National Healthcare Quality and Disparities Report
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- Cancer (1)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 11 of 11 Research Studies DisplayedMorrone K, Andreca M, Silver EJ
Associating a standardized reporting tool for chest radiographs with clinical complications in pediatric acute chest syndrome.
The objective of this retrospective cohort study was to analyze the interobserver agreement among pediatric radiologists' interpretations for pediatric acute chest syndrome (ACS) chest radiographs. The researchers also explored the association of radiographic findings with ACS complications. Data was taken from pediatric ACS admissions from a single institution in 2019. The results showed moderate to near-perfect agreement between radiologists. Left lower opacity, and pleural effusion were associated with increased risk of ACS complications.
AHRQ-funded.
Citation: Morrone K, Andreca M, Silver EJ .
Associating a standardized reporting tool for chest radiographs with clinical complications in pediatric acute chest syndrome.
Pediatr Pulmonol 2023 Nov; 58(11):3139-46. doi: 10.1002/ppul.26634..
Keywords: Children/Adolescents, Imaging, Sickle Cell Disease, Respiratory Conditions
Geanacopoulos AT, Neuman MI, Lipsett SC
Association of chest radiography with outcomes in pediatric pneumonia: a population-based study.
This study’s objective was to evaluate the association of performing a chest radiograph (CXR) with 7-day hospitalization after emergency department (ED) discharge among pediatric patients with community-acquired pneumonia (CAP). This retrospective cohort study included 206,694 children aged 3 months to 17 years discharged from any ED within 8 states from 2014 to 2019. Secondary outcomes included 7-day ED revisits and a 7-day hospitalization with severe CAP. Among these children diagnosed with CAP, rates of 7-day ED revisit, hospitalization, and severe CAP were 8.9%, 1.6%, and 0.4%, respectively. After adjusting for illness severity, CXR was associated with fewer 7-day hospitalizations (1.6% vs 1.7%). CXR performance varied somewhat between EDs (median 91.5%). EDs in the highest quartile had fewer 7-day hospitalizations (1.4% vs 1.9%), ED revisits (8.5% vs 9.4%), and hospitalizations for severe CAP (0.3% vs 0.5%) as compared to EDs with the lowest quartile of CXR utilization.
AHRQ-funded; HS026503.
Citation: Geanacopoulos AT, Neuman MI, Lipsett SC .
Association of chest radiography with outcomes in pediatric pneumonia: a population-based study.
Hosp Pediatr 2023 Jul; 13(7):614-23. doi: 10.1542/hpeds.2023-007142..
Keywords: Children/Adolescents, Imaging, Pneumonia, Respiratory Conditions, Community-Acquired Infections
Westafer LM, Kunz A, Bugajska P
Provider perspectives on the use of evidence-based risk stratification tools in the evaluation of pulmonary embolism: a qualitative study.
Providers often pursue imaging in patients at low risk of pulmonary embolism (PE), resulting in imaging yields <10% and false-positive imaging rates of 10% to 25%. Attempts to curb overtesting have had only modest success and no interventions have used implementation science frameworks. The objective of this study was to identify barriers and facilitators to the adoption of evidence-based diagnostic testing for PE.
AHRQ-funded; HS025701.
Citation: Westafer LM, Kunz A, Bugajska P .
Provider perspectives on the use of evidence-based risk stratification tools in the evaluation of pulmonary embolism: a qualitative study.
Acad Emerg Med 2020 Jun;27(6):447-56. doi: 10.1111/acem.13908..
Keywords: Respiratory Conditions, Evidence-Based Practice, Diagnostic Safety and Quality, Imaging, Decision Making, Clinical Decision Support (CDS), Practice Patterns, Provider: Physician, Provider: Clinician, Provider
Kotok D, Yang L, Evankovich JW
The evolution of radiographic edema in ARDS and its association with clinical outcomes: a prospective cohort study in adult patients.
The authors assessed the longitudinal evolution of radiographic edema using chest X-rays in patients with Acute Respiratory Distress Syndrome (ARDS) and examined its association with prognostic biomarkers, ARDS sub-phenotypes, and outcomes. They found that the Radiographic Assessment of Lung Edema (RALE) score was easily implementable with high inter-rater reliability. They concluded that the longitudinal RALE scoring appeared to be a reproducible approach to track the evolution of radiographic edema in patients with ARDS and could potentially predict prolonged need for mechanical ventilation.
AHRQ-funded; HS025455.
Citation: Kotok D, Yang L, Evankovich JW .
The evolution of radiographic edema in ARDS and its association with clinical outcomes: a prospective cohort study in adult patients.
J Crit Care 2020 Apr;56:222-28. doi: 10.1016/j.jcrc.2020.01.012..
Keywords: Respiratory Conditions, Imaging, Diagnostic Safety and Quality
Russell FM, Ehman RR, Ferre R
Design and rationale of the B-lines lung ultrasound guided emergency department management of acute heart failure (BLUSHED-AHF) pilot trial.
Medical treatment for acute heart failure (AHF) has not changed substantially over the last four decades. Emergency department (ED)-based evidence for treatment is limited. The investigators discuss BLUSHED-AHF, a multicenter, randomized, pilot trial designed to test whether a strategy of care that utilizes a LUS-driven treatment protocol outperforms usual care for reducing pulmonary congestion in the ED.
AHRQ-funded; HS025411.
Citation: Russell FM, Ehman RR, Ferre R .
