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- Antibiotics (1)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 16 of 16 Research Studies DisplayedChovatiya R, Silverberg JI
Association of herpes zoster and chronic inflammatory skin disease in US inpatients.
The purpose of this study was to determine whether chronic inflammatory skin disease (CISD) is associated with herpes zoster (HZ). Data from the Nationwide Inpatient Sample 2002-2012 were analyzed. Findings showed that many CISDs are associated with increased hospitalization for HZ, even below the ages recommended for HZ vaccination. Recommendations included additional studies to establish CISD-specific vaccination guidelines.
AHRQ-funded; HS023011.
Citation: Chovatiya R, Silverberg JI .
Association of herpes zoster and chronic inflammatory skin disease in US inpatients.
J Am Acad Dermatol 2021 Dec;85(6):1437-45. doi: 10.1016/j.jaad.2019.12.073..
Keywords: Healthcare Cost and Utilization Project (HCUP), Skin Conditions, Chronic Conditions
Shaheen MS, Silverberg JI
Association of inflammatory skin diseases with venous thromboembolism in US adults.
Patients with certain inflammatory skin diseases have multiple risk factors for venous thromboembolism (VTE). The objective of the study was to determine whether atopic dermatitis (AD), psoriasis, pemphigus, pemphigoid and/or hidradenitis was associated with VTE in US adults. Data were analyzed from the 2002-2012 Nationwide Inpatient Sample, a representative cohort of US hospitalizations.
AHRQ-funded; HS023011.
Citation: Shaheen MS, Silverberg JI .
Association of inflammatory skin diseases with venous thromboembolism in US adults.
Arch Dermatol Res 2021 May;313(4):281-89. doi: 10.1007/s00403-020-02099-6..
Keywords: Healthcare Cost and Utilization Project (HCUP), Skin Conditions, Blood Clots, Risk
Narla S, Silverberg JI
The inpatient burden and comorbidities of pyoderma gangrenosum in adults in the United States.
The objective of this study was to determine the prevalence, predictors, outcomes, and costs of hospitalization for pyoderma gangrenosum (PG) in United States adults. Data from the 2002-2012 National Inpatient Sample were analyzed. Findings showed that PG admissions were more likely at teaching and medium or large hospitals. The majority of inpatients with PG were classified with minor or moderate likelihood of dying, but moderate and major loss of function. PG was associated with numerous other health disorders. This study demonstrated a substantial and increasing inpatient burden of PG in the United States, with considerable disability and mortality risk, multiple comorbid health disorders, and costs.
AHRQ-funded; HS023011.
Citation: Narla S, Silverberg JI .
The inpatient burden and comorbidities of pyoderma gangrenosum in adults in the United States.
Arch Dermatol Res 2021 May;313(4):245-53. doi: 10.1007/s00403-020-02098-7..
Keywords: Healthcare Cost and Utilization Project (HCUP), Skin Conditions, Injuries and Wounds, Hospitalization, Healthcare Costs
Lee HH, Patel KR, Singam V
Associations of cutaneous and extracutaneous infections with hidradenitis suppurativa in U.S. children and adults.
The purpose of this study was to determine whether Hidradenitis suppurativa (HS) is associated with cutaneous and extracutaneous infections and related outcomes. Using data from the Nationwide Inpatient Sample, results showed that adults and children with HS had increased acute and chronic, cutaneous, extracutaneous, and systemic infections, which were associated with increased mortality and cost.
AHRQ-funded; HS023011.
Citation: Lee HH, Patel KR, Singam V .
Associations of cutaneous and extracutaneous infections with hidradenitis suppurativa in U.S. children and adults.
Br J Dermatol 2020 Feb;182(2):327-34. doi: 10.1111/bjd.18093..
Keywords: Healthcare Cost and Utilization Project (HCUP), Skin Conditions, Children/Adolescents
Singam V, Rastogi S, Patel KR
The mental health burden in acne vulgaris and rosacea: an analysis of the US National Inpatient Sample.
