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Research Studies is a monthly compilation of research articles funded by AHRQ or authored by AHRQ researchers and recently published in journals or newsletters.
Results1 to 17 of 17 Research Studies Displayed
Yunusa I, Gagne JJ, Yoshida K
Risk of opioid overdose associated with concomitant use of oxycodone and selective serotonin reuptake inhibitors.
Oxycodone is a potent prescription opioid. Some Selective Serotonin Reuptake Inhibitors (SSRIs) inhibit oxycodone metabolism in the body, but the clinical consequences of this interaction on overdose risk have not been adequately determined. The study researchers compared the rates of opioid overdoses in patients who had initiated oxycodone while taking enzyme-inhibiting SSRIs with the overdose rates of patents who had initiated oxycodone while taking non-enzyme inhibiting SSRIs. Data from 3 U.S. health insurance databases was used to analyze a cohort of adults who initiated oxycodone while receiving SSRI therapy between the years 2000 and 2020. Of the total of 2,037,490 who initiated oxycodone, 69.6% were receiving SSRIs at the time of the initiation of the oxycodone. One-thousand-thirty-five overdose events were observed during this time, and the resulting incidence rate in those initiating oxycodone while using enzyme-inhibiting SSRI’s was higher than in those using other SSRIs. The researchers concluded that in the study cohort of U.S. adults, there is a small increased risk of opioid overdose when initiating oxycodone in patients taking enzyme-inhibiting SSRIs.
Citation: Yunusa I, Gagne JJ, Yoshida K . Risk of opioid overdose associated with concomitant use of oxycodone and selective serotonin reuptake inhibitors. JAMA Netw Open 2022 Feb;5(2):e220194. doi: 10.1001/jamanetworkopen.2022.0194..
Keywords: Opioids, Medication, Risk, Depression, Adverse Drug Events (ADE), Adverse Events
Sico JJ, Kundu S, So-Armah K
Depression as a risk factor for incident ischemic stroke among HIV-positive veterans in the veterans aging cohort study.
Background HIV infection and depression are each associated with increased ischemic stroke risk. Whether depression is a risk factor for stroke within the HIV population is unknown. In this study the investigators examined depression as a risk factor for incident ischemic stroke among HIV-positive veterans in the veterans aging cohort study. The investigators concluded that depression is associated with an increased risk of stroke among HIV-positive people after adjusting for sociodemographic characteristics, traditional cerebrovascular risk factors, and HIV-specific factors.
Citation: Sico JJ, Kundu S, So-Armah K . Depression as a risk factor for incident ischemic stroke among HIV-positive veterans in the veterans aging cohort study. J Am Heart Assoc 2021 Jul 6;10(13):e017637. doi: 10.1161/jaha.119.017637..
Keywords: Depression, Behavioral Health, Risk, Veterans, Human Immunodeficiency Virus (HIV), Stroke, Cardiovascular Conditions
Kuperberg M, Katz D, Greenebaum SLA
Psychotic symptoms during bipolar depressive episodes and suicidal ideation.
Researchers examined the relationship between psychotic symptoms during a depressive episode and suicidal ideation in bipolar patients. Psychotic symptoms in adult, depressed outpatients with bipolar disorder (BD) in a comparative effectiveness study of quetiapine versus lithium were assessed via Bipolar Inventory of Signs and Symptoms Scale (BISS); depressive episodes were assessed via Mini-International Neuropsychiatric Interview (MINI). The researchers found that, while a small proportion of bipolar disorder outpatients had current symptoms of psychosis during their depressive episode, those who did were more likely to endorse active suicidal thoughts, including suicide methods and plans.
Citation: Kuperberg M, Katz D, Greenebaum SLA . Psychotic symptoms during bipolar depressive episodes and suicidal ideation. J Affect Disord 2021 Mar 1;282:1241-46. doi: 10.1016/j.jad.2020.12.184..
Keywords: Depression, Behavioral Health, Risk
Guglielminotti J, Li G
Exposure to general anesthesia for cesarean delivery and odds of severe postpartum depression requiring hospitalization.