Design and rationale of the B-lines lung ultrasound guided emergency department management of acute heart failure (BLUSHED-AHF) pilot trial.
Heart Lung 2019 May - Jun;48(3):186-92. doi: 10.1016/j.hrtlng.2018.10.027..
Keywords: Emergency Department, Heart Disease and Health, Cardiovascular Conditions, Imaging, Respiratory Conditions
Koziatek CA, Simon E, Horwitz LI
Automated pulmonary embolism risk classification and guideline adherence for computed tomography pulmonary angiography ordering.
The objective of this study was to measure the performance of automated, structured data-only versions of the Wells and revised Geneva risk scores in emergency department encounters during which a computed tomography pulmonary angiography was ordered. The hypothesis was that such an automated method would classify a patient's pulmonary embolism risk with high accuracy compared to manual chart review.
AHRQ-funded; HS024376.
Citation: Koziatek CA, Simon E, Horwitz LI .
Automated pulmonary embolism risk classification and guideline adherence for computed tomography pulmonary angiography ordering.
Acad Emerg Med 2018 Sep;25(9):1053-61. doi: 10.1111/acem.13442..
Keywords: Respiratory Conditions, Risk, Diagnostic Safety and Quality, Emergency Department, Imaging, Guidelines
Morabito J, Bell MT, Montenij LJ
Perioperative considerations for chylothorax.
This paper presents the case report of a 73 year old man with recurrent right pleural effusions, and a mediastinal mass of indeterminate etiology after a computer tomography-guided biopsy and thoracentesis. It discusses the perioperative considerations for chylothorax.
AHRQ-funded; HS024124.
Citation: Morabito J, Bell MT, Montenij LJ .
Perioperative considerations for chylothorax.
J Cardiothorac Vasc Anesth 2017 Dec;31(6):2277-81. doi: 10.1053/j.jvca.2017.06.001..
Keywords: Case Study, Imaging, Respiratory Conditions, Surgery
Wang RC, Bent S, Weber E
The impact of clinical decision rules on computed tomography use and yield for pulmonary embolism: a systematic review and meta-analysis.
The researchers performed a systematic review of impact analyses on clinical decision rules for pulmonary embolism. They found that among participants with suspected pulmonary embolism, implementation of the Wells criteria was associated with a modest increase in CT angiography yield. They concluded that there is a lack of cluster-randomized trials to confirm the efficacy of clinical decision rules for the diagnosis of pulmonary embolism.
AHRQ-funded; HS021281.
Citation: Wang RC, Bent S, Weber E .
The impact of clinical decision rules on computed tomography use and yield for pulmonary embolism: a systematic review and meta-analysis.
Ann Emerg Med 2016 Jun;67(6):693-701.e3. doi: 10.1016/j.annemergmed.2015.11.005.
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Keywords: Clinical Decision Support (CDS), Decision Making, Imaging, Respiratory Conditions
Gullett J, Donnelly JP, Sinert R
Interobserver agreement in the evaluation of B-lines using bedside ultrasound.
The researchers evaluated agreement among trained emergency physicians assessing the degree of B-line presence on bedside ultrasound in patients presenting to the emergency department (ED) with acute undifferentiated dyspnea. They concluded that interrater agreement was best in the anterior/superior thoracic zones followed by the lateral/superior zones for both expert/expert and expert/novice pairs.
AHRQ-funded; HS013852.
Citation: Gullett J, Donnelly JP, Sinert R .
Interobserver agreement in the evaluation of B-lines using bedside ultrasound.
J Crit Care 2015 Dec;30(6):1395-9. doi: 10.1016/j.jcrc.2015.08.021.
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Keywords: Emergency Department, Imaging, Respiratory Conditions
Smith SS, Ference EH, Evans CT
The prevalence of bacterial infection in acute rhinosinusitis: a systematic review and meta-analysis.
The primary objective of this systematic review of 29 studies was to assess the prevalence of bacterial infection in adults with clinically diagnosed acute rhinosinusitis (ARS) who undergo culture from antral puncture or endoscopically directed middle meatus culture. The review provides evidence that the prevalence of bacterial infection in patients with clinically diagnosed ARS remains poorly defined, but is likely greater than the 0.5% to 2% figure previously widely quoted.
AHRQ-funded; HS000078.
Citation: Smith SS, Ference EH, Evans CT .
The prevalence of bacterial infection in acute rhinosinusitis: a systematic review and meta-analysis.
Laryngoscope 2015 Jan;125(1):57-69. doi: 10.1002/lary.24709..
Keywords: Diagnostic Safety and Quality, Imaging, Respiratory Conditions
Deppen SA, Blume JD, Kensinger CD
Accuracy of FDG-PET to diagnose lung cancer in areas with infectious lung disease: a meta-analysis.
The purpose of this study was to estimate the diagnostic accuracy of positron emission tomography (PET) combined with fludeoxyglucose F18 (FDG) for pulmonary modules suspicious for lung cancer in regions where infectious lung disease is endemic and compare the accuracy in regions where such disease is rare. It found that the accuracy of FDG-PET was extremely heterogeneous.
AHRQ-funded; HS021554.
Citation: Deppen SA, Blume JD, Kensinger CD .
Accuracy of FDG-PET to diagnose lung cancer in areas with infectious lung disease: a meta-analysis.
JAMA 2014 Sep 24;312(12):1227-36. doi: 10.1001/jama.2014.11488..
Keywords: Cancer, Cancer: Lung Cancer, Diagnostic Safety and Quality, Respiratory Conditions, Imaging