Association’s Pediatric Health Information System (PHIS) database to assess the association of race/ethnicity and social determinants (insurance payer, neighborhood median household income, and rurality of patient home location) with 90-day rehospitalization. Among 23,556 index hospitalizations, 5.9% (n = 1382) were rehospitalized for mental health within 90 days. Non-Hispanic Black children were 26% more likely to be rehospitalized than non-Hispanic White children. Those with government insurance were 18% more likely to rehospitalized than those with private insurance. Those living in a suburban location were 22% less likely to be rehospitalized than those living in an urban location.
Citation: Carroll AR, Hall M, Brown CM . Association of race/ethnicity and social determinants with rehospitalization for mental health conditions at acute care children's hospitals. J Pediatr 2022 Jan;240:228-34.e1. doi: 10.1016/j.jpeds.2021.08.078..
Keywords: Children/Adolescents, Hospital Readmissions, Behavioral Health, Social Determinants of Health, Racial / Ethnic Minorities
Penfold RB, Thompson EE, Hilt RJ
Development of a symptom-focused model to guide the prescribing of antipsychotics in children and adolescents: results of the first phase of the Safer Use of Antipsychotics in Youth (SUAY) Clinical Trial.
The purpose of this study was to develop a new approach to prescribing guidelines as part of a pragmatic trial, Safer Use of Antipsychotics in Youth (SUAY; ClinicalTrials.gov Identifier: NCT03448575), which supports prescribers in delivering high-quality mental health care to youths. Prescribing guidelines are often ignored because they do not incorporate the real-world availability of first-line psychosocial treatments, comorbid conditions, and clinical complexity. The investigators indicated that their approach addressed some of these concerns.
AHRQ-funded; HS026001; HS023258.
Citation: Penfold RB, Thompson EE, Hilt RJ . Development of a symptom-focused model to guide the prescribing of antipsychotics in children and adolescents: results of the first phase of the Safer Use of Antipsychotics in Youth (SUAY) Clinical Trial. J Am Acad Child Adolesc Psychiatry 2022 Jan;61(1):93-102. doi: 10.1016/j.jaac.2021.04.010..
Keywords: Children/Adolescents, Medication, Behavioral Health, Patient Safety, Guidelines, Evidence-Based Practice
Chien AT, Leyenaar J, Tomaino M
Difficulty obtaining behavioral health services for children: A national survey of multiphysician practices.
Researchers estimated the proportion of practices that have difficulty accessing resources to deliver evidence-based care for children with behavioral health disorders and investigated whether practices owned by a health system or participating in Medicaid accountable care organizations (ACOs) report less difficulty. They found that more than 85% of practices found it difficult to obtain help with evidence-based elements of pediatric behavioral health care. The percent experiencing difficulty was similar between system-owned and independent practices but was less for Medicaid ACO participants for medication advice and evidence-based psychotherapy; differences were not significant for family-based treatment.
Citation: Chien AT, Leyenaar J, Tomaino M . Difficulty obtaining behavioral health services for children: A national survey of multiphysician practices. Ann Fam Med 2022 Jan-Feb;20(1):42-50. doi: 10.1370/afm.2759..
Keywords: Children/Adolescents, Behavioral Health, Access to Care
Curcija K, Zittleman L, Fisher M
Does a rural community-based intervention improve knowledge and attitudes of opioid use disorder and medication-assisted treatment? A report from the IT MATTTRs study.
As part of the Implementing Technology and Medication Assisted Treatment Team Training in Rural Colorado study, this paper describes the implementation of community-based interventions developed by rural community members and researchers to increase awareness and to promote positive attitudes toward medication-assisted treatment (MAT) for opioid use disorder (OUD) and explores changes in community members' OUD and MAT knowledge and beliefs. Findings showed that partnering with local community members resulted in the successful development and implementation of community-based interventions, exposure to which was associated with OUD knowledge and beliefs. Locally-created interventions should be included in comprehensive approaches to stem the OUD epidemic.
Citation: Curcija K, Zittleman L, Fisher M . Does a rural community-based intervention improve knowledge and attitudes of opioid use disorder and medication-assisted treatment? A report from the IT MATTTRs study. J Rural Health 2022 Jan;38(1):120-28. doi: 10.1111/jrh.12545..
