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Search All Research Studies
AHRQ Research Studies Date
Topics
- Adverse Drug Events (ADE) (3)
- Adverse Events (1)
- Ambulatory Care and Surgery (2)
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- (-) Opioids (17)
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- Policy (2)
- Practice Patterns (1)
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- Substance Abuse (10)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 17 of 17 Research Studies DisplayedMeisel ZF, Metlay JP, Sinnenberg L
A randomized trial testing the effect of narrative vignettes versus guideline summaries on provider response to a professional organization clinical policy for safe opioid prescribing.
The authors compared whether narrative vignettes embedded in the American College of Emergency Physicians (ACEP) daily e-newsletter improved dissemination of the clinical policy to ACEP members, and engagement of members with the clinical policy, compared with traditional summary text. They found that the vignettes outperformed traditional guideline text in promoting engagement with an evidence-based clinical guideline related to opioid prescriptions.
AHRQ-funded; HS021956.
Citation: Meisel ZF, Metlay JP, Sinnenberg L .
A randomized trial testing the effect of narrative vignettes versus guideline summaries on provider response to a professional organization clinical policy for safe opioid prescribing.
Ann Emerg Med 2016 Dec;68(6):719-28. doi: 10.1016/j.annemergmed.2016.03.007.
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Keywords: Communication, Evidence-Based Practice, Guidelines, Opioids, Medication, Medication: Safety, Policy, Provider
Ducoffe AR, York A, Hu DJ
AHRQ Author: Perfetto D
National action plan for adverse drug event prevention: recommendations for safer outpatient opioid use.
This article focuses on recommendations from the Adverse Drug Events (ADE) Action Plan to help guide safer opioid use in healthcare delivery settings. Its aim is to discuss current federal methods in place to prevent opioid ADEs while also providing evidence to encourage providers and hospitals to innovate new systems and practices to increase prevention.
AHRQ-authored.
Citation: Ducoffe AR, York A, Hu DJ .
National action plan for adverse drug event prevention: recommendations for safer outpatient opioid use.
Pain Med 2016 Dec;17(12):2291-304. doi: 10.1093/pm/pnw106.
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Keywords: Prevention, Opioids, Patient Safety, Ambulatory Care and Surgery, Adverse Drug Events (ADE)
Banerjee G, Edelman EJ, Barry DT
Non-medical use of prescription opioids is associated with heroin initiation among US veterans: a prospective cohort study.
The researchers estimated the influence of non-medical use of prescription opioids on heroin initiation among US veterans receiving medical care. Using a multivariable Cox regression model, they found that non-medical use of prescription opioids was associated positively and independently with heroin initiation.
AHRQ-funded; HS021112; HS023258.
Citation: Banerjee G, Edelman EJ, Barry DT .
Non-medical use of prescription opioids is associated with heroin initiation among US veterans: a prospective cohort study.
Addiction 2016 Nov;111(11):2021-31. doi: 10.1111/add.13491.
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Keywords: Medication, Opioids, Substance Abuse
Gaither JR, Goulet JL, Becker WC
The effect of substance use disorders on the association between guideline-concordant long-term opioid therapy and all-cause mortality.
The objective of this study was to determine whether the presence of a substance use disorder (SUD) modifies the association between guideline-concordant care and 1-year all-cause mortality among patients receiving long-term opioid therapy (LtOT) for pain. It found that for clinicians prescribing LtOT to patients with untreated SUDs, engaging patients with psychotherapeutic and SUD treatment services may reduce mortality.
AHRQ-funded; U19 HS021112.
Citation: Gaither JR, Goulet JL, Becker WC .
The effect of substance use disorders on the association between guideline-concordant long-term opioid therapy and all-cause mortality.
J Addict Med 2016 Nov/Dec;10(6):418-28. doi: 10.1097/adm.0000000000000255.
