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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 32 Research Studies DisplayedBoland MR, Rusanov A, So Y
From expert-derived user needs to user-perceived ease of use and usefulness: a two-phase mixed-methods evaluation framework.
This paper presents a two-phase evaluation framework involving usability experts (phase 1) and end-users (phase 2). In phase 1, a cross-system functionality alignment between expert-derived user needs and system functions was performed to inform the choice of ‘‘the best available’’ comparison system to enable a cognitive walkthrough in phase 1 and a comparative effectiveness evaluation in phase 2.
AHRQ-funded; HS019853.
Citation: Boland MR, Rusanov A, So Y .
From expert-derived user needs to user-perceived ease of use and usefulness: a two-phase mixed-methods evaluation framework.
J Biomed Inform 2014 Dec;52:141-50. doi: 10.1016/j.jbi.2013.12.004..
Keywords: Comparative Effectiveness, Evidence-Based Practice, Research Methodologies
Dulai PS, Siegel CA, Colombel JF
Systematic review: monotherapy with antitumour necrosis factor alpha agents versus combination therapy with an immunosuppressive for IBD.
The authors discussed the efficacy and the risks of anti-TNF monotherapy versus combination therapy with an immunosuppressive in patients with IBD. They concluded that the addition of an immunosuppressive to anti-TNF therapy improves treatment efficacy for infliximab in ulcerative colitis and Crohn’s disease. Further, the use of combination therapy appears to add no significant incremental risk for serious infections above that seen with anti-TNF or immunosuppressive monotherapy in most patients.
AHRQ-funded; HS021747.
Citation: Dulai PS, Siegel CA, Colombel JF .
Systematic review: monotherapy with antitumour necrosis factor alpha agents versus combination therapy with an immunosuppressive for IBD.
Gut 2014 Dec;63(12):1843-53. doi: 10.1136/gutjnl-2014-307126.
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Keywords: Comparative Effectiveness, Evidence-Based Practice, Medication, Outcomes, Patient-Centered Outcomes Research, Treatments
Viswanathan M, Carey TS, Belinson SE
AHRQ Author: Berliner E, Chang SM
A proposed approach may help systematic reviews retain needed expertise while minimizing bias from nonfinancial conflicts of interest.
The researchers sought to create practical guidance on ensuring adequate clinical or content expertise while maintaining independence of judgment on systematic review teams. They discussed their approach and concluded that the feasibility and utility of this approach to ensuring needed expertise on systematic reviews and minimizing bias from nonfinancial conflicts of interest must be investigated.
AHRQ-authored.
Citation: Viswanathan M, Carey TS, Belinson SE .
A proposed approach may help systematic reviews retain needed expertise while minimizing bias from nonfinancial conflicts of interest.
J Clin Epidemiol 2014 Nov;67(11):1229-38. doi: 10.1016/j.jclinepi.2014.02.023.
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Keywords: Comparative Effectiveness, Evidence-Based Practice, Research Methodologies
Berliner E
AHRQ Author: Berliner E
Adopting medical technology.
This editorial described a study by Gold and colleagues within this issue concerning the treatment accelerated partial breast irradiation (APBI), which was incorporated into clinical practice with few data on its benefits and risks. Berliner recommends a coordinated approach to evidence generation.
AHRQ-authored.
Citation: Berliner E .
Adopting medical technology.
Med Decis Making 2014 Nov;34(8):948-50. doi: 10.1177/0272989x14546378.
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Keywords: Evidence-Based Practice, Medical Devices
Guise JM, Chang C, Viswanathan M
AHRQ Author: Chang C, Berliner E
Agency for Healthcare Research and Quality Evidence-based Practice Center methods for systematically reviewing complex multicomponent health care interventions.
The purpose of this AHRQ EPC methods white paper was to outline approaches to conducting systematic reviews of complex multicomponent health care interventions. It provided a framework for synthesizing studies of multicomponent interventions and also provided an initial list of critical reporting elements for such studies in order to help systematic reviewers understand the options and tradeoffs available for such reviews.
AHRQ-authored; AHRQ-funded; 290201200010I; 290201200012I; 290201200011I; 290201200015I; 290201200008I; 290201200004C.
Citation: Guise JM, Chang C, Viswanathan M .
Agency for Healthcare Research and Quality Evidence-based Practice Center methods for systematically reviewing complex multicomponent health care interventions.
J Clin Epidemiol 2014 Nov;67(11):1181-91. doi: 10.1016/j.jclinepi.2014.06.010.
