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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 1 of 1 Research Studies DisplayedKrutsinger DC, Yadav KN, Harhay MO
A systematic review and meta-analysis of enrollment into ARDS and sepsis trials published between 2009 and 2019 in major journals.
This systematic review and meta-analysis looked at enrollment rates for randomized controlled trials (RCTs) conducted in the ICU, with the focus on patients with acute respiratory distress syndrome (ARDS), acute lung injury (ALI), or sepsis, and which factors influenced enrollment rates. The authors conducted a systematic review using PubMed for ARD/ALI and sepsis to identify individually published RCTs among the seven highest impact general medicine and seven highest impact critical care journals between 2009 and 2019. A total of 457 articles were identified, with 94 trials meeting inclusion criteria. Trials most commonly evaluated were pharmaceutical interventions (53%), were non-industry funded (78%), and required prospective informed consent (81%). The overall enrollment rate was less than 1 participant per site per month, with single-center trials having a significantly higher enrollment rate than multicenter trials. Enrollment for sepsis trials was almost twice the rate as ARDS/ALI.
AHRQ-funded; HS027795.
Citation: Krutsinger DC, Yadav KN, Harhay MO .
A systematic review and meta-analysis of enrollment into ARDS and sepsis trials published between 2009 and 2019 in major journals.
Crit Care 2021 Nov 15;25(1):392. doi: 10.1186/s13054-021-03804-1..
Keywords: Sepsis, Respiratory Conditions