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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
51 to 68 of 68 Research Studies DisplayedMa X, Chen Y, Cole SR
A hybrid Bayesian hierarchical model combining cohort and case-control studies for meta-analysis of diagnostic tests: accounting for partial verification bias.
In this paper, the authors proposed a novel hybrid Bayesian hierarchical model combining cohort and case-control studies while simultaneously correcting partial verification bias. They presented two case studies on assessing the diagnostic accuracy of gadolinium-enhanced magnetic resonance imaging in detecting lymph node metastases and of adrenal fluorine-18 fluorodeoxyglucose positron emission tomography in characterizing adrenal masses.
AHRQ-funded; HS022900.
Citation: Ma X, Chen Y, Cole SR .
A hybrid Bayesian hierarchical model combining cohort and case-control studies for meta-analysis of diagnostic tests: accounting for partial verification bias.
Stat Methods Med Res 2016 Dec;25(6):3015-37. doi: 10.1177/0962280214536703.
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Keywords: Cancer, Diagnostic Safety and Quality, Imaging, Research Methodologies
Henke L, Kashani R, Yang D
Simulated online adaptive magnetic resonance-guided stereotactic body radiation therapy for the treatment of oligometastatic disease of the abdomen and central thorax: characterization of potential advantages.
This study characterized potential advantages of online-adaptive magnetic resonance (MR)-guided stereotactic body radiation therapy (SBRT) to treat oligometastatic disease of the non-liver abdomen and central thorax. It concluded that online-adaptive MRI-guided SBRT may allow planning target volume dose escalation and/or simultaneous tumor/organ at risk sparing compared with nonadaptive SBRT.
AHRQ-funded; HS022888.
Citation: Henke L, Kashani R, Yang D .
Simulated online adaptive magnetic resonance-guided stereotactic body radiation therapy for the treatment of oligometastatic disease of the abdomen and central thorax: characterization of potential advantages.
Int J Radiat Oncol Biol Phys 2016 Dec 1;96(5):1078-86. doi: 10.1016/j.ijrobp.2016.08.036.
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Keywords: Cancer, Imaging
Murphy DR, Meyer AN, Bhise V
Computerized triggers of big data to detect delays in follow-up of chest imaging results.
A "trigger" algorithm was used to identify delays in follow-up of abnormal chest imaging results in a large national clinical data warehouse of electronic health record (EHR) data. In this study, the authors applied a trigger in a repository hosting EHR data from all Department of Veterans Affairs health-care facilities and analyzed data from seven facilities. The investigators concluded that application of triggers on "big" EHR data may aid in identifying patients experiencing delays in diagnostic evaluation of chest imaging results suspicious for malignancy.
Citation: Murphy DR, Meyer AN, Bhise V .
Computerized triggers of big data to detect delays in follow-up of chest imaging results.
Chest 2016 Sep;150(3):613-20. doi: 10.1016/j.chest.2016.05.001..
Keywords: Imaging, Electronic Health Records (EHRs), Health Information Technology (HIT), Data, Diagnostic Safety and Quality, Cancer
Croswell J, Owings J
Screening for breast cancer.
This case study involves a 47-year-old woman who presents to your office for a well-woman visit. She is healthy, takes no medications, and has no health concerns. She has never been diagnosed with breast cancer, nor have any of her first-degree relatives. Her digital mammography two years ago was negative, and she asks whether she should be screened again this year. The study poses three multiple choice questions together with the U.S. Preventive Services Task Force recommendations and related background information.
AHRQ-authored.
Citation: Croswell J, Owings J .
Screening for breast cancer.
Am Fam Physician 2016 Jul 15;94(2):143-4.
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Keywords: U.S. Preventive Services Task Force (USPSTF), Cancer: Breast Cancer, Cancer, Screening, Prevention, Evidence-Based Practice, Women, Imaging, Case Study
Healy MA, Yin H, Reddy RM
Use of positron emission tomography to detect recurrence and associations with survival in patients with lung and esophageal cancers.
