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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
176 to 200 of 237 Research Studies DisplayedOlfson M, Blanco C, Marcus SC
Treatment of adult depression in the United States.
The researchers characterized the treatment of adult depression in the United States. They concluded that most US adults who screen positive for depression did not receive treatment for depression, whereas most who were treated did not screen positive. In light of these findings, it is important to strengthen efforts to align depression care with each patient's clinical needs.
AHRQ-funded; HS02112.
Citation: Olfson M, Blanco C, Marcus SC .
Treatment of adult depression in the United States.
JAMA Intern Med 2016 Oct;176(10):1482-91. doi: 10.1001/jamainternmed.2016.5057.
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Keywords: Medication, Depression, Diagnostic Safety and Quality, Medical Expenditure Panel Survey (MEPS)
Carney RM, Freedland KE, Steinmeyer BC
Collaborative care for depression symptoms in an outpatient cardiology setting: a randomized clinical trial.
The purpose of this study was to determine whether collaborative care (CC) for patients who screen positive for depression during an outpatient cardiology visit results in greater improvement in depression symptoms and better medical outcomes than seen in patients who screen positive for depression but receive only usual care (UC). Tthis trial did not show that CC produces better depression outcomes than UC.
AHRQ-funded; HS018335.
Citation: Carney RM, Freedland KE, Steinmeyer BC .
Collaborative care for depression symptoms in an outpatient cardiology setting: a randomized clinical trial.
Int J Cardiol 2016 Sep 15;219:164-71. doi: 10.1016/j.ijcard.2016.06.045.
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Keywords: Care Management, Cardiovascular Conditions, Depression, Healthcare Delivery, Behavioral Health, Outcomes, Ambulatory Care and Surgery, Teams
Womack VY, De Chavez PJ, Albrecht SS
A longitudinal relationship between depressive symptoms and development of metabolic syndrome: the Coronary Artery Risk Development in Young Adults study.
The researchers tested whether baseline and time-varying depressive symptoms were associated with metabolic syndrome incidence in black and white men and women from the Coronary Artery Risk Development in Young Adults study. They found that, over 15 years, the incidence rate of metabolic syndrome varied by race and sex, with the highest rate in black women followed by white men, black men, and white women. Depressive symptoms were associated with incident metabolic syndrome in white men and white women. However, they found no significant association between depression and metabolic syndrome among black men or black women.
AHRQ-funded; HS023009.
Citation: Womack VY, De Chavez PJ, Albrecht SS .
A longitudinal relationship between depressive symptoms and development of metabolic syndrome: the Coronary Artery Risk Development in Young Adults study.
Psychosom Med 2016 Sep;78(7):867-73. doi: 10.1097/psy.0000000000000347.
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Keywords: Cardiovascular Conditions, Depression, Racial and Ethnic Minorities, Sex Factors, Young Adults
Albrecht JS, Park Y, Hur P
Adherence to maintenance medications among older adults with chronic obstructive pulmonary disease. the role of depression.
The objective of this study was to assess the impact of depression on COPD maintenance medication adherence among of Medicare beneficiaries newly diagnosed with COPD. Average monthly adherence to COPD maintenance medications was low, peaking at 57 percent in the month after first fill and decreasing to 35 percent within 6 months. In the adjusted regression model, depression was associated with decreased adherence to COPD maintenance medications.
AHRQ-funded; HS024560.
Citation: Albrecht JS, Park Y, Hur P .
Adherence to maintenance medications among older adults with chronic obstructive pulmonary disease. the role of depression.
Ann Am Thorac Soc 2016 Sep;13(9):1497-504. doi: 10.1513/AnnalsATS.201602-136OC.
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Keywords: Respiratory Conditions, Elderly, Medication, Patient Adherence/Compliance, Depression
Connolly Gibbons MB, Gallop R, Thompson D
Comparative effectiveness of cognitive therapy and dynamic psychotherapy for major depressive disorder in a community mental health setting: a randomized clinical noninferiority trial.
The authors sought to determine whether dynamic psychotherapy (DT) is not inferior to cognitive therapy (CT) in the treatment of major depressive disorder (MDD) in a community mental health setting. This study suggests that DT is not inferior to CT on change in depression for the treatment of MDD in a community mental health setting.
AHRQ-funded; HS018440.
Citation: Connolly Gibbons MB, Gallop R, Thompson D .