Keywords: Opioids, Substance Abuse, Behavioral Health, Medication, Rural Health
Zittleman L, Curcija K, Nease DE
Increasing capacity for treatment of opioid use disorder in rural primary care practices.
Evidence supports treatment for opioid use disorder (OUD) with buprenorphine in primary care practices (PCPs). Barriers that slow implementation of this treatment include inadequately trained staff. This study aimed to increase the number of rural PCPs providing OUD treatment with buprenorphine. This evaluation described the impact of a practice team training on the implementation and delivery of OUD treatment with buprenorphine in PCPs of rural Colorado.
Citation: Zittleman L, Curcija K, Nease DE . Increasing capacity for treatment of opioid use disorder in rural primary care practices. Ann Fam Med 2022 Jan-Feb;20(1):18-23. doi: 10.1370/afm.2757..
Keywords: Opioids, Rural Health, Primary Care, Substance Abuse, Behavioral Health, Training, Implementation, Medication
Akingbade O, Peek ME, Tung EL. O, Peek ME, Tung EL
Network size or proximity? Association of network characteristics with violence-related stress and PTSD among racial/ethnic minorities in Chicago.
This research brief examined the association of network size compared to network size and proximity and the psychosocial health and PTSD rates among high-risk racial/ethnic minorities in two Chicago neighborhoods. A sample of 504 adults were surveyed from one South and one West side Chicago clinic in 2018. Only participants who self-reported lifetime exposure in the Brief Trauma Questionnaire to community violence were included, decreasing the sample size to 297. The majority of participants were female (69%) and non-Hispanic Black (75%). Two-thirds were direct victims of robbery or assault, and one-third tested positive for PTSD. Median number of network confidants was found to be 2. A larger network size (> 3 confidants) within 30 minutes from home was significantly associated with 67% lower adjusted odds of PTSD compared to those with no confidants within 30 minutes from home.
Citation: Akingbade O, Peek ME, Tung EL. O, Peek ME, Tung EL . Network size or proximity? Association of network characteristics with violence-related stress and PTSD among racial/ethnic minorities in Chicago. J Gen Intern Med 2022 Jan;37(1):255-57. doi: 10.1007/s11606-021-06607-w..
Keywords: Behavioral Health, Racial / Ethnic Minorities, Stress, Domestic Violence
Choi KR, Bhakta B, Knight EA
Patient outcomes after applied behavior analysis for autism spectrum disorder.
The purpose of this study was to examine patterns of service receipt and patient outcomes for children receiving applied behavior analysis (ABA) for autism spectrum disorder (ASD) in an integrated health care system in which commercially insured children were covered by a state autism mandate. Findings showed that, in a health system implementation of ABA for children with ASD, there were high rates of ABA discontinuation and low ABA dosing. These challenges may diminish the potential benefits of ABA, even with mandated commercial insurance coverage.
Citation: Choi KR, Bhakta B, Knight EA . Patient outcomes after applied behavior analysis for autism spectrum disorder. J Dev Behav Pediatr 2022 Jan;43(1):9-16. doi: 10.1097/dbp.0000000000000995..
Keywords: Children/Adolescents, Autism, Behavioral Health, Outcomes, Patient-Centered Outcomes Research, Evidence-Based Practice
Sun N, Hua CL, Qiu X
Urban and rural differences in trajectories of depressive symptoms in later life in the United States.
This research had two primary goals: to examine the relationship between urban residence and trajectories of depressive symptoms and to investigate whether this relationship differs by social isolation and loneliness. The investigators conducted latent growth curve analysis to predict both baseline and trajectories of depression based on urban or rural residency. Findings of this study served to better understand how social and geographic contexts shaped long-term well-being of older adults.
Citation: Sun N, Hua CL, Qiu X . Urban and rural differences in trajectories of depressive symptoms in later life in the United States. J Appl Gerontol 2022 Jan;41(1):148-57. doi: 10.1177/0733464820972527..
Keywords: Elderly, Rural Health, Depression, Behavioral Health
McClellan C, Moriya A, Simon K
AHRQ Author: McClellan C Moriya A
Users of retail medications for opioid use disorders faced high out-of-pocket prescription spending in 2011-2017.