The researchers sought to evaluate utilization of positron emission tomography (PET) to detect recurrence in asymptomatic patients and relationships with survival for patients with lung and esophageal cancers. Despite statistically significant variation in use of PET to detect tumor recurrence, there was no association with improved two-year survival.
AHRQ-funded; HS020937.
Citation: Healy MA, Yin H, Reddy RM .
Use of positron emission tomography to detect recurrence and associations with survival in patients with lung and esophageal cancers.
J Natl Cancer Inst 2016 Jul;108(7). doi: 10.1093/jnci/djv429.
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Keywords: Imaging, Cancer, Cancer: Lung Cancer, Healthcare Utilization
Kim EH, Vetter JM, Kuxhausen AN
Limited use of surveillance imaging following nephrectomy for renal cell carcinoma.
The researchers evaluated the utilization of follow-up imaging after nephrectomy for renal cell carcinoma (RCC) in nationally representative data. Using Surveillance, Epidemiology, End Results (SEER) data, they found that, in the Medicare population, surveillance imaging is performed in a limited number of patients following nephrectomy for RCC but that increasing tumor stage is predictive of both increased chest and abdominal imaging surveillance.
AHRQ-funded; HS019455.
Citation: Kim EH, Vetter JM, Kuxhausen AN .
Limited use of surveillance imaging following nephrectomy for renal cell carcinoma.
Urol Oncol 2016 May;34(5):237.e11-8. doi: 10.1016/j.urolonc.2015.11.017.
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Keywords: Cancer, Healthcare Utilization, Imaging, Medicare
Mohapatra A, Vemana G, Bhayani S
Trends in the utilization of imaging for upper tract urothelial carcinoma.
The researchers evaluated the changes in use of the different imaging modalities for diagnosing upper tract urothelial carcinoma (UTUC) and assess how these changes have affected tumor stage at the time of surgery. They found trends toward the utilization of newer imaging modalities to diagnose UTUC and more modalities per patient. Endoscopy and retrograde pyelography were associated with smaller tumors, whereas magnetic resonance urography was associated with larger tumors. They recommended further studies to evaluate the utility of the different modalities in diagnosing UTUC.
AHRQ-funded; HS019455.
Citation: Mohapatra A, Vemana G, Bhayani S .
Trends in the utilization of imaging for upper tract urothelial carcinoma.
Urol Oncol 2016 May;34(5):236.e23-8. doi: 10.1016/j.urolonc.2015.12.002.
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Keywords: Cancer, Diagnostic Safety and Quality, Healthcare Utilization, Imaging
Liu S, Wu Y, Wooten HO
Methods to model and predict the ViewRay treatment deliveries to aid patient scheduling and treatment planning.
A software tool is developed to predict treatment delivery time for radiation therapy (RT) treatments of patients on ViewRay magnetic resonance image-guided radiation therapy (MR-IGRT) delivery system. This tool is necessary for managing patient treatment scheduling in a clinic. After modeling and quantitative analysis, the researchers proposed an algorithm that is able to predict the ViewRay treatment delivery time with the average prediction error 0.22min or 1.82 percent.
AHRQ-funded; HS022888.
Citation: Liu S, Wu Y, Wooten HO .
Methods to model and predict the ViewRay treatment deliveries to aid patient scheduling and treatment planning.
J Appl Clin Med Phys 2016 Mar 8;17(2):5907.
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Keywords: Cancer, Health Information Technology (HIT), Imaging
Nelson HD, O'Meara ES, Kerlikowske K
Factors associated with rates of false-positive and false-negative results from digital mammography screening: an analysis of registry data.
The researchers sought to determine factors associated with false-positive and false-negative digital mammography results, additional imaging, and biopsies among a general population of women screened for breast cancer. They found that false-positive mammography results and additional imaging are common, particularly for younger women and those with risk factors, whereas biopsies occur less often. Rates of false-negative results are low.
AHRQ-funded; 290201200015I.
Citation: Nelson HD, O'Meara ES, Kerlikowske K .
Factors associated with rates of false-positive and false-negative results from digital mammography screening: an analysis of registry data.
