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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 11 of 11 Research Studies DisplayedPatel DK, Duncan MS, Shah AS
Association of cardiac rehabilitation with decreased hospitalization and mortality risk after cardiac valve surgery.
Investigators sought to characterize cardiac rehabilitation (CR) enrollment after cardiac valve surgery and its association with outcomes, including hospitalizations and mortality. Subjects were all fee-for-service Medicare beneficiaries undergoing open cardiac valve surgery in 2014, identified by inpatient diagnosis codes for open aortic, mitral, tricuspid, and pulmonary valve surgery. They found that fewer than half of Medicare beneficiaries undergoing cardiac valve surgery enrolled in CR programs, and there were marked racial/ethnic disparities among those who do. They recommend further study on barriers to CR enrollment in this population.
AHRQ-funded; HS022990.
Citation: Patel DK, Duncan MS, Shah AS .
Association of cardiac rehabilitation with decreased hospitalization and mortality risk after cardiac valve surgery.
JAMA Cardiol 2019 Dec;4(12):11887-1301. doi: 10.1001/jamacardio.2019.4032..
Keywords: Cardiovascular Conditions, Heart Disease and Health, Rehabilitation, Hospitalization, Surgery, Mortality, Risk, Elderly
Kundi H, Strom JB, Valsdottir LR
Trends in isolated surgical aortic valve replacement according to hospital-based transcatheter aortic valve replacement volumes.
This research analyzed trends in isolated surgical aortic valve replacement (SAVR) procedures with the advent of the transcatheter aortic valve replacement (TAVR) procedure. Hospitalizations of adults from January 2011 through December 2014 was analyzed with data from the Medicare Provider Analysis and Review database using ICD-9 Revision-Clinical Modification procedure codes. The annual value of isolated SAVR went down as TAVR volumes increased which also decreased short- and long-term mortality over the study period.
AHRQ-funded; HS024520.
Citation: Kundi H, Strom JB, Valsdottir LR .
Trends in isolated surgical aortic valve replacement according to hospital-based transcatheter aortic valve replacement volumes.
JACC Cardiovasc Interv 2018 Nov 12;11(21):2148-56. doi: 10.1016/j.jcin.2018.07.002..
Keywords: Surgery, Heart Disease and Health, Cardiovascular Conditions, Hospitals
Brescia AA, Wu X, Paone G
Effect of sex on nadir hematocrit and rates of acute kidney injury in coronary artery bypass.
Researchers explored whether there a sex-related difference on nadir hematocrit and rates of acute kidney injury in coronary artery bypass. A prospective, observational study was conducted of 17,363 patients not on dialysis undergoing the procedure between 2011 and 2016 across 41 institutions from the Perfusion Measure and Outcomes registry. There was no sex-related differences found for nadir hematocrit or rates of acute kidney injury.
AHRQ-funded; HS026003; HS022535.
Citation: Brescia AA, Wu X, Paone G .
Effect of sex on nadir hematocrit and rates of acute kidney injury in coronary artery bypass.
J Thorac Cardiovasc Surg 2019 Oct;158(4):1073-80.e4. doi: 10.1016/j.jtcvs.2019.03.042..
Keywords: Injuries and Wounds, Sex Factors, Kidney Disease and Health, Adverse Events, Surgery, Heart Disease and Health, Cardiovascular Conditions
Kundi H, Popma JJ, Valsdottir LR
The value of claims-based nontraditional risk factors in predicting long-term mortality after MitraClip procedure.
The goals of this study were to identify nontraditional risk factors coded in administrative claims data and to evaluate their ability to improve prediction of long-term mortality in patients undergoing percutaneous mitral valve repair. Patients undergoing transcatheter mitral valve repair using MitraClip implantation were identified among Medicare fee-for-service beneficiaries; researchers used nested Cox regression models to identify claims codes predictive of long-term mortality. Four groups of variables were introduced: cardiac, noncardiac, and nontraditional risk factors, and presentation characteristics. The authors conclude that risk-prediction models, which include nontraditional risk factors as identified in claims data, can be used to predict long-term mortality risk more accurately in patients who have undergone MitraClip procedures.
