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AHRQ Research Studies Date
Topics
- Adverse Drug Events (ADE) (2)
- Ambulatory Care and Surgery (1)
- (-) Asthma (15)
- Behavioral Health (1)
- Children/Adolescents (10)
- Chronic Conditions (1)
- Clinical Decision Support (CDS) (1)
- Clinician-Patient Communication (1)
- Comparative Effectiveness (3)
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- Evidence-Based Practice (2)
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- Low-Income (1)
- Medicaid (2)
- Medication (6)
- Obesity (1)
- Outcomes (1)
- Patient-Centered Outcomes Research (1)
- Patient Adherence/Compliance (2)
- Patient Safety (1)
- Patient Self-Management (4)
- Primary Care (1)
- Racial and Ethnic Minorities (1)
- Social Determinants of Health (1)
- Tobacco Use (1)
- Urban Health (1)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 15 of 15 Research Studies DisplayedNkoy F, Fassl B, Stone B
Improving pediatric asthma care and outcomes across multiple hospitals.
This study aimed to assess the impact of an evidence-based care process model 5 years after implementation at Primary Children's Hospital, a tertiary care facility, and after its dissemination to 7 community hospitals. The intervention resulted in sustained, long-term improvement in asthma care and outcomes at the tertiary care hospital and successful dissemination to community hospitals.
AHRQ-funded; HS018166; HS018678.
Citation: Nkoy F, Fassl B, Stone B .
Improving pediatric asthma care and outcomes across multiple hospitals.
Pediatrics 2015 Dec;136(6):e1602-10. doi: 10.1542/peds.2015-0285..
Keywords: Children/Adolescents, Asthma, Hospitalization, Evidence-Based Practice, Patient-Centered Outcomes Research
Miligkos M, Bannuru RR, Alkofide H
Leukotriene-receptor antagonists versus placebo in the treatment of asthma in adults and adolescents: a systematic review and meta-analysis.
The purpose of this study was to determine the benefits and harms of leukotriene-receptor antagonists (LTRAs) as monotherapy or in combination with inhaled corticosteroids compared with placebo in adults and adolescents with asthma. It found that leukotriene-receptor antagonists as monotherapy improved asthma control compared with placebo, but which patients are most likely to respond to treatment with LTRAs remains unclear.
AHRQ-funded; HS021396.
Citation: Miligkos M, Bannuru RR, Alkofide H .
Leukotriene-receptor antagonists versus placebo in the treatment of asthma in adults and adolescents: a systematic review and meta-analysis.
Ann Intern Med 2015 Nov 17;163(10):756-67. doi: 10.7326/m15-1059.
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Keywords: Asthma, Children/Adolescents, Medication, Comparative Effectiveness
Wechsler ME, Yawn BP, Fuhlbrigge AL
Anticholinergic vs long-acting beta-agonist in combination with inhaled corticosteroids in Black adults with asthma: the BELT randomized clinical trial.
The researchers compared the effectiveness and safety of tiotropium vs long-acting beta agonists (LABAs), when used with inhaled corticosteroids (ICS) in black adults with asthma. They found that among black adults with asthma treated with ICS, adding a LABA did not improve time to asthma exacerbation compared with adding tiotropium. These findings were not affected by polymorphisms at the Arg16Gly locus of ADRB2.
AHRQ-funded; HS019408.
Citation: Wechsler ME, Yawn BP, Fuhlbrigge AL .
Anticholinergic vs long-acting beta-agonist in combination with inhaled corticosteroids in Black adults with asthma: the BELT randomized clinical trial.
JAMA 2015 Oct 27;314(16):1720-30. doi: 10.1001/jama.2015.13277..
Keywords: Comparative Effectiveness, Patient Safety, Asthma, Medication
Luo G, Stone BL, Fassl B
Predicting asthma control deterioration in children.
The researchers developed and tested the first set of models for predicting a child’s asthma control deterioration one week prior to occurrence. Their best model successfully predicted a child’s asthma control level one week ahead. With adequate accuracy, the model could be integrated into electronic asthma self-monitoring systems.
AHRQ-funded; HS018166; HS018678.
Citation: Luo G, Stone BL, Fassl B .
Predicting asthma control deterioration in children.
BMC Med Inform Decis Mak 2015 Oct 14;15:84. doi: 10.1186/s12911-015-0208-9..
Keywords: Asthma, Children/Adolescents, Health Information Technology (HIT), Patient Self-Management
Yawn BP, Rank MA, Bertram SL
Obesity, low levels of physical activity and smoking present opportunities for primary care asthma interventions: an analysis of baseline data from the asthma tools study.
