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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
9726 to 9750 of 12139 Research Studies DisplayedEichen DM, Kass AE, Fitzsimmons-Craft EE
Non-suicidal self-injury and suicidal ideation in relation to eating and general psychopathology among college-age women.
Limited research has examined the effects of combined non-suicidal self-injury (NSSI)+suicidal ideation; thus concurrent examination is needed to understand potential differential effects on psychopathology. In this study, college-aged women completed self-report measures of NSSI, suicidal ideation, general psychopathology, and Eating Disorder-specific psychopathology. The study found that the NSSI+Suicidal Ideation group was only greater than Suicidal Ideation-only on measures of depression and eating concern.
AHRQ-funded; HS000078.
Citation: Eichen DM, Kass AE, Fitzsimmons-Craft EE .
Non-suicidal self-injury and suicidal ideation in relation to eating and general psychopathology among college-age women.
Psychiatry Res 2016 Jan 30;235:77-82. doi: 10.1016/j.psychres.2015.11.046.
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Keywords: Behavioral Health, Nutrition, Depression, Risk
Depp TB, McGinnis KA, Kraemer K
Risk factors associated with acute exacerbation of chronic obstructive pulmonary disease in HIV-infected and uninfected patients.
This study sought to determine the association between HIV infection and other risk factors for acute exacerbation of chronic obstructive pulmonary disease (AECOPD). It concluded that HIV infection, especially with lower CD4 cell count, is an independent risk factor for AECOPD. Enhanced susceptibility to harm from current smoking or unhealthy alcohol use in HIV-infected patients may also contribute to the greater rate of AECOPD.
AHRQ-funded; HS023258.
Citation: Depp TB, McGinnis KA, Kraemer K .
Risk factors associated with acute exacerbation of chronic obstructive pulmonary disease in HIV-infected and uninfected patients.
AIDS 2016 Jan 28;30(3):455-63. doi: 10.1097/qad.0000000000000940.
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Keywords: Respiratory Conditions, Human Immunodeficiency Virus (HIV), Risk, Substance Abuse, Tobacco Use
Fisher ES, Shortell SM, Savitz LA
Implementation science: A potential catalyst for delivery system reform.
Understanding which of the multitude of technological, policy, and organizational changes under way are most effective at improving care is a critical challenge. This article describes 3 ideas that could be helpful: application of a well-grounded conceptual framework; distinguishing 3 distinct types of innovations that health systems are using to improve care; and a focus on building the information systems needed to accelerate timely learning.
AHRQ-funded; HS024075.
Citation: Fisher ES, Shortell SM, Savitz LA .
Implementation science: A potential catalyst for delivery system reform.
JAMA 2016 Jan 26;315(4):339-40. doi: 10.1001/jama.2015.17949..
Keywords: Healthcare Delivery, Implementation, Quality Improvement, Quality of Care, Health Systems
Albright KC, Boehme AK, Tanner RM
Addressing stroke risk factors in black and white Americans: Findings from the National Health and Nutrition Examination Survey, 2009-2010.
The authors examined racial differences in risk factors being addressed among stroke survivors and those at risk for stroke. They found that addressed hypertension and hyperlipidemia in stroke-naïve participants were significantly lower in blacks than in whites. They concluded that a better understanding of this information is critical to preventing stroke and other vascular diseases.
AHRQ-funded; HS023009; HS013852.
Citation: Albright KC, Boehme AK, Tanner RM .
Addressing stroke risk factors in black and white Americans: Findings from the National Health and Nutrition Examination Survey, 2009-2010.
Ethn Dis 2016 Jan 21;26(1):9-16. doi: 10.18865/ed.26.1.9.
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Keywords: Disparities, Racial and Ethnic Minorities, Patient-Centered Outcomes Research, Prevention, Stroke
Wang TY, Vora AN, Peng SA
Effectiveness and safety of aldosterone antagonist therapy use among older patients with reduced ejection fraction after acute myocardial infarction.
The purpose of this paper is to describe how aldosterone antagonist treatment is used among older myocardial infarction (MI) patients in routine practice. They found that aldosterone antagonist use was not associated with lower mortality except in symptomatic HF patients, and risks of hyperkalemia were low at 30 days, but significantly higher among patients prescribed aldosterone antagonists, as was risk of acute renal failure compared with patients not prescribed aldosterone antagonists. They concluded that these results underscore the importance of close post-discharge monitoring of this patient population.
AHRQ-funded; HS021092.
Citation: Wang TY, Vora AN, Peng SA .
Effectiveness and safety of aldosterone antagonist therapy use among older patients with reduced ejection fraction after acute myocardial infarction.
J Am Heart Assoc 2016 Jan 21;5(1). doi: 10.1161/jaha.115.002612.
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Keywords: Comparative Effectiveness, Elderly, Medication, Heart Disease and Health, Patient-Centered Outcomes Research
Blecker S, Johnson NJ, Altekruse S
Association of occupation as a physician with likelihood of dying in a hospital.
