National Healthcare Quality and Disparities Report
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
151 to 175 of 267 Research Studies DisplayedMokhateb-Rafii T, Bakar A, Gangadharan S
Hemodynamic impact of oxygen desaturation during tracheal intubation among critically ill children with cyanotic and noncyanotic heart disease.
The objective of this study was to determine a level of oxygen desaturation associated with increased risk of tracheal intubation events in children in a pediatric or cardiac ICU with cyanotic and noncyanotic heart disease. Oxygen desaturation was measured by a fall in pulse oximetry from baseline after pre-oxygenation. The primary outcome was occurrence of hemodynamic tracheal intubation associated events defined as cardiac arrest, hypotension, or dysrhythmia. Results indicate that oxygen desaturation by 30% or more is associated with increased odds for adverse hemodynamic events, after adjusting for confounders. Oxygen desaturation was observed more often in children with cyanotic than those with noncyanotic heart disease, but hemodynamic tracheal intubation associated event rates were similar.
AHRQ-funded; HS021583; HS022464; HS024511.
Citation: Mokhateb-Rafii T, Bakar A, Gangadharan S .
Hemodynamic impact of oxygen desaturation during tracheal intubation among critically ill children with cyanotic and noncyanotic heart disease.
Pediatr Crit Care Med 2019 Jan;20(1):19-26. doi: 10.1097/pcc.0000000000001766..
Keywords: Adverse Events, Cardiovascular Conditions, Children/Adolescents, Heart Disease and Health, Respiratory Conditions, Intensive Care Unit (ICU), Patient Safety, Risk
Wang D, Ing C, Blinderman CD
Latent class analysis of specialized palliative care needs in adult intensive care units from a single academic medical center.
The purpose of this study was to use latent class analysis to separate ICU patients into different classes of palliative care needs, and to determine if these classes differ in their resource requirements. Using information from ICU patients who received specialized palliative care, researchers extracted reason(s) for consultation from the initial note and entered it into a latent class analysis model to generate mutually exclusive patient classes. Four classes were identified: Pain and Symptom Management, Goals of Care and Advance Directives (GCAD), All Needsand Supportive Care. GCAD patients were least likely to be high utilizers.
AHRQ-funded; HS022941.
Citation: Wang D, Ing C, Blinderman CD .
Latent class analysis of specialized palliative care needs in adult intensive care units from a single academic medical center.
J Pain Symptom Manage 2019 Jan;57(1):73-78. doi: 10.1016/j.jpainsymman.2018.10.270..
Keywords: Care Management, Inpatient Care, Intensive Care Unit (ICU), Palliative Care
Lee JH, Nuthall G, Ikeyama T
Tracheal intubation practice and safety across international PICUs: a report from national emergency airway registry for children.
Researchers hypothesized that there would be differences in the process of care and adverse outcomes for tracheal intubation across pediatric ICUs (PICUs) in six different geographical regions: Germany, Japan, Singapore, India, New Zealand, and North America. Adverse tracheal intubation-associated events and desaturation occurrences in PICUS in these regions were evaluated, and the international PICUs compared with those in North America. The proportion of tracheal intubations for endotracheal tube change was greater in international PICUs, and the median age for international tracheal intubations was younger when compared with North America PICUs. Occurrences of adverse tracheal intubation-associated events were slightly lower for international than for North American PICUs, except for Germany and Japan, which were slightly higher.
AHRQ-funded; HS021583; HS022464; HS024511.
Citation: Lee JH, Nuthall G, Ikeyama T .
Tracheal intubation practice and safety across international PICUs: a report from national emergency airway registry for children.
Pediatr Crit Care Med 2019 Jan;20(1):1-8. doi: 10.1097/pcc.0000000000001782..
Keywords: Adverse Events, Care Management, Children/Adolescents, Intensive Care Unit (ICU), Respiratory Conditions, Outcomes, Patient Safety
Wang S, Allen D, Perkins A
Validation of a new clinical tool for post-intensive care syndrome.