AHRQ-funded; HS024520.
Citation: Kundi H, Popma JJ, Valsdottir LR .
The value of claims-based nontraditional risk factors in predicting long-term mortality after MitraClip procedure.
Can J Cardiol 2018 Dec;34(12):1648-54. doi: 10.1016/j.cjca.2018.10.002..
Keywords: Cardiovascular Conditions, Elderly, Mortality, Heart Disease and Health, Medicare, Risk, Surgery
Bath J, Smith JB, Kruse RL
Association of neutrophil-to-lymphocyte ratio with outcomes after elective abdominal aortic aneurysm repair.
This study investigated postoperative outcomes from elective abdominal aortic aneurysm surgery (AAA) repair using neutrophil-to-lymphocyte ratio as the predictor. Inpatients from the Cerner Health Facts database undergoing elective AAA repair from 2008 to 2015 were selected using ICD-9 procedure codes. Patients with a high postoperative NLR experienced longer hospital stays; higher rates of in-hospital death; high rates of renal failure, cardiac problems, respiratory problems, and infection compared to patients with a low postoperative NLR. The authors recommend future study of NLR to help provide clinically important risk profiles.
AHRQ-funded; HS022140.
Citation: Bath J, Smith JB, Kruse RL .
Association of neutrophil-to-lymphocyte ratio with outcomes after elective abdominal aortic aneurysm repair.
J Vasc Nurs 2019 Sep;37(3):213-20. doi: 10.1016/j.jvn.2019.06.001..
Keywords: Cardiovascular Conditions, Heart Disease and Health, Surgery, Patient-Centered Outcomes Research, Outcomes, Evidence-Based Practice
Kundi H, Popma JJ, Reynolds MR
Frailty and related outcomes in patients undergoing transcatheter valve therapies in a nationwide cohort.
In this study, the investigators sought to identify the prevalence and related outcomes of frail individuals undergoing transcatheter mitral valve repair and transcatheter aortic valve replacement (TAVR). Patients aged 65 and older were included in the study if they had at least one procedural code for transcatheter mitral valve repair or TAVR between 1 January 2016 and 31 December 2016 in the Centers for Medicare and Medicaid Services Medicare Provider and Review database.
Citation: Kundi H, Popma JJ, Reynolds MR .
Frailty and related outcomes in patients undergoing transcatheter valve therapies in a nationwide cohort.
Eur Heart J 2019 Jul 14;40(27):2231-39. doi: 10.1093/eurheartj/ehz187.
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Keywords: Elderly, Heart Disease and Health, Cardiovascular Conditions, Surgery, Outcomes, Treatments
Hoch JM, Fatusin O, Yenokyan G
Feeding methods for infants with single ventricle physiology are associated with length of stay during stage 2 surgery hospitalization.
The purpose of this paper was to identify types of feeding methods following stage 2 palliation and their influence on length of stay. Results showed that feeding methods established at admission for stage 2 palliation are not likely to change by discharge, and that length of stay is more likely to be impacted by tube feeding and intubation history than by age or weight-for-age z score at admission. Recommendations included a better understanding for selection of feeding methods and their impact on patient outcomes in order to develop evidence-based guidelines to decrease variability in clinical practice patterns and to provide appropriate counseling to caregivers.
AHRQ-funded; HS021114.
Citation: Hoch JM, Fatusin O, Yenokyan G .
Feeding methods for infants with single ventricle physiology are associated with length of stay during stage 2 surgery hospitalization.
Congenit Heart Dis 2019 May;14(3):438-45. doi: 10.1111/chd.12742.
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Keywords: Nutrition, Newborns/Infants, Children/Adolescents, Hospitalization, Surgery, Heart Disease and Health, Cardiovascular Conditions, Evidence-Based Practice, Patient-Centered Outcomes Research
de Cordova PB, Johnansen ML, Riman KA
Public reporting of cardiac outcomes for patients with acute myocardial infarction: a systematic review of the evidence.
