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AHRQ Research Studies Date
Topics
- Cancer (1)
- (-) Comparative Effectiveness (7)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 7 of 7 Research Studies DisplayedMa X, Lin L, Qu Z
Performance of between-study heterogeneity measures in the Cochrane Library.
The growth in comparative effectiveness research and evidence-based medicine has increased attention to systematic reviews and meta-analyses. Assessing heterogeneity is critical for performing a meta-analysis and interpreting results. This article evaluates two heterogeneity measures. To evaluate these measures' performance empirically, the investigators applied them to 20,599 meta-analyses in the Cochrane Library.
AHRQ-funded; HS024743.
Citation: Ma X, Lin L, Qu Z .
Performance of between-study heterogeneity measures in the Cochrane Library.
Epidemiology 2018 Nov;29(6):821-24. doi: 10.1097/ede.0000000000000857..
Keywords: Comparative Effectiveness, Evidence-Based Practice, Patient-Centered Outcomes Research, Research Methodologies
Simon KC, Tideman S, Hillman L
Design and implementation of pragmatic clinical trials using the electronic medical record and an adaptive design.
The purpose of this study was to demonstrate the feasibility of pragmatic clinical trials comparing the effectiveness of treatments using the electronic medical record (EMR) and an adaptive assignment design. The authors suggest that the demonstration of successful pragmatic clinical trials based on a customized EMR and adaptive design is an important next step in achieving personalized medicine and provides a framework for future studies of comparative effectiveness.
AHRQ-funded; HS024057.
Citation: Simon KC, Tideman S, Hillman L .
Design and implementation of pragmatic clinical trials using the electronic medical record and an adaptive design.
JAMIA Open 2018 Jul;1(1):99-106. doi: 10.1093/jamiaopen/ooy017..
Keywords: Comparative Effectiveness, Electronic Health Records (EHRs), Health Information Technology (HIT), Research Methodologies, System Design
Tian L, Fu H, Ruberg SJ
Efficiency of two sample tests via the restricted mean survival time for analyzing event time observations.
This article assesses the relative efficiency of the hazard ratio (HR) and restricted means survival time or t-year mean survival time (t-MST) tests with respect to the statistical power under various proportional hazards (PH) and non-PH models, both theoretically and empirically. The results indicate that when the PH assumption is valid, the t-MST test performs almost as well as the HR test, but for non-PH models, the t-MST test can substantially outperform its HR counterpart. The authors discuss issues and implications regarding their sample tests.
AHRQ-funded; HS022193.
Citation: Tian L, Fu H, Ruberg SJ .
Efficiency of two sample tests via the restricted mean survival time for analyzing event time observations.
Biometrics 2018 Jun;74(2):694-702. doi: 10.1111/biom.12770..
Keywords: Comparative Effectiveness, Research Methodologies
Hoffman SR, Vines AI, Halladay JR
Optimizing research in symptomatic uterine fibroids with development of a computable phenotype for use with electronic health records.
The objective of the study was to develop an electronic health record-based algorithm to identify women with symptomatic uterine fibroids for a comparative effectiveness study of medical or surgical treatments on quality-of-life measures. The study concluded that an electronic health record-based algorithm is capable of identifying cases of symptomatic uterine fibroids with moderate positive predictive value and may be an efficient approach for large-scale study recruitment.
AHRQ-funded; HS023418.
Citation: Hoffman SR, Vines AI, Halladay JR .
Optimizing research in symptomatic uterine fibroids with development of a computable phenotype for use with electronic health records.
Am J Obstet Gynecol 2018 Jun;218(6):610.e1-10.e7. doi: 10.1016/j.ajog.2018.02.002..
Keywords: Comparative Effectiveness, Electronic Health Records (EHRs), Research Methodologies, Women
Horiguchi M, Tian L, Uno H
Quantification of long-term survival benefit in a comparative oncology clinical study.
The authors discuss the quantification of long-term survival benefit in a comparative oncology clinical study. They assert that from the perspective of cost-risk-benefit, using a long-term survival benefit criterion for selecting anticancer therapies may be more appropriate.
AHRQ-funded; HS022193.
Citation: Horiguchi M, Tian L, Uno H .
Quantification of long-term survival benefit in a comparative oncology clinical study.
JAMA Oncol 2018 Jun;4(6):881-82. doi: 10.1001/jamaoncol.2018.0518..
Keywords: Cancer, Comparative Effectiveness, Outcomes, Research Methodologies
Dahabreh IJ, Chung M, Kitsios GD
Survey of the methods and reporting practices in published meta-analyses of test performance: 1987 to 2009.
The researchers performed a survey of meta-analyses of test performance to describe the evolution in their methods and reporting. They found that the most common clinical areas were cardiovascular disease and oncology, while the most common test categories were imaging and biomarker tests. They concluded that the methods employed in meta-analyses of test performance have improved with the introduction of quality assessment checklists and the development of more sophisticated statistical methods.
AHRQ-funded; 290200710055I; HS013328.
Citation: Dahabreh IJ, Chung M, Kitsios GD .
Survey of the methods and reporting practices in published meta-analyses of test performance: 1987 to 2009.
Res Synth Methods 2013 Sep;4(3):242-55. doi: 10.1002/jrsm.1083.
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Keywords: Comparative Effectiveness, Diagnostic Safety and Quality, Research Methodologies
Schneeweiss S, Seeger JD, Jackson JW
AHRQ Author: Smith SR
Methods for comparative effectiveness research/patient-centered outcomes research: from efficacy to effectiveness.
This article provides an overview of papers in this supplement resulting from a June 2012 AHRQ-sponsored symposium on research methods for CER and patient-centered outcomes research.
AHRQ-authored.
Citation: Schneeweiss S, Seeger JD, Jackson JW .
Methods for comparative effectiveness research/patient-centered outcomes research: from efficacy to effectiveness.
J Clin Epidemiol 2013 Aug;66(8 Suppl):S1-4. doi: 10.1016/j.jclinepi.2013.05.012.
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Keywords: Comparative Effectiveness, Evidence-Based Practice, Patient-Centered Healthcare, Patient-Centered Outcomes Research, Research Methodologies