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Keywords: Evidence-Based Practice, Healthcare Delivery, Health Services Research (HSR), Patient-Centered Outcomes Research, Research Methodologies
Finnerty M, Neese-Todd S, Bilder S
Best practices: MEDNET: a multistate policy maker-researcher collaboration to improve prescribing practices.
The authors describe the Medicaid/ Mental Health Network for Evidence-Based Treatment (MEDNET), the first multistate Medicaid QI collaborative to focus on improving psychotropic prescribing. In particular, this article includes the development, infrastructure challenges, and early evidence of success of this public-academic partnership.
AHRQ-funded; HSO19937; HS021112.
Citation: Finnerty M, Neese-Todd S, Bilder S .
Best practices: MEDNET: a multistate policy maker-researcher collaboration to improve prescribing practices.
Psychiatr Serv 2014 Nov 1;65(11):1297-9. doi: 10.1176/appi.ps.201400343..
Keywords: Behavioral Health, Evidence-Based Practice, Medication, Medicaid, Practice Patterns
Shaikh U, Nettiksimmons J, Joseph JG
Collaborative practice improvement for childhood obesity in rural clinics: the Healthy Eating Active Living Telehealth Community of Practice (HEALTH COP).
The authors assessed the impact of participation in a virtual quality improvement (QI) learning network on adherence to clinical guidelines for childhood obesity prevention in rural clinics. They found that children who received care from clinicians who led the implementation of the intervention at their clinic showed significant improvements in nutrition and physical activity. Virtual QI learning networks in geographically dispersed clinics can significantly increase clinicians' adherence to guidelines for childhood obesity and improve access to recommended care for rural and underserved children.
AHRQ-funded; HS018567.
Citation: Shaikh U, Nettiksimmons J, Joseph JG .
Collaborative practice improvement for childhood obesity in rural clinics: the Healthy Eating Active Living Telehealth Community of Practice (HEALTH COP).
Am J Med Qual 2014 Nov-Dec;29(6):467-75. doi: 10.1177/1062860613506252.
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Keywords: Children/Adolescents, Evidence-Based Practice, Health Information Technology (HIT), Lifestyle Changes, Nutrition, Obesity, Prevention, Quality Improvement, Rural Health, Telehealth
Cook EA, Schneider KM, Robinson J
Field methods in medical record abstraction: assessing the properties of comparative effectiveness estimates.
Comparative effectiveness studies using Medicare claims data are vulnerable to treatment selection biases and supplemental data from a sample of patients has been recommended for examining the magnitude of this bias. The investigators collected medical record data from a subsample of patients to assess the validity of assumptions and to aid in the interpretation of our estimates. In this paper, they sought to describe and document the process used to collect and validate this supplemental information.
AHRQ-funded; HS018381.
Citation: Cook EA, Schneider KM, Robinson J .
Field methods in medical record abstraction: assessing the properties of comparative effectiveness estimates.
BMC Health Serv Res 2014 Sep 15;14:391. doi: 10.1186/1472-6963-14-391..
Keywords: Comparative Effectiveness, Medicare, Evidence-Based Practice, Research Methodologies
Simianu VV, Bastawrous AL, Farrokhi ET
Addressing the appropriateness of elective colon resection for diverticulitis: a report from the SCOAP CERTAIN collaborative.
The aim of this study was to assess the clinician-reported indications for elective colectomy and describe trends in the number of prior episodes of diverticulitis. It found an increase in the proportion of cases that met expert-established guidelines for appropriate surgery, but nearly 1 in 3 still do not meet established criteria.
AHRQ-funded; HS020025
Citation: Simianu VV, Bastawrous AL, Farrokhi ET .
Addressing the appropriateness of elective colon resection for diverticulitis: a report from the SCOAP CERTAIN collaborative.
Ann Surg. 2014 Sep;260(3):533-8; discussion 38-9. doi: 10.1097/sla.0000000000000894..
Keywords: Decision Making, Surgery, Evidence-Based Practice, Guidelines
Tang DH, Warholak TL, Hines LE
Evaluation of Pharmacy and Therapeutic (P&T) Committee member knowledge, attitudes and ability regarding the use of comparative effectiveness research (CER) in health care decision-making.
This study was conducted to evaluate changes in CER knowledge, attitudes, and ability among Pharmacy and Therapeutics (P&T) Committee members and support staff after attending a tailored educational program. It found that the CER educational program was effective in increasing participants’ CER knowledge and self-perceived ability to evaluate relevant evidence.
AHRQ-funded; HS019220.
Citation: Tang DH, Warholak TL, Hines LE .
