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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 11 of 11 Research Studies DisplayedKhodneva Y, Goyal P, Levitan EB
Depressive symptoms and incident hospitalization for heart failure: findings From the REGARDS Study.
The purpose of this study was to determine whether depressive symptoms are associated with incident heart failure (HF), including hospitalization for HF overall or by subtype: HF with preserved (HFpEF) or reduced ejection fraction (HFrEF). The study found that over a median of 9.2 years of follow-up, there were 872 incident HF hospitalizations, 526 among those without CHD and 334 among those with CHD. The age-adjusted HF hospitalization incidence rates per 1000 person-years were 4.9 for participants with depressive symptoms compared with 3.2 for participants without depressive symptoms. For overall HF, the elevated risk lessened after controlling for covariates. Among those without baseline CHD, when HFpEF was evaluated separately, after controlling for all covariates, depressive symptoms were related with incident hospitalization. In contrast, depressive symptoms were not related with incident HFrEF hospitalizations. The researchers concluded that among individuals without CHD at baseline, depressive symptoms were related with incident hospitalization for HFpEF, but not for those with baseline CHD or HFrEF.
AHRQ-funded; HS013852.
Citation: Khodneva Y, Goyal P, Levitan EB .
Depressive symptoms and incident hospitalization for heart failure: findings From the REGARDS Study.
J Am Heart Assoc 2022 Apr 5;11(7):e022818. doi: 10.1161/jaha.121.022818..
Keywords: Depression, Behavioral Health, Heart Disease and Health, Cardiovascular Conditions, Hospitalization, Risk
Dixon DD, Xu M, Akwo EA
Depressive symptoms and incident heart failure risk in the Southern Community Cohort Study.
This study’s aim was to examine whether greater frequency of depressive symptoms associates with increased risk of incident heart failure (HF). The authors studied 23,937 Black or White Southern Community Cohort Study participants (median age: 53 years, 70% Black, 64% women) enrolled between 2002 and 2009, without prevalent HF, who were receiving Centers for Medicare and Medicaid Services coverage. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (CESD-10) and incident HF ascertained from the Centers for Medicare and Medicaid Services International Classification of Diseases-9th Revision (ICD-9) (code: 428.x) and ICD-10 (codes: I50, I110) codes through December 31, 2016. The median CESD-10 score was 9. Over a median 11-year follow-up, 25% of participants developed HF. The strongest correlates of depressive symptoms were antidepressant medication use, age, and socioeconomic factors, rather than traditional HF risk factors. Greater frequency of depressive symptoms was associated with increased incident HF risk without variation by race or sex.
AHRQ-funded; HS026395.
Citation: Dixon DD, Xu M, Akwo EA .
Depressive symptoms and incident heart failure risk in the Southern Community Cohort Study.
JACC Heart Fail 2022 Apr;10(4):254-62. doi: 10.1016/j.jchf.2021.11.007..
Keywords: Depression, Heart Disease and Health, Cardiovascular Conditions, Risk
Sico JJ, Kundu S, So-Armah K
Depression as a risk factor for incident ischemic stroke among HIV-positive veterans in the veterans aging cohort study.
Background HIV infection and depression are each associated with increased ischemic stroke risk. Whether depression is a risk factor for stroke within the HIV population is unknown. In this study the investigators examined depression as a risk factor for incident ischemic stroke among HIV-positive veterans in the veterans aging cohort study. The investigators concluded that depression is associated with an increased risk of stroke among HIV-positive people after adjusting for sociodemographic characteristics, traditional cerebrovascular risk factors, and HIV-specific factors.
AHRQ-funded; HS023464.
Citation: Sico JJ, Kundu S, So-Armah K .
Depression as a risk factor for incident ischemic stroke among HIV-positive veterans in the veterans aging cohort study.
J Am Heart Assoc 2021 Jul 6;10(13):e017637. doi: 10.1161/jaha.119.017637..
Keywords: Depression, Behavioral Health, Risk, Human Immunodeficiency Virus (HIV), Stroke, Cardiovascular Conditions
Bobo WV, Ryu E, Petterson TM
Bi-directional association between depression and HF: an electronic health records-based cohort study.