Comparative effectiveness of cognitive therapy and dynamic psychotherapy for major depressive disorder in a community mental health setting: a randomized clinical noninferiority trial.
JAMA Psychiatry 2016 Sep;73(9):904-11. doi: 10.1001/jamapsychiatry.2016.1720.
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Keywords: Comparative Effectiveness, Community-Based Practice, Depression, Behavioral Health, Patient-Centered Outcomes Research
Biegler K, Mollica R, Sim SE
AHRQ Author: Ngo-Metzger Q
Rationale and study protocol for a multi-component health information technology (HIT) screening tool for depression and post-traumatic stress disorder in the primary care setting.
The authors described the rationale and protocol of a clustered randomized controlled trial to test the effectiveness of a health information technology (HIT) intervention that provides a multi-component approach to delivering culturally competent mental health care in the primary care setting. They expect the outcomes to include assessing the potential of the HIT intervention to improve screening rates, clinical detection, provider initiation of treatment, and patient outcomes for depression and post-traumatic stress disorder. They suggest that this technology has the potential to be adapted in order to facilitate mental health screening and treatment in the primary care setting.
AHRQ-authored.
Citation: Biegler K, Mollica R, Sim SE .
Rationale and study protocol for a multi-component health information technology (HIT) screening tool for depression and post-traumatic stress disorder in the primary care setting.
Contemp Clin Trials 2016 Sep;50:66-76. doi: 10.1016/j.cct.2016.07.001.
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Keywords: Health Information Technology (HIT), Behavioral Health, Depression, Screening, Primary Care
Kato E, Beswick-Escanlar V
AHRQ Author: Kato E
Screening for depression in adults.
This case study involves a 29-year-old man, who presents to your office for a routine visit. He has a history of being overweight and has hypertension that is controlled by diet and exercise. It poses three multiple choice questions about screening for depression together with the U.S. Preventive Services Task Force recommendations and related background information.
AHRQ-authored.
Citation: Kato E, Beswick-Escanlar V .
Screening for depression in adults.
Am Fam Physician 2016 Aug 15;94(4):305-6.
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Keywords: U.S. Preventive Services Task Force (USPSTF), Screening, Depression, Behavioral Health, Case Study
Aronson BD, Palombi LC, Walls ML
Rates and consequences of posttraumatic distress among American Indian adults with type 2 diabetes.
This study examined the prevalence of screened posttraumatic stress disorder (PTSD) and associated diabetes-related outcomes. It found that when grouped by mental health conditions (neither screened PTSD nor depressive symptoms, screened PTSD only, depressive symptoms only, and both), those with both screened PTSD and depressive symptoms reported the highest proportion of any past month hyperglycemia, past year hospitalization, and low self-rated health status.
AHRQ-funded; HS024180.
Citation: Aronson BD, Palombi LC, Walls ML .
Rates and consequences of posttraumatic distress among American Indian adults with type 2 diabetes.
J Behav Med 2016 Aug;39(4):694-703. doi: 10.1007/s10865-016-9733-y.
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Keywords: Racial and Ethnic Minorities, Behavioral Health, Diabetes, Racial and Ethnic Minorities, Depression
Jonassaint CR, Jones VL, Leong S
A systematic review of the association between depression and health care utilization in children and adults with sickle cell disease.
The authors sought to determine whether depression or depressive symptoms are associated with health care utilization among children and adults with sickle cell disease (SCD). They found that, overall, depressive symptoms are common in SCD and may increase risk for poor outcomes including health care utilization. They further found a modest association between depression and health care utilization in SCD.
AHRQ-funded; HS022989.
Citation: Jonassaint CR, Jones VL, Leong S .
A systematic review of the association between depression and health care utilization in children and adults with sickle cell disease.
Br J Haematol 2016 Jul;174(1):136-47. doi: 10.1111/bjh.14023.
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Keywords: Children/Adolescents, Depression, Healthcare Utilization, Patient-Centered Healthcare, Sickle Cell Disease
Lewandowski RE, O'Connor B, Bertagnolli A
Screening for and diagnosis of depression among adolescents in a large health maintenance organization.
The researchers determined changes in patterns of depression screening and diagnosis over three years in primary and specialty mental health care in a large HMO. They found that the rate of depression screening in primary care increased over the study period, corresponding to an increase in the number of depression diagnoses made in primary care and a shift in the location in which depression diagnoses were made, from the mental health department to primary care.
AHRQ-funded; HS020503.
Citation: Lewandowski RE, O'Connor B, Bertagnolli A .