Evaluation of Pharmacy and Therapeutic (P&T) Committee member knowledge, attitudes and ability regarding the use of comparative effectiveness research (CER) in health care decision-making.
Res Social Adm Pharm 2014 Sep-Oct;10(5):768-80. doi: 10.1016/j.sapharm.2013.11.008..
Keywords: Comparative Effectiveness, Decision Making, Evidence-Based Practice
Jaana M, Vartak S, Ward MM
Evidence-based health care management: what is the research evidence available for health care managers?
The authors conducted a scoping review of systematic reviews and meta-analyses to determine the availability and accessibility of evidence for health care managers. They found that 96.5% of their search results were not on target, and they suggested a better classification within PubMed to increase the accessibility of meaningful resources and to facilitate evidence retrieval. They recommended that health care journals take initiatives encouraging the publication of reviews in relevant management areas.
AHRQ-funded; HS018396.
Citation: Jaana M, Vartak S, Ward MM .
Evidence-based health care management: what is the research evidence available for health care managers?
Eval Health Prof 2014 Sep;37(3):314-34. doi: 10.1177/0163278713511325.
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Keywords: Evidence-Based Practice, Health Services Research (HSR), Research Methodologies
Kealey E, Scholle SH, Byron SC
Quality concerns in antipsychotic prescribing for youth: a review of treatment guidelines.
The authors reviewed treatment guidelines relevant to 7 quality concepts for appropriate use and management of youth on antipsychotics.They found that all 7 quality concepts were strongly endorsed by 1 or more guidelines, and 2 or more guidelines assigned their highest strength of recommendation ratings to 6 of the 7 concepts. Two guidelines rated evidence, providing high strength of evidence for 2 quality concepts.
AHRQ-funded; HS020503.
Citation: Kealey E, Scholle SH, Byron SC .
Quality concerns in antipsychotic prescribing for youth: a review of treatment guidelines.
Acad Pediatr 2014 Sep-Oct;14(5 Suppl):S68-75. doi: 10.1016/j.acap.2014.05.009.
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Keywords: Evidence-Based Practice, Children/Adolescents, Guidelines, Quality of Care, Medication
Henrikson NB, Anderson ML, Hubbard RA
Employee knowledge of value-based insurance design benefits.
The authors assessed knowledge of features of a value-based insurance design (VBD). They concluded that incomplete knowledge of benefits is prevalent in an employee population soon after VBD rollout.
AHRQ-funded; HS018913.
Citation: Henrikson NB, Anderson ML, Hubbard RA .
Employee knowledge of value-based insurance design benefits.
Am J Prev Med 2014 Aug;47(2):115-22. doi: 10.1016/j.amepre.2014.03.005.
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Keywords: Evidence-Based Practice, Healthcare Delivery, Health Insurance
Smith SR
AHRQ Author: Smith SR
Preface to the AHRQ supplement.
AHRQ, through its Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) Research Network, sponsored this supplement to present various strategies in the design, analysis, and conduct of health outcomes studies relevant to rare diseases. The purpose of this supplement is to disseminate illustrative examples of research methods that can be applied to understand health outcomes and potentially to stimulate new patient-centered outcomes studies for rare diseases.
AHRQ-authored.
Citation: Smith SR .
Preface to the AHRQ supplement.
J Gen Intern Med 2014 Aug;29 Suppl 3:S712-3. doi: 10.1007/s11606-014-2922-x.
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Keywords: Comparative Effectiveness, Evidence-Based Practice, Outcomes, Patient-Centered Outcomes Research, Research Methodologies
Cook JM, Newman E
A consensus statement on trauma mental health: the New Haven Competency Conference process and major findings.
The purpose of this article was to state the need for a comprehensive model of trauma-focused, empirically informed competencies for psychiatrists, and describe the work resulting from the New Haven Competencies consensus conference. The 60 participating experts outlined 5 broad foundational and functional competencies in the areas of trauma-focused and trauma-informed scientific knowledge, psychosocial assessment, psychosocial interventions, professionalism, and relational and systems. Eight cross-cutting competencies were voted into the resulting consensus statement.
AHRQ-funded; HS021602.
Citation: Cook JM, Newman E .
A consensus statement on trauma mental health: the New Haven Competency Conference process and major findings.
Psychol Trauma 2014 Jul;6(4):300-07. doi: 10.1037/a0036747..
Keywords: Trauma, Behavioral Health, Evidence-Based Practice, Education: Continuing Medical Education, Training
Kronick R
AHRQ Author: Kronick R
Patient safety: the Agency for Healthcare Research and Quality’s ongoing commitment.