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Keywords: Care Management, Medication, Mortality, Substance Abuse, Opioids, Patient-Centered Outcomes Research
Naples JG, Gellad WF, Hanlon JT
The role of opioid analgesics in geriatric pain management.
This article reviews the epidemiology of opioid use and their effectiveness for chronic noncancer pain (CNCP) in older adults and summarizes important age-related changes in opioid pharmacokinetics and pharmacodynamics that increase the risks of adverse effects in the elderly. Finally, to assist clinicians with selecting appropriate therapy, the article concludes with an evidence-based approach to optimize opioid prescribing in older adults with CNCP.
AHRQ-funded; HS023779.
Citation: Naples JG, Gellad WF, Hanlon JT .
The role of opioid analgesics in geriatric pain management.
Clin Geriatr Med 2016 Nov;32(4):725-35. doi: 10.1016/j.cger.2016.06.006.
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Keywords: Chronic Conditions, Elderly, Medication, Opioids, Pain, Patient Safety
Kennedy-Hendricks A, McGinty EE, Barry CL
Effects of competing narratives on public perceptions of opioid pain reliever addiction during pregnancy.
The researchers tested the effects of narratives portraying a woman with opioid pain reliever addiction during pregnancy on beliefs about people addicted to opioid pain relievers, perceptions of treatment effectiveness, policy attitudes, and emotional responses. They found that the extent to which narratives portraying successfully treated addiction affected public attitudes depended on the socioeconomic status of the woman portrayed.
AHRQ-funded; HS000029.
Citation: Kennedy-Hendricks A, McGinty EE, Barry CL .
Effects of competing narratives on public perceptions of opioid pain reliever addiction during pregnancy.
J Health Polit Policy Law 2016 Oct;41(5):873-916. doi: 10.1215/03616878-3632230.
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Keywords: Opioids, Pain, Pregnancy, Social Stigma, Substance Abuse
Kennedy-Hendricks A, Busch SH, McGinty EE
Primary care physicians' perspectives on the prescription opioid epidemic.
The authors aimed to determine primary care physicians' perceptions of the seriousness of the prescription opioid epidemic, its causes, groups responsible for addressing it, attitudes toward individuals with prescription opioid use disorder, beliefs about the effectiveness of addiction treatments, and support for various policies. They found that respondents largely attributed the causes to individual-oriented factors and certain physician-oriented factors, and that respondents believed that individuals with prescription opioid use disorder and physicians were primarily responsible for addressing the problem. The researchers also found that negative attitudes toward people with prescription opioid use disorder were prevalent, but a majority believed that treatment could be effective.
AHRQ-funded; HS000029.
Citation: Kennedy-Hendricks A, Busch SH, McGinty EE .
Primary care physicians' perspectives on the prescription opioid epidemic.
Drug Alcohol Depend 2016 Aug 1;165:61-70. doi: 10.1016/j.drugalcdep.2016.05.010.
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Keywords: Behavioral Health, Medication, Opioids, Primary Care, Substance Abuse
Kennedy-Hendricks A, Gielen A, McDonald E
Medication sharing, storage, and disposal practices for opioid medications among US adults.
The authors conducted a national survey among US adults with recent opioid medication use to examine the pervasiveness of sharing opioid medications, medication storage and disposal practices, and the sources of information received. Their findings suggested that current practices related to sharing, storing, and disposing of opioid medications, as well as communication of information on these topics, are suboptimal. They recommended that more research is needed to identify effective strategies to advance safer practices related to opioid medication sharing, storage, and disposal.
AHRQ-funded; HS000029.
Citation: Kennedy-Hendricks A, Gielen A, McDonald E .
Medication sharing, storage, and disposal practices for opioid medications among US adults.
JAMA Intern Med 2016 Jul;176(7):1027-9. doi: 10.1001/jamainternmed.2016.2543.
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Keywords: Medication: Safety, Medication, Opioids, Patient Safety, Substance Abuse
Penti B, Liebschutz JM, Kopcza B
Novel peer review method for improving controlled substance prescribing in primary care.
