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Research Studies is a monthly compilation of research articles funded by AHRQ or authored by AHRQ researchers and recently published in journals or newsletters.
Results1 to 5 of 5 Research Studies Displayed
Huda A, Castaño A, Niyogi A
A machine learning model for identifying patients at risk for wild-type transthyretin amyloid cardiomyopathy.
Transthyretin amyloid cardiomyopathy, an often-unrecognized cause of heart failure, is now treatable with a transthyretin stabilizer. It is therefore important to identify at-risk patients who can undergo targeted testing for earlier diagnosis and treatment, prior to the development of irreversible heart failure. In this study, the investigators showed that a random forest machine learning model could identify potential wild-type transthyretin amyloid cardiomyopathy using medical claims data.
Citation: Huda A, Castaño A, Niyogi A . A machine learning model for identifying patients at risk for wild-type transthyretin amyloid cardiomyopathy. Nat Commun 2021 May 11;12(1):2725. doi: 10.1038/s41467-021-22876-9..
Keywords: Heart Disease and Health, Cardiovascular Conditions, Neurological Disorders, Diagnostic Safety and Quality, Risk
Kole MJ, Shea P, Albrecht JS
Utility of the Hijdra sum score in predicting risk of aneurysm in patients with subarachnoid hemorrhage: a single-center experience with 550 patients.
This study’s objective was to generate a model to assist in predicting risk of aneurysm in patients with subarachnoid hemorrhage (SAH). A retrospective cohort study was conducted of all patients 18 years and older admitted to a single center from March 2008 to March 2018 with non-traumatic SAH (n = 550). Risk factors examined included female sex, higher modified Fisher or Hijdra score, nonperimesencephalic location, presence of intracerebral hemorrhage, World Federation of Neurological Societies (WFNS) score ≥3, need for cerebrospinal fluid diversion on admission, and history of tobacco use. Greater modified Fisher, greater Hijdra score, WFNS ≥3, and hydrocephalus present on admission presented a significantly greater risk of an aneurysm. The authors concluded a simple scoring tool based on patient sex, SAH location and SAH burden can assist in predicting the presence of an aneurysm in patients with nontraumatic SAH.
Citation: Kole MJ, Shea P, Albrecht JS . Utility of the Hijdra sum score in predicting risk of aneurysm in patients with subarachnoid hemorrhage: a single-center experience with 550 patients. Neurosurgery 2020 Jun;86(6):783-91. doi: 10.1093/neuros/nyz346.
Keywords: Cardiovascular Conditions, Neurological Disorders, Risk
Trivedi LU, Alvarez CA, Mansi IA
Association of statin therapy with risk of epilepsy in 2 propensity score-matched cohorts.
The objective of this study was to examine the association between statin use and epilepsy risk in a general population and in a healthy population (individuals with no severe comorbidities). The study did not demonstrate a significant beneficial or deleterious effect of statin use on risk of being diagnosed with epilepsy. The authors assert that clinicians should not withhold statins, whenever indicated, in patients with epilepsy.
Citation: Trivedi LU, Alvarez CA, Mansi IA . Association of statin therapy with risk of epilepsy in 2 propensity score-matched cohorts. Ann Pharmacother 2018 Jun;52(6):546-53. doi: 10.1177/1060028018756650..
Keywords: Medication, Medication: Safety, Adverse Drug Events (ADE), Adverse Events, Cardiovascular Conditions, Neurological Disorders, Risk
Sterling MR, Safford MM, Goggins K
Numeracy, health literacy, cognition, and 30-day readmissions among patients with heart failure.
Numeracy, health literacy, and cognition are important for chronic disease management. Prior studies have found them to be associated with poorer selfcare and worse clinical outcomes, but limited data exists in the context of heart failure (HF), a condition that requires patients to monitor their weight, fluid intake, and dietary salt, especially in the post hospitalization period. The purpose of this study was to examine the relationship between numeracy, health literacy, and cognition with 30-day readmissions among patients hospitalized for acute decompensated HF (ADHF).
Citation: Sterling MR, Safford MM, Goggins K . Numeracy, health literacy, cognition, and 30-day readmissions among patients with heart failure. J Hosp Med 2018 Mar;13(3):145-51. doi: 10.12788/jhm.2932..
Keywords: Health Literacy, Hospital Readmissions, Hospitalization, Heart Disease and Health, Cardiovascular Conditions, Neurological Disorders, Risk
Fink HA, Hemmy LS, MacDonald R
Intermediate- and long-term cognitive outcomes after cardiovascular procedures in older adults: a systematic review.
This study summarized evidence about cognitive outcomes in adults aged 65 years or older at least 3 months after coronary or carotid revascularization, cardiac valve procedures, or ablation for atrial fibrillation. It concluded that intermediate- and long-term cognitive impairment in older adults attributable to the studied cardiovascular procedures may be uncommon.
Citation: Fink HA, Hemmy LS, MacDonald R . Intermediate- and long-term cognitive outcomes after cardiovascular procedures in older adults: a systematic review. Ann Intern Med 2015 Jul 21;163(2):107-17. doi: 10.7326/m14-2793..
Keywords: Cardiovascular Conditions, Elderly, Neurological Disorders, Outcomes, Patient-Centered Outcomes Research, Risk, Surgery