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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 42 Research Studies DisplayedLi Z, Frost HR, Tosteson TD
A semiparametric joint model for terminal trend of quality of life and survival in palliative care research.
A unique feature of palliative care clinical trials is that patients will experience decreasing quality of life (QOL) during the trial despite potentially beneficial treatment. Often longitudinal QOL and survival data are highly correlated which, in the face of censoring, makes it challenging to properly analyze and interpret terminal QOL trend. To address these issues, the authors of this study proposed a novel semiparametric statistical approach to jointly model the terminal trend of QOL and survival data.
AHRQ-funded; HS020263.
Citation: Li Z, Frost HR, Tosteson TD .
A semiparametric joint model for terminal trend of quality of life and survival in palliative care research.
Stat Med 2017 Dec 20;36(29):4692-704. doi: 10.1002/sim.7445..
Keywords: Palliative Care, Quality of Life
Vakharia PP, Chopra R, Sacotte R
Burden of skin pain in atopic dermatitis.
This study sought to characterize the patient burden of skin pain in AD. It found that twenty-four (16.8 percent) patients thought the skin pain was part of their itch, 16 (11.2 percent) from scratching, and 77 (72.0 percent) from both. Patients with skin pain were more likely to describe their itch using terms that resembled neuropathic pain.
AHRQ-funded; HS023011.
Citation: Vakharia PP, Chopra R, Sacotte R .
Burden of skin pain in atopic dermatitis.
Ann Allergy Asthma Immunol 2017 Dec;119(6):548-52.e3. doi: 10.1016/j.anai.2017.09.076.
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Keywords: Chronic Conditions, Pain, Quality of Life, Skin Conditions
Adam SS, Flahiff CM, Kamble S
Depression, quality of life, and medical resource utilization in sickle cell disease.
Researchers performed an analytic epidemiologic prospective study to determine the prevalence of depression in adult patients with sickle cell disease and its association with health-related quality of life (HRQoL) and medical resource utilization. They found that depression was associated with worse physical and mental HRQoL scores and during the 6 months following diagnosis, mean total health care costs were significantly higher in depressed patients than in nondepressed patients.
AHRQ-funded; HS017645.
Citation: Adam SS, Flahiff CM, Kamble S .
Depression, quality of life, and medical resource utilization in sickle cell disease.
Blood Adv 2017 Oct 12;1(23):1983-92. doi: 10.1182/bloodadvances.2017006940.
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Keywords: Depression, Healthcare Costs, Healthcare Utilization, Quality of Life, Sickle Cell Disease
Burgette JM, Preisser JS, Weinberger M
Early head start, pediatric dental use, and oral health-related quality of life.
The objective of the study was to examine the mediating effect of child dental use on the effectiveness of North Carolina Early Head Start (EHS) in improving oral health-related quality of life (OHRQoL). It concluded that EHS increases child dental use, which worsens family OHRQoL. However, EHS is associated with improved OHRQoL overall.
AHRQ-funded; HS000032.
Citation: Burgette JM, Preisser JS, Weinberger M .
Early head start, pediatric dental use, and oral health-related quality of life.
JDR Clin Trans Res 2017 Oct;2(4):353-62. doi: 10.1177/2380084417709758.
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Keywords: Children/Adolescents, Dental and Oral Health, Quality of Life, Children/Adolescents
Burgette JM, Preisser JS, Weinberger M
Enrollment in early head start and oral health-related quality of life.
Researchers examined the effect of enrollment in North Carolina Early Head Start (EHS) - a federally funded early education program for children under three years of age and their families - on oral health-related quality of life (OHRQoL). Their study is the first to demonstrate that families of young children enrolled in EHS report improved OHRQoL compared to their non-enrolled peers.
AHRQ-funded; HS000032.
Citation: Burgette JM, Preisser JS, Weinberger M .
Enrollment in early head start and oral health-related quality of life.
Qual Life Res 2017 Oct;26(10):2607-18. doi: 10.1007/s11136-017-1584-7.
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Keywords: Children/Adolescents, Dental and Oral Health, Quality of Life
Rhoten BA
Conceptual issues surrounding body image for oncology nurses.
This paper discusses conceptual issues surrounding cancer survivors’ body image. It targets oncology nurses so they may have a better understanding of the historic overview of body image conceptualization, as well as a more contemporary, cancer-specific approach to understanding how this population of patients may be particularly affected.