The objective of this study was to validate the self-report version of the Healthy Aging Brain Care Monitor as a clinical tool for detecting post-intensive care syndrome. 142 patients who survived stays in intensive care units (ICUs) following a critical illness completed the self-report and standardized assessments of their cognition, their psychological symptoms, and physical functioning. Patients who had post-ICU syndrome were compared with a sample of primary care patients. Based on their findings, the researchers conclude that the self-report version is a valid clinical tool for the assessment of symptoms of post-ICU syndrome.
AHRQ-funded; HS024384.
Citation: Wang S, Allen D, Perkins A .
Validation of a new clinical tool for post-intensive care syndrome.
Am J Crit Care 2019 Jan;28(1):10-18. doi: 10.4037/ajcc2019639..
Keywords: Diagnostic Safety and Quality, Intensive Care Unit (ICU), Neurological Disorders, Patient Safety
Bardossy AC, Williams T, Jones K
Culturing practices and the care of the urinary catheter in reducing NHSN-defined catheter-associated urinary tract infections: the tale of two teaching hospitals.
This study compared 2 teaching hospitals’ intervention programs for preventing catheter-associated urinary tract infections (CAUTI). The comparisons were done in their adult intensive care units.
AHRQ-funded; 290201000025I; 29032001T.
Citation: Bardossy AC, Williams T, Jones K .
Culturing practices and the care of the urinary catheter in reducing NHSN-defined catheter-associated urinary tract infections: the tale of two teaching hospitals.
Infect Control Hosp Epidemiol 2018 Dec;39(12):1494-96. doi: 10.1017/ice.2018.251..
Keywords: Catheter-Associated Urinary Tract Infection (CAUTI), Healthcare-Associated Infections (HAIs), Intensive Care Unit (ICU), Patient-Centered Outcomes Research, Patient Safety, Urinary Tract Infection (UTI)
Govindan S, Snyder A, Flanders SA
Peripherally inserted central catheters in the ICU: a retrospective study of adult medical patients in 52 hospitals.
This study quantified use of peripherally inserted central catheters in the ICU versus the general ward in 52 Michigan hospitals. Variation in complications and outcomes of use were compared. Use in the ICU produced worse outcomes than those inserted in the general ward.
AHRQ-funded; HS022835.
Citation: Govindan S, Snyder A, Flanders SA .
Peripherally inserted central catheters in the ICU: a retrospective study of adult medical patients in 52 hospitals.
Crit Care Med 2018 Dec;46(12):e1136-e44. doi: 10.1097/ccm.0000000000003423..
Keywords: Adverse Events, Healthcare-Associated Infections (HAIs), Inpatient Care, Intensive Care Unit (ICU), Patient Safety
Barbash IJ
Cognitive impairment, anesthesia, and critical illness: learning from the past to gain perspective on the future.
This study examined the link between cognitive impairment, ICU admission and anesthesia. The author’s hypothesis was that patients with cognitive impairment would be more likely to undergo surgical procedures. However, analysis using data from the Mayo Clinical Study on Aging on 1,977 cognitive normal patients, 387 patients with mild cognitive impairment (MCI), and 72 patients with established dementia found that patients with MCI were more likely to undergo anesthesia and those with dementia were less likely to undergo procedural anesthesia. The author hypothesizes this may be linked to impaired decision-making of the patient and the risk-benefit analysis of performing surgery on patients with established dementia. However, ICU admissions were increased in patients with MCI and dementia.
AHRQ-funded; HS025455.
Citation: Barbash IJ .
Cognitive impairment, anesthesia, and critical illness: learning from the past to gain perspective on the future.
Mayo Clin Proc 2018 Nov;93(11):1537-39. doi: 10.1016/j.mayocp.2018.09.007..
Keywords: Adverse Events, Critical Care, Medication, Intensive Care Unit (ICU), Neurological Disorders
Stolldorf DP, Dietrich MS, Chidume T
Nurse-initiated mobilization practices in 2 community intensive care units: a pilot study.
The purposes of this study were to describe nurse-led mobilization practices in 2 community hospital ICUs and to report differences and similarities between the 2 settings. The investigators found that differences in patient characteristics and nurse-led mobilization activities were observed between ICUs. After controlling for patient characteristics, they found statistically significant differences in nurse-led mobilization activities between the 2 units, suggesting that factors other than patient characteristics may explain differences in nurse-led mobilization practices.
