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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 25 of 45 Research Studies DisplayedTracer H, Lorei NC
AHRQ Author: Tracer H
Preexposure prophylaxis to prevent acquisition of HIV.
This case study described a 28-year-old woman presented to a community health clinic for sexually transmitted infection (STI) testing. Case study questions related to the USPSTF recommendation on Preexposure Prophylaxis (PrEP) to prevent acquisition of HIV, guidelines for candidacy for PrEP, guidelines for the use of PrEP for the primary prevention of HIV in adults.
AHRQ-authored.
Citation: Tracer H, Lorei NC .
Preexposure prophylaxis to prevent acquisition of HIV.
Am Fam Physician 2023 Dec; 108(6):617-18..
Keywords: U.S. Preventive Services Task Force (USPSTF), Human Immunodeficiency Virus (HIV), Prevention, Evidence-Based Practice
Chou R, Spencer H, Bougatsos C
Preexposure prophylaxis for the prevention of HIV: updated evidence report and systematic review for the US Preventive Services Task Force.
This article updates research used in the 2019 US Preventive Services Task Force final recommendation on use of oral preexposure prophylaxis (PrEP) to prevent HIV in adults at increased risk. The summary includes newer PrEP regimens that were not available for the 2019 final recommendation. A literature review was conducted that included randomized clinical trials of PrEP vs placebo or no PrEP or newer vs older PrEP regimens and diagnostic accuracy studies of instruments for predicting incident HIV infection. Thirty-two studies were included in the review (20 randomized clinical trials [n = 36,543] and 12 studies of diagnostic accuracy [n = 5,544,500]). Eleven trials in the 2019 review found oral PrEP associated with decreased HIV infection risk vs placebo or no PrEP. One new trial (n = 5335) found oral tenofovir alafenamide/emtricitabine (TAF/FTC) to be noninferior to tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) in men who have sex with men. Two new trials found long-acting injectable cabotegravir associated with decreased risk of HIV infection vs oral TDF/FTC in cisgender men who have sex with men and transgender women [n = 4490] and RR, 0.11 in cisgender women [n = 3178]). Discrimination of instruments for predicting incident HIV infection was found to be moderate in men who have sex with men (5 studies; n = 25,488) and moderate to high in general populations of persons without HIV (2 studies; n = 5,477,291).
AHRQ-funded; 75Q80120D00006.
Citation: Chou R, Spencer H, Bougatsos C .
Preexposure prophylaxis for the prevention of HIV: updated evidence report and systematic review for the US Preventive Services Task Force.
JAMA 2023 Aug 22; 330(8):746-63. doi: 10.1001/jama.2023.9865..
Keywords: U.S. Preventive Services Task Force (USPSTF), Human Immunodeficiency Virus (HIV), Prevention, Medication, Evidence-Based Practice
Van Gerwen OT, Austin EL, Camino AF
"It's behaviors, not identity": attitudes and beliefs related to HIV risk and pre-exposure prophylaxis among transgender women in the Southeastern United States.
Investigators aimed to explore beliefs associated with HIV Pre-Exposure Prophylaxis (PrEP) among transgender women (TGW) in the Southeastern U.S., framed by the Health Belief Model. They identified several themes: frustration with conflation of transgender identity and HIV risk, inappropriate transgender representation in PrEP advertising, concerns for interactions between PrEP and hormone therapy, perception that PrEP is meant for cisgender men who have sex with men, and limited trans-affirming healthcare. Given the diversity of this population, they recommended nuanced messaging to educate and engage TGW in HIV prevention strategies, including PrEP.
AHRQ-funded; HS013852.
Citation: Van Gerwen OT, Austin EL, Camino AF .
"It's behaviors, not identity": attitudes and beliefs related to HIV risk and pre-exposure prophylaxis among transgender women in the Southeastern United States.
PLoS One 2022 Jan 27;17(1):e0262205. doi: 10.1371/journal.pone.0262205..