A systematic review was conducted to evaluate the effect of public reporting for patients with acute myocardial infarction (AMI), specifically for those patients who receive percutaneous coronary intervention (PCI). The investigators concluded that although public reporting may have had intentions of improving care, there was strong evidence that this policy did not result in more timely PCIs or improved mortality of patients with AMI. In fact, public reporting resulted in unintended consequences of not providing care for the most vulnerable patients in fear of an adverse outcome.
AHRQ-funded; HS024339.
Citation: de Cordova PB, Johnansen ML, Riman KA .
Public reporting of cardiac outcomes for patients with acute myocardial infarction: a systematic review of the evidence.
J Cardiovasc Nurs 2019 Mar/Apr;34(2):115-23. doi: 10.1097/jcn.0000000000000524..
Keywords: Cardiovascular Conditions, Heart Disease and Health, Surgery, Evidence-Based Practice
Dunn T, Saeed MJ, Shpigel A
The association of preoperative cardiac stress testing with 30-day death and myocardial infarction among patients undergoing kidney transplantation.
This study examined whether the use of preoperative cardiac stress testing of patients undergoing kidney transplantation reduced 30-day- death and myocardial infarction post-transplantation. ESRD patients 40 years or older with primary Medicare insurance between 2006 and 2013 were identified using the United States Renal Data System. In a matched cohort of 17,304 patients, there was little difference in 30-day post-transplantation mortality and myocardial infarction between those receiving a stress test and those who did not.
AHRQ-funded; HS019455.
Citation: Dunn T, Saeed MJ, Shpigel A .
The association of preoperative cardiac stress testing with 30-day death and myocardial infarction among patients undergoing kidney transplantation.
PLoS One 2019 Feb;14(2):e0211161. doi: 10.1371/journal.pone.0211161..
Keywords: Transplantation, Kidney Disease and Health, Heart Disease and Health, Cardiovascular Conditions, Chronic Conditions, Risk, Surgery
Chui PW, Parzynski CS, Ross JS
Association of statewide certificate of need regulations with percutaneous coronary intervention appropriateness and outcomes.
This study sought to characterize the association between state certificate of need (CON) regulations and percutaneous coronary interventions (PCI) appropriateness. The investigators found that states with CON had lower proportions of rarely appropriate PCI s, but the absolute differences were small. The investigators note that the findings suggest that CON regulations alone may not limit rarely appropriate PCI among patients with and without acute coronary syndrome.
AHRQ-funded; HS023000.
Citation: Chui PW, Parzynski CS, Ross JS .
Association of statewide certificate of need regulations with percutaneous coronary intervention appropriateness and outcomes.
J Am Heart Assoc 2019 Jan 22;8(2):e010373. doi: 10.1161/jaha.118.010373..
Keywords: Cardiovascular Conditions, Outcomes, Patient-Centered Outcomes Research, Heart Disease and Health, Policy, Surgery
Lam L, Ahn HJ, Okajima K
Gender differences in the rate of 30-day readmissions after percutaneous coronary intervention for acute coronary syndrome.
This study investigated whether women have higher 30-day hospital readmission rates than men who have undergone percutaneous coronary intervention (PCI) after acute coronary syndrome (ACS). In general, women have been reported having higher readmission rates than men after ACS. Statewide hospitalization data for 2010 to 2015 in Hawaii was analyzed to compare gender differences. Overall, the women in the study were older, more identified as Native Hawaiian and have more cardiovascular risk factors compared with the men. Readmission rates were found to be higher than for men after undergoing PCI, but as shown above there were more risk factors for these women.
AHRQ-funded; HS019990.
Citation: Lam L, Ahn HJ, Okajima K .
Gender differences in the rate of 30-day readmissions after percutaneous coronary intervention for acute coronary syndrome.
Womens Health Issues 2019 Jan-Feb;29(1):17-22. doi: 10.1016/j.whi.2018.09.002..
Keywords: Cardiovascular Conditions, Hospital Readmissions, Heart Disease and Health, Sexual Health, Surgery