The authors sought to determine if peer feedback through a chart review tool (CRT) can impact opioid prescribing for patients with chronic noncancer pain in an outpatient family medicine clinic at an urban, safety-net teaching hospital. They reviewed 99 patient charts from 14 physicians over 1 year. They found that the mean dose of opioids decreased 2.6 mg morphine equivalent dose (MED)/day from time of chart review until the end of the project, compared to a 6.9 mg MED/day increase that occurred from 12 months prior to chart review to the time of chart review, and 14 patients were taken off of opioids after the chart review.
AHRQ-funded; HS022242.
Citation: Penti B, Liebschutz JM, Kopcza B .
Novel peer review method for improving controlled substance prescribing in primary care.
J Opioid Manag 2016 Jul-Aug;12(4):269-79. doi: 10.5055/jom.2016.0342.
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Keywords: Adverse Drug Events (ADE), Medication, Opioids, Primary Care, Practice Patterns
Gaither JR, Goulet JL, Becker WC
The association between receipt of guideline-concordant long-term opioid therapy and all-cause mortality.
The researchers' objective was to determine the association between receipt of guideline-concordant long-term opioid therapy (LtOT) and 1-year all-cause mortality. They found no association between all-cause mortality and primary care visits or urine drug testing and recommended that providers use caution in initiating LtOT in conjunction with benzodiazepines and untreated substance use disorders.
AHRQ-funded; HS021112.
Citation: Gaither JR, Goulet JL, Becker WC .
The association between receipt of guideline-concordant long-term opioid therapy and all-cause mortality.
J Gen Intern Med 2016 May;31(5):492-501. doi: 10.1007/s11606-015-3571-4.
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Keywords: Guidelines, Mortality, Opioids, Patient-Centered Outcomes Research, Substance Abuse
McGinty EE, Kennedy-Hendricks A, Baller J
Criminal activity or treatable health condition? News media framing of opioid analgesic abuse in the United States, 1998-2012.
The authors conducted an analysis of the volume and content of news media coverage of opioid analgesic abuse over a 15-year period from 1998 to 2012. They found that news media more often frame the problem as a criminal justice issue, rather than a public health crisis. The most frequently mentioned cause of the problem was illegal drug dealing, and the most frequently mentioned solutions were law enforcement solutions. Prevention-oriented approaches were mentioned more frequently in the latter years of the study period, but few of the news stories overall mentioned expanding substance abuse treatment, and even fewer mentioned expanding access to evidence-based medication-assisted treatments.
AHRQ-funded; HS000029.
Citation: McGinty EE, Kennedy-Hendricks A, Baller J .
Criminal activity or treatable health condition? News media framing of opioid analgesic abuse in the United States, 1998-2012.
Psychiatr Serv 2016 Apr;67(4):405-11. doi: 10.1176/appi.ps.201500065.
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Keywords: Communication, Medication, Opioids, Substance Abuse
Kennedy-Hendricks A, Richey M, McGinty EE
Opioid overdose deaths and Florida's crackdown on pill mills.
The researchers examined the effect on opioid overdose mortality of Florida state laws and law enforcement operations targeting "pill mills." They found that Florida's actions were associated with an estimated 1029 lives saved from prescription opioid overdose over a 34-month period, and estimated reductions in deaths grew over the intervention period.
AHRQ-funded; HS000029.
Citation: Kennedy-Hendricks A, Richey M, McGinty EE .
Opioid overdose deaths and Florida's crackdown on pill mills.
Am J Public Health 2016 Feb;106(2):291-7. doi: 10.2105/ajph.2015.302953.
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Keywords: Policy, Medication, Medication: Safety, Mortality, Opioids
Waljee JF, Zhong L, Hou H
The use of opioid analgesics following common upper extremity surgical procedures: a national, population-based study.
The authors examined the use of opioids following outpatient upper extremity procedures to discern the variation by procedure type and patient factors. They found that current opioid users are more likely to require postoperative opioid analgesics for routine procedures and more likely to receive inappropriate prescriptions.
