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Research Studies is a monthly compilation of research articles funded by AHRQ or authored by AHRQ researchers and recently published in journals or newsletters.
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1 to 13 of 13 Research Studies DisplayedCheng TL, Mistry KB, Wang G
Folate nutrition status in mothers of the Boston birth cohort, sample of a US urban low-income population.
Researchers examined maternal folic acid supplementation and plasma folate concentrations in the Boston Birth Cohort, a predominantly urban, low-income, minority population. Their findings indicated that fewer than 5 percent of mothers in the Boston Birth Cohort started folic acid supplements before pregnancy, and approximately one third of mothers had either too low or too high plasma folate levels.
AHRQ-authored.
Citation: Cheng TL, Mistry KB, Wang G .
Folate nutrition status in mothers of the Boston birth cohort, sample of a US urban low-income population.
Am J Public Health 2018 Jun;108(6):799-807. doi: 10.2105/ajph.2018.304355.
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Keywords: Nutrition, Pregnancy, Low-Income, Urban Health, Vitamins and Supplements
Rizvi RF, Adam TJ, Lindemann EA
Comparing existing resources to represent dietary supplements.
Dietary supplements (DS) are widely consumed despite limited knowledge around their safety/efficacy and any well-established regulatory policies. In this pilot study, five DS resources were evaluated and compared both quantitatively and qualitatively. The authors found fragmented and inconsistent distribution of DS representation in terms of essential data elements across five resources.
AHRQ-funded; HS022085.
Citation: Rizvi RF, Adam TJ, Lindemann EA .
Comparing existing resources to represent dietary supplements.
AMIA Jt Summits Transl Sci Proc 2018 May 18;2017:207-16..
Keywords: Comparative Effectiveness, Nutrition, Patient Safety, Vitamins and Supplements
Spatz ES, Wang Y, Beckman AL
Traditional Chinese medicine for acute myocardial infarction in western medicine hospitals in China.
This study examined the use of traditional Chinese medicine (TCM) in patients admitted for acute myocardial infarction (AMI) in China during the first 24 hours of hospitalization. The data came from the China Patient-centered Evaluative Assessment of Cardiac Events Retrospective Study of Acute Myocardial Infarction. A chart review was done of randomly sampled patients in 2001, 2006 and 2011 in 162 Western medicine hospitals across China. Nearly all (99%) hospitals used some form of TCM, with Salvia miltiorrhiza being the most commonly prescribed. This TCM treatment (and others) was used intravenously and use has increased over the span of the study, despite lack of evidence of benefit or harm.
AHRQ-funded; HS023000.
Citation: Spatz ES, Wang Y, Beckman AL .
Traditional Chinese medicine for acute myocardial infarction in western medicine hospitals in China.
Circ Cardiovasc Qual Outcomes 2018 Mar;11(3):e004190. doi: 10.1161/circoutcomes.117.004190..
Keywords: Adverse Events, Cardiovascular Conditions, Complementary and Alternative Medicine, Heart Disease and Health, Hospitals, Mortality, Outcomes, Patient-Centered Outcomes Research, Patient Safety, Practice Patterns, Risk, Vitamins and Supplements
Butler M, Nelson VA, Davila H
Over-the-counter supplement interventions to prevent cognitive decline, mild cognitive impairment, and clinical Alzheimer-type dementia: a systematic review.
This review summarizes the evidence on efficacy and harms of over-the-counter (OTC) supplements to prevent or delay cognitive decline, mild cognitive impairment (MCI), or clinical Alzheimer-type dementia in adults with normal cognition or MCI but no dementia diagnosis. It concluded that evidence is insufficient to recommend any OTC supplement for cognitive protection in adults with normal cognition or MCI.
AHRQ-funded; 290201500008I.
Citation: Butler M, Nelson VA, Davila H .
Over-the-counter supplement interventions to prevent cognitive decline, mild cognitive impairment, and clinical Alzheimer-type dementia: a systematic review.