This retrospective cohort study evaluated the risk of general anesthesia use in cesarean delivery versus neuraxial anesthesia on maternal mental health. Cesarean deliveries performed in New York State hospitals between 2006 and 2013 were included. Exclusion criteria included having more than 1 cesarean delivery during the study period, residing outside of New York State, and having a general anesthetic for other surgery or delivery in the year before or after the index case. The primary outcome looked at was severe postpartum depression (PPD), and secondary outcomes were suicidal ideation, anxiety disorders, and posttraumatic stress disorder (PTSD). The majority of cesareans used neuraxial anesthesia and only 8% (34,356) had general anesthesia. Severe PPD requiring hospitalization occurred in 1158 women with 60% identified during readmission. General anesthesia was found to be associated with a 54% increased odds of PPD, and a 91% increased odds of suicidal ideation or self-inflicted injury. There was insufficient evidence for increased risk of anxiety orders.
Citation: Guglielminotti J, Li G . Exposure to general anesthesia for cesarean delivery and odds of severe postpartum depression requiring hospitalization. Anesth Analg 2020 Nov;131(5):1421-29. doi: 10.1213/ane.0000000000004663..
Keywords: Labor and Delivery, Pregnancy, Women, Depression, Behavioral Health, Surgery, Risk, Hospitalization, Medication, Adverse Drug Events (ADE), Adverse Events
Katz D, Petersen T, Amado S
An evaluation of suicidal risk in bipolar patients with comorbid posttraumatic stress disorder.
The impact of concurrent diagnosis posttraumatic stress disorder (PTSD) on persons with bipolar disorder (BD) was analyzed to determine if there was a higher risk of suicidal ideation. Baseline data from the 482 individuals enrolled in the Clinical and Health Outcomes Initiative in Comparative Effectiveness for bipolar disorder study (Bipolar CHOICE) was used. The association of comorbid PTSD with increased suicidal ideation was assessed by the Concise Health Risk Tracking Scale (CHRT) total and factor scores. As the authors hypothesized, diagnosis of comorbid PTSD was a significant predictor of the CHRT total score. All participants with comorbid PTSD (n=58) endorsed current suicidal ideation and were more likely to have had a previous suicide attempt compared to those without PTSD.
Citation: Katz D, Petersen T, Amado S . An evaluation of suicidal risk in bipolar patients with comorbid posttraumatic stress disorder. J Affect Disord 2020 Apr 1;266:49-56. doi: 10.1016/j.jad.2020.01.091..
Keywords: Behavioral Health, Risk, Evidence-Based Practice, Comparative Effectiveness, Patient-Centered Outcomes Research, Depression
Albrecht JS, Barbour L, Abariga SA
Risk of depression after traumatic brain injury in a large national sample.
The goal of this study was to estimate the risk of depression post-traumatic brain injury (TBI) among adults 18 years of age and older and to identify risk factors associated with developing depression post-TBI. Claims data for privately insured and Medicare Advantage enrollees was used. Results showed that history of neuropsychiatric disturbances pre-TBI was the strongest predictor of depression post-TBI. The risk of depression increases substantially post-TBI. Groups at increased risk include those with a history of neuropsychiatric disturbances, older adults, and men. This study highlights the importance of long-term monitoring for depression post-TBI.
Citation: Albrecht JS, Barbour L, Abariga SA . Risk of depression after traumatic brain injury in a large national sample. J Neurotrauma 2019 Jan 15;36(2):300-07. doi: 10.1089/neu.2017.5608..
Keywords: Depression, Behavioral Health, Brain Injury, Trauma, Risk
Goldmann E, Roberts ET, Parikh NS
Chronic physical illness burden and suicidal ideation among Dominicans in New York City.
This study used data from a community survey of 2753 Dominican adults in New York City to investigate the association between chronic illness and suicidal ideation. The investigators concluded that the association of interest did not differ significantly between younger and older adults. They suggest that screening for SI in health care practice, particularly among Dominican men with multiple chronic health conditions, may be warranted.