Ann Intern Med 2016 Feb 16;164(4):226-35. doi: 10.7326/m15-0971.
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Keywords: Cancer: Breast Cancer, Cancer, Imaging, Diagnostic Safety and Quality, Women, Screening, Prevention
Acharya S, Fischer-Valuck BW, Kashani R
Online magnetic resonance image guided adaptive radiation therapy: first clinical applications.
The authors demonstrated the feasibility of online adaptive magnetic resonance (MR) image guided radiation therapy (MR-IGRT) with five patients with abdominopelvic malignancies. They successfully implemented online adaptive MR-IGRT with planning and quality assurance workflow suitable for routine clinical application. Clinical trials are in development to formally evaluate adaptive treatments for a variety of disease sites.
AHRQ-funded; HS022888.
Citation: Acharya S, Fischer-Valuck BW, Kashani R .
Online magnetic resonance image guided adaptive radiation therapy: first clinical applications.
Int J Radiat Oncol Biol Phys 2016 Feb;94(2):394-403. doi: 10.1016/j.ijrobp.2015.10.015.
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Keywords: Cancer, Cancer: Colorectal Cancer, Imaging, Workflow
Patel R, Lim RP, Saric M
Diagnostic performance of cardiac magnetic resonance imaging and echocardiography in evaluation of cardiac and paracardiac masses.
The researchers evaluated the predictive value of echocardiography and cardiac magnetic resonance (CMR) imaging parameters to identify tumors and malignancy and to provide histopathologic diagnosis of cardiac masses. They found that CMR identified 6 masses missed on transthoracic echocardiography (4 of which were outside the heart) and provided significantly more correct histopathologic diagnoses compared to echocardiography (77 percent vs 43 percent).
AHRQ-funded; HS019473.
Citation: Patel R, Lim RP, Saric M .
Diagnostic performance of cardiac magnetic resonance imaging and echocardiography in evaluation of cardiac and paracardiac masses.
Am J Cardiol 2016 Jan;117(1):135-40. doi: 10.1016/j.amjcard.2015.10.014..
Keywords: Diagnostic Safety and Quality, Cardiovascular Conditions, Imaging, Cancer, Comparative Effectiveness
Highfield L, Rajan SS, Valerio MA
A non-randomized controlled stepped wedge trial to evaluate the effectiveness of a multi-level mammography intervention in improving appointment adherence in underserved women.
This study evaluated a theoretically based, systematically designed implementation strategy to support adoption and implementation of a patient navigation-based intervention, called Peace of Mind Program (PMP), aimed at improving breast cancer screening among underserved women.. Any potential confounding or bias will be controlled in the analysis. Outcomes such as appointment adherence, patient referral to diagnostics, time to diagnostic referral, patient referral to treatment, time to treatment referral, and budget impact of the intervention will be assessed.
AHRQ-funded; HS023255.
Citation: Highfield L, Rajan SS, Valerio MA .
A non-randomized controlled stepped wedge trial to evaluate the effectiveness of a multi-level mammography intervention in improving appointment adherence in underserved women.
Implement Sci 2015 Oct 14;10:143. doi: 10.1186/s13012-015-0334-x.
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Keywords: Cancer: Breast Cancer, Cancer, Screening, Patient Adherence/Compliance, Women, Vulnerable Populations, Prevention, Imaging
Irvin VL, Breen N, Meissner HI
AHRQ Author: Kaplan RM
Non-normal screening mammography results, lumpectomies, and breast cancer reported by California women, 2001-2009.
This study report trends in self-reported non-normal screening mammography results, lumpectomies, and breast cancer in California women. Between 2001 and 2009, the percent of California women who reported having been diagnosed with breast cancer was relatively stable. For each of the three age groups studied, the percentage of non-normal mammography results increased and the percentages of lumpectomies decreased.
AHRQ-authored.
Citation: Irvin VL, Breen N, Meissner HI .
Non-normal screening mammography results, lumpectomies, and breast cancer reported by California women, 2001-2009.
AHRQ-authored..
Keywords: Cancer: Breast Cancer, Cancer, Screening, Imaging, Women
Chou R, Cuevas C, Fu R
Imaging techniques for the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis.
