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Research Studies is a monthly compilation of research articles funded by AHRQ or authored by AHRQ researchers and recently published in journals or newsletters.
Results1 to 4 of 4 Research Studies Displayed
Wang SV, Maro JC, Baro E
Data mining for adverse drug events with a propensity score-matched tree-based scan statistic.
In this study, the investigators propose a method that combines tree-based scan statistics with propensity score-matched analysis of new initiator cohorts, a robust design for investigations of drug safety. They subsequently conducted plasmode simulations to evaluate performance. The authors suggest that TreeScan with propensity score matching shows promise as a method for screening and prioritization of potential adverse events.
Citation: Wang SV, Maro JC, Baro E . Data mining for adverse drug events with a propensity score-matched tree-based scan statistic. Epidemiology 2018 Nov;29(6):895-903. doi: 10.1097/ede.0000000000000907..
Keywords: Adverse Drug Events (ADE), Adverse Events, Patient Safety, Medication, Medication: Safety, Data, Research Methodologies
Bell SK, Etchegaray JM, Gaufberg E
A multi-stakeholder consensus-driven research agenda for better understanding and supporting the emotional impact of harmful events on patients and families.
A one-day conference of diverse stakeholder groups convened to establish a consensus-driven research agenda focused on the impact of patient and family emotional harm stemming from preventable medical error. Stakeholder groups reached consensus and designed a path forward to inform approaches that better support harmed patients and families, with both immediately actionable and longer-term research strategies.
Citation: Bell SK, Etchegaray JM, Gaufberg E . A multi-stakeholder consensus-driven research agenda for better understanding and supporting the emotional impact of harmful events on patients and families. Jt Comm J Qual Patient Saf 2018 Jul;44(7):424-35. doi: 10.1016/j.jcjq.2018.03.007..
Keywords: Adverse Events, Medical Errors, Patient Safety, Research Methodologies
Chou R, Baker WL, Banez LL
Agency for Healthcare Research and Quality Evidence-based Practice Center methods provide guidance on prioritization and selection of harms in systematic reviews.
A workgroup of methodologists from Evidence-based Practice Centers (EPCs) developed consensus-based guidance on selection and prioritization of harms in systematic reviews. Ten recommendations were developed on selection and prioritization of harms, including routinely focusing on serious as well as less serious but frequent or bothersome harms; and routinely engaging stakeholders and using literature searches and other data sources to identify important harms.
AHRQ-authored; AHRQ-funded; HS022998.
Citation: Chou R, Baker WL, Banez LL . Agency for Healthcare Research and Quality Evidence-based Practice Center methods provide guidance on prioritization and selection of harms in systematic reviews. J Clin Epidemiol 2018 Jun;98:98-104. doi: 10.1016/j.jclinepi.2018.01.007.
Keywords: Adverse Events, Evidence-Based Practice, Patient-Centered Outcomes Research, Research Methodologies
Mehta HB, Dimou F, Adhikari D
Comparison of comorbidity scores in predicting surgical outcomes.
The purpose of this study was to compare diagnosis-based and prescription-based comorbidity scores for predicting surgical outcomes. It concluded that the Centers for Medicare and Medicaid Services-Hierarchical Condition Categories had superior performance in predicting surgical outcomes. Prescription-based scores, alone or in addition to diagnosis-based scores, were not better than any diagnosis-based scoring system.
Citation: Mehta HB, Dimou F, Adhikari D . Comparison of comorbidity scores in predicting surgical outcomes. Med Care 2016 Feb;54(2):180-7. doi: 10.1097/mlr.0000000000000465..
Keywords: Comparative Effectiveness, Surgery, Research Methodologies, Diagnostic Safety and Quality, Adverse Events