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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 4 of 4 Research Studies DisplayedAlthoff KN, Gebo KA, Moore RD
Contributions of traditional and HIV-related risk factors on non-AIDS-defining cancer, myocardial infarction, and end-stage liver and renal diseases in adults with HIV in the USA and Canada: a collaboration of cohort studies.
Adults with HIV have an increased burden of non-AIDS-defining cancers, myocardial infarction, end-stage liver disease, and end-stage renal disease. The objective of this study was to estimate the population attributable fractions (PAFs) of preventable or modifiable HIV-related and traditional risk factors for non-AIDS-defining cancers, myocardial infarction, end-stage liver disease, and end-stage renal disease outcomes.
AHRQ-funded; 90047713.
Citation: Althoff KN, Gebo KA, Moore RD .
Contributions of traditional and HIV-related risk factors on non-AIDS-defining cancer, myocardial infarction, and end-stage liver and renal diseases in adults with HIV in the USA and Canada: a collaboration of cohort studies.
Lancet HIV 2019 Feb;6(2):e93-e104. doi: 10.1016/s2352-3018(18)30295-9.
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Keywords: Cancer, Cardiovascular Conditions, Chronic Conditions, Kidney Disease and Health, Human Immunodeficiency Virus (HIV), Heart Disease and Health, Risk
Muzaale AD, Althoff KN, Sperati CJ
Risk of end-stage renal disease in HIV-positive potential live kidney donors.
New federal regulations allow HIV-positive individuals to be live kidney donors; however, potential candidacy for donation is poorly understood given the increased risk of end-stage renal disease (ESRD) associated with HIV infection. To better understand this risk, the investigators compared the incidence of ESRD among 41 968 HIV-positive participants of North America AIDS Cohort Collaboration on Research and Design with the incidence of ESRD among comparable HIV-negative participants of National Health and Nutrition Examination III.
AHRQ-funded; 90047713.
Citation: Muzaale AD, Althoff KN, Sperati CJ .
Risk of end-stage renal disease in HIV-positive potential live kidney donors.
Am J Transplant 2017 Jul;17(7):1823-32. doi: 10.1111/ajt.14235..
Keywords: Kidney Disease and Health, Human Immunodeficiency Virus (HIV), Kidney Disease and Health
Abraham AG, Althoff KN, Jing Y
End-stage renal disease among HIV-infected adults in North America.
Given the many potential contributors to ESRD risk, the goal of this study was to assess the relative contributions of clinical and demographic factors to ESRD. It found that HIV-infected ESRD cases were more likely to be of black race, have diabetes mellitus or hypertension, inject drugs, and/or have a prior AIDS-defining illness.
AHRQ-funded; 290201100007C.
Citation: Abraham AG, Althoff KN, Jing Y .
End-stage renal disease among HIV-infected adults in North America.
Clin Infect Dis 2015 Mar 15;60(6):941-9. doi: 10.1093/cid/ciu919..
Keywords: Kidney Disease and Health, Human Immunodeficiency Virus (HIV), Risk, Diabetes
Althoff KN, McGinnis KA, Wyatt CM
Comparison of risk and age at diagnosis of myocardial infarction, end-stage renal disease, and non-AIDS-defining cancer in HIV-infected versus uninfected adults.
The objective of this study was to compare the median age at, and risk of, incident diagnosis of 3 age-associated diseases in HIV-infected and demographically similar uninfected adults. It found that HIV-infected adults had a higher risk of these age-associated diseases (myocardial infarction, end-stage renal disease, and non-AIDS-defining cancer), but they occurred at similar ages to those without HIV.
AHRQ-funded; HS018372.
Citation: Althoff KN, McGinnis KA, Wyatt CM .
Comparison of risk and age at diagnosis of myocardial infarction, end-stage renal disease, and non-AIDS-defining cancer in HIV-infected versus uninfected adults.
Clin Infect Dis 2015 Feb 15;60(4):627-38. doi: 10.1093/cid/ciu869..
Keywords: Human Immunodeficiency Virus (HIV), Heart Disease and Health, Kidney Disease and Health, Cancer