AHRQ-funded; HS022990.
Citation: Rhoten BA .
Conceptual issues surrounding body image for oncology nurses.
Oncol Nurs Forum 2017 Sep 1;44(5):534-36. doi: 10.1188/17.onf.534-536..
Keywords: Cancer, Patient-Centered Healthcare, Provider, Quality of Life
Thomas HN, Hamm M, Hess R
Patient-centered outcomes and treatment preferences regarding sexual problems: a qualitative study among midlife women.
This study sought a better understanding of the sexual function outcomes that were most important to sexually active women 45 to 60 years old and the types of treatments they would prefer from individual interviews and focus groups. It found that many midlife women in the sample expressed a preference for behavioral approaches over pharmaceutical approaches for the treatment of sexual dysfunction.
AHRQ-funded; HS022989.
Citation: Thomas HN, Hamm M, Hess R .
Patient-centered outcomes and treatment preferences regarding sexual problems: a qualitative study among midlife women.
J Sex Med 2017 Aug;14(8):1011-17. doi: 10.1016/j.jsxm.2017.05.014..
Keywords: Sexual Health, Women, Patient-Centered Outcomes Research, Quality of Life
Roydhouse JK, Wilson IB
Systematic review of caregiver responses for patient health-related quality of life in adult cancer care.
The aim of this review is to help cancer researchers select a validated health-related quality of life tool if they anticipate using proxy-reported data. It concluded that the evidence base is strongest for the EORTC (disease-specific tools), COOP/WONCA (generic tools), and MQOL (end-of-life-specific tools).
AHRQ-funded; HS000011.
Citation: Roydhouse JK, Wilson IB .
Systematic review of caregiver responses for patient health-related quality of life in adult cancer care.
Qual Life Res 2017 Aug;26(8):1925-54. doi: 10.1007/s11136-017-1540-6.
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Keywords: Cancer, Caregiving, Patient-Centered Outcomes Research, Quality of Life
Lin C, Lee J, Chatterjee N
Predicting domain-specific health-related quality of life using acute infarct volume.
This study evaluated whether acute infarct volume predicts domain-specific Neuro-Quality of Life scores at 3 months after stroke. It found that acute infarct volume is a poor predictor of health-related quality of life (HRQOL) domains after ischemic stroke, with the exception of the cognitive domain. Overall, clinical and imaging variables explained less than 50 percent of the variance in HRQOL outcomes at 3 months.
AHRQ-funded; HS023437.
Citation: Lin C, Lee J, Chatterjee N .
Predicting domain-specific health-related quality of life using acute infarct volume.
Stroke 2017 Jul;48(7):1925-31. doi: 10.1161/strokeaha.117.017094.
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Keywords: Quality of Life, Stroke, Patient-Centered Outcomes Research
Silverberg JI
Selected comorbidities of atopic dermatitis: atopy, neuropsychiatric, and musculoskeletal disorders.
Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease with substantial morbidity and quality of life impairment. This review summarizes recent developments in the atopic and neuropsychiatric comorbidities of AD. For example, it concludes that persons with AD appear to be at higher risk for multiple neuropsychiatric disorders, including depression, attention-deficit/hyperactivity disorder, speech disorders in childhood, headaches, and seizures.
AHRQ-funded; HS023011.
Citation: Silverberg JI .
Selected comorbidities of atopic dermatitis: atopy, neuropsychiatric, and musculoskeletal disorders.
Clin Dermatol 2017 Jul - Aug;35(4):360-66. doi: 10.1016/j.clindermatol.2017.03.008.
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Keywords: Skin Conditions, Chronic Conditions, Behavioral Health, Quality of Life, Children/Adolescents
Pisu M, Demark-Wahnefried W, Kenzik KM
A dance intervention for cancer survivors and their partners (RHYTHM).
The purpose of this study was to assess the feasibility, acceptability, and impact of a ballroom dance intervention on improving quality of life (QOL) and relationship outcomes in cancer survivors and their partners. It found that survivors saw this light-intensity physical activity as easing them into becoming more physically active. Light intensity ballroom dancing has the potential to improve cancer survivors' QOL.
AHRQ-funded; HS023009.
Citation: Pisu M, Demark-Wahnefried W, Kenzik KM .