Screening for and diagnosis of depression among adolescents in a large health maintenance organization.
Psychiatr Serv 2016 Jun;67(6):636-41. doi: 10.1176/appi.ps.201400465.
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Keywords: Children/Adolescents, Depression, Diagnostic Safety and Quality, Behavioral Health, Screening
Olin SC, O'Connor BC, Storfer-Isser A
Access to care for youth in a state mental health system: a simulated patient approach.
The researchers examined access to psychiatric care for adolescents with depression in outpatient specialty clinics within a state mental health system, using a simulated patient approach. They concluded that access to psychiatric care for youth with depression was variable in a state system. State-sponsored trainings on strategies to reduce wait times appear to improve care access.
AHRQ-funded; HS020503.
Citation: Olin SC, O'Connor BC, Storfer-Isser A .
Access to care for youth in a state mental health system: a simulated patient approach.
J Am Acad Child Adolesc Psychiatry 2016 May;55(5):392-9. doi: 10.1016/j.jaac.2016.02.014.
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Keywords: Access to Care, Children/Adolescents, Behavioral Health, Depression, Training
Taylor CB, Kass AE, Trockel M
Reducing eating disorder onset in a very high risk sample with significant comorbid depression: a randomized controlled trial.
The authors evaluated an online eating disorder (ED) intervention designed to reduce ED and comorbid pathology. They found that ED attitudes and behaviors improved more in the intervention group than in the control group. They concluded that an inexpensive, easily disseminated intervention might reduce ED onset among those at highest risk.
AHRQ-funded; HS000078.
Citation: Taylor CB, Kass AE, Trockel M .
Reducing eating disorder onset in a very high risk sample with significant comorbid depression: a randomized controlled trial.
J Consult Clin Psychol 2016 May;84(5):402-14. doi: 10.1037/ccp0000077.
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Keywords: Behavioral Health, Depression, Prevention, Web-Based
Ryu E, Chamberlain AM, Pendergraft RS
Quantifying the impact of chronic conditions on a diagnosis of major depressive disorder in adults: a cohort study using linked electronic medical records.
In this study, the researchers aimed to quantify the relative contribution of selected chronic conditions to identify the conditions most influential to major depressive disorder (MDD) risk in adults and identify differences by age. Their results suggest that specific chronic conditions such as diabetes mellitus and rheumatoid arthritis/osteoarthritis may have greater influence than others on the risk of MDD.
AHRQ-funded; HS023077.
Citation: Ryu E, Chamberlain AM, Pendergraft RS .
Quantifying the impact of chronic conditions on a diagnosis of major depressive disorder in adults: a cohort study using linked electronic medical records.
BMC Psychiatry 2016 Apr 26;16:114. doi: 10.1186/s12888-016-0821-x.
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Keywords: Chronic Conditions, Depression, Electronic Health Records (EHRs), Primary Care
Lin LY, Sidani JE, Shensa A
Association between social media use and depression among U.S. young adults.
The authors assessed the association between social media use and depression in a nationally representative sample of young adults. They found that participants in the highest quartile of total time per day using social media had significantly increased odds of depression. They conluded that social media use was significantly associated with increased depression.
AHRQ-funded; HS022989.
Citation: Lin LY, Sidani JE, Shensa A .
Association between social media use and depression among U.S. young adults.
Depress Anxiety 2016 Apr;33(4):323-31. doi: 10.1002/da.22466.
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Keywords: Social Media, Depression, Young Adults, Behavioral Health, Patient-Centered Outcomes Research
Heberlein EC, Picklesimer AH, Billings DL
The comparative effects of group prenatal care on psychosocial outcomes.
This study compared the psychosocial outcomes of the CenteringPregnancy (CP) model of group prenatal care to individual prenatal care. It used a prospective cohort study of women who chose CP group or individual prenatal care. Among women with high pregnancy-specific distress in early pregnancy, group participants had an 8.3 percent greater increase in prenatal planning-preparation coping strategies in late pregnancy and a 4.9 percent greater decrease in postpartum depressive symptom scores.
AHRQ-funded; HS021975.
Citation: Heberlein EC, Picklesimer AH, Billings DL .
The comparative effects of group prenatal care on psychosocial outcomes.
Arch Womens Ment Health 2016 Apr;19(2):259-69. doi: 10.1007/s00737-015-0564-6.