AHRQ-funded; HS025486.
Citation: Stolldorf DP, Dietrich MS, Chidume T .
Nurse-initiated mobilization practices in 2 community intensive care units: a pilot study.
Dimens Crit Care Nurs 2018 Nov/Dec;37(6):318-23. doi: 10.1097/dcc.0000000000000320..
Keywords: Critical Care, Intensive Care Unit (ICU)
Bordley J, Sakata KK, Bierman J
Use of a novel, electronic health record-centered, interprofessional ICU rounding simulation to understand latent safety issues.
The electronic health record is a primary source of information for all professional groups participating in ICU rounds. However, it is unclear how team dynamics impacts identification and verbalization of viewed data. Therefore, the investigators created an ICU rounding simulation to assess how the interprofessional team recognized and reported data and its impact on decision-making.
AHRQ-funded; HS023793.
Citation: Bordley J, Sakata KK, Bierman J .
Use of a novel, electronic health record-centered, interprofessional ICU rounding simulation to understand latent safety issues.
Crit Care Med 2018 Oct;46(10):1570-76. doi: 10.1097/ccm.0000000000003302..
Keywords: Decision Making, Electronic Health Records (EHRs), Intensive Care Unit (ICU), Patient Safety, Teams
Law AC, Stevens JP, Hohmann S
Patient outcomes after the introduction of statewide ICU nurse staffing regulations.
The objective of this study was to assess whether Massachusetts legislation directed at ICU nurse staffing was associated with improvements in patient outcomes. The investigators found that state regulation of patient-to-nurse staffing with the aid of patient complexity scores in intensive care was not associated with either increased nurse staffing or changes in patient outcomes.
AHRQ-funded; HS024288.
Citation: Law AC, Stevens JP, Hohmann S .
Patient outcomes after the introduction of statewide ICU nurse staffing regulations.
Crit Care Med 2018 Sep 4;46(10):1563-69. doi: 10.1097/ccm.0000000000003286..
Keywords: Intensive Care Unit (ICU), Policy, Nursing, Outcomes, Patient Safety
Satchidanand N, Servoss TJ, Singh R
Development of a risk tool to support discussions of care for older adults admitted to the ICU with pneumonia.
The purpose of this study was to develop a 30-day mortality prediction tool for older patients in intensive care unit (ICU) with pneumonia that will initiate palliative care earlier in hospital course. The authors suggest that their risk tool can help care teams make more informed decisions among care options by identifying a patient group for whom a careful review of goals of care is indicated both during and after hospitalization.
AHRQ-funded; HS023656.
Citation: Satchidanand N, Servoss TJ, Singh R .
Development of a risk tool to support discussions of care for older adults admitted to the ICU with pneumonia.
Am J Hosp Palliat Care 2018 Sep;35(9):1201-06. doi: 10.1177/1049909118764093..
Keywords: Decision Making, Elderly, Health Status, Intensive Care Unit (ICU), Palliative Care, Risk
Khan SH, Kitsis M, Golovyan D
Effects of music intervention on inflammatory markers in critically ill and post-operative patients: a systematic review of the literature.
This systematic review was conducted to determine if music has a beneficial effect on inflammatory biomarkers in intensive care and post-operative patients. After screening, a total of 26 studies were identified for review and 14 were selected for inclusion. Only seven studies showed a significant decrease in cortisol levels. Three of the studies had a low risk of bias, but 11 studies had a high risk. None of the studies had a high level of evidence.
AHRQ-funded; HS024384.
Citation: Khan SH, Kitsis M, Golovyan D .
Effects of music intervention on inflammatory markers in critically ill and post-operative patients: a systematic review of the literature.
Heart Lung 2018 Sep - Oct;47(5):489-96. doi: 10.1016/j.hrtlng.2018.05.015..
Keywords: Complementary and Alternative Medicine, Intensive Care Unit (ICU), Surgery
Bergl PA, Nanchal RS, Singh H
Diagnostic error in the critically ill: defining the problem and exploring next steps to advance intensive care unit safety.
