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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 3 of 3 Research Studies DisplayedDesai RJ, Wyss R, Jin Y
Extension of disease risk score-based confounding adjustments for multiple outcomes of interest: an empirical evaluation.
Use of disease risk score (DRS)-based confounding adjustment when estimating treatment effects on multiple outcomes is not well studied. In this empirical cohort study, the investigators compared dabigatran initiators and warfarin initiators with respect to risks of ischemic stroke and major bleeding in 12 sequential monitoring periods (90 days each), using data from the Truven Marketscan database (Truven Health Analytics, Ann Arbor, Michigan).
AHRQ-funded; HS022193.
Citation: Desai RJ, Wyss R, Jin Y .
Extension of disease risk score-based confounding adjustments for multiple outcomes of interest: an empirical evaluation.
Am J Epidemiol 2018 Nov;187(11):2439-48. doi: 10.1093/aje/kwy130.
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Keywords: Blood Thinners, Cardiovascular Conditions, Medication, Outcomes, Research Methodologies, Risk, Stroke
Wang SV, Maro JC, Baro E
Data mining for adverse drug events with a propensity score-matched tree-based scan statistic.
In this study, the investigators propose a method that combines tree-based scan statistics with propensity score-matched analysis of new initiator cohorts, a robust design for investigations of drug safety. They subsequently conducted plasmode simulations to evaluate performance. The authors suggest that TreeScan with propensity score matching shows promise as a method for screening and prioritization of potential adverse events.
AHRQ-funded; HS022193.
Citation: Wang SV, Maro JC, Baro E .
Data mining for adverse drug events with a propensity score-matched tree-based scan statistic.
Epidemiology 2018 Nov;29(6):895-903. doi: 10.1097/ede.0000000000000907..
Keywords: Adverse Drug Events (ADE), Adverse Events, Patient Safety, Medication, Medication: Safety, Data, Research Methodologies
Crossley JR, Tan TP, Smith KH
Review of clinical trial settings of drugs commonly used in primary care and approved between 2005 and 2012.
This study examined where clinical trial settings are conducted for drugs commonly used in primary care that were approved by the FDA between 2005 and 2012. The majority of clinical trials did not specify if the trials were conducted at a primary care facility or a specialist, however, of the principal investigators (PIs) the vast majority were specialty physicians. The authors believe that more adverse drug events would occur in clinical trials taking place at specialist offices due to more patients with comorbidities going there for treatment. An initiative called the FDA Drug Trials Snapshots was cited as a way to provide more demographic information of trial participants.
AHRQ-funded; HS022882.
Citation: Crossley JR, Tan TP, Smith KH .
Review of clinical trial settings of drugs commonly used in primary care and approved between 2005 and 2012.
J Gen Intern Med 2018 Sep;33(9):1431-32. doi: 10.1007/s11606-018-4486-7..
Keywords: Medication, Primary Care, Research Methodologies