Little is known about the mental health (MH) hospitalization among patients with acne and rosacea. The purpose of this study was to determine the MH disorders and cost burden associated with acne and rosacea. The investigators concluded that inpatients with acne or rosacea had increased odds of comorbid MH disorders. In particular, there was an increased number of hospital admissions secondary to a primary MH disorder with coexistent acne/rosacea. MH comorbidities were associated with considerable excess costs among inpatients with acne or rosacea.
AHRQ-funded; HS023011.
Citation: Singam V, Rastogi S, Patel KR .
The mental health burden in acne vulgaris and rosacea: an analysis of the US National Inpatient Sample.
Clin Exp Dermatol 2019 Oct;44(7):766-22. doi: 10.1111/ced.13919..
Keywords: Healthcare Cost and Utilization Project (HCUP), Skin Conditions, Behavioral Health, Hospitalization
Ren Z, Laumann AE, Silverberg JI
Association of dermatomyositis with systemic and opportunistic infections in the United States.
This study examined whether dermatomyositis is associated with opportunistic and antibiotic-resistant infections. Data was analyzed from the Nationwide Inpatient Sample from 2002 to 2012 with a cross-sectional representative 20% sample of all hospitalizations in the US. There was an association found with serious infections in adults and children, with more associated with adults. Infections were found in the skin, bone, joints, brain, heart, lungs, and gastrointestinal system. Predictors of infections included non-white race/ethnicity, insurance status, history of long-term corticosteroid usage, Cushing’s syndrome, diabetes and cancer. This in turn caused higher odds, costs, and inpatient mortality from these infections.
AHRQ-funded; HS023011.
Citation: Ren Z, Laumann AE, Silverberg JI .
Association of dermatomyositis with systemic and opportunistic infections in the United States.
Arch Dermatol Res 2019 Jul;311(5):377-87. doi: 10.1007/s00403-019-01913-0..
Keywords: Antibiotics, Healthcare Cost and Utilization Project (HCUP), Infectious Diseases, Risk, Skin Conditions
Ren Z, Hsu D, Brieva J
Association between climate, pollution and hospitalization for pemphigus in the USA.
The goal of this study was to determine whether the impact of ultraviolet exposure, climate factors and pollutants are associated with pemphigus exacerbation resulting in hospitalization. Data from the National Inpatient Sample was used. The findings indicate a significant statewide variation in the prevalence of hospitalization for pemphigus, with ‘hotspots’ in the southwest and northeast states. Higher rates of admission for pemphigus occurred during the summer and autumn months. All associations remained significant in multilevel regression models that controlled for age, sex and race/ethnicity, except for ultraviolet index, which was associated with pemphigus hospitalization only for Hispanic patients. The authors conclude that higher temperature, UV exposure. and small particle air pollution are associated with increased hospitalization for pemphigus, and that patients with pemphigus may benefit from avoidance of these potential environmental triggers.
AHRQ-funded; HS023011.
Citation: Ren Z, Hsu D, Brieva J .
Association between climate, pollution and hospitalization for pemphigus in the USA.
Clin Exp Dermatol 2019 Mar;44(2):135-43. doi: 10.1111/ced.13650..
Keywords: Healthcare Cost and Utilization Project (HCUP), Hospitalization, Skin Conditions
Patel KR, Singam V, Rastogi S
Association of vitiligo with hospitalization for mental health disorders in US adults.
The goal of this study was to examine the relationship between vitiligo and mental-health hospitalizations in the US using data from the National Inpatient Sample. Prevalence of hospitalization for mental-health disorders, length of stay (LOS), and cost of care were examined for patients with vitiligo in comparison with those without vitiligo. Hospitalization for mental-health disorders occurred more commonly in those with vitiligo. Vitiligo patients who were hospitalized with any mental-health disorder had higher LOS as well as cost of inpatient care.