Keywords: Human Immunodeficiency Virus (HIV), Prevention, Sexual Health
Calabrese SK, Lane SB, Caldwell A
Electronic dissemination of a web-based video promotes PrEP contemplation and conversation among US women engaged in care at Planned Parenthood.
This study evaluated the acceptability and impact of a web-based PrEP educational video among women (n = 126) by comparing two Planned Parenthood centers: one using a Web Video and the other using standard education tools. Most women reported the video helped them understand better what PrEP is (92%), how it works (93%), and how to take PrEP (92%). One month post-intervention, more women in the Web Video group reported a high level of comfort discussing PrEP with a provider (82% vs 48%) and commonly thinking about PrEP (36.% vs. 4%).
AHRQ-funded; HS022242.
Citation: Calabrese SK, Lane SB, Caldwell A .
Electronic dissemination of a web-based video promotes PrEP contemplation and conversation among US women engaged in care at Planned Parenthood.
AIDS Behav 2021 Aug;25(8):2483-500. doi: 10.1007/s10461-021-03210-2..
Keywords: Human Immunodeficiency Virus (HIV), Sexual Health, Education: Patient and Caregiver, Health Promotion, Prevention, Health Information Technology (HIT), Communication, Women
Razon N, Rodriguez A, Carlson K
"Far more than just a prescription": Focus groups with U.S. family planning providers and staff about integrating PrEP for HIV prevention into their work.
Cisgender women in the United States have been found to use pre-exposure prophylaxis (PrEP) for HIV prevention at lower rates relative to other groups. Family planning clinics are identified as the preferred sites to lead PrEP implementation for women in the United States. Qualitative focus groups were conducted with a sample of family planning clinicians, counselors, and clinic managers to explore barriers and facilitators to PrEP provision in US family planning clinics. Six focus groups (n = 37) were conducted at family planning clinics in San Francisco, Kansas City, Missouri; and Philadelphia. Key themes emerged highlighting how PrEP counseling can interfere with other family planning agendas including efficient clinic visits, condom promotion, and long-acting contraception counseling. Participants expressed discomfort with HIV vulnerabilities rooted in social and structural determinants of health.
AHRQ-funded; HS022241.
Citation: Razon N, Rodriguez A, Carlson K .
"Far more than just a prescription": Focus groups with U.S. family planning providers and staff about integrating PrEP for HIV prevention into their work.
Womens Health Issues 2021 May-Jun;31(3):294-300. doi: 10.1016/j.whi.2021.02.006..
Keywords: Human Immunodeficiency Virus (HIV), Prevention, Women
Hill LM, Lightfoot AF, Riggins L
Awareness of and attitudes toward pre-exposure prophylaxis among African American women living in low-income neighborhoods in a Southeastern city.
The authors conducted a venue-based community survey with 53 African American women living in low-income neighborhoods of a Southeastern city in order to understand women's knowledge of and attitudes toward pre-exposure prophylaxis (PrEP). They found that awareness of PrEP was very low, with only 16% being aware that PrEP is used for HIV prevention. The vast majority reported that they would use or would consider using PrEP, most frequently citing a general interest in HIV prevention or a lack of awareness of their partners' HIV status as motivations for their interest. Some women expressed concerns about side effects or low perceived HIV risk as disincentives for PrEP use.
AHRQ-funded; HS000032.
Citation: Hill LM, Lightfoot AF, Riggins L .
Awareness of and attitudes toward pre-exposure prophylaxis among African American women living in low-income neighborhoods in a Southeastern city.
AIDS Care 2021 Feb;33(2):239-43. doi: 10.1080/09540121.2020.1769834..
Keywords: Human Immunodeficiency Virus (HIV), Racial and Ethnic Minorities, Women, Low-Income, Prevention, Medication
Rodriguez PJ, Roberts DA, Meisner J
Cost-effectiveness of dual maternal HIV and syphilis testing strategies in high and low HIV prevalence countries: a modelling study.