This study examined whether heart failure (HF) patients were more likely to be diagnosed with depression, or patients with depression were more likely to be diagnosed with HF. This retrospective cohort study utilized electronic health records (EHRs) from a large healthcare system in 2006 for adults who received primary care services. The EHR identified 10,649 people with depression, and 5,911 people with HF between 2006 to 2018. In the depression cohort there were 2,024 newly diagnosed occurrences of HF, and 944 occurrences of newly diagnosed depression in the HF cohort over 4-6 years of follow-up. There was a significantly higher risk of developing HF in the depression cohort than vice versa.
AHRQ-funded; HS023077.
Citation: Bobo WV, Ryu E, Petterson TM .
Bi-directional association between depression and HF: an electronic health records-based cohort study.
J Comorb 2020 Jan-Dec;10:2235042x20984059. doi: 10.1177/2235042x20984059..
Keywords: Heart Disease and Health, Cardiovascular Conditions, Depression, Electronic Health Records (EHRs), Health Information Technology (HIT), Chronic Conditions
Jannat-Khah DP, Khodneva Y, Bryant K
Depressive symptoms do not discriminate: racial and economic influences between time-varying depressive symptoms and mortality among REGARDS participants.
This study examined whether time-varying depressive symptoms (TVDS) predict mortality and if racial and income differences moderate the association in a large cohort. The cohort from the REGARDS study was used to look at that determination. The REGARDS study used community-dwelling U.S. adults aged 45 years or older. They found that there was similar and statistically significant differences with white, black, and low-income ($35,000 or less) participants for the association between TVDS and mortality. High-income participants were found to have a lower hazard.
AHRQ-funded; HS025198.
Citation: Jannat-Khah DP, Khodneva Y, Bryant K .
Depressive symptoms do not discriminate: racial and economic influences between time-varying depressive symptoms and mortality among REGARDS participants.
Ann Epidemiol 2020 Jun;46:31-40.e2. doi: 10.1016/j.annepidem.2020.04.004..
Keywords: Depression, Behavioral Health, Racial and Ethnic Minorities, Cardiovascular Conditions, Cancer, Low-Income, Social Determinants of Health, Mortality
Moise N, Thanataveerat A, Florez-Salamanca L
Willingness to engage in traditional and novel depression treatment modalities among myocardial infarction survivors.
The authors assessed depression treatment attitudes, acceptability, and willingness by modality among myocardial infarction survivors with elevated depressive symptoms. They found that, despite positive attitudes and general willingness, only 20% were currently in therapy, perhaps due to suboptimal guideline implementation/symptom recognition, low motivation, and access/cost. Additionally, interest in self-help apps was low. The authors recommend further study to understand gaps between generally positive treatment attitudes and low treatment initiation rates.
AHRQ-funded; HS025198.
Citation: Moise N, Thanataveerat A, Florez-Salamanca L .
Willingness to engage in traditional and novel depression treatment modalities among myocardial infarction survivors.
J Gen Intern Med 2020 May;35(5):1620-22. doi: 10.1007/s11606-019-05406-8..
Keywords: Depression, Behavioral Health, Heart Disease and Health, Cardiovascular Conditions, Patient Adherence/Compliance
Yeh VM, Mayberry LS, Bachmann JM
Depressed mood, perceived health competence and health behaviors: a cross-sectional mediation study in outpatients with coronary heart disease.
Identifying potential mechanisms that link depressed mood with worse health behaviors is important given the prevalence of depressed mood in patients with coronary heart disease (CHD) and its relationship with subsequent mortality. Perceived health competence is an individual's confidence in his/her ability to successfully engineer solutions to achieve health goals and may explain how depressed mood affects multiple health behaviors. The objective of this study was to examine whether or not perceived health competence mediated the relationship between depressed mood and worse health behaviors.
AHRQ-funded; HS022990.
Citation: Yeh VM, Mayberry LS, Bachmann JM .
Depressed mood, perceived health competence and health behaviors: a cross-sectional mediation study in outpatients with coronary heart disease.
J Gen Intern Med 2019 Jul;34(7):1123-30. doi: 10.1007/s11606-018-4767-1..