Despite progress in ICU safety, diagnostic errors remain largely unexplored and under-studied in critical care. Compared to other safety problems, diagnostic errors are more difficult to identify and, due to the intricacies of the diagnostic process, are more difficult to unravel. This paper discusses diagnostic error in critically ill patients, defines the problem and explores next steps to advance ICU safety.
AHRQ-funded; HS022087.
Citation: Bergl PA, Nanchal RS, Singh H .
Diagnostic error in the critically ill: defining the problem and exploring next steps to advance intensive care unit safety.
Ann Am Thorac Soc 2018 Aug;15(8):903-07. doi: 10.1513/AnnalsATS.201801-068PS..
Keywords: Adverse Events, Critical Care, Diagnostic Safety and Quality, Intensive Care Unit (ICU), Medical Errors, Patient Safety
Sobotka SA, Peters S, Pinto NP
Neurodevelopmental disorders in the PICU population.
Attention deficit hyperactivity disorder (ADHD), affecting 11% of children and adolescents, increases risk for injury and may predispose children to illness. However, the prevalence of ADHD and other developmental disorders in the pediatric intensive care unit (PICU) has not been previously studied. In this study, the investigators performed a single-center, prospective cohort study of children aged 6 to 12 years who were hospitalized in the PICU from May through August 2016.
AHRQ-funded; HS023007.
Citation: Sobotka SA, Peters S, Pinto NP .
Neurodevelopmental disorders in the PICU population.
Clin Pediatr 2018 Jul;57(8):913-19. doi: 10.1177/0009922817737080..
Keywords: Children/Adolescents, Intensive Care Unit (ICU), Critical Care, Behavioral Health
Gradidge EA, Bakar A, Tellez D
Safety of tracheal intubation in the presence of cardiac disease in paediatric ICUs.
In this retrospective analysis the investigators sought to evaluate the occurrence of adverse tracheal-intubation-associated events in children with cardiac disease compared to children with non-cardiac disease. The authors found that the overall incidence of adverse tracheal-intubation-associated events in cardiac patients was not different from that in non-cardiac patients. However, the presence of a cardiac diagnosis was associated with a higher occurrence of both tracheal-intubation-associated cardiac arrest and oxygen desaturation.
AHRQ-funded; HS024511.
Citation: Gradidge EA, Bakar A, Tellez D .
Safety of tracheal intubation in the presence of cardiac disease in paediatric ICUs.
Cardiol Young 2018 Jul;28(7):928-37. doi: 10.1017/s1047951118000495..
Keywords: Adverse Events, Cardiovascular Conditions, Children/Adolescents, Intensive Care Unit (ICU), Patient Safety
Boyle WA, Murray DJ, Beyatte MB
Simulation-based assessment of critical care "front-line" providers.
The researchers developed a standardized simulation method to assess clinical skills of ICU providers. Their simulation assessments yielded reasonably reliable measures of Critical Care Medicine decision-making skills. Despite a wide range of performance, those with more ICU training and experience performed better, providing evidence to support the validity of the scores.
AHRQ-funded; HS018734; HS022265.
Citation: Boyle WA, Murray DJ, Beyatte MB .
Simulation-based assessment of critical care "front-line" providers.
Crit Care Med 2018 Jun;46(6):e516-e22. doi: 10.1097/ccm.0000000000003073.
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Keywords: Critical Care, Decision Making, Intensive Care Unit (ICU), Provider Performance, Training
Gabrani A, Kojima T, Sanders RC, Jr.
Downward trend in pediatric resident laryngoscopy participation in PICUs.
The investigators hypothesized that laryngoscopy by pediatric residents has decreased over time, with a more pronounced decrease after the July 2013 guideline change concerning proficiency in non-neonatal tracheal intubation. They found that laryngoscopy by pediatric residents has substantially decreased over time and this downward trend was not associated with the 2013 Accreditation Council for Graduate Medical Education change in residency requirements.
AHRQ-funded; HS021583; HS022464; HS024511.
