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Research Studies is a monthly compilation of research articles funded by AHRQ or authored by AHRQ researchers and recently published in journals or newsletters.
Results1 to 3 of 3 Research Studies Displayed
Pierorazio PM, Johnson MH, Patel HD
Management of renal masses and localized renal cancer: Systematic review and meta-analysis.
This review aimed to summarize evidence on effectiveness and comparative effectiveness of active surveillance (AS), thermal ablation (TA), and radical (RN) or partial nephrectomy (PN) for patients with a renal mass suspicious for localized renal cancer. It concluded that comparative studies demonstrated similar cancer-secific survival across management strategies, with some differences in renal functional outcomes, perioperative outcomes, and postoperative harms that should be considered when choosing a management strategy.
Citation: Pierorazio PM, Johnson MH, Patel HD . Management of renal masses and localized renal cancer: Systematic review and meta-analysis. J Urol 2016 Oct;296(4):989-99. doi: 10.1016/j.juro.2016.04.081.
Keywords: Cancer, Cancer: Renal Cancer, Comparative Effectiveness, Outcomes
Lipworth L, Morgans AK, Edwards TL
Renal cell cancer histological subtype distribution differs by race and sex.
The researchers examined racial differences in the distribution of histological subtypes of renal cell carcinoma (RCC) and associations with established RCC risk factors by subtype. They observed marked racial differences in the proportional subtype distribution of RCCs diagnosed at a large tertiary care academic centre. To their knowledge, no previous study has examined racial differences in the distribution of RCC histologies while adjusting for ESRD.
Citation: Lipworth L, Morgans AK, Edwards TL . Renal cell cancer histological subtype distribution differs by race and sex. BJU Int 2016 Feb;117(2):260-5. doi: 10.1111/bju.12950.
Keywords: Kidney Disease and Health, Cancer: Renal Cancer, Cancer, Racial / Ethnic Minorities, Racial / Ethnic Minorities
Geynisman DM, Hu JC, Liu L
Treatment patterns and costs for metastatic renal cell carcinoma patients with private insurance in the United States.
The researchers used a large claims database to examine the evolution of treatment patterns and associated costs for 1527 metastatic renal cell carcinoma (mRCC) patients in the United States. They found that the treatment of mRCC has transitioned from cytokines and cytotoxic chemotherapy to almost exclusively targeted therapy. Cost of care for mRCC is rising each year, and out-of-pocket costs for patients are significant.
AHRQ-funded; HS018535; HS020263.
Citation: Geynisman DM, Hu JC, Liu L . Treatment patterns and costs for metastatic renal cell carcinoma patients with private insurance in the United States. Clin Genitourin Cancer 2015 Apr;13(2):e93-100. doi: 10.1016/j.clgc.2014.08.013..
Keywords: Cancer: Renal Cancer, Health Insurance, Value, Healthcare Costs, Data