AHRQ-funded; HS023011.
Citation: Patel KR, Singam V, Rastogi S .
Association of vitiligo with hospitalization for mental health disorders in US adults.
J Eur Acad Dermatol Venereol 2019 Jan;33(1):191-97. doi: 10.1111/jdv.15255..
Keywords: Healthcare Cost and Utilization Project (HCUP), Healthcare Costs, Hospitalization, Behavioral Health, Skin Conditions
Hsu DY, Smith B, Silverberg JI
Atopic dermatitis and hospitalization for mental health disorders in the United States.
Investigators analyzed data from the Nationwide Inpatient Sample (NIS) from 2002 to 2012 to determine the incidence of mental health (MH) emergencies with atopic dermatitis (AD). Primary admission for MH disorders associated with AD is known for adults with mood disorders, schizophrenia and developmental disorders.
AHRQ-funded; HS023011.
Citation: Hsu DY, Smith B, Silverberg JI .
Atopic dermatitis and hospitalization for mental health disorders in the United States.
Dermatitis 2019 Jan/Feb;30(1):54-61. doi: 10.1097/der.0000000000000418.
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Keywords: Healthcare Cost and Utilization Project (HCUP), Hospitalization, Behavioral Health, Skin Conditions
Kwa MC, Silverberg JI, Ardalan K
Inpatient burden of juvenile dermatomyositis among children in the United States.
The purpose of this study was to determine the prevalence and risk factors for hospitalization with juvenile dermatomyositis and assess inpatient burden of juvenile dermatomyositis (JDM). The study authors found that JDM contributes to both increased length of hospitalization and inpatient cost of care. Non-Medicaid government insurance was associated with higher rates of hospitalization for JDM while Hispanic and other non-white racial/ethnic groups demonstrated increased length of stay and cost of care.
AHRQ-funded; HS023011.
Citation: Kwa MC, Silverberg JI, Ardalan K .
Inpatient burden of juvenile dermatomyositis among children in the United States.
Pediatr Rheumatol Online J 2018 Nov 13;16(1):70. doi: 10.1186/s12969-018-0286-1..
Keywords: Children/Adolescents, Healthcare Costs, Healthcare Cost and Utilization Project (HCUP), Hospitalization, Skin Conditions
Hsu DY, Shinkai K, Silverberg JI
Epidemiology of eczema herpeticum in hospitalized U.S. children: analysis of a nationwide cohort.
This study used data from the Nationwide Inpatient Sample 2002-2012 to determine incidence, risk factors, comorbidities, costs, length of stay, and mortality in hospitalized children with Eczema herpeticum (EH). A higher risk was associated with younger age and non-white ethnicity (Asian in particular). However there was less frequency of hospitalization associated with lower income quartiles. The mortality incidence was 0.1%.
AHRQ-funded; HS023011.
Citation: Hsu DY, Shinkai K, Silverberg JI .
Epidemiology of eczema herpeticum in hospitalized U.S. children: analysis of a nationwide cohort.
J Invest Dermatol 2018 Feb;138(2):265-72. doi: 10.1016/j.jid.2017.08.039..
Keywords: Children/Adolescents, Healthcare Cost and Utilization Project (HCUP), Healthcare Costs, Hospitalization, Skin Conditions
Kwa MC, Silverberg JI
Association between inflammatory skin disease and cardiovascular and cerebrovascular co-morbidities in US adults: analysis of Nationwide Inpatient Sample data.
The objective of this study was to determine whether these inflammatory skin diseases are associated with increased cardiovascular/cerebrovascular risk and/or disease. It concluded that atopic dermatitis or eczema (AD-E), pemphigus, bullous pemphigoid (BP), and hidradenitis were all associated with increased cardiovascular and cerebrovascular risk, especially at younger age.
AHRQ-funded; HS023011.
Citation: Kwa MC, Silverberg JI .
