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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 5 of 5 Research Studies DisplayedMaloney MH, Payne SR, Herrin J
Risk of systemic adverse events after intravitreal bevacizumab, ranibizumab, and aflibercept in routine clinical practice.
Intravitreal anti-vascular endothelial growth factor (VEGF) pharmacotherapy plays a central role in the management of neovascular age-related macular degeneration (nAMD), diabetic retinal disease (DRD), and retinal venous occlusive disease (RVO). The goal of this study was to compare the systemic safety of intravitreal bevacizumab, ranibizumab, and aflibercept in real-world practice. The investigators observed no differences in the risk of acute MI, CVD, major bleeding, or all-cause hospitalization after treatment initiation with intravitreal bevacizumab, ranibizumab, or aflibercept during routine clinical practice.
AHRQ-funded; HS024075; HS025164; HS025402; HS025517; HS026379.
Citation: Maloney MH, Payne SR, Herrin J .
Risk of systemic adverse events after intravitreal bevacizumab, ranibizumab, and aflibercept in routine clinical practice.
Ophthalmology 2021 Mar;128(3):417-24. doi: 10.1016/j.ophtha.2020.07.062..
Keywords: Eye Disease and Health, Medication, Risk, Adverse Drug Events (ADE), Adverse Events
Roberto SA, Bayes J, Karner PE
Patient harm in cataract surgery: a series of adverse events in Massachusetts.
This study examined the reported adverse events (AEs) involving cataract surgery in Massachusetts from 2011 to 2015. There were 37 AEs reported, with 15 anesthesia related, 5 were wrong eye blocks, 3 cases of hemodynamic instability, 2 retrobulbar hematoma/hemorrhages, and 5 globe perforations resulting in permanent loss of vision. However, the authors believe the numbers reported to Massachusetts state agencies are lower than the true number of AEs.
AHRQ-funded; HS024764.
Citation: Roberto SA, Bayes J, Karner PE .
Patient harm in cataract surgery: a series of adverse events in Massachusetts.
Anesth Analg 2018 May;126(5):1548-50. doi: 10.1213/ane.0000000000002526..
Keywords: Adverse Events, Eye Disease and Health, Patient Safety, Risk, Surgery
Lipton BJ, Decker SL
AHRQ Author: Decker SL
Association between diagnosed diabetes and trouble seeing, National Health Interview Survey, 2011-13.
This study used nationally representative 2011–2013 data from the United States to estimate the association between diagnosed diabetes and trouble seeing. Diagnosed diabetes was associated with approximately double the odds of self-reported trouble seeing. Older age, less education, and a history of comorbid conditions were positively correlated, while male sex, being married, and having health insurance were negatively correlated with trouble seeing.
AHRQ-authored.
Citation: Lipton BJ, Decker SL .
Association between diagnosed diabetes and trouble seeing, National Health Interview Survey, 2011-13.
J Diabetes 2015 Sep;7(5):743-6. doi: 10.1111/1753-0407.12311.
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Keywords: Chronic Conditions, Diabetes, Elderly, Eye Disease and Health, Risk
Bartels CM, Wong JC, Johnson SL
Rheumatoid arthritis and the prevalence of diabetic retinopathy.
The objective of this study was to examine RA as a risk factor for diabetic retinopathy compared with other vascular risk factors. It found that compared with patients without RA, the adjusted model demonstrated that patients with diabetes and RA were 28 percent less likely to have diabetic retinopathy.
AHRQ-funded; HS018368.
Citation: Bartels CM, Wong JC, Johnson SL .
Rheumatoid arthritis and the prevalence of diabetic retinopathy.
Rheumatology 2015 Aug;54(8):1415-9. doi: 10.1093/rheumatology/kev012..
Keywords: Arthritis, Risk, Eye Disease and Health, Diabetes
Steinman BA, Allen SM, Chen J
Functional limitations as potential mediators of the effects of self-reported vision status on fall risk of older adults.
The purpose of this study was to examine mediating effects of two indices of physical functioning (mobility and large-muscle functioning) on self-reported vision status, as it relates to falls in older adults. Limited evidence was found for a mediating effect among women; however, large-muscle groups were implicated as partially mediating risk factors for falls among men with fair self-reported vision status.
AHRQ-funded; HS000011.
Citation: Steinman BA, Allen SM, Chen J .
Functional limitations as potential mediators of the effects of self-reported vision status on fall risk of older adults.
J Aging Health 2015 Feb;27(1):158-76. doi: 10.1177/0898264314543473..
Keywords: Elderly, Falls, Eye Disease and Health, Risk