Keywords: Depression, Behavioral Health, Heart Disease and Health, Cardiovascular Conditions, Patient Adherence/Compliance
Sumner JA, Khodneva Y, Muntner P
Effects of concurrent depressive symptoms and perceived stress on cardiovascular risk in low- and high-income participants: findings from the Reasons for Geographical and Racial Differences in Stroke (REGARDS) study.
Using data from the Reasons for Geographical and Racial Differences in Stroke (REGARDS) study, the authors examined associations among depressive symptoms and stress, alone and in combination, and incident cardiovascular disease (CVD) and all-cause mortality as a function of socioeconomic status. They found that screening for a combination of elevated depressive symptoms and stress in low-income persons may help identify those at increased risk of incident CVD and mortality.
AHRQ-funded; HS023009.
Citation: Sumner JA, Khodneva Y, Muntner P .
Effects of concurrent depressive symptoms and perceived stress on cardiovascular risk in low- and high-income participants: findings from the Reasons for Geographical and Racial Differences in Stroke (REGARDS) study.
J Am Heart Assoc 2016 Oct 10;5(10). doi: 10.1161/jaha.116.003930.
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Keywords: Cardiovascular Conditions, Depression, Social Determinants of Health, Stress, Stroke
Carney RM, Freedland KE, Steinmeyer BC
Collaborative care for depression symptoms in an outpatient cardiology setting: a randomized clinical trial.
The purpose of this study was to determine whether collaborative care (CC) for patients who screen positive for depression during an outpatient cardiology visit results in greater improvement in depression symptoms and better medical outcomes than seen in patients who screen positive for depression but receive only usual care (UC). Tthis trial did not show that CC produces better depression outcomes than UC.
AHRQ-funded; HS018335.
Citation: Carney RM, Freedland KE, Steinmeyer BC .
Collaborative care for depression symptoms in an outpatient cardiology setting: a randomized clinical trial.
Int J Cardiol 2016 Sep 15;219:164-71. doi: 10.1016/j.ijcard.2016.06.045.
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Keywords: Care Management, Cardiovascular Conditions, Depression, Healthcare Delivery, Behavioral Health, Outcomes, Ambulatory Care and Surgery, Teams
Womack VY, De Chavez PJ, Albrecht SS
A longitudinal relationship between depressive symptoms and development of metabolic syndrome: the Coronary Artery Risk Development in Young Adults study.
The researchers tested whether baseline and time-varying depressive symptoms were associated with metabolic syndrome incidence in black and white men and women from the Coronary Artery Risk Development in Young Adults study. They found that, over 15 years, the incidence rate of metabolic syndrome varied by race and sex, with the highest rate in black women followed by white men, black men, and white women. Depressive symptoms were associated with incident metabolic syndrome in white men and white women. However, they found no significant association between depression and metabolic syndrome among black men or black women.
AHRQ-funded; HS023009.
Citation: Womack VY, De Chavez PJ, Albrecht SS .
A longitudinal relationship between depressive symptoms and development of metabolic syndrome: the Coronary Artery Risk Development in Young Adults study.
Psychosom Med 2016 Sep;78(7):867-73. doi: 10.1097/psy.0000000000000347.
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Keywords: Cardiovascular Conditions, Depression, Racial and Ethnic Minorities, Sex Factors, Young Adults
Cummings DM, Kirian K, Howard G
Consequences of comorbidity of elevated stress and/or depressive symptoms and incident cardiovascular outcomes in diabetes: results from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.
The authors evaluated the impact of comorbid depressive symptoms and/or stress on adverse cardiovascular (CV) outcomes in individuals with diabetes compared with those without diabetes. They concluded that comorbid stress and/or depressive symptoms are common in individuals with diabetes and together are associated with progressively increased risks for adverse CV outcomes.
AHRQ-funded; HS023009.
Citation: Cummings DM, Kirian K, Howard G .
Consequences of comorbidity of elevated stress and/or depressive symptoms and incident cardiovascular outcomes in diabetes: results from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.
Diabetes Care 2016 Jan;39(1):101-9. doi: 10.2337/dc15-1174.
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Keywords: Cardiovascular Conditions, Depression, Diabetes, Patient-Centered Outcomes Research, Stress