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AHRQ Research Studies Date
Topics
- Comparative Effectiveness (1)
- Decision Making (1)
- Diagnostic Safety and Quality (1)
- Dialysis (1)
- Emergency Department (2)
- Emergency Preparedness (1)
- Evidence-Based Practice (1)
- Guidelines (1)
- Healthcare Cost and Utilization Project (HCUP) (3)
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- (-) Influenza (7)
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- Vaccination (3)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 7 of 7 Research Studies DisplayedBartsch SM, Mitgang EA, Geller G
What if the influenza vaccine did not offer such variable protection?
This study looked at the impact of reducing the variability in responses to the influenza vaccine across the population. Protection from the vaccine can vary significantly from person to person due to differences in immune systems, body types, and other factors. The authors compared the projected cases, direct medical costs, and productivity losses at the 30%, 50%, and 70% efficacy rates.
AHRQ-funded; HS023317.
Citation: Bartsch SM, Mitgang EA, Geller G .
What if the influenza vaccine did not offer such variable protection?
J Infect Dis 2020 Sep 1;222(7):1138-44. doi: 10.1093/infdis/jiaa240..
Keywords: Influenza, Vaccination, Respiratory Conditions, Public Health
Butler AM, Layton JB, Dharnidharka VR
Comparative effectiveness of high-dose versus standard-dose influenza vaccine among patients receiving maintenance hemodialysis.
This study compared outcomes of routine dialysis patients who received either the standard dose vaccine (SDV) for influenza or a high-dose vaccine (HDV). Out of 22,215 influenza patient-seasons among adults 65 years and older, 97.4% received SDV and 2.6% received HDV. There did not seem to be any additional protection provided by the HDV for all-cause mortality or influenza-related outcomes.
AHRQ-funded; HS019455.
Citation: Butler AM, Layton JB, Dharnidharka VR .
Comparative effectiveness of high-dose versus standard-dose influenza vaccine among patients receiving maintenance hemodialysis.
Am J Kidney Dis 2020 Jan;75(1):72-83. doi: 10.1053/j.ajkd.2019.05.018..
Keywords: Vaccination, Influenza, Comparative Effectiveness, Dialysis, Kidney Disease and Health, Hospitalization, Outcomes
Dugas AF, Hsieh YH, LoVecchio F
Derivation and validation of a clinical decision guideline for influenza testing in 4 US emergency departments.
This study looked at which patients should be tested for influenza among adult emergency department (ED) patients with fever or respiratory symptoms who met criteria for antiviral treatment per 2013 CDC guidelines. A prospective cohort study was conducted at 4 US EDs from November 2013 to April 2014. All 1941 enrolled participants were tested for influenza using polymerase chain reaction (PCR), and 183 patients (9.4%) had influenza. The CDC clinical decision guidelines (CDGs) for influenza testing includes new or increased cough (2 points), headache (1 point), subjective fever (1 point), and triage temperature >100.4F degrees. The CDG had a sensitivity and specificity of 94.1% and 36.6% respectively in the derivation set and the validation set.
AHRQ-funded; HS009699.
Citation: Dugas AF, Hsieh YH, LoVecchio F .
Derivation and validation of a clinical decision guideline for influenza testing in 4 US emergency departments.
Clin Infect Dis 2020 Jan;70(1):49-58. doi: 10.1093/cid/ciz171..
Keywords: Guidelines, Decision Making, Influenza, Respiratory Conditions, Emergency Department, Evidence-Based Practice, Diagnostic Safety and Quality
Frentzel E, Jump RLP, Archbald-Pannone L
Recommendations for mandatory influenza vaccinations for health care personnel from AMDA's Infection Advisory Subcommittee.
Preventing influenza infections is a national health priority, particularly among geriatric and adults with frailty who reside in post-acute and long-term care (PALTC) settings. Older adults account for more than 70% of deaths from influenza, a reflection of decreased vaccine effectiveness in that age group. Annually vaccinating health care personnel (HCP) working with these patients against influenza is critical to reducing influenza morbidity and mortality among patients. In this paper, the authors discuss the recommendations for mandatory influenza vaccinations for health care personnel.
AHRQ-funded; HS023779.
Citation: Frentzel E, Jump RLP, Archbald-Pannone L .
Recommendations for mandatory influenza vaccinations for health care personnel from AMDA's Infection Advisory Subcommittee.
J Am Med Dir Assoc 2020 Jan;21(1):25-28.e2. doi: 10.1016/j.jamda.2019.11.008..
Keywords: Influenza, Vaccination, Provider, Policy
Shrestha S, Foxman B, Weinberger DM
AHRQ Author: Steiner C
Identifying the interaction between influenza and pneumococcal pneumonia using incidence data.
The authors integrated weekly incidence reports and a mechanistic transmission model within a likelihood-based inference framework to characterize the nature, timing, and magnitude of the interaction between influenza and pneumococcal pneumonia. They found support for a strong but short-lived interaction, with influenza infection increasing susceptibility to pneumococcal pneumonia ~100-fold. They inferred modest population-level impacts arising from strong processes at the level of an individual.
AHRQ-authored.
Citation: Shrestha S, Foxman B, Weinberger DM .
Identifying the interaction between influenza and pneumococcal pneumonia using incidence data.
Sci Transl Med 2013 Jun 26;5(191):191ra84. doi: 10.1126/scitranslmed.3005982.
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Keywords: Healthcare Cost and Utilization Project (HCUP), Influenza, Pneumonia
Braithwaite S, Friedman B, Mutter R
AHRQ Author: Friedman B, Mutter R
Microsimulation of financial impact of demand surge on hospitals: the H1N1 influenza pandemic of fall 2009.
Microsimulation was used to assess the financial impact on hospitals of a surge in influenza admissions in advance of the H1N1 pandemic in the fall of 2009 with the goal of estimating net income and losses of a response of filling unused hospital bed capacity proportionately and postponing elective admissions. They concluded that aggregate and distributional results did not suggest that a policy of promising additional financial compensation to hospitals in anticipation of the surge in flu cases was necessary.
AHRQ-authored.
Citation: Braithwaite S, Friedman B, Mutter R .
Microsimulation of financial impact of demand surge on hospitals: the H1N1 influenza pandemic of fall 2009.
Health Serv Res 2013 Apr;48(2 Pt 2):735-52. doi: 10.1111/1475-6773.12041.
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Keywords: Healthcare Costs, Healthcare Cost and Utilization Project (HCUP), Hospitalization, Influenza
Rubinson L, Mutter R, Viboud C
AHRQ Author: Mutter R
Impact of the fall 2009 influenza A(H1N1)pdm09 pandemic on US hospitals.
The authors investigated the impact of the 2009 influenza A(H1N1)pdm09 pandemic on US hospitals. They found that the fall 2009 pandemic period substantially impacted US hospitals, mostly through increased emergency department visits. Furhter, for a small proportion of hospitals that experienced a high surge in inpatient admissions, increased mortality from selected clinical conditions was associated with both prepandemic outcomes and surge, highlighting the linkage between daily hospital operations and disaster preparedness.
AHRQ-authored.
Citation: Rubinson L, Mutter R, Viboud C .
Impact of the fall 2009 influenza A(H1N1)pdm09 pandemic on US hospitals.
Med Care 2013 Mar;51(3):259-65. doi: 10.1097/MLR.0b013e31827da8ea.
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Keywords: Emergency Department, Emergency Preparedness, Healthcare Cost and Utilization Project (HCUP), Hospitals, Influenza