Ann Intern Med 2018 Jan 2;168(1):52-62. doi: 10.7326/m17-1530.
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Keywords: Comparative Effectiveness, Dementia, Patient-Centered Outcomes Research, Prevention, Vitamins and Supplements
Chilukuri N, Cheng TL, Psoter KJ
Effectiveness of a pediatric primary care intervention to increase maternal folate use: results from a cluster randomized controlled trial.
This study assessed the impact of provision of folate vitamins and a preconception health intervention on folate use among a group of mostly African-American and low-income mothers bringing infants to pediatric primary care. It found that among all participants, daily vitamin intake increased from baseline to 6-month follow-up (33.8 percent vs 42.6 percent).
AHRQ-authored.
Citation: Chilukuri N, Cheng TL, Psoter KJ .
Effectiveness of a pediatric primary care intervention to increase maternal folate use: results from a cluster randomized controlled trial.
J Pediatr 2018 Jan;192:247-52.e1. doi: 10.1016/j.jpeds.2017.09.020.
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Keywords: Maternal Care, Patient Adherence/Compliance, Social Determinants of Health, Primary Care, Vitamins and Supplements
Zhang R, Manohar N, Arsoniadis E
Evaluating term coverage of herbal and dietary supplements in electronic health records.
Some supplements can interact with prescription medications, potentially leading to clinically important and potentially preventable adverse reactions. Clinical notes and corresponding medication lists from an integrated healthcare system were extracted and compared with online databases. The authors found that, overall, about 40% of listed medications are supplements, most of which are included in medication lists as nutritional or miscellaneous products. They found gaps between supplement and standard medication terminologies and identified supplements which were not mentioned in the medication lists.
AHRQ-funded; HS022085.
Citation: Zhang R, Manohar N, Arsoniadis E .
Evaluating term coverage of herbal and dietary supplements in electronic health records.
AMIA Annu Symp Proc 2015 Nov 5;2015:1361-70.
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Keywords: Adverse Drug Events (ADE), Data, Electronic Health Records (EHRs), Medication, Vitamins and Supplements
Singh JA, Bharat A, Edwards NL
An internet survey of common treatments used by patients with gout including cherry extract and juice and other dietary supplements.
The researchers aimed to assess the prevalent use of cherry extract/products and other supplements by gout patients and the characteristics of these patients. They found that almost 50 percent of gout patients used cherry extract, juice or other supplements. Twenty-seven percent of men and 18 percent of women reported using other food items/natural supplements.
AHRQ-funded; HS021110.
Citation: Singh JA, Bharat A, Edwards NL .
An internet survey of common treatments used by patients with gout including cherry extract and juice and other dietary supplements.
J Clin Rheumatol 2015 Jun;21(4):225-6. doi: 10.1097/rhu.0000000000000246..
Keywords: Vitamins and Supplements, Comparative Effectiveness, Centers for Education and Research on Therapeutics (CERTs)
Wang JW, Hogan PG, Hunstad DA
Vitamin D sufficiency and Staphylococcus aureus infection in children.
Vitamin D sufficiency may be one of a myriad of host and environmental factors that can be directly impacted to reduce the frequency of S. aureus skin and soft tissue infection. The researchers found that children with vitamin D deficiency or insufficiency [25-hydroxyvitamin D <30 ng/mL] were more likely to present with recurrent, rather than primary, S. aureus skin or soft tissue infection.
AHRQ-funded; HS021736.
Citation: Wang JW, Hogan PG, Hunstad DA .
Vitamin D sufficiency and Staphylococcus aureus infection in children.
Pediatr Infect Dis J 2015 May;34(5):544-5. doi: 10.1097/inf.0000000000000667..
Keywords: Vitamins and Supplements, Children/Adolescents
Cantor AG, Bougatsos C, Blazina I
Routine iron supplementation and screening for iron deficiency anemia in pregnancy: a systematic review for the U.S. Preventive Services Task Force.