Citation: Goldmann E, Roberts ET, Parikh NS . Chronic physical illness burden and suicidal ideation among Dominicans in New York City. J Immigr Minor Health 2017 Jun;19(3):616-22. doi: 10.1007/s10903-016-0477-0..
Keywords: Chronic Conditions, Depression, Behavioral Health, Racial / Ethnic Minorities, Risk
Hoffman GJ, Hays RD, Wallace SP
Depressive symptomatology and fall risk among community-dwelling older adults.
The directionality of observed relationship between falls and depressive symptoms (DS) is in need of elaboration given that cross-sectional study designs can yield biased estimates of the DS-falls relationship. This study found that the DS-falls relationship was not significant when use of psychiatric medications, which was positively associated with falls, was included in the model.
Citation: Hoffman GJ, Hays RD, Wallace SP . Depressive symptomatology and fall risk among community-dwelling older adults. Soc Sci Med 2017 Apr;178:206-13. doi: 10.1016/j.socscimed.2017.02.020.
Keywords: Depression, Elderly, Falls, Patient Safety, Risk
Iyer AS, Bhatt SP, Garner JJ
Depression is associated with readmission for acute exacerbation of chronic obstructive pulmonary disease.
The authors characterized the associations between depression and anxiety and COPD readmission risk. They found that depression is an independent risk factor for both short- and long-term readmissions for acute exacerbation of COPD and may represent a modifiable risk factor. They also found that in-hospital tobacco cessation counseling was associated with reduced 1-year readmission.
Citation: Iyer AS, Bhatt SP, Garner JJ . Depression is associated with readmission for acute exacerbation of chronic obstructive pulmonary disease. Ann Am Thorac Soc 2016 Feb;13(2):197-203. doi: 10.1513/AnnalsATS.201507-439OC.
Keywords: Respiratory Conditions, Depression, Hospital Readmissions, Risk, Tobacco Use
Eichen DM, Kass AE, Fitzsimmons-Craft EE
Non-suicidal self-injury and suicidal ideation in relation to eating and general psychopathology among college-age women.
Limited research has examined the effects of combined non-suicidal self-injury (NSSI)+suicidal ideation; thus concurrent examination is needed to understand potential differential effects on psychopathology. In this study, college-aged women completed self-report measures of NSSI, suicidal ideation, general psychopathology, and Eating Disorder-specific psychopathology. The study found that the NSSI+Suicidal Ideation group was only greater than Suicidal Ideation-only on measures of depression and eating concern.
Citation: Eichen DM, Kass AE, Fitzsimmons-Craft EE . Non-suicidal self-injury and suicidal ideation in relation to eating and general psychopathology among college-age women. Psychiatry Res 2016 Jan 30;235:77-82. doi: 10.1016/j.psychres.2015.11.046.
Keywords: Behavioral Health, Nutrition, Depression, Risk
Yu SH, Silverberg JI
Association between atopic dermatitis and depression in US adults.
The researchers sought to determine the prevalence of depression in US adults with atopic dermatitis (AD). They concluded that approximately one in three US adults with AD reported any symptoms of depression and one in three adults with AD met diagnostic criteria for major depressive disorder.
Citation: Yu SH, Silverberg JI . Association between atopic dermatitis and depression in US adults. J Invest Dermatol 2015 Dec;135(12):3183-6. doi: 10.1038/jid.2015.337..
Keywords: Depression, Behavioral Health, Risk, Skin Conditions
Alcantara C, Muntner P, Edmondson D
Perfect storm: concurrent stress and depressive symptoms increase risk of myocardial infarction or death.
A recently offered psychosocial perfect storm conceptual model hypothesizes amplified risk will occur in those with concurrent stress and depressive symptoms. The authors tested this hypothesis in a large sample of US adults with coronary heart disease. They found that those with low stress and high depressive symptoms or high stress and low depressive symptoms were not at increased risk, while participants with concurrent high stress and high depressive symptoms had increased risk for myocardial infarction or death relative to those with low stress and low depressive symptoms. They concluded that their results provide initial support for a psychosocial perfect storm conceptual model.
