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Research Studies is a monthly compilation of research articles funded by AHRQ or authored by AHRQ researchers and recently published in journals or newsletters.
Results1 to 7 of 7 Research Studies Displayed
Wiese AD, Griffin MR, Grijalva CG
Impact of pneumococcal conjugate vaccines on hospitalizations for pneumonia in the United States.
In this study, the investigators described the existing evidence for both the direct and indirect impact of Pneumococcal conjugate vaccines (PCVs) on pneumonia among children and adults in the US since PCV introduction. The introduction of PCVs into the US routine infant vaccination schedule led to important reductions in the burden of invasive pneumococcal diseases and non-invasive pneumonia among vaccinated and unvaccinated populations. The impact of direct vaccination of older adults in the US since 2014, though difficult to quantify, is currently being evaluated.
Citation: Wiese AD, Griffin MR, Grijalva CG . Impact of pneumococcal conjugate vaccines on hospitalizations for pneumonia in the United States. Expert Rev Vaccines 2019 Apr;18(4):327-41. doi: 10.1080/14760584.2019.1582337..
Keywords: Vaccination, Pneumonia, Respiratory Conditions, Hospitalization, Prevention
Albright K, Hurley LP, Lockhart S
Attitudes about adult vaccines and reminder/recall in a safety net population.
The objective of this study was to determine patient perspectives on adult vaccines generally; attitudes about Tdap, pneumococcal polysaccharide (PPSV-23), and seasonal influenza vaccines specifically; and preferences for adult reminder/recall delivery.
Citation: Albright K, Hurley LP, Lockhart S . Attitudes about adult vaccines and reminder/recall in a safety net population. Vaccine 2017 Dec 19;35(52):7292-96. doi: 10.1016/j.vaccine.2017.11.001..
Keywords: Influenza, Pneumonia, Prevention, Safety Net, Vaccination
McFarland M, Szasz TP, Zhou JY
Colonization with 19F and other pneumococcal conjugate vaccine serotypes in children in St. Louis, Missouri, USA.
The primary goal of this study was to determine the vaccine-type (VT) serotype prevalence of nasopharyngeal (NP) pneumococcal colonization of children residing in the St. Louis, MO, USA metropolitan area following introduction of the 13-valent pneumococcal conjugate vaccine in 2010. It concluded that children in St. Louis exhibit a higher prevalence of VT serotypes among pneumococcal carriage isolates than has been reported in other areas in the US.
AHRQ-funded; HS021736; HS024269.
Citation: McFarland M, Szasz TP, Zhou JY . Colonization with 19F and other pneumococcal conjugate vaccine serotypes in children in St. Louis, Missouri, USA. Vaccine 2017 Aug 3;35(34):4389-95. doi: 10.1016/j.vaccine.2017.06.047.
Keywords: Vaccination, Children/Adolescents, Pneumonia, Infectious Diseases
Brown T, Goldman SN, Persell SD
Development and evaluation of a patient education video promoting pneumococcal vaccination.
The researchers aimed to develop and refine a patient education video about pneumococcal polysaccharide vaccination (PPSV23) and to assess patient perceptions regarding video content and receipt of video during a clinic visit. They found that focus group participants had positive reactions to the video but suggested reducing the intensity of messages about pneumonia severity. Participants shown the revised video during a clinic visit perceived it to be easy to understand and informative.
Citation: Brown T, Goldman SN, Persell SD . Development and evaluation of a patient education video promoting pneumococcal vaccination. Patient Educ Couns 2017 May;100(5):1024-27. doi: 10.1016/j.pec.2016.12.025.
Keywords: Education: Patient and Caregiver, Health Promotion, Pneumonia, Vaccination
Iroh Tam PY, Thielen BK, Obaro SK
Childhood pneumococcal disease in Africa - a systematic review and meta-analysis of incidence, serotype distribution, and antimicrobial susceptibility.
This study provided updated estimates of the incidence, serotype distribution, and antimicrobial susceptibility profile of Streptococcus pneumoniae causing disease in Africa. It concluded that, although the incidence of invasive pneumococcal disease (IPD) in young children in Africa is substantial, currently available conjugate vaccines are estimated to cover the majority of invasive disease-causing pneumococcal serotypes.
Citation: Iroh Tam PY, Thielen BK, Obaro SK . Childhood pneumococcal disease in Africa - a systematic review and meta-analysis of incidence, serotype distribution, and antimicrobial susceptibility. Vaccine 2017 Apr 4;35(15):1817-27. doi: 10.1016/j.vaccine.2017.02.045.
Keywords: Children/Adolescents, Infectious Diseases, Medication, Pneumonia, Vaccination
Nace DA, Archbald-Pannone LR, Ashraf MS
Pneumococcal vaccination guidance for post-acute and long-term care settings: recommendations from AMDA's infection advisory committee.
Sorting out the indications and timing for 13 pneumococcal serotypes and 23 pneumococcal serotypes administration is complex. The authors discuss the importance of pneumococcal vaccination for older adults, detail AMDA-The Society for Post-Acute and Long-Term Care Medicine (The Society)'s recommendations for pneumococcal vaccination practice and procedures, and offer guidance to postacute and long-term care providers supporting the development and effective implementation of pneumococcal vaccine policies.
Citation: Nace DA, Archbald-Pannone LR, Ashraf MS . Pneumococcal vaccination guidance for post-acute and long-term care settings: recommendations from AMDA's infection advisory committee. J Am Med Dir Assoc 2017 Feb;18(2):99-104. doi: 10.1016/j.jamda.2016.11.010.
Keywords: Elderly, Guidelines, Nursing Homes, Pneumonia, Vaccination
de St Maurice A, Schaffner W, Griffin MR
Persistent sex disparities in invasive pneumococcal diseases in the conjugate vaccine era.
The authors examined sex differences in rates of invasive pneumococcal disease (IPD) and trends after the introduction of pneumococcal conjugate vaccines (PCVs). They concluded that rates of IPD were generally higher in male than in female subjects.
Citation: de St Maurice A, Schaffner W, Griffin MR . Persistent sex disparities in invasive pneumococcal diseases in the conjugate vaccine era. J Infect Dis 2016 Sep 01;214(5):792-7. doi: 10.1093/infdis/jiw222.
Keywords: Pneumonia, Sex Factors, Vaccination, Prevention