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Research Studies is a monthly compilation of research articles funded by AHRQ or authored by AHRQ researchers and recently published in journals or newsletters.
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1 to 4 of 4 Research Studies Displayed
Wisk LE, Nelson EB, Magane KM
Clinical trial recruitment and retention of college students with type 1 diabetes via social media: an implementation case study.
The purpose of this study was to quantify the efficiency and acceptability of Internet-based recruitment for engaging college-students with type 1 diabetes (T1D) and to describe the approach used for implementing a health-related trial entirely online using off-the-shelf Internet tools. Young people aged 17-25 years with T1D were recruited through social media platforms and other outreach channels; Facebook was the highest yield recruitment source. Demographics differed by platform. Response rate and participant characteristics were quantified and engagement metrics tracked via Google Analytics and participant survey data. The researchers conclude that recruitment of college students with T1D for a trial via social media is feasible, efficient, acceptable, and yields a sample that represents the user-base from which they were drawn.
AHRQ-funded; HS022986.
Citation:
Wisk LE, Nelson EB, Magane KM .
Clinical trial recruitment and retention of college students with type 1 diabetes via social media: an implementation case study.
J Diabetes Sci Technol 2019 May;13(3):445-56. doi: 10.1177/1932296819839503..
Keywords:
Diabetes, Health Services Research (HSR), Research Methodologies, Social Media, Young Adults
Dunn AG, Orenstein L, Coiera E
The timing and frequency of trial inclusion in systematic reviews of type 2 diabetes drugs was associated with trial characteristics.
The purpose of this study was to determine whether certain trial characteristics are associated with faster or more frequent inclusion in systematic reviews for drug interventions in type 2 diabetes. Results showed that time to inclusion was shorter for trials with industry funding, more participants, and published in higher impact factor journals, while frequency of inclusion was greater for trials with industry funding, more participants, positive conclusions, and published in higher impact factor journals.
AHRQ-funded; HS024798.
Citation:
Dunn AG, Orenstein L, Coiera E .
The timing and frequency of trial inclusion in systematic reviews of type 2 diabetes drugs was associated with trial characteristics.
J Clin Epidemiol 2019 May;109:62-69. doi: 10.1016/j.jclinepi.2019.01.009..
Keywords:
Diabetes, Medication, Research Methodologies
Stocco FG, Evaristo E, Shah NR
Marked exercise-induced T-wave heterogeneity in symptomatic diabetic patients with nonflow-limiting coronary artery stenosis.
The authors investigated whether T-wave heterogeneity (TWH) is elevated during exercise tolerance testing (ETT) in symptomatic diabetic patients with nonflow-limiting coronary artery stenosis compared to control subjects without diabetes. They found that TWH is capable of detecting latent repolarization abnormalities, which are present during ETT in diabetic patients with nonflow-limiting stenosis but not in control subjects. They concluded that the technique developed in this study permits TWH analysis from archived ECGs and thereby enables mining of extensive databases for retrospective studies and hypothesis testing.
AHRQ-funded; HS022998.
Citation:
Stocco FG, Evaristo E, Shah NR .
Marked exercise-induced T-wave heterogeneity in symptomatic diabetic patients with nonflow-limiting coronary artery stenosis.
Ann Noninvasive Electrocardiol 2018 Mar;23(2):e12503. doi: 10.1111/anec.12503.
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Keywords:
Cardiovascular Conditions, Data, Diabetes, Research Methodologies
Grijalva CG, Roumie CL, Murff HJ
The role of matching when adjusting for baseline differences in the outcome variable of comparative effectiveness studies.
The aim of this study was to evaluate performance of analytical strategies commonly used to adjust for baseline differences in continuous outcome variables for comparative effectiveness studies. It found that with increasing HbA1c baseline differences between groups, bias in effect estimates and suboptimal confidence interval coverage probabilities increased in all approaches. These issues were further compounded by measurement error. Matching on baseline HbA1c, substantially mitigated these issues.
AHRQ-funded; 2902010000161.
Citation:
Grijalva CG, Roumie CL, Murff HJ .
The role of matching when adjusting for baseline differences in the outcome variable of comparative effectiveness studies.
J Comp Eff Res 2015;4(4):341-9. doi: 10.2217/cer.15.16..
Keywords:
Comparative Effectiveness, Research Methodologies, Diabetes