Dual HIV and syphilis testing might help to prevent mother-to-child transmission (MTCT) of HIV and syphilis through increased case detection and treatment. In this study, the investigators aimed to model and assess the cost-effectiveness of dual testing during antenatal care in four countries with varying HIV and syphilis prevalence. The authors concluded that incorporating dual rapid diagnostic tests in antenatal care could be cost-saving across countries with varying HIV prevalence.
AHRQ-funded; HS013853.
Citation: Rodriguez PJ, Roberts DA, Meisner J .
Cost-effectiveness of dual maternal HIV and syphilis testing strategies in high and low HIV prevalence countries: a modelling study.
Lancet Glob Health 2021 Jan;9(1):e61-e71. doi: 10.1016/s2214-109x(20)30395-8..
Keywords: Human Immunodeficiency Virus (HIV), Infectious Diseases, Prevention, Pregnancy, Women, Diagnostic Safety and Quality, Healthcare Costs
Iribarren S, Lentz C, Sheinfil AZ
Using an HIV self-test kit to test a partner: attitudes and preferences among high-risk populations.
Researchers explored attitudes and preferences among HIV-negative men who have sex with men and HIV-negative transgender women using an HIV self-testing (HIVST) kit to test partners. They found that most preferred gum swab over fingerprick tests, but would prefer a blood test if it gave results for other sexually transmitted infections (STIs). They concluded that efforts to improve HIVST uptake should focus on incorporating testing for other STIs, reducing test kit size, and reducing cost.
AHRQ-funded; HS026383.
Citation: Iribarren S, Lentz C, Sheinfil AZ .
Using an HIV self-test kit to test a partner: attitudes and preferences among high-risk populations.
AIDS Behav 2020 Nov;24(11):3232-43. doi: 10.1007/s10461-020-02885-3..
Keywords: Human Immunodeficiency Virus (HIV), Diagnostic Safety and Quality, Infectious Diseases, Prevention
Lentz C, Iribarren S, Giguere R
Broaching the topic of HIV self-testing with potential sexual partners among men and transgender women who have sex with men in New York and Puerto Rico.
This randomized controlled trial examined whether access to free HIV self-testing (ST) kits had an impact on use of condoms during anal intercourse for 272 transgender women and men who have sex with men in New York City and San Juan, Puerto Rico. The trial included 136 persons in an intervention group and 136 persons in a control group. The intervention group had 32% fewer condomless anal intercourse (CAI) encounters- with the New York City group being statistically significant. In San Juan the results were non-significant, but two hurricanes may have impacted results in unmeasured ways.
AHRQ-funded; HS026383.
Citation: Lentz C, Iribarren S, Giguere R .
Broaching the topic of HIV self-testing with potential sexual partners among men and transgender women who have sex with men in New York and Puerto Rico.
AIDS Behav 2020 Nov;24(11):3033-43. doi: 10.1007/s10461-020-02851-z..
Keywords: Human Immunodeficiency Virus (HIV), Infectious Diseases, Sexual Health, Prevention, Screening
Skaathun B, Pho MT, Pollack HA
Comparison of effectiveness and cost for different HIV screening strategies implemented at large urban medical centre in the United States.
This analysis compared the effectiveness and cost of three HIV testing strategies in a high HIV burden area in the U.S. in identifying new HIV infections. The investigators performed a cost analysis comparing three HIV testing strategies in Chicago: (1) routine screening (RS) in an inpatient and outpatient setting, (2) modified partner services (MPS) among networks of the recently HIV infected and diagnosed, and (3) a respondent drive sampling (RDS)-based social network (SN) approach targeting young African-American men who have sex with men.
AHRQ-funded; HS000084.
Citation: Skaathun B, Pho MT, Pollack HA .
Comparison of effectiveness and cost for different HIV screening strategies implemented at large urban medical centre in the United States.
J Int AIDS Soc 2020 Oct;23(10):e25554. doi: 10.1002/jia2.25554..
Keywords: Human Immunodeficiency Virus (HIV), Screening, Healthcare Costs, Prevention, Infectious Diseases
Rael CT, Giguere R, Lopez-Rios J
Transgender women's experiences using a home HIV-testing kit for partner-testing.