Association between inflammatory skin disease and cardiovascular and cerebrovascular co-morbidities in US adults: analysis of Nationwide Inpatient Sample data.
Am J Clin Dermatol 2017 Dec;18(6):813-23. doi: 10.1007/s40257-017-0293-x.
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Keywords: Cardiovascular Conditions, Healthcare Cost and Utilization Project (HCUP), Risk, Skin Conditions
Kwa L, Kwa MC, Silverberg JI
Cardiovascular comorbidities of pediatric psoriasis among hospitalized children in the United States.
This study sought to determine if there is an association between pediatric psoriasis and cardiovascular comorbidities. It found that in multivariate survey logistic regression models adjusting for age, sex, and race/ethnicity, pediatric psoriasis was significantly associated with 5 of 10 cardiovascular comorbidities.
AHRQ-funded; HS023011.
Citation: Kwa L, Kwa MC, Silverberg JI .
Cardiovascular comorbidities of pediatric psoriasis among hospitalized children in the United States.
J Am Acad Dermatol 2017 Dec;77(6):1023-29. doi: 10.1016/j.jaad.2017.08.034.
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Keywords: Cardiovascular Conditions, Children/Adolescents, Healthcare Cost and Utilization Project (HCUP), Hospitalization, Skin Conditions
Kwa MC, Ardalan K, Laumann AE
Predictors of hospitalization, length of stay and costs of care among adults with dermatomyositis in the United States.
The researchers sought to determine the prevalence and risk factors for hospitalization with dermatomyositis and to assess inpatient burden of dermatomyositis. They concluded that there is a significant and increasing inpatient burden for dermatomyositis in the US. Also, there appear to be racial differences as non-whites have higher prevalence of admission, increased length of stay and cost of care.
AHRQ-funded; HS023011.
Citation: Kwa MC, Ardalan K, Laumann AE .
Predictors of hospitalization, length of stay and costs of care among adults with dermatomyositis in the United States.
Arthritis Care Res 2017 Sep;69(9):1391-99. doi: 10.1002/acr.23190.
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Keywords: Healthcare Cost and Utilization Project (HCUP), Hospitalization, Health Insurance, Skin Conditions
Narla S, Hsu DY, Thyssen JP
Inpatient financial burden of atopic dermatitis in the United States.
Little is known about the inpatient burden of atopic dermatitis (AD). The researchers sought to determine some risk factors and financial-burden of hospitalizations for AD in the US. They found that the high prevalence of hospitalization resulted in total inpatient costs of $8,288,083 per-year for adults and $3,333,868 per-year for children. In conclusion, there is a substantial inpatient financial-burden of AD in the US.
AHRQ-funded; HS023011.
Citation: Narla S, Hsu DY, Thyssen JP .
Inpatient financial burden of atopic dermatitis in the United States.
J Invest Dermatol 2017 Jul;137(7):1461-67. doi: 10.1016/j.jid.2017.02.975.
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Keywords: Healthcare Cost and Utilization Project (HCUP), Skin Conditions, Healthcare Costs, Hospitalization
Hsu DY, Brieva J, Silverberg NB
Pediatric Stevens-Johnson syndrome and toxic epidermal necrolysis in the United States.
In this study, the investigators sought to determine the morbidity, mortality, and comorbid health conditions of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in US children. They found that the incidences of SJS, SJS-TEN, and TEN were a mean 5.3, 0.8, and 0.4 cases per million children per year in the US, respectively.The investigators concluded that pediatric SJS/TEN poses a substantial health burden in the United States.
AHRQ-funded; HS023011.
Citation: Hsu DY, Brieva J, Silverberg NB .
Pediatric Stevens-Johnson syndrome and toxic epidermal necrolysis in the United States.
J Am Acad Dermatol 2017 May;76(5):811-17.e4. doi: 10.1016/j.jaad.2016.12.024..
Keywords: Children/Adolescents, Healthcare Cost and Utilization Project (HCUP), Skin Conditions