A dance intervention for cancer survivors and their partners (RHYTHM).
J Cancer Surviv 2017 Jun;11(3):350-59. doi: 10.1007/s11764-016-0593-9.
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Keywords: Cancer, Health Promotion, Quality of Life
Waldfogel JM, Nesbit SA, Dy SM
Pharmacotherapy for diabetic peripheral neuropathy pain and quality of life: a systematic review.
This review systematically assessed the effect of pharmacologic treatments of diabetic peripheral neuropathy (DPN) on pain and quality of life. It concluded that for reducing pain, duloxetine and venlafaxine, pregabalin and oxcarbazepine, tricyclic antidepressants, atypical opioids, and botulinum toxin were more effective than placebo. However, quality of life was poorly reported, studies were short-term, drugs had substantial dropout rates, and opioids have significant risks.
AHRQ-funded; 2902015000061.
Citation: Waldfogel JM, Nesbit SA, Dy SM .
Pharmacotherapy for diabetic peripheral neuropathy pain and quality of life: a systematic review.
Neurology 2017 May 16;88(20):1958-67. doi: 10.1212/wnl.0000000000003882.
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Keywords: Diabetes, Chronic Conditions, Medication, Quality of Life, Patient-Centered Outcomes Research
Cho H, Iribarren S, Schnall R
Technology-mediated interventions and quality of life for persons living with HIV/AIDS. A systematic review.
The aim of this review was to assess the impact of technology-mediated interventions on quality of life (QoL) and to identify the instruments used to measure the QoL of persons living with HIV/AIDS (PLWH). It identified four types of technology-mediated interventions and two types of QoL instruments used to examine the impact of technology-mediated interventions on PLWH. However, the evidence to support the improvement of QoL using technology-mediated interventions was insufficient.
AHRQ-funded; HS023963.
Citation: Cho H, Iribarren S, Schnall R .
Technology-mediated interventions and quality of life for persons living with HIV/AIDS. A systematic review.
Appl Clin Inform 2017 Apr 12;8(2):348-68. doi: 10.4338/aci-2016-10-r-0175.
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Keywords: Evidence-Based Practice, Human Immunodeficiency Virus (HIV), Patient-Centered Outcomes Research, Quality of Life
Fogelberg DJ, Leland NE, Blanchard J
Qualitative experience of sleep in individuals with spinal cord injury.
The objective of this study was to examine the experience of sleep among individuals with spinal cord injury (SCI). Sleep-related data were found in transcripts for 90 percent of the sample. Participants described diminished sleep duration and irregular sleep patterns. Several factors contributing to poor sleep were identified, including SCI-related circumstances and sleep environment. Participants also discussed how poor sleep affected occupational engagement.
AHRQ-funded; HS022907.
Citation: Fogelberg DJ, Leland NE, Blanchard J .
Qualitative experience of sleep in individuals with spinal cord injury.
OTJR 2017 Apr;37(2):89-97. doi: 10.1177/1539449217691978.
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Keywords: Sleep Problems, Quality of Life, Injuries and Wounds
Chen RC, Basak R, Meyer AM
Association between choice of radical prostatectomy, external beam radiotherapy, brachytherapy, or active surveillance and patient-reported quality of life among men with localized prostate cancer.
This study compared quality of life after radical prostatectomy, external beam radiotherapy, and brachytherapy vs active surveillance. By 24 months, mean scores between treatment groups vs active surveillance were not significantly different in most domains. However, each treatment strategy was associated with distinct patterns of adverse effects over 2 years.
AHRQ-funded; AHRQ contract (no number given).
Citation: Chen RC, Basak R, Meyer AM .
Association between choice of radical prostatectomy, external beam radiotherapy, brachytherapy, or active surveillance and patient-reported quality of life among men with localized prostate cancer.
JAMA 2017 Mar 21;317(11):1141-50. doi: 10.1001/jama.2017.1652.
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Keywords: Comparative Effectiveness, Patient-Centered Outcomes Research, Cancer: Prostate Cancer, Surgery, Quality of Life
DunnGalvin A, Koman E, Raver E
An examination of the food allergy quality of life questionnaire performance in a countrywide american sample of children: cross-cultural differences in age and impact in the United States and Europe.