HIV partner-testing (PT) may represent a unique and empowering HIV prevention strategy for groups that face structural and institutional barriers to HIV testing and care, including transgender women. In this study, the investigators reported on in-depth interviews (IDIs) with transgender women who used HIV self-test kits for three months to screen potential sexual partners in a randomized controlled trial that took place in New York City and San Juan, Puerto Rico.
AHRQ-funded; HS026383.
Citation: Rael CT, Giguere R, Lopez-Rios J .
Transgender women's experiences using a home HIV-testing kit for partner-testing.
AIDS Behav 2020 Sep;24(9):2732-41. doi: 10.1007/s10461-020-02829-x..
Keywords: Human Immunodeficiency Virus (HIV), Prevention, Vulnerable Populations, Women, Patient Experience, Screening
Jackman KP, Murray S, Hightow-Weidman
Digital technology to address HIV and other sexually transmitted infection disparities: intentions to disclose online personal health records to sex partners among students at a historically Black college.
Among an online survey sample of co-ed students, the authors described latent constructs and other variables associated with perceived behavioral intentions to disclose sexually transmitted infection (STI) test history using patient portals. They found that latent constructs representing communication valuation beliefs and practices were not associated with intentions, while self-reporting prior STI diagnosis was associated with intentions to disclose. They concluded that point-of-care messages focused on improvements to validating test results, communication, and empowerment, may be an effective strategy to support the adoption of patient portals for STI prevention among populations of college-aged Black youth.
AHRQ-funded; HS023057.
Citation: Jackman KP, Murray S, Hightow-Weidman .
Digital technology to address HIV and other sexually transmitted infection disparities: intentions to disclose online personal health records to sex partners among students at a historically Black college.
PLoS One 2020 Aug 21;15(8):e0237648. doi: 10.1371/journal.pone.0237648..
Keywords: Human Immunodeficiency Virus (HIV), Infectious Diseases, Electronic Health Records (EHRs), Health Information Technology (HIT), Young Adults, Racial and Ethnic Minorities, Prevention
Hill LM, Maseko B, Chagomerana M
HIV risk, risk perception, and PrEP interest among adolescent girls and young women in Lilongwe, Malawi: operationalizing the PrEP cascade.
The objective of this study was to understand the level of interest in oral pre-exposure prophylaxis (PrEP) among adolescent girls and young women (AGYW) at highest HIV risk and the potential role of perceived risk in motivating PrEP interest. Findings highlighted key relationships between epidemiologic HIV risk, risk perception, and interest in PrEP. The high number of participants with risk scores below the high-risk cutoff who both expressed high perceived risk and interest in PrEP suggested that the demand for PrEP among AGYW may not be well-aligned with epidemiologic risk.
AHRQ-funded; HS000032.
Citation: Hill LM, Maseko B, Chagomerana M .
HIV risk, risk perception, and PrEP interest among adolescent girls and young women in Lilongwe, Malawi: operationalizing the PrEP cascade.
J Int AIDS Soc 2020 Jun;23 Suppl 3:e25502. doi: 10.1002/jia2.25502..
Keywords: Human Immunodeficiency Virus (HIV), Risk, Prevention, Women, Children/Adolescents, Young Adults
Brault MA, Spiegelman D, Abdool Karim SS
Integrating and interpreting findings from the latest treatment as prevention trials.
This paper examined findings from some 2018-2019 international studies assessing the effectiveness of reducing HIV incidence by expanding HIV testing, linkage to HIV treatment, and helping persons living with HIV adhere to their medications (called the 90-90-90 strategy). A number of these “treatment as prevention” (TasP) tests had complex results. The studies examined included the TasP/ANRS 12249 study in South Africa, the SEARCH study in Kenya and Uganda, and one comparison (arms A to C) of the HPtn 071 (PopART) study in South Africa and Zambia as well as the Botswana Ya Tsie study. All but the Botswana Ya Tsie study and the second comparison (arms B to C) of PopART did not demonstrate a community impact on HIV incidence. But those two studies indicated significant (30%) reductions in HIV incidence in the intervention communities.