This study reviews screening and supplementation for iron deficiency anemia in pregnancy. Prevalence in the U.S. rises to 28.4 percent in the final trimester from 5 percent in early pregnancy. There is inconclusive evidence that prenatal iron supplementation improves maternal or infant health outcomes, but supplementation may improve maternal hematological indices.
AHRQ-funded; 290201200015I
Citation: Cantor AG, Bougatsos C, Blazina I .
Routine iron supplementation and screening for iron deficiency anemia in pregnancy: a systematic review for the U.S. Preventive Services Task Force.
Ann Intern Med. 2015 Apr 21;162(8):566-76. doi: 10.7326/m14-2932..
Keywords: U.S. Preventive Services Task Force (USPSTF), Pregnancy, Vitamins and Supplements, Screening
McDonagh MS, Blazina I, Dana T
Screening and routine supplementation for iron deficiency anemia: a systematic review.
The goal of this study was to review the evidence regarding the benefits and harms of screening and routine supplementation for IDA for the US Preventive Services Task Force. It found that no studies assessed the benefits or harms of screening or the association between improvement in impaired iron status and clinical outcomes.
AHRQ-funded; 290201200015I.
Citation: McDonagh MS, Blazina I, Dana T .
Screening and routine supplementation for iron deficiency anemia: a systematic review.
Pediatrics 2015 Apr;135(4):723-33. doi: 10.1542/peds.2014-3979..
Keywords: U.S. Preventive Services Task Force (USPSTF), Children/Adolescents, Screening, Vitamins and Supplements
Daiello LA, Gongvatana A, Dunsiger S
Association of fish oil supplement use with preservation of brain volume and cognitive function.
The aim of this study was to investigate whether the use of fish oil supplements (FOSs) is associated with concomitant reduction in cognitive decline and brain atrophy in older adults. It found that FOS use during follow-up was associated with significantly lower mean cognitive subscale of the Alzheimer’s Disease Assessment Scale and higher Mini-Mental State Examination scores among those with normal cognition.
AHRQ-funded; HS017735.
Citation: Daiello LA, Gongvatana A, Dunsiger S .
Association of fish oil supplement use with preservation of brain volume and cognitive function.
Alzheimers Dement 2015 Feb;11(2):226-35. doi: 10.1016/j.jalz.2014.02.005..
Keywords: Dementia, Elderly, Vitamins and Supplements
LeBlanc ES, Zakher B, Daeges M
Screening for vitamin D deficiency: a systematic review for the U.S. Preventive Services Task Force.
This review of benefits and harms associated with vitamin screening in asymptomatic adults found that treatment of vitamin D deficiency in asymptomatic adults might reduce mortality risk in institutionalized elderly persons and risks for falls but not fractures.
AHRQ-funded; 290200710057I
Citation: LeBlanc ES, Zakher B, Daeges M .
Screening for vitamin D deficiency: a systematic review for the U.S. Preventive Services Task Force.
Ann Intern Med. 2015 Jan 20;162(2):109-22. doi: 10.7326/M14-1659..
Keywords: U.S. Preventive Services Task Force (USPSTF), Vitamins and Supplements, Screening, Elderly, Prevention
Manohar N, Adam TJ, Pakhomov SV
Evaluation of herbal and dietary supplement resource term coverage.
This pilot study investigated coverage of supplement databases to one another as well as coverage by the Unified Medical Language System (UMLS) and RxNorm for supplement terms. It found that none of the supplement databases completely covers supplement terms.
AHRQ-funded; HS022085.
Citation: Manohar N, Adam TJ, Pakhomov SV .
Evaluation of herbal and dietary supplement resource term coverage.
Stud Health Technol Inform 2015;216:785-9..
Keywords: Health Information Technology (HIT), Vitamins and Supplements, Data