Citation: Gabrani A, Kojima T, Sanders RC, Jr. .
Downward trend in pediatric resident laryngoscopy participation in PICUs.
Pediatr Crit Care Med 2018 May;19(5):e242-e50. doi: 10.1097/pcc.0000000000001470.
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Keywords: Children/Adolescents, Intensive Care Unit (ICU), Children/Adolescents
Bordley J, Sakata KK, Bierman J
Medication history versus point-of-care platelet activity testing in patients with intracerebral hemorrhage.
This study evaluated whether reduced platelet activity detected by point-of-care (POC) testing was a better predictor of hematoma expansion and poor functional outcomes in patients with intracerebral hemorrhage (ICH) than a history of antiplatelet medication exposure. A history of antiplatelet medication use better identified patients at risk for hematoma growth and poor functional outcomes than POC measures of platelet activity after spontaneous ICH.
AHRQ-funded; HS023793.
Citation: Bordley J, Sakata KK, Bierman J .
Medication history versus point-of-care platelet activity testing in patients with intracerebral hemorrhage.
Crit Care Med 2018 Oct;46(10):1570-76. doi: 10.1097/ccm.0000000000003302..
Keywords: Decision Making, Electronic Health Records (EHRs), Intensive Care Unit (ICU), Patient Safety, Teams
Colwell BRL, Williams CN, Kelly SP
Mobilization therapy in the pediatric intensive care unit: a multidisciplinary quality improvement initiative.
The authors sought to implement a standardized mobilization therapy protocol in a pediatric intensive care unit and improve mobilization of patients. They found that a multidisciplinary, multiprofessional, goal-directed mobilization protocol achieved goal mobilization in more than 50% of patients in the studied pediatric intensive care unit, with undermobilized patients being older, less ill, and more likely to have mobilization barriers at the patient and provider level.
AHRQ-funded; HS022981.
Citation: Colwell BRL, Williams CN, Kelly SP .
Mobilization therapy in the pediatric intensive care unit: a multidisciplinary quality improvement initiative.
Am J Crit Care 2018 May;27(3):194-203. doi: 10.4037/ajcc2018193.
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Keywords: Children/Adolescents, Intensive Care Unit (ICU), Patient-Centered Healthcare, Children/Adolescents, Quality Improvement
Mahmoud L, Zullo AR, Thompson BB
Outcomes of protocolised analgesia and sedation in a neurocritical care unit.
Researchers conducted a retrospective cohort study of 1197 mechanically ventilated patients admitted to a 12-bed neurocritical care unit (NCCU) over four years in order to evaluate the effect of an analgesia-based sedation protocol on medication use and costs in the NCCU. The protocol resulted in increased in fentanyl use and decreased in propofol use, but their findings indicate no effect on healthcare utilization, healthcare costs, or in-hospital mortality. Based on these results, the researchers suggest that similar NCCUs should consider using population-specific protocols to manage analgesia and sedation.
AHRQ-funded; HS022998.
Citation: Mahmoud L, Zullo AR, Thompson BB .
Outcomes of protocolised analgesia and sedation in a neurocritical care unit.
Brain Inj 2018;32(7):941-47. doi: 10.1080/02699052.2018.1469167..
Keywords: Care Management, Brain Injury, Critical Care, Healthcare Costs, Intensive Care Unit (ICU), Medication, Neurological Disorders, Outcomes, Patient-Centered Outcomes Research
Lee YSH, Stone PW, Pogorzelska-Maziarz M
Differences in work environment for staff as an explanation for variation in central line bundle compliance in intensive care units.
The objective of this study was to determine what aspects of the work environment lead to better adherence to best safety practice for central line-associated bloodstream infections (CLABSIs) prevention. Data was obtained from the Prevention of Nosocomial Infections and Cost-Effectiveness Refined Survey with data on ICU and hospital characteristics obtained from the National Healthcare Safety Network. Workload and a quality-conscious environment were the most important factors associated with CLABSI bundle compliance.
AHRQ-funded; HS018987.
Citation: Lee YSH, Stone PW, Pogorzelska-Maziarz M .
Differences in work environment for staff as an explanation for variation in central line bundle compliance in intensive care units.