AHRQ-funded; HS023000.
Citation: Brault MA, Spiegelman D, Abdool Karim SS .
Integrating and interpreting findings from the latest treatment as prevention trials.
Curr HIV/AIDS Rep 2020 Jun;17(3):249-58. doi: 10.1007/s11904-020-00492-4..
Keywords: Human Immunodeficiency Virus (HIV), Prevention, Implementation, Medication, Screening
Carballo-Dieguez A, Giguere R, Balan IC
Use of rapid HIV self-test to screen potential sexual partners: results of the ISUM study.
This randomized controlled trial examined whether access to free HIV self-testing (ST) kits had an impact on use of condoms during anal intercourse for 272 transgender women and men who have sex with men in New York City and San Juan, Puerto Rico. The trial included 136 persons in an intervention group and 136 persons in a control group. The intervention group had 32% fewer condomless anal intercourse (CAI) encounters- with the New York City group being statistically significant. In San Juan the results were non-significant but two hurricanes may have impacted results in unmeasured ways.
AHRQ-funded; HS026383.
Citation: Carballo-Dieguez A, Giguere R, Balan IC .
Use of rapid HIV self-test to screen potential sexual partners: results of the ISUM study.
AIDS Behav 2020 Jun;24(6):1929-41. doi: 10.1007/s10461-019-02763-7..
Keywords: Human Immunodeficiency Virus (HIV), Infectious Diseases, Sexual Health, Prevention
Sun CJ, Anderson KM, Kuhn T
A sexual health promotion app for transgender women (Trans Women Connected): development and usability study.
HIV severely impacts the transgender communities in the United States, and transgender women have the highest HIV incidence rates among any identified risk group. Guided by formative research with transgender women and by an expert advisory panel of transgender women, the investigators designed a prototype mobile app to promote HIV prevention among transgender women. This study aimed to develop and test the usability and acceptability of the prototype Trans Women Connected mobile app.
AHRQ-funded; HS022981.
Citation: Sun CJ, Anderson KM, Kuhn T .
A sexual health promotion app for transgender women (Trans Women Connected): development and usability study.
JMIR Mhealth Uhealth 2020 May 12;8(5):e15888. doi: 10.2196/15888..
Keywords: Human Immunodeficiency Virus (HIV), Health Promotion, Sexual Health, Infectious Diseases, Prevention, Women
Gravett RM, Westfall AO, Overton ET
Sexually transmitted infections and sexual behaviors of men who have sex with men in an American Deep South PrEP clinic.
This study examines the behavior of men who have sex with men (MSM) who use HIV pre-exposure prophylaxis (PrEP). A higher incidence of sexually transmitted infections (STIs) has been associated with PrEP use. A retrospective analysis of MSM in the Deep South was conducted at a PrEP clinic to calculate the prevalence and incidence of bacterial STIs and identify associated risk factors. There was an 11% STI prevalence out of 139 MSM who accessed the clinic between 2014 and 2018. Higher proportions of high PrEP adherence, multiple sexual partners, and inconsistent condom use were associated with incident STI.
AHRQ-funded; HS023009.
Citation: Gravett RM, Westfall AO, Overton ET .
Sexually transmitted infections and sexual behaviors of men who have sex with men in an American Deep South PrEP clinic.
Int J STD AIDS 2020 Feb;31(2):127-35. doi: 10.1177/0956462419886228..
Keywords: Infectious Diseases, Sexual Health, Men's Health, Prevention, Human Immunodeficiency Virus (HIV)
Brault MA, Spiegelman D, Hargreaves J
Treatment as prevention: concepts and challenges for reducing HIV incidence.