AHRQ-funded; HS023313.
Citation: Waljee JF, Zhong L, Hou H .
The use of opioid analgesics following common upper extremity surgical procedures: a national, population-based study.
Plast Reconstr Surg 2016 Feb;137(2):355e-64e. doi: 10.1097/01.prs.0000475788.52446.7b..
Keywords: Ambulatory Care and Surgery, Medication, Opioids, Pain, Surgery
Kuo YF, Raji MA, Chen NW
Trends in opioid prescriptions among Part D Medicare recipients From 2007 to 2012.
The researchers used national Medicare data from 2007-2012 to assess temporal and geographic trends in rates of opioid prescription and relationship to opioid toxicity and different state regulations in Part D Medicare recipients. Their analyses of the Medicare data demonstrated substantial growth in opioid prescriptions from 2007 to 2011 and large variation in opioid prescriptions across states.
AHRQ-funded; HS022134.
Citation: Kuo YF, Raji MA, Chen NW .
Trends in opioid prescriptions among Part D Medicare recipients From 2007 to 2012.
Am J Med 2016 Feb;129(2):221.e21-30. doi: 10.1016/j.amjmed.2015.10.002..
Keywords: Chronic Conditions, Elderly, Medicare, Medication, Opioids, Pain
Barry CL, Kennedy-Hendricks A, Gollust SE
Understanding Americans' views on opioid pain reliever abuse.
Using a public opinion survey, the authors examined Americans' personal experience with opioid pain reliever use and abuse, and views about the seriousness of the problem, factors causing it, responsibility for addressing it and support for policies to resolve it. Fifty-eight percent of respondents ranked the problem as serious, on a par with other major health concerns. Individual-orientated factors, including a lack of understanding about how easy it is to become addicted and improper storage and disposal ranked highest as causes, and those abusing opioid pain relievers and their physicians were viewed as most responsible for solving the problem. Of the policies recommended to curb the epidemic, 14 out of 16 were supported by a majority of Americans.
AHRQ-funded; HS000029.
Citation: Barry CL, Kennedy-Hendricks A, Gollust SE .
Understanding Americans' views on opioid pain reliever abuse.
Addiction 2016 Jan;111(1):85-93. doi: 10.1111/add.13077.
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Keywords: Medication, Opioids, Pain, Substance Abuse
Raebel MA, Newcomer SR, Reifler LM
Chronic use of opioid medications before and after bariatric surgery.
This study of 11,179 obese patients receiving bariatric surgery found that among the 933 who were using opioids chronically before bariatric surgery, 77 percent continued chronic opioid use in the year following surgery (excluding the first 30 days after surgery). The amount of chronic opioid use was greater postoperatively than preoperatively.
AHRQ-funded; HS019912
Citation: Raebel MA, Newcomer SR, Reifler LM .
Chronic use of opioid medications before and after bariatric surgery.
JAMA. 2013 Oct 2;310(13):1369-76. doi: 10.1001/jama.2013.278344..
Keywords: Medication, Obesity, Opioids, Pain, Substance Abuse, Surgery
Katz DF, Sun J, Khatri V
QTc interval screening in an opioid treatment program.
This pilot study supports the feasibility of implementing a population-based electrocardiographic monitoring program in order to decrease the QTc interval in high-risk patients undergoing methadone maintenance in an opioid treatment program. Clinical characteristics alone were inadequate to identify patients in need of electrocardiographic screening.
AHRQ-funded; HS021138
Citation: Katz DF, Sun J, Khatri V .
QTc interval screening in an opioid treatment program.
Am J Cardiol. 2013 Oct 1;112(7):1013-8. doi: 10.1016/j.amjcard.2013.05.037..
Keywords: Opioids, Medication, Substance Abuse, Screening, Adverse Drug Events (ADE), Adverse Events, Medication: Safety, Risk, Implementation