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Research Studies is a monthly compilation of research articles funded by AHRQ or authored by AHRQ researchers and recently published in journals or newsletters.
Results1 to 4 of 4 Research Studies Displayed
Chetta MD, Aliu O, Zhong L
Reconstruction of the irradiated breast: a national claims-based assessment of postoperative morbidity.
This study aims to assess the morbidity associated with various breast reconstruction techniques in irradiated patients. It found that overall complication rates were 45.3 percent and 30.8 percent for patients with implant and autologous reconstruction, respectively. Failure of reconstruction occurred in 29.4 percent of patients with implant reconstruction compared with 4.3 percent of patients with autologous reconstruction.
Citation: Chetta MD, Aliu O, Zhong L . Reconstruction of the irradiated breast: a national claims-based assessment of postoperative morbidity. Plast Reconstr Surg 2017 Apr;139(4):783-92. doi: 10.1097/prs.0000000000003168.
Keywords: Cancer, Cancer: Breast Cancer, Surgery, Adverse Events, Patient-Centered Outcomes Research
Nickel KB, Fox IK, Margenthaler JA
Effect of noninfectious wound complications after mastectomy on subsequent surgical procedures and early implant loss.
The authors determined the rates of noninfectious wound complications (NIWCs) among women undergoing mastectomy and assessed the impact of immediate reconstruction (IR). They found that the rate of NIWC was approximately 2-fold higher after mastectomy with IR than after mastectomy only and that noninfectious wound complications were associated with additional surgical treatment, particularly in women with implant reconstruction, and with early implant loss.
Citation: Nickel KB, Fox IK, Margenthaler JA . Effect of noninfectious wound complications after mastectomy on subsequent surgical procedures and early implant loss. J Am Coll Surg 2016 May;222(5):844-52.e1. doi: 10.1016/j.jamcollsurg.2016.01.050.
Keywords: Adverse Events, Cancer: Breast Cancer, Injuries and Wounds, Surgery
Gidengil CA, Predmore Z, Mattke S
Breast implant-associated anaplastic large cell lymphoma: a systematic review.
The purpose of this study was to identify and analyze recently published cases of breast implant-associated anaplastic large cell lymphoma (ALCL), with an emphasis on diagnosis, staging, treatment, and outcomes. The researchers found that, of 54 cases, most patients presented with a seroma, approximately half were associated with the capsule, most presented as stage IE, and all but one case were ALK-negative. Most patients received chemotherapy and radiation therapy, and 11 percent received stem cell transplants. Approximately one-quarter recurred, and 9 percent died.
Citation: Gidengil CA, Predmore Z, Mattke S . Breast implant-associated anaplastic large cell lymphoma: a systematic review. Plast Reconstr Surg 2015 Mar;135(3):713-20. doi: 10.1097/prs.0000000000001037.
Keywords: Adverse Events, Cancer: Breast Cancer, Diagnostic Safety and Quality, Patient-Centered Outcomes Research, Surgery
Olsen MA, Nickel KB, Margenthaler JA
Increased risk of surgical site infection among breast-conserving surgery re-excisions.
The aim of this study was to determine the risk of surgical site infection (SSI) after primary breast-conserving surgery (BCS) versus re-excision among women with carcinoma in situ or invasive breast cancer. It found that the risk of SSI after re-excision remained significantly higher after accounting for multiple procedures within a woman.
Citation: Olsen MA, Nickel KB, Margenthaler JA . Increased risk of surgical site infection among breast-conserving surgery re-excisions. Ann Surg Oncol 2015;22(6):2003-9. doi: 10.1245/s10434-014-4200-x..
Keywords: Surgery, Risk, Cancer: Breast Cancer, Cancer, Healthcare-Associated Infections (HAIs), Injuries and Wounds, Adverse Events, Patient Safety, Women