The primary aim of the present study was to examine the performance of the Food Allergy Quality of Life Questionnaire - Parent Form (FAQLQ-PF) in a countrywide American sample of children with food allergy. The FAQLQ-PF has high convergent validity and discriminant validity, internal consistency was excellent. US health-related quality of life was worse than European health-related quality of life, as indicated by higher FAQLQ-PF scores in US samples.
AHRQ-funded; HS024599.
Citation: DunnGalvin A, Koman E, Raver E .
An examination of the food allergy quality of life questionnaire performance in a countrywide american sample of children: cross-cultural differences in age and impact in the United States and Europe.
J Allergy Clin Immunol Pract 2017 Mar - Apr;5(2):363-68.e2. doi: 10.1016/j.jaip.2016.09.049.
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Keywords: Children/Adolescents, Nutrition, Quality of Life
Sisic M, Kirby JS, Boyal S
Development of a quality-of-life measure for hidradenitis suppurativa.
The objective of this study was to develop a QoL instrument for hidradenitis suppurativa (HS-QoL) in accordance with recommended standards. : Concept elicitation interviews with patients with HS generated 12 themes. Most frequently reported were impacts on daily activities and symptoms due to HS. These themes, along with literature review and input from clinical experts, informed development of the HS-QoL-v1.
AHRQ-funded; HS024585.
Citation: Sisic M, Kirby JS, Boyal S .
Development of a quality-of-life measure for hidradenitis suppurativa.
J Cutan Med Surg 2017 Mar/Apr;21(2):152-55. doi: 10.1177/1203475416677721.
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Keywords: Patient Experience, Quality Measures, Quality of Life, Skin Conditions
Krouse RS, You YN
Prospective comparative effectiveness trial for malignant bowel obstruction: SWOG S1316.
This paper is an update on the status of the Prospective Comparative Effectiveness Trial for Malignant Bowel Obstruction trial (S1316), the aim of which is to assess the quality of life outcome of “good days” for patients with malignant bowel obstruction (MBO) who receive surgical intervention in comparison with patients who undergo nonsurgical intervention.
AHRQ-funded; HS021491.
Citation: Krouse RS, You YN .
Prospective comparative effectiveness trial for malignant bowel obstruction: SWOG S1316.
Bull Am Coll Surg 2015 Dec;100(12):49-50.
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Keywords: Comparative Effectiveness, Digestive Disease and Health, Patient-Centered Outcomes Research, Quality of Life
McCarthy IM
Putting the patient in patient reported outcomes: a robust methodology for health outcomes assessment.
Through a series of Monte Carlo simulations, this paper illustrates that reliance solely on the summary score may lead to biased estimates of incremental effects, and proposes a novel two-stage approach that allows for unbiased estimation of incremental effects. The proposed methodology essentially reverses the order of the analysis, from one of 'aggregate, then estimate' to one of 'estimate, then aggregate'.
AHRQ-funded; HS022431.
Citation: McCarthy IM .
Putting the patient in patient reported outcomes: a robust methodology for health outcomes assessment.
Health Econ 2015 Dec;24(12):1588-603. doi: 10.1002/hec.3113.
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Keywords: Patient-Centered Outcomes Research, Outcomes, Quality of Life, Research Methodologies
Morgans AK, van Bommel AC, Stowell C
Development of a standardized set of patient-centered outcomes for advanced prostate cancer: an international effort for a unified approach.
The International Consortium for Health Outcomes Measurement assembled a multidisciplinary working group to develop a standard set of outcomes relevant to men with advanced prostate cancer to follow during routine clinical care. The international multidisciplinary group identified clinical data and patient-reported outcome measures that serve as a basis for international health outcome comparisons and quality-of-care assessments. The set will be revised annually.
AHRQ-funded; HS022990.
Citation: Morgans AK, van Bommel AC, Stowell C .
Development of a standardized set of patient-centered outcomes for advanced prostate cancer: an international effort for a unified approach.
Eur Urol 2015 Nov;68(5):891-8. doi: 10.1016/j.eururo.2015.06.007.
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Keywords: Cancer: Prostate Cancer, Patient-Centered Outcomes Research, Quality of Life, Adverse Events, Quality Indicators (QIs)
Buscher AL, Kallen MA, Suarez-Almazor ME
Development of an "Impact of HIV" instrument for HIV survivors.