Citation: Alcantara C, Muntner P, Edmondson D . Perfect storm: concurrent stress and depressive symptoms increase risk of myocardial infarction or death. Circ Cardiovasc Qual Outcomes 2015 Mar;8(2):146-54. doi: 10.1161/circoutcomes.114.001180.
Keywords: Depression, Heart Disease and Health, Mortality, Risk, Stress
Gibbons RD, Coca Perraillon M, Hur K
Antidepressant treatment and suicide attempts and self-inflicted injury in children and adolescents.
This study explores the relationship between antidepressant treatment and suicide attempt and self-inflicted injury in depressed children ages 5–17. Using two large claim datasets (LifeLink and MarketScan), the researchers find that after taking into account the time-varying effect of confounders, the apparent link between antidepressant use and suicide attempts and self-inflicted injury is diminished and not statistically significant.
AHRQ-funded; HS021093; HS000084
Citation: Gibbons RD, Coca Perraillon M, Hur K . Antidepressant treatment and suicide attempts and self-inflicted injury in children and adolescents. Pharmacoepidemiol Drug Saf 2015 Feb;24(2):208-14. doi: 10.1002/pds.3713..
Keywords: Medication, Children/Adolescents, Depression, Risk
Olfson M, Gerhard T
Re-examining antidepressant risk of self-injury in children and adolescents.
This commentary discusses issues raised in the study by Gibbons, et al. that focused on the association between antidepressant treatment and risk of medically injurious self-inflicted harm in young people diagnosed with depression. One example is the threat of unmeasured confounding that arises from the wide range of self-injury risk factors that are not represented in claims data.
Citation: Olfson M, Gerhard T . Re-examining antidepressant risk of self-injury in children and adolescents. Pharmacoepidemiol Drug Saf 2015 Feb;24(2):215-7. doi: 10.1002/pds.3737..
Keywords: Medication, Children/Adolescents, Depression, Risk
Ojard C, Donnelly JP, Safford MM
Psychosocial stress as a risk factor for sepsis: a population-based cohort study.
This study characterized the relationship between stress and future risk of sepsis and evaluated the role of depression in this relationship. It found that increased stress was associated with higher 1-year adjusted incidence of sepsis, even after accounting for depressive symptoms.
Citation: Ojard C, Donnelly JP, Safford MM . Psychosocial stress as a risk factor for sepsis: a population-based cohort study. Psychosom Med 2015 Jan;77(1):93-100. doi: 10.1097/psy.0000000000000120..
Keywords: Risk, Depression, Stress
Anand V, Downs SM, Bauer NS
Prevalence of infant television viewing and maternal depression symptoms.
This study evaluated how the risk of very early TV viewing by infants relates to the mother’s reported symptoms of depression. It found that TV viewing by infants increased by almost 50 percent with maternal report of depression symptoms.
AHRQ-funded; HS018453; HS017939
Citation: Anand V, Downs SM, Bauer NS . Prevalence of infant television viewing and maternal depression symptoms. J Dev Behav Pediatr. 2014 Apr;35(3):216-24. doi: 10.1097/dbp.0000000000000035..
Keywords: Newborns/Infants, Depression, Risk, Lifestyle Changes
Albrecht JS, Gruber-Baldini AL, Hirshon JM
Depressive symptoms and hospital readmission in older adults.
The purpose of this study was to quantify the risk of 30-day unplanned hospital readmission in adults aged 65 and older with depressive symptoms. The investigators concluded that, although not associated with hospital readmission, depressive symptoms were associated with other poor outcomes and may be underdiagnosed in hospitalized older adults. They asserted that hospitals interested in reducing readmission should focus on older adults with more comorbid illness and recent hospitalizations.
Citation: Albrecht JS, Gruber-Baldini AL, Hirshon JM . Depressive symptoms and hospital readmission in older adults. J Am Geriatr Soc 2014 Mar;62(3):495-9. doi: 10.1111/jgs.12686..
Keywords: Depression, Elderly, Emergency Department, Hospital Readmissions, Risk