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Keywords: Pregnancy, Stress, Depression, Outcomes
O'Connor BC, Lewandowski RE, Rodriguez S
Usual care for adolescent depression from symptom identification through treatment initiation.
The researchers sought to determine rates of appropriate follow-up care for adolescents with newly identified depression symptoms in 3 large health systems. They concluded that most adolescents with newly identified depression symptoms received some treatment, usually including psychotherapy, within the first 3 months after identification. However, follow-up care was low and substantial variation existed between sites.
AHRQ-funded; HS020503.
Citation: O'Connor BC, Lewandowski RE, Rodriguez S .
Usual care for adolescent depression from symptom identification through treatment initiation.
JAMA Pediatr 2016 Apr;170(4):373-80. doi: 10.1001/jamapediatrics.2015.4158.
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Keywords: Medication, Children/Adolescents, Depression, Behavioral Health
Gartlehner G, Gaynes BN, Amick HR
Comparative benefits and harms of antidepressant, psychological, complementary, and exercise treatments for major depression: An evidence report for a clinical practice guideline from the American College of Physicians.
This evidence report compared the benefits and harms of second-generation antidepressants and psychological, complementary and alternative medicine (CAM), and exercise treatments as first- and second-step interventions for adults with acute major depressive disorder (MDD). It concluded tht, given their similar efficacy, cognitive behavioral therapy and antidepressants are both viable choices for initial treatment of MDD.
AHRQ-funded.
Citation: Gartlehner G, Gaynes BN, Amick HR .
Comparative benefits and harms of antidepressant, psychological, complementary, and exercise treatments for major depression: An evidence report for a clinical practice guideline from the American College of Physicians.
Ann Intern Med 2016 Mar 1;164(5):331-41. doi: 10.7326/m15-1813.
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Keywords: Medication, Comparative Effectiveness, Complementary and Alternative Medicine, Depression, Behavioral Health
Forman-Hoffman V, McClure E, McKeeman J
Screening for major depressive disorder in children and adolescents: a systematic review for the U.S. Preventive Services Task Force.
This report updates the 2009 U.S. Preventive Services Task Force (USPSTF) systematic review on screening for and treatment of Major depressive disorder (MDD) in children and adolescents in primary care settings. No evidence was found of a direct link between screening children and adolescents for MDD in primary care or similar settings and depression or other health-related outcomes. Evidence showed that some screening tools are accurate.
AHRQ-funded; 290201200015.
Citation: Forman-Hoffman V, McClure E, McKeeman J .
Screening for major depressive disorder in children and adolescents: a systematic review for the U.S. Preventive Services Task Force.
Ann Intern Med 2016 Mar 1;164(5):342-9. doi: 10.7326/m15-2259.
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Keywords: U.S. Preventive Services Task Force (USPSTF), Screening, Depression, Behavioral Health, Children/Adolescents
Sawchuk CN, Roy-Byrne P, Noonan C
The association of panic disorder, posttraumatic stress disorder, and major depression with smoking in American Indians.
This survey asked whether lifetime panic disorder, posttraumatic stress disorder, and major depression were related to lifetime cigarette smoking in two geographically distinct American Indian tribes. It found that the odds of smoking were two times higher in Southwest participants with panic disorder and major depression, and 1.7 times higher in those with posttraumatic stress disorder, after controlling for sociodemographic variables.
AHRQ-funded; HS010854.
Citation: Sawchuk CN, Roy-Byrne P, Noonan C .
The association of panic disorder, posttraumatic stress disorder, and major depression with smoking in American Indians.
Nicotine Tob Res 2016 Mar;18(3):259-66. doi: 10.1093/ntr/ntv071.
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Keywords: Depression, Tobacco Use, Racial and Ethnic Minorities, Stress
Iyer AS, Bhatt SP, Garner JJ
Depression is associated with readmission for acute exacerbation of chronic obstructive pulmonary disease.
The authors characterized the associations between depression and anxiety and COPD readmission risk. They found that depression is an independent risk factor for both short- and long-term readmissions for acute exacerbation of COPD and may represent a modifiable risk factor. They also found that in-hospital tobacco cessation counseling was associated with reduced 1-year readmission.
AHRQ-funded; HS013852.
Citation: Iyer AS, Bhatt SP, Garner JJ .
Depression is associated with readmission for acute exacerbation of chronic obstructive pulmonary disease.
Ann Am Thorac Soc 2016 Feb;13(2):197-203. doi: 10.1513/AnnalsATS.201507-439OC.
