National Healthcare Quality and Disparities Report
Latest available findings on quality of and access to health care
Data
- Data Infographics
- Data Visualizations
- Data Tools
- Data Innovations
- All-Payer Claims Database
- Healthcare Cost and Utilization Project (HCUP)
- Medical Expenditure Panel Survey (MEPS)
- AHRQ Quality Indicator Tools for Data Analytics
- State Snapshots
- United States Health Information Knowledgebase (USHIK)
- Data Sources Available from AHRQ
Search All Research Studies
Topics
- Adverse Events (1)
- Children/Adolescents (1)
- COVID-19 (2)
- Critical Care (1)
- Evidence-Based Practice (2)
- Healthcare-Associated Infections (HAIs) (1)
- Health Information Technology (HIT) (2)
- Hospitalization (1)
- Hospitals (2)
- (-) Infectious Diseases (6)
- Intensive Care Unit (ICU) (1)
- Medication (1)
- Mortality (1)
- Obesity (1)
- (-) Outcomes (6)
- Patient-Centered Outcomes Research (1)
- Patient Safety (2)
- Practice Patterns (1)
- Telehealth (1)
- Treatments (1)
AHRQ Research Studies
Sign up: AHRQ Research Studies Email updates
Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 6 of 6 Research Studies DisplayedBramante CT, Buse J, Tamaritz L
Outpatient metformin use is associated with reduced severity of COVID-19 disease in adults with overweight or obesity.
This study investigated whether outpatient metformin use is associated with reduced severity of COVID-19 in adults with overweight or obesity. Metformin can decrease interleukin-6 and tumor-necrosis factor- α, which appears to contribute to COVID-19 mortality. The authors conducted a retrospective cohort analysis of electronic health record (EHR) data that was pooled across multiple EHR systems from 12 hospitals and 60 primary care clinics in the Midwest between March and December 2020. Inclusion criteria included data for BMI > 25 kg/m(2); age range 30-85 years; and a positive SARS-CoV-2 polymerase chain reaction test. Metformin was associated with a decrease in mortality from COVID-19 and a nonsignificant decrease in hospital admission in the overall cohort.
AHRQ-funded; HS026379.
Citation: Bramante CT, Buse J, Tamaritz L .
Outpatient metformin use is associated with reduced severity of COVID-19 disease in adults with overweight or obesity.
J Med Virol 2021 Jul;93(7):4273-79. doi: 10.1002/jmv.26873..
Keywords: COVID-19, Infectious Diseases, Obesity, Medication, Treatments, Outcomes
Anesi GL, Jablonski J, Harhay MO
Characteristics, outcomes, and trends of patients with COVID-19-related critical illness at a learning health system in the United States.
This study’s objective is to describe the epidemiology of COVID-19-related critical illness, including trends in outcomes and care delivery, using five hospitals within the University of Pennsylvania Health System as a setting. Findings showed that, among patients with COVID-19-related critical illness admitted to ICUs of a learning health system in the United States, mortality seemed to decrease over time despite stable patient characteristics. Recommendations included further studies to confirm this result and to investigate causal mechanisms.
AHRQ-funded; HS026372.
Citation: Anesi GL, Jablonski J, Harhay MO .
Characteristics, outcomes, and trends of patients with COVID-19-related critical illness at a learning health system in the United States.
Ann Intern Med 2021 May;174(5):613-21. doi: 10.7326/m20-5327..
Keywords: COVID-19, Critical Care, Intensive Care Unit (ICU), Mortality, Hospitals, Outcomes, Infectious Diseases
Burnham JP, Fritz SA, Yaeger LH
Telemedicine infectious diseases consultations and clinical outcomes: a systematic review.
Researchers reviewed the current evidence for clinical effectiveness of telemedicine infectious diseases consultations. They found that the outcomes tracked were heterogeneous, precluding meta-analysis, and the majority of studies were of poor quality. Overall, clinical outcomes with telemedicine infectious diseases consultation seem comparable to in-person infectious diseases consultation. They concluded that, although in widespread use, the clinical effectiveness of telemedicine infectious diseases consultations has yet to be sufficiently studied.
AHRQ-funded; R01 HS024269.
Citation: Burnham JP, Fritz SA, Yaeger LH .
Telemedicine infectious diseases consultations and clinical outcomes: a systematic review.
Open Forum Infect Dis 2019 Dec 5;6(12):ofz517. doi: 10.1093/ofid/ofz517..
Keywords: Telehealth, Infectious Diseases, Health Information Technology (HIT), Evidence-Based Practice, Outcomes, Patient-Centered Outcomes Research
Chopra V, Kaatz S, Swaminathan L
Variation in use and outcomes related to midline catheters: results from a multicentre pilot study.
This study examined complication rates from placement of midline vascular catheters. They have become more common in use recently. Complications were analyzed using medical records from hospitalized patients in 12 hospitals from January 2017 to February 2018. Most midline catheters were placed in general ward settings for difficult intravenous access. About half were removed within 5 days of insertion. Major or minor complications occurred in 10.3% of midlines with minor complications accounting for 71% of all adverse events. These minor complications included dislodgement, leaking, and infiltration. Major complications included occlusion, upper-extremity DVT and BSI. Use of midlines and outcomes varied widely across hospitals.
AHRQ-funded; HS025891.
Citation: Chopra V, Kaatz S, Swaminathan L .
Variation in use and outcomes related to midline catheters: results from a multicentre pilot study.
BMJ Qual Saf 2019 Sep;28(9):714-20. doi: 10.1136/bmjqs-2018-008554..
Keywords: Patient Safety, Healthcare-Associated Infections (HAIs), Infectious Diseases, Adverse Events, Practice Patterns, Outcomes, Hospitals
Burnham JP, Fritz SA, Yaeger LH
Telemedicine infectious diseases consultations and clinical outcomes: a systematic review and meta-analysis protocol.
This article describes a proposed systematic review that will evaluate the current evidence on the effect of telemedicine infectious diseases consultation within a range of clinical outcomes, including mortality, hospital readmission, antimicrobial use, and cost. Standard systematic review methodology will be used. Data will be grouped by outcome. Primary outcome will be 30-day all-cause mortality. Secondary outcomes will include: readmission within 30 days after discharge from an initial hospitalization with an infection; patient compliance/adherence; patient satisfaction; cost effectiveness; hospital length of stay, use of antimicrobials and antimicrobial stewardship. The findings of this review will add to the established literature regarding feasibility of telemedicine consultation.
AHRQ-funded; HS024269.
Citation: Burnham JP, Fritz SA, Yaeger LH .
Telemedicine infectious diseases consultations and clinical outcomes: a systematic review and meta-analysis protocol.
Syst Rev 2019 Jun 7;8(1):135. doi: 10.1186/s13643-019-1056-y..
Keywords: Evidence-Based Practice, Health Information Technology (HIT), Infectious Diseases, Outcomes, Patient Safety
Gauguet S, Ahmed AA, Zhou J
Group A streptococcal bacteremia without a source is associated with less severe disease in children.
The authors analyzed characteristics of 86 Group A streptococcal bacteremia cases at Boston Children's Hospital from 1992 to 2012. They found that children with bacteremia without a source (30% of cases) were less likely to have severe disease than children with focal infections.
AHRQ-funded; HS013908.
Citation: Gauguet S, Ahmed AA, Zhou J .
Group A streptococcal bacteremia without a source is associated with less severe disease in children.
Pediatr Infect Dis J 2015 Apr;34(4):447-9. doi: 10.1097/inf.0000000000000587.
.
.
Keywords: Children/Adolescents, Hospitalization, Infectious Diseases, Outcomes