This paper provides national estimates of financial costs faced by the population receiving retail medications for opioid use disorders (MOUD). Using MEPS data, findings showed that patients with retail MOUD prescriptions spent 3.4 times more out-of-pocket for prescriptions on average than the rest of the U.S. population, with 18.8% of this population paying entirely out-of-pocket for their MOUD prescriptions. Insurance coverage was associated with reduced annual out-of-pocket MOUD expenditures. Future policies that expand insurance and address out-of-pocket spending on MOUD could increase access to medications among individuals with opioid use disorders.
Citation: McClellan C, Moriya A, Simon K . Users of retail medications for opioid use disorders faced high out-of-pocket prescription spending in 2011-2017. J Subst Abuse Treat 2022 Jan;132:108645. doi: 10.1016/j.jsat.2021.108645..
Keywords: Medical Expenditure Panel Survey (MEPS), Opioids, Substance Abuse, Behavioral Health, Healthcare Costs, Medication
Rhee TG, Sint K, Olfson M
Association of ECT with risks of all-cause mortality and suicide in older Medicare patients.
This observational study examined the effects of electroconvulsive therapy (ECT) on suicide and all-cause mortality risk in Medicare psychiatric patients age 65 or older. Patients receiving ECT were exact matched to control subjects in a 1-to-3 ratio on age, gender, principal hospital diagnosis, past-year psychiatric hospitalizations, past-year suicide attempts, and Elixhauser comorbidity index. A total of 10,46 patients were in the ECT group and 31,160 in the control group. Compared with the control group, patients receiving ECT had lower all-cause mortality for up to 1 year following hospital discharge. For death by suicide, ECT was associated with short-lived effects which waned over time.
Citation: Rhee TG, Sint K, Olfson M . Association of ECT with risks of all-cause mortality and suicide in older Medicare patients. Am J Psychiatry 2021 Dec;178(12):1089-97. doi: 10.1176/appi.ajp.2021.21040351..
Keywords: Elderly, Behavioral Health, Mortality, Treatments
Ching JH, Owens DK, Trafton JA
Impact of treatment duration on mortality among Veterans with opioid use disorder in the United States Veterans Health Administration.
This study used simulation of a Veterans Health Administration cohort to identify the opioid use disorder (OUD) treatment durations necessary for the elevated mortality risks during treatment transitions balanced by reductions in mortality while receiving medication-assisted treatment (MAT) with methadone or buprenorphine. A simulated cohort of 10,000 individuals with OUD was created by using parameters obtained through calibration and published meta-analyses of studies from North America, Europe, and Australia. Methadone treatment for 4 months or longer or buprenorphine for 2 months or longer resulted in 54 and 65 fewer deaths relative to not receiving MAT for the same duration. The authors estimated shorter treatment durations necessary to achieve net mortality benefits of 2 months or longer for methadone and 1 month or longer for buprenorphine. Necessary treatment increased more with smaller mortality reductions on treatment with larger relative risks during treatment transitions.
AHRQ-funded; HS027935; HS026128.
Citation: Ching JH, Owens DK, Trafton JA . Impact of treatment duration on mortality among Veterans with opioid use disorder in the United States Veterans Health Administration. Addiction 2021 Dec;116(12):3494-503. doi: 10.1111/add.15574.
AHRQ-funded; HS027935; HS026128..
AHRQ-funded; HS027935; HS026128..
Keywords: Opioids, Substance Abuse, Behavioral Health, Veterans, Mortality
Geneslaw AS, Lu Y, Miles CH
Long-term increases in mental disorder diagnoses after invasive mechanical ventilation for severe childhood respiratory disease: a propensity matched observational cohort study.
They found that children without major comorbidity requiring invasive mechanical ventilation for severe respiratory illness had a 43% higher incidence of subsequent mental disorder diagnoses and a 67% higher incidence of psychotropic medication use. Both increases were substantially higher than in PICU patients with respiratory illness not necessitating invasive mechanical ventilation. They recommended further research to determine which factors related to invasive mechanical ventilation and severe respiratory illness are associated with abnormal neurodevelopment.
Citation: Geneslaw AS, Lu Y, Miles CH . Long-term increases in mental disorder diagnoses after invasive mechanical ventilation for severe childhood respiratory disease: a propensity matched observational cohort study. Pediatr Crit Care Med 2021 Dec;22(12):1013-25. doi: 10.1097/pcc.0000000000002790..
Keywords: Children/Adolescents, Respiratory Conditions, Behavioral Health, Critical Care