A newly created Impact of HIV Survey, modified from Zebrack's Impact of Cancer Scale, was developed and completed by 356 HIV-infected patients on antiretroviral therapy. Factor analyses confirmed seven scales within 38 items: Health Awareness, Positive Self-Evaluation, Positive Outlook, Value of Relationships, Negative Self-Evaluation-Outlook, Health Anxiety, and Body Change.
AHRQ-funded; HS016093.
Citation: Buscher AL, Kallen MA, Suarez-Almazor ME .
Development of an "Impact of HIV" instrument for HIV survivors.
J Assoc Nurses AIDS Care 2015 Nov-Dec;26(6):720-31. doi: 10.1016/j.jana.2015.08.002.
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Keywords: Human Immunodeficiency Virus (HIV), Quality of Life, Health Status
Waljee JF, Ghaferi A, Finks JF
Variation in patient-reported outcomes across hospitals following surgery.
The researchers examined variation in patient-reported outcomes (PROs), specifically health-related quality of life (HRQOL), across hospitals performing bariatric surgery. They found that patient factors explain a large proportion of hospital-level variation in PROs following bariatric surgery, underscoring the importance of risk adjustment.
AHRQ-funded; HS023313.
Citation: Waljee JF, Ghaferi A, Finks JF .
Variation in patient-reported outcomes across hospitals following surgery.
Med Care 2015 Nov;53(11):960-6. doi: 10.1097/mlr.0000000000000425..
Keywords: Quality of Life, Surgery, Obesity, Patient-Centered Outcomes Research, Patient Experience
Cantor SB, Deshmukh AA, Krahn MD
Use of forecasted assessment of quality of life to validate time-trade-off utilities and a prostate cancer screening decision-analytic model.
The researchers sought to determine whether the forecasted assessment of how someone would feel in a future health state can be predictive of utilities (e.g. as elicited by the time-trade-off method) and also predictive of optimal decisions as determined by a decision-analytic model. They concluded that anticipated difficulty adjusting to adverse health effects were highly related to preferences and could be used as a proxy measure of utility.
AHRQ-funded; HS08992.
Citation: Cantor SB, Deshmukh AA, Krahn MD .
Use of forecasted assessment of quality of life to validate time-trade-off utilities and a prostate cancer screening decision-analytic model.
Health Expect 2015 Oct;18(5):1610-20. doi: 10.1111/hex.12150.
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Keywords: Decision Making, Cancer: Prostate Cancer, Elderly, Quality of Life, Screening
Fernandes-Taylor S, Adesoye T, Bloom JR
Managing psychosocial issues faced by young women with breast cancer at the time of diagnosis and during active treatment.
This review examines recent literature on the psychosocial needs of and interventions for young women. It focuses on the active treatment period given the toxicity of treatment, the incidence of anxiety, and depressive symptoms in these women during treatment. It concluded that shared decision-making, balancing body image, fear of recurrence, and recommended treatment, and palliative care for metastasis are essential research priorities for the clinical setting.
AHRQ-funded; HS023395.
Citation: Fernandes-Taylor S, Adesoye T, Bloom JR .
Managing psychosocial issues faced by young women with breast cancer at the time of diagnosis and during active treatment.
Curr Opin Support Palliat Care 2015 Sep;9(3):279-84. doi: 10.1097/spc.0000000000000161..
Keywords: Anxiety, Cancer: Breast Cancer, Decision Making, Depression, Quality of Life
Ware JE, Gandek B, Kulasekaran A
Evaluation of smoking-specific and generic quality of life measures in current and former smokers in Germany and the United States.
The researchers evaluated the psychometric properties of German- and English-language versions of survey scales representing both types of measures in samples of current and former smokers. They concluded that German- and English-language Tobacco Quality of Life Impact Tool (TQOLIT) surveys have comparable and satisfactory psychometric properties. Cross-sectional tests, including correlations with four biomarkers, support the validity of the new smoking-specific measures for use in studies of otherwise healthy smokers.
AHRQ-funded; HS023117.
Citation: Ware JE, Gandek B, Kulasekaran A .
Evaluation of smoking-specific and generic quality of life measures in current and former smokers in Germany and the United States.
Health Qual Life Outcomes 2015 Aug 16;13:128. doi: 10.1186/s12955-015-0316-3..
Keywords: Quality of Life, Tobacco Use