The author, director of the Agency for Healthcare Research and Quality, highlights AHRQ’s role in producing evidence to make care safer and fostering the use of that evidence. In particular, he discusses the following goals: preventing healthcare-acquired infections; reducing harm associated with obstetrical care in labor and delivery; improving safety and reducing medical liability; and, accelerating patient safety improvement in nursing homes.
AHRQ-authored
Citation: Kronick R .
Patient safety: the Agency for Healthcare Research and Quality’s ongoing commitment.
J Nurs Care Qual. 2014 Jul-Sep;29(3):195-9. doi: 10.1097/NCQ.0000000000000065..
Keywords: Evidence-Based Practice, Quality of Care, Healthcare-Associated Infections (HAIs), Patient Safety
Padula WV, Mishra MK, Makic MB
A framework of quality improvement interventions to implement evidence-based practices for pressure ulcer prevention.
The purpose of this paper is to enhance the learner’s competence with knowledge about a framework of quality improvement (QI) interventions to implement evidence-based practices for pressure ulcer (PrU) prevention. The best-practice framework offers a reference point to initiating a bundle of QI interventions in support of evidence-based practices. Hospitals and clinicians tasked with quality improvement efforts can use this framework to problem-solve PrU prevention and other critical issues.
AHRQ-funded; HS023710.
Citation: Padula WV, Mishra MK, Makic MB .
A framework of quality improvement interventions to implement evidence-based practices for pressure ulcer prevention.
Adv Skin Wound Care 2014 Jun;27(6):280-4; quiz 85-6. doi: 10.1097/01.ASW.0000450703.87099.5b..
Keywords: Quality Improvement, Patient Safety, Evidence-Based Practice, Pressure Ulcers, Guidelines
Camp KM, Parisi MA, Acosta PB
AHRQ Author: Chang CS
Phenylketonuria Scientific Review Conference: state of the science and future research needs.
An NIH State-of-the-Science Conference was convened in 2012 to address new findings, particularly the use of the medication sapropterin to treat some individuals with phenylketonuria (PKU), and to develop a research agenda. An AHRQ Evidence-based Practice Center conducted a systematic review of adjuvant treatments for PKU and presented its conclusions at the conference. New drugs that are safe, efficacious, and impact a larger proportion of individuals with PKU are needed. The identification of a research agenda has facilitated the development of clinical practice guidelines by professional organizations and serves as a model for other inborn errors of metabolism.
AHRQ-authored.
Citation: Camp KM, Parisi MA, Acosta PB .
Phenylketonuria Scientific Review Conference: state of the science and future research needs.
Mol Genet Metab 2014 Jun;112(2):87-122. doi: 10.1016/j.ymgme.2014.02.013.
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Keywords: Comparative Effectiveness, Evidence-Based Practice, Guidelines, Medication, Research Methodologies
Lavallee DC, Wicks P, Alfonso Cristancho R
Stakeholder engagement in patient-centered outcomes research: high-touch or high-tech?
In this article, the authors compared and contrasted high-tech and high-touch approaches to engaging stakeholders and suggested hybrid processes.
AHRQ-funded; HS022135; HS022959.
Citation: Lavallee DC, Wicks P, Alfonso Cristancho R .
Stakeholder engagement in patient-centered outcomes research: high-touch or high-tech?
Expert Rev Pharmacoecon Outcomes Res 2014 Jun;14(3):335-44. doi: 10.1586/14737167.2014.901890.
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Keywords: Patient-Centered Outcomes Research, Evidence-Based Practice, Patient-Centered Healthcare, Patient and Family Engagement
Wasserman M, Renfrew MR, Green AR
AHRQ Author: Brach C
Identifying and preventing medical errors in patients with limited English proficiency: key findings and tools for the field.
This article describes the development, content, and testing of two new evidence-based AHRQ tools for limited English proficiency (LEP) patient safety in the hospital setting. These tools contain recommendations to improve detection and prevention of medical errors across diverse populations and to improve team communication through incorporating interpreters in the care process.
AHRQ-authored
Citation: Wasserman M, Renfrew MR, Green AR .
Identifying and preventing medical errors in patients with limited English proficiency: key findings and tools for the field.
J Healthc Qual. 2014 May-Jun;36(3):5-16. doi: 10.1111/jhq.12065..
Keywords: Disparities, Evidence-Based Practice, Patient Safety, Clinician-Patient Communication, TeamSTEPPS
Kappagoda S, Ioannidis JP
Prevention and control of neglected tropical diseases: overview of randomized trials, systematic reviews and meta-analyses.