This paper reviews the results and lessons learned from four large-scale HIV antiretroviral therapy (ART) clinical trials that were held in sub-Saharan Africa to reduce HIV transmission. These trials used treatment as prevention (TasP) to improve overall health and protect HIV-uninfected sexual partners from infection. There were seemingly inconsistent findings in the major TasP trials held in South African, Kenya, Uganda, Botswana, and Zambia. The review highlighted implementation challenges and identified approaches to optimize programs and incentivize uptake and engagement in HIV testing and ART-based care.
AHRQ-funded; HS023000.
Citation: Brault MA, Spiegelman D, Hargreaves J .
Treatment as prevention: concepts and challenges for reducing HIV incidence.
J Acquir Immune Defic Syndr 2019 Dec 1;82 Suppl 2:S104-s12. doi: 10.1097/qai.0000000000002168..
Keywords: Human Immunodeficiency Virus (HIV), Prevention, Infectious Diseases, Public Health, Screening
Tracer H, Jasmin W
AHRQ Author: Tracer H
Screening for HIV Infection and Preexposure Prophylaxis for the Prevention of HIV Infection.
This case study provides questions and answers on the topic of screening for HIV infection and preexposure prophylaxis for the prevention of HIV infection.
AHRQ-authored.
Citation: Tracer H, Jasmin W .
Screening for HIV Infection and Preexposure Prophylaxis for the Prevention of HIV Infection.
Am Fam Physician 2019 Nov 15;100(10):637-38..
Keywords: U.S. Preventive Services Task Force (USPSTF), Human Immunodeficiency Virus (HIV), Screening, Prevention
Rice WS, Stringer KL, Sohail M
Accessing pre-exposure prophylaxis (PrEP): perceptions of current and potential prEP users in Birmingham, Alabama.
Limited studies to date assess barriers to and facilitators of pre-exposure prophylaxis (PrEP) uptake and utilization using a patient-centered access to care framework, among diverse socio-demographic groups, or in the U.S. Deep South, an area with disproportionate HIV burden. In this study, the investigators examine perceptions of PrEP access in qualitative interviews with 44 current and potential PrEP users in Birmingham, Alabama.
AHRQ-funded; HS013852.
Citation: Rice WS, Stringer KL, Sohail M .
Accessing pre-exposure prophylaxis (PrEP): perceptions of current and potential prEP users in Birmingham, Alabama.
AIDS Behav 2019 Nov;23(11):2966-79. doi: 10.1007/s10461-019-02591-9..
Keywords: Human Immunodeficiency Virus (HIV), Prevention, Healthcare Utilization, Patient-Centered Healthcare, Racial and Ethnic Minorities, Health Literacy, Education: Patient and Caregiver, Access to Care, Health Promotion
Kim B, Callander D, DiClemente R
Location of pre-exposure prophylaxis services across New York City neighborhoods: do neighborhood socio-demographic characteristics and HIV incidence Matter?
This study analyzed the New York City geographic distribution of pre-exposure prophylaxis (PrEP) providers and the relationship between their location, neighborhood characteristics, and HIV incidence using spatial analytic methods. Results showed that neighborhood socio-demographic measures of race/ethnicity, income, insurance coverage, or same-sex couple household, were not associated with PrEP provider density, and PrEP providers were located in high HIV-incidence neighborhoods. These findings validate the need for ongoing policy interventions in relation to PrEP provider locations in New York City and inform the design of future PrEP implementation strategies, such as public health campaigns and navigation assistance for low-cost insurance.
AHRQ-funded; HS026120.
Citation: Kim B, Callander D, DiClemente R .
Location of pre-exposure prophylaxis services across New York City neighborhoods: do neighborhood socio-demographic characteristics and HIV incidence Matter?
AIDS Behav 2019 Oct;23(10):2795-802. doi: 10.1007/s10461-019-02609-2..
Keywords: Human Immunodeficiency Virus (HIV), Prevention, Access to Care, Social Determinants of Health
Adamson B, Garrison L, Barnabas RV
Competing biomedical HIV prevention strategies: potential cost-effectiveness of HIV vaccines and PrEP in Seattle, WA.