The researchers calculated cross-sectional frequencies of activity levels, smoking, secondhand smoke exposure and the presence of obesity, as well as rates of out-of-control asthma and asthma exacerbations. They found that tobacco smoke exposure, obesity, low activity levels, poverty, inadequately controlled asthma and high asthma-related health-care utilization were common. Across all age groups, obesity was associated with poorer asthma outcomes.
AHRQ-funded; HS018431.
Citation: Yawn BP, Rank MA, Bertram SL .
Obesity, low levels of physical activity and smoking present opportunities for primary care asthma interventions: an analysis of baseline data from the asthma tools study.
NPJ Prim Care Respir Med 2015 Oct 1;25:15058. doi: 10.1038/npjpcrm.2015.58..
Keywords: Asthma, Obesity, Tobacco Use, Primary Care, Outcomes
Rangachari P, Mehta R, Rethemeyer RK
Short or long end of the lever? Associations between provider communication of the "asthma-action plan" and outpatient revisits for pediatric asthma.
This study addresses the gap in understanding the extent of leverage that healthcare providers may have in preventing hospital revisits for asthma through effective communication of the Asthma-Action Plan (AAP) in the outpatient setting. The Children's Hospital of Georgia survey results suggest limited potential of effective provider communication of AAP in reducing outpatient revisits for pediatric asthma and indicate a need for broader community-based interventions to address patient life variables impacting self-management and hospital revisits for pediatric asthma.
AHRQ-funded; HS019785.
Citation: Rangachari P, Mehta R, Rethemeyer RK .
Short or long end of the lever? Associations between provider communication of the "asthma-action plan" and outpatient revisits for pediatric asthma.
J Hosp Adm 2015 Oct;4(5):26-39. doi: 10.5430/jha.v4n5p26.
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Keywords: Asthma, Children/Adolescents, Ambulatory Care and Surgery, Clinician-Patient Communication, Patient Self-Management
Lu CY, Zhang F, Lakoma MD
Asthma treatments and mental health visits after a Food and Drug Administration label change for leukotriene inhibitors.
This study investigated how a label change to include neuropsychiatric adverse events (e.g., depression and suicidality) affected the use of leukotriene inhibitors (LTIs) and other asthma controller medications, mental health visits, and suicide attempts. The label change was associated with abrupt reductions in LTI use among all age groups.
AHRQ-funded; HS019669.
Citation: Lu CY, Zhang F, Lakoma MD .
Asthma treatments and mental health visits after a Food and Drug Administration label change for leukotriene inhibitors.
Clin Ther 2015 Jun;37(6):1280-91. doi: 10.1016/j.clinthera.2015.03.027..
Keywords: Adverse Drug Events (ADE), Asthma, Children/Adolescents, Medication, Behavioral Health
Butz AM, Ogborn J, Mudd S
Factors associated with high short-acting beta2-agonist use in urban children with asthma.
The investigators examined factors associated with high short-acting β₂ agonist (SABA) use in inner-city children with asthma. They found that high SABA users were more than 5 times more likely to have an asthma hospitalization, almost 3 times more likely to have an asthma intensive care unit admission, and more than 3 times more likely to have prior specialty asthma care or positive cockroach sensitization than low to moderate SABA users.
AHRQ-funded; HS000029.
Citation: Butz AM, Ogborn J, Mudd S .
Factors associated with high short-acting beta2-agonist use in urban children with asthma.
Ann Allergy Asthma Immunol 2015 May;114(5):385-92. doi: 10.1016/j.anai.2015.03.002.
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Keywords: Asthma, Children/Adolescents, Medication, Urban Health
Kuhn L, Reeves K, Taylor Y
Planning for action: the impact of an asthma action plan decision support tool integrated into an electronic health record (EHR) at a large health care system.
This project aimed to embed an electronic asthma action plan decision support tool (eAAP) into the medical record to streamline evidence-based guidelines for providers at the point of care, create individualized patient handouts, and evaluate effects on disease outcomes. Its findings supports existing evidence that patient self-management plays an important role in reducing asthma exacerbations.
AHRQ-funded; HS019946.
Citation: Kuhn L, Reeves K, Taylor Y .
Planning for action: the impact of an asthma action plan decision support tool integrated into an electronic health record (EHR) at a large health care system.
J Am Board Fam Med 2015 May-Jun;28(3):382-93. doi: 10.3122/jabfm.2015.03.140248..
Keywords: Electronic Health Records (EHRs), Clinical Decision Support (CDS), Asthma, Patient Self-Management, Evidence-Based Practice
Fiks AG, Mayne SL, Karavite DJ
Parent-reported outcomes of a shared decision-making portal in asthma: a practice-based RCT.
This study evaluated the feasibility, acceptability, and impact of MyAsthma, an EHR-linked patient portal supporting shared decision-making for pediatric asthma. It found that parents of children with moderate to severe persistent asthma used the portal more than others; 92 percent were satisfied with MyAsthma. Parents reported that use improved their communication with the office, ability to manage asthma, and awareness of the importance of ongoing attention to treatment.