The purpose of this review was to analyze evidence from randomized controlled trials (RCTs) on the prevention and control of neglected tropical diseases (NTDs) and to identify areas where evidence is lacking. The most studied diseases were geohelminth infection (51 RCTs) and leishmaniasis (46 RCTs). Vaccines, chemoprophylaxis and interventions targeting insect vectors were evaluated in 113, 99 and 39 RCTs, respectively. Few addressed how best to deliver preventive chemotherapy.
AHRQ-funded; HS000028.
Citation: Kappagoda S, Ioannidis JP .
Prevention and control of neglected tropical diseases: overview of randomized trials, systematic reviews and meta-analyses.
Bull World Health Organ 2014 May;92(5):356-66c. doi: 10.2471/blt.13.129601..
Keywords: Prevention, Infectious Diseases, Evidence-Based Practice
Tugwell P, Boers M, D'Agostino MA
Updating the OMERACT filter: implications of filter 2.0 to select outcome instruments through assessment of "truth": content, face, and construct validity.
Two discussion groups critically reviewed the variety of ways in which five case studies of current OMERACT Working Groups complied with the ‘Truth’ component of the Filter and what issues remained to be resolved. The case studies showed that there is broad agreement on criteria for meeting the ‘Truth’ criteria through demonstration of content, face and construct validity; however several issues were identified that the Filter Working Group will need to address.
AHRQ-funded; HS013852
Citation: Tugwell P, Boers M, D'Agostino MA .
Updating the OMERACT filter: implications of filter 2.0 to select outcome instruments through assessment of "truth": content, face, and construct validity.
J Rheumatol. 2014 May;41(5):1000-4. doi: 10.3899/jrheum.131310..
Keywords: Evidence-Based Practice, Patient-Centered Outcomes Research, Research Methodologies
Agwu AL, Neptune A, Voss C
CD4 counts of nonperinatally HIV-infected youth and young adults presenting for HIV care between 2002 and 2010.
This study of nonperinatally HIV-infected 12- to 24-year-olds presenting for care at HIV Research Network (HIVRN) sites between 2002 and 2010 sought to determine if fewer nPHIV–infected youth are presenting for care at lower CD4 counts. It found that the proportion of nPHIV-infected youth presenting to HIVRN sites with a CD4 count less than 350 cells/mm3 remained essentially unchanged between 2002 and 2010.
AHRQ-funded; 290010012.
Citation: Agwu AL, Neptune A, Voss C .
CD4 counts of nonperinatally HIV-infected youth and young adults presenting for HIV care between 2002 and 2010.
JAMA Pediatr 2014 Apr;168(4):381-3. doi: 10.1001/jamapediatrics.2013.4531..
Keywords: Human Immunodeficiency Virus (HIV), Children/Adolescents, Evidence-Based Practice
Boyd CM, Kent DM
Evidence-based medicine and the hard problem of multimorbidity.
In this article on evidence-based medicine and multimorbidity, the authors discuss the issue and assert that it remains to be determined whether sustained and concentrated attention will permit investigators to address the problem of multimorbidity using the “normal science” available with the tools of EBM, or whether such attention will produce the sort of crisis that is the first prerequisite for a new paradigm.
AHRQ-funded; HS017653; HS018597.
Citation: Boyd CM, Kent DM .
Evidence-based medicine and the hard problem of multimorbidity.
J Gen Intern Med 2014 Apr;29(4):552-3. doi: 10.1007/s11606-013-2658-z..
Keywords: Evidence-Based Practice, Research Methodologies
O'Brien EC, Holmes DN, Ansell JE
Physician practices regarding contraindications to oral anticoagulation in atrial fibrillation: findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry.
This study describes the frequencies of and factors associated with oral anticoagulation (OAC) contraindications in clinical practice for patients with atrial fibrillation (AF). Contraindications to OAC therapy among patients with AF are common but subjective. Many patients with reported contraindications were receiving OAC, suggesting that the perceived benefits outweighed the potential harm posed by the relative contraindication.
AHRQ-funded; HS021092
Citation: O'Brien EC, Holmes DN, Ansell JE .
Physician practices regarding contraindications to oral anticoagulation in atrial fibrillation: findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry.
Am Heart J. 2014 Apr;167(4):601-609.e1. doi: 10.1016/j.ahj.2013.12.014..
Keywords: Heart Disease and Health, Blood Thinners, Medication, Registries, Cardiovascular Conditions, Patient-Centered Outcomes Research, Evidence-Based Practice, Practice Patterns