The authors estimated the cost-effectiveness of HIV vaccines considering their potential interaction with pre-exposure prophylaxis (PrEP) and condom use. They concluded that access to an HIV vaccine is desirable, as it could increase the overall effectiveness of combination HIV prevention efforts and improve population health. They recommended carefully considering the design of policies that guide interactions between vaccine and PrEP utilization and potential competition when planning for the rollout and scale-up of HIV vaccines.
AHRQ-funded; HS013853.
Citation: Adamson B, Garrison L, Barnabas RV .
Competing biomedical HIV prevention strategies: potential cost-effectiveness of HIV vaccines and PrEP in Seattle, WA.
J Int AIDS Soc 2019 Aug;22(8):e25373. doi: 10.1002/jia2.25373..
Keywords: Human Immunodeficiency Virus (HIV), Prevention, Healthcare Costs, Vaccination
Sun CJ, Tobin K, Spikes P
Correlates of same-sex behavior disclosure to health care providers among Black MSM in the United States: implications for HIV prevention.
Disclosure of same-sex behavior to health care providers (HCPs) by men who have sex with men (MSM) has been argued to be an important aspect of HIV prevention. However, Black MSM are less likely to disclose compared to white MSM. This analysis of data collected in the United States from 2006-2009 identified individual and social network characteristics of Black MSM that were associated with disclosure that may be leveraged to increase disclosure.
AHRQ-funded; HS022981.
Citation: Sun CJ, Tobin K, Spikes P .
Correlates of same-sex behavior disclosure to health care providers among Black MSM in the United States: implications for HIV prevention.
AIDS Care 2019 Aug;31(8):1011-18. doi: 10.1080/09540121.2018.1548753..
Keywords: Human Immunodeficiency Virus (HIV), Racial and Ethnic Minorities, Sexual Health, Men's Health, Prevention
Chou R, Dana T, Grusing S
Screening for HIV infection in asymptomatic, nonpregnant adolescents and adults: updated evidence report and systematic review for the US Preventive Services Task Force.
Untreated HIV infection can result in significant morbidity, mortality, and HIV transmission. A 2012 review for the US Preventive Services Task Force (USPSTF) found antiretroviral therapy (ART) associated with improved clinical outcomes and decreased transmission risk in persons with CD4 cell counts less than 500/mm3. The objective of this study was to update the 2012 review on HIV screening to inform the USPSTF.
AHRQ-funded; 290201500009I.
Citation: Chou R, Dana T, Grusing S .
Screening for HIV infection in asymptomatic, nonpregnant adolescents and adults: updated evidence report and systematic review for the US Preventive Services Task Force.
JAMA 2019 Jun 18;321(23):2337-48. doi: 10.1001/jama.2019.2592..
Keywords: U.S. Preventive Services Task Force (USPSTF), Children/Adolescents, Human Immunodeficiency Virus (HIV), Screening, Prevention, Evidence-Based Practice
Chou R, Evans C, Hoverman A
Preexposure prophylaxis for the prevention of HIV infection: evidence report and systematic review for the US Preventive Services Task Force.
The purpose of this study was to synthesize evidence on the benefits and harms of PrEP (preexposure prophylaxis), instruments for predicting incident HIV infection, and PrEP adherence, to inform the US Preventive Services Task Force. The study found that in adults at increased risk of HIV infection, PrEP with oral tenofovir disoproxil fumarate monotherapy or tenofovir disoproxil fumarate/emtricitabine was associated with decreased risk of acquiring HIV infection compared with placebo or no PrEP, with effectiveness decreasing with suboptimal adherence. Most adverse events were mild and reversible.
AHRQ-funded; 290201500009I.
Citation: Chou R, Evans C, Hoverman A .
Preexposure prophylaxis for the prevention of HIV infection: evidence report and systematic review for the US Preventive Services Task Force.
JAMA 2019 Jun 11;321(22):2214-30. doi: 10.1001/jama.2019.2591..
Keywords: Evidence-Based Practice, Human Immunodeficiency Virus (HIV), Medication, Prevention, U.S. Preventive Services Task Force (USPSTF)