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Keywords: Respiratory Conditions, Depression, Hospital Readmissions, Risk, Tobacco Use
Bogner HR, Joo JH, Hwang S
Does a depression management program decrease mortality in older adults with specific medical conditions in primary care? An exploratory analysis.
The objective of this study was to determine whether treating depression decreases mortality from various chronic medical conditions. It found evidence of a statistically significant intervention effect on mortality for diabetes mellitus in persons with major depression.
AHRQ-funded; HS023445.
Citation: Bogner HR, Joo JH, Hwang S .
Does a depression management program decrease mortality in older adults with specific medical conditions in primary care? An exploratory analysis.
J Am Geriatr Soc 2016 Jan;64(1):126-31. doi: 10.1111/jgs.13711..
Keywords: Chronic Conditions, Depression, Elderly, Mortality, Primary Care
Eichen DM, Kass AE, Fitzsimmons-Craft EE
Non-suicidal self-injury and suicidal ideation in relation to eating and general psychopathology among college-age women.
Limited research has examined the effects of combined non-suicidal self-injury (NSSI)+suicidal ideation; thus concurrent examination is needed to understand potential differential effects on psychopathology. In this study, college-aged women completed self-report measures of NSSI, suicidal ideation, general psychopathology, and Eating Disorder-specific psychopathology. The study found that the NSSI+Suicidal Ideation group was only greater than Suicidal Ideation-only on measures of depression and eating concern.
AHRQ-funded; HS000078.
Citation: Eichen DM, Kass AE, Fitzsimmons-Craft EE .
Non-suicidal self-injury and suicidal ideation in relation to eating and general psychopathology among college-age women.
Psychiatry Res 2016 Jan 30;235:77-82. doi: 10.1016/j.psychres.2015.11.046.
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Keywords: Behavioral Health, Nutrition, Depression, Risk
Cummings DM, Kirian K, Howard G
Consequences of comorbidity of elevated stress and/or depressive symptoms and incident cardiovascular outcomes in diabetes: results from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.
The authors evaluated the impact of comorbid depressive symptoms and/or stress on adverse cardiovascular (CV) outcomes in individuals with diabetes compared with those without diabetes. They concluded that comorbid stress and/or depressive symptoms are common in individuals with diabetes and together are associated with progressively increased risks for adverse CV outcomes.
AHRQ-funded; HS023009.
Citation: Cummings DM, Kirian K, Howard G .
Consequences of comorbidity of elevated stress and/or depressive symptoms and incident cardiovascular outcomes in diabetes: results from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.
Diabetes Care 2016 Jan;39(1):101-9. doi: 10.2337/dc15-1174.
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Keywords: Cardiovascular Conditions, Depression, Diabetes, Patient-Centered Outcomes Research, Stress
Strobino DM, Ahmed S, Mistry K
AHRQ Author: Mistry KB
Maternal depressive symptoms and attained size among children in the first 2 years of life.
The researchers evaluated the relation of maternal depressive symptoms with attained size and whether it is stronger for young children in low-income families. They found that odds of short stature were significantly increased at 6 months in the total sample and among low/middle-income families for children whose mothers reported symptoms. Other measures of attained size were not associated with depressive symptoms.
AHRQ-authored.
Citation: Strobino DM, Ahmed S, Mistry K .
Maternal depressive symptoms and attained size among children in the first 2 years of life.
Acad Pediatr 2016 Jan-Feb;16(1):75-81. doi: 10.1016/j.acap.2015.10.003.
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Keywords: Depression, Newborns/Infants, Health Status, Pregnancy, Social Determinants of Health
Gordon M, Henderson R, Holmes JH
Participatory design of ehealth solutions for women from vulnerable populations with perinatal depression.
Using a participatory design approach, the Stress in Pregnancy: Improving Results with Interactive Technology group developed specifications for a suite of eHealth applications to improve the quality of perinatal mental health care. Three apps were developed by the group: an app to support high-risk women after discharge from hospital, a screening tool for depression, and a patient decision aid for supporting treatment choice.
AHRQ-funded; HS022441.
Citation: Gordon M, Henderson R, Holmes JH .
Participatory design of ehealth solutions for women from vulnerable populations with perinatal depression.
J Am Med Inform Assoc 2016 Jan;23(1):105-9. doi: 10.1093/jamia/ocv109.
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Keywords: Telehealth, Women, Pregnancy, Depression, Social Determinants of Health