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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 2 of 2 Research Studies DisplayedMcKernan LC, Johnson BN, Crofford LJ
Posttraumatic stress symptoms mediate the effects of trauma exposure on clinical indicators of central sensitization in patients with chronic pain.
This study examines the relationship between posttraumatic stress disorder (PTSD) and chronic pain involving central sensitization (CS). A sample of 202 patients (79% female) with chronic pain filled out surveys describing their trauma exposure, current PTSD symptoms, experiential avoidance and 3 manifestations of CS which are widespread pain, greater pain severity, and polysomatic symptom reporting. All 3 clinical indicators of CS were significantly associated with trauma exposure and PTSD symptoms. Further investigation is needed on the mediating effect of current PTSD symptoms.
AHRQ-funded; HS022990.
Citation: McKernan LC, Johnson BN, Crofford LJ .
Posttraumatic stress symptoms mediate the effects of trauma exposure on clinical indicators of central sensitization in patients with chronic pain.
Clin J Pain 2019 May;35(5):385-93. doi: 10.1097/ajp.0000000000000689..
Keywords: Chronic Conditions, Behavioral Health, Pain, Trauma
McKernan LC, Johnson BN, Reynolds WS
Posttraumatic stress disorder in interstitial cystitis/bladder pain syndrome: relationship to patient phenotype and clinical practice implications.
The relationship between exposure to abuse and interstitial cystitis/bladder pain syndrome (IC/BPS) is well-documented. However, studies have yet to examine posttraumatic stress disorder (PTSD), which develops following exposure to trauma and worsens health outcomes in chronic pain. The authors of this study aimed to assess the prevalence and impact of PTSD in patients with IC/BPS, including their relation to genitourinary symptom presentation and widespread pain phenotype.
AHRQ-funded; HS022990.
Citation: McKernan LC, Johnson BN, Reynolds WS .
Posttraumatic stress disorder in interstitial cystitis/bladder pain syndrome: relationship to patient phenotype and clinical practice implications.
Neurourol Urodyn 2019 Jan;38(1):353-62. doi: 10.1002/nau.23861..
Keywords: Behavioral Health, Pain, Trauma