This review evaluated the test performance of ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI) in the detection of hepatocellular carcinoma (HCC). It concluded that CT and MRI are associated with higher sensitivity than ultrasonography without contrast for detection of HCC. For detection of focal liver lesions, the sensitivities of all three techniques are similar.
AHRQ-funded; 290200710057I
Citation: Chou R, Cuevas C, Fu R .
Imaging techniques for the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis.
Ann Intern Med. 2015 May 19;162(10):697-711. doi: 10.7326/m14-2509..
Keywords: Cancer, Comparative Effectiveness, Diagnostic Safety and Quality, Imaging
Patel N, Yopp AC, Singal AG
Diagnostic delays are common among patients with hepatocellular carcinoma.
The primary goals of this study were to quantify diagnostic delays among patients diagnosed with HCC and identify factors associated with delays in follow-up testing. It found that 1 in 5 patients experienced significant diagnostic delays, allowing for interval tumor growth. Delays in diagnosis are particularly common among patients who present as an outpatient, being present in more than one-third of cases.
AHRQ-funded; HS022418.
Citation: Patel N, Yopp AC, Singal AG .
Diagnostic delays are common among patients with hepatocellular carcinoma.
J Natl Compr Canc Netw 2015 May;13(5):543-9..
Keywords: Cancer, Diagnostic Safety and Quality, Imaging
Carter JL, Coletti RJ, Harris RP
Quantifying and monitoring overdiagnosis in cancer screening: a systematic review of methods.
The authors conducted a systematic review to identify and evaluate the methods that have been used for measuring overdiagnosis of cancer. Their systematic review highlights the high potential for bias and the reliance on unproven assumptions in modeling studies and studies that quantify overdiagnosis using pathological or imaging characteristics.
AHRQ-funded; HS021133.
Citation: Carter JL, Coletti RJ, Harris RP .
Quantifying and monitoring overdiagnosis in cancer screening: a systematic review of methods.
BMJ 2015 Jan 7;350:g7773. doi: 10.1136/bmj.g7773..
Keywords: Cancer, Diagnostic Safety and Quality, Imaging, Screening
Smieliauskas F, MacMahon H, Salgia R
Geographic variation in radiologist capacity and widespread implementation of lung cancer CT screening.
The researchers estimated the prevalence of capacity constraints in the radiologist workforce and resulting potential disparities in access to lung cancer screening. They found that scaling up lung cancer screening would increase imaging procedures by an average of 4% across Health Service Areas (HSAs). HSAs that were rural, with many eligible smokers, and disproportionately Hispanic or low-income smokers had significantly higher odds of facing capacity constraints.
AHRQ-funded; HS018535.
Citation: Smieliauskas F, MacMahon H, Salgia R .
Geographic variation in radiologist capacity and widespread implementation of lung cancer CT screening.
J Med Screen 2014 Dec;21(4):207-15. doi: 10.1177/0969141314548055..
Keywords: U.S. Preventive Services Task Force (USPSTF), Cancer, Cancer: Lung Cancer, Screening, Imaging
Deppen SA, Blume JD, Kensinger CD
Accuracy of FDG-PET to diagnose lung cancer in areas with infectious lung disease: a meta-analysis.
The purpose of this study was to estimate the diagnostic accuracy of positron emission tomography (PET) combined with fludeoxyglucose F18 (FDG) for pulmonary modules suspicious for lung cancer in regions where infectious lung disease is endemic and compare the accuracy in regions where such disease is rare. It found that the accuracy of FDG-PET was extremely heterogeneous.
AHRQ-funded; HS021554.
Citation: Deppen SA, Blume JD, Kensinger CD .
Accuracy of FDG-PET to diagnose lung cancer in areas with infectious lung disease: a meta-analysis.
JAMA 2014 Sep 24;312(12):1227-36. doi: 10.1001/jama.2014.11488..
Keywords: Cancer, Cancer: Lung Cancer, Diagnostic Safety and Quality, Respiratory Conditions, Imaging