AHRQ-funded; HS021645.
Citation: Fiks AG, Mayne SL, Karavite DJ .
Parent-reported outcomes of a shared decision-making portal in asthma: a practice-based RCT.
Pediatrics 2015 Apr;135(4):e965-73. doi: 10.1542/peds.2014-3167..
Keywords: Asthma, Children/Adolescents, Decision Making, Electronic Health Records (EHRs), Health Information Technology (HIT)
Rust G, Zhang S, McRoy L
Potential savings from increasing adherence to inhaled corticosteroid therapy in Medicaid-enrolled children.
This study simulated the cost impact of achieving various levels of increase in inhaled corticosteroid therapy (ICS-Rx) adherence levels among elementary school–aged children (5-12 years) initially receiving a new ICS-Rx for asthma. It found that increasing the proportion of children who maintain higher adherence to 40 percent would generate savings of $95 per child per year.
AHRQ-funded; HS022444.
Citation: Rust G, Zhang S, McRoy L .
Potential savings from increasing adherence to inhaled corticosteroid therapy in Medicaid-enrolled children.
Am J Manag Care 2015 Mar;21(3):173-80..
Keywords: Children/Adolescents, Asthma, Patient Adherence/Compliance, Healthcare Costs, Medicaid
Ejebe IH, Jacobs EA, Wisk LE
Persistent differences in asthma self-efficacy by race, ethnicity, and income in adults with asthma.
The objective of this population-based study was to determine if and to what extent there are differences in asthma self-efficacy by race/ethnicity and income, and whether health status, levels of acculturation, and health care factors may explain these differences. It found that racial/ethnic minorities and individuals living in poverty have the lowest levels of asthma self-efficacy.
AHRQ-funded; HS000063.
Citation: Ejebe IH, Jacobs EA, Wisk LE .
Persistent differences in asthma self-efficacy by race, ethnicity, and income in adults with asthma.
J Asthma 2015 Feb;52(1):105-13. doi: 10.3109/02770903.2014.947429..
Keywords: Asthma, Patient Self-Management, Social Determinants of Health, Low-Income, Racial and Ethnic Minorities
Valet RS, Gebretsadik T, Minton PA
Prevalence and characteristics of medication sharing behavior in a pediatric Medicaid population with asthma.
The researchers described features surrounding the sharing and borrowing of nonprescription medications and examine the effects of this behavior on adverse asthma outcomes among children with asthma. They found a trend toward decreased Asthma Control Test (ACT) score and a higher proportion of patients with ACT scores of 19 or lower among those who shared or borrowed medication.
AHRQ-funded; HS019669.
Citation: Valet RS, Gebretsadik T, Minton PA .
Prevalence and characteristics of medication sharing behavior in a pediatric Medicaid population with asthma.
Ann Allergy Asthma Immunol 2015 Feb;114(2):151-3. doi: 10.1016/j.anai.2014.11.007..
Keywords: Medication, Children/Adolescents, Medicaid, Asthma, Adverse Drug Events (ADE)
Rust G, Zhang S, Holloway K
Timing of emergency department visits for childhood asthma after initial inhaled corticosteroid use.
This study measured the incidence and timing of emergency department (ED) visits in the first 90 days after an initial inhaled corticosteroid prescription (ICS-Rx). It found that one in 5 children with asthma had at least 1 ED visit in the first 90 days after initial ICS-Rx; 10 percent of these visits occurred within the first 48 hours, and 25 percent occurred within the first week.
AHRQ-funded; HS022444; HS019470.
Citation: Rust G, Zhang S, Holloway K .
Timing of emergency department visits for childhood asthma after initial inhaled corticosteroid use.
Popul Health Manag 2015 Feb;18(1):54-60. doi: 10.1089/pop.2013.0126..
Keywords: Asthma, Children/Adolescents, Emergency Department, Medication
Mowrer JL, Tapp H, Ludden T
Patients' and providers' perceptions of asthma and asthma care: a qualitative study.
The primary goal of this qualitative study was to further explore patient and provider perceptions of asthma and asthma care as part of a larger Asthma Comparative Effectiveness Study. Three overarching themes, with a variety of subthemes, emerged as the main findings of this study. The three main themes were Cost/Economic Barriers/Process, Self-Governance/Adherence and Education.
AHRQ-funded; HS019946.
Citation: Mowrer JL, Tapp H, Ludden T .
Patients' and providers' perceptions of asthma and asthma care: a qualitative study.
J Asthma 2015;52(9):949-56. doi: 10.3109/02770903.2015.1010731..
Keywords: Asthma, Comparative Effectiveness, Patient Adherence/Compliance, Chronic Conditions