Health Care Manage Rev 2018 Apr/Jun;43(2):138-47. doi: 10.1097/hmr.0000000000000134..
Keywords: Central Line-Associated Bloodstream Infections (CLABSI), Healthcare-Associated Infections (HAIs), Intensive Care Unit (ICU), Patient Safety, Prevention
Costa DK, Valley TS, Miller MA
AHRQ Author: Miller MA
ICU team composition and its association with ABCDE implementation in a quality collaborative.
Awakening, Breathing Coordination, Delirium, and Early Mobility bundle (ABCDE) should involve an interprofessional team, yet no studies describe what team composition supports implementation. This study found that ABCDE implementation was associated with frequent involvement of team members, suggesting a need for role articulation and coordination.
AHRQ-authored; AHRQ-funded; HS024552.
Citation: Costa DK, Valley TS, Miller MA .
ICU team composition and its association with ABCDE implementation in a quality collaborative.
J Crit Care 2018 Apr;44:1-6. doi: 10.1016/j.jcrc.2017.09.180.
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Keywords: Critical Care, Intensive Care Unit (ICU), Patient Safety, Quality Improvement, Teams
Arthurs BJ, Mohan V, McGrath K
Impact of passive laboratory alerts on navigating electronic health records in intensive care simulations. Sage Open 2018 Apr/Jun;8(2).
This study examined whether the use of passive alerts highlighting abnormal results in electronic health records (EHRs) contribute to alert fatigue among clinicians. Researchers employed eye tracking during chart review. Passive alerts were associated with reduced gaze fixations. However, the alerts had no impact on the duration of physician trainees reviewing laboratory results and charts or identification of patient safety issues.
AHRQ-funded; HS023793; HS021637.
Citation: Arthurs BJ, Mohan V, McGrath K .
Impact of passive laboratory alerts on navigating electronic health records in intensive care simulations. Sage Open 2018 Apr/Jun;8(2).
Sage Open 2018 Apr/Jun;8(2)..
Keywords: Electronic Health Records (EHRs), Health Information Technology (HIT), Intensive Care Unit (ICU), Patient Safety, Provider
Wang S, Hammes J, Khan S
Improving Recovery and Outcomes Every Day after the ICU (IMPROVE): study protocol for a randomized controlled trial.
The Improving Recovery and Outcomes Every Day after the ICU (IMPROVE) trial is an ongoing clinical trial which evaluates the efficacy of a combined physical exercise and cognitive training on cognitive function among ICU survivors 50 years and older who experienced delirium during an ICU stay. This article describes the study protocol for IMPROVE.
AHRQ-funded; HS024384.
Citation: Wang S, Hammes J, Khan S .
Improving Recovery and Outcomes Every Day after the ICU (IMPROVE): study protocol for a randomized controlled trial.
Trials 2018 Mar 27;19(1):196. doi: 10.1186/s13063-018-2569-8.
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Keywords: Critical Care, Elderly, Intensive Care Unit (ICU), Neurological Disorders, Patient-Centered Outcomes Research
Gradidge EA, Bakar A, Tellez D
Effect of location on tracheal intubation safety in cardiac disease-are cardiac ICUs safer?
In this retrospective cohort study, the investigators evaluate differences in tracheal intubation-associated events and process variances (i.e., multiple intubation attempts and oxygen desaturation) between pediatric cardiac ICUs and noncardiac PICUs in children with underlying cardiac disease. The authors found that in children with underlying cardiac disease, rates of adverse tracheal intubation-associated events were not lower in cardiac ICUs as compared to noncardiac ICUs, even after adjusting for differences in patient characteristics and care models.
AHRQ-funded; HS024511.
Citation: Gradidge EA, Bakar A, Tellez D .
Effect of location on tracheal intubation safety in cardiac disease-are cardiac ICUs safer?
Pediatr Crit Care Med 2018 Mar;19(3):218-27. doi: 10.1097/pcc.0000000000001422..
Keywords: Adverse Events, Cardiovascular Conditions, Children/Adolescents, Intensive Care Unit (ICU), Patient Safety