This study compared location of death for physicians with that of other clinicians, non–health care professionals with similar education levels, and the general population. It found that rates of death in a facility were 63.3 percent for physicians, 65.4 percent for other health professionals, 66.1 percent for other higher education, and 72.4 percent for all others.
AHRQ-funded; HS023683.
Citation: Blecker S, Johnson NJ, Altekruse S .
Association of occupation as a physician with likelihood of dying in a hospital.
JAMA 2016 Jan 19;315(3):301-3. doi: 10.1001/jama.2015.16976..
Keywords: Mortality, Provider: Physician
Johnson KE, Neta G, Dember LM
Use of PRECIS ratings in the National Institutes of Health (NIH) health care systems research collaboratory.
This analysis applied the PRECIS-2 pragmatic trial criteria to five NIH Collaboratory pragmatic trials to better understand 1) the pragmatic aspects of the design and implementation of treatments delivered in real world settings and 2) the usability of the PRECIS-2 criteria for assessing pragmatic features across studies and across time. All five trials were rated to be more pragmatic than explanatory.
AHRQ-funded; HS022982.
Citation: Johnson KE, Neta G, Dember LM .
Use of PRECIS ratings in the National Institutes of Health (NIH) health care systems research collaboratory.
Trials 2016 Jan 16;17:32. doi: 10.1186/s13063-016-1158-y.
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Keywords: Research Methodologies, Patient-Centered Outcomes Research, Healthcare Delivery
Ladapo JA, Blecker S, Douglas PS
Appropriateness of cardiac stress test use among primary care physicians and cardiologists in the United States.
In this study, the researchers used nationally-representative data to examine differences in appropriate use of cardiac stress testing between cardiologists and primary care physicians (PCPs) in the US. Using permissive criteria to determine appropriateness, they found that primary care physicians are more likely to order or perform a rarely appropriate cardiac stress test than cardiologists.
AHRQ-funded; HS023683.
Citation: Ladapo JA, Blecker S, Douglas PS .
Appropriateness of cardiac stress test use among primary care physicians and cardiologists in the United States.
Int J Cardiol 2016 Jan 15;203:584-6. doi: 10.1016/j.ijcard.2015.10.238.
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Keywords: Cardiovascular Conditions, Diagnostic Safety and Quality, Imaging, Primary Care, Decision Making
Zanwar P, Lin YL, Kuo YF
Downstream tests, treatments, and annual direct payments in older men cared for by primary care providers with high or low prostate-specific antigen screening rates using 100 percent Texas U.S. Medicare public insurance claims data: a retrospective cohort
The investigators assessed the tests, treatments, and payments for prostate cancer care in men aged 75 or older who have primary care physicians (PCPs) with high or low prostate specific antigen (PSA) testing rates. They found that older men seeing PCPs with high rates of PSA testing undergo more testing and treatments for prostate cancer, with higher Medicare insurance payments.
AHRQ-funded; HS022134.
Citation: Zanwar P, Lin YL, Kuo YF .
Downstream tests, treatments, and annual direct payments in older men cared for by primary care providers with high or low prostate-specific antigen screening rates using 100 percent Texas U.S. Medicare public insurance claims data: a retrospective cohort
BMC Health Serv Res 2016 Jan 15;16:17. doi: 10.1186/s12913-016-1265-1.
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Keywords: Elderly, Medicare, Primary Care, Cancer: Prostate Cancer, Screening
Chen Y, Hong C, Ning Y
Meta-analysis of studies with bivariate binary outcomes: a marginal beta-binomial model approach.
In this paper, the researchers propose a marginal beta-binomial model for the meta-analysis of studies with binary outcomes. This model is based on the composite likelihood approach and has several attractive features compared with the existing models such as bivariate generalized linear mixed model (Chu and Cole, 2006) and Sarmanov beta-binomial model (Chen et al., 2012).
AHRQ-funded; HS022900.
Citation: Chen Y, Hong C, Ning Y .
Meta-analysis of studies with bivariate binary outcomes: a marginal beta-binomial model approach.
Stat Med 2016 Jan 15;35(1):21-40. doi: 10.1002/sim.6620.
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Keywords: Research Methodologies, Comparative Effectiveness
Sjoding MW, Valley TS, Prescott HC
Rising billing for intermediate intensive care among hospitalized Medicare bbetween 1996 and 2010.
This study characterized trends in intermediate care use among U.S. hospitals. Only 8.2 percent of Medicare hospitalizations in 1996 were billed for intermediate care, but billing steadily increased to 22.8 percent by 2010, whereas the percentage billed for ICU care and ward-only care declined. Patients billed for intermediate care had more acute organ failures diagnoses codes compared with general ward patients.
AHRQ-funded; HS020672.
Citation: Sjoding MW, Valley TS, Prescott HC .
Rising billing for intermediate intensive care among hospitalized Medicare bbetween 1996 and 2010.
Am J Respir Crit Care Med 2016 Jan 15;193(2):163-70. doi: 10.1164/rccm.201506-1252OC.
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Keywords: Payment, Hospitals, Intensive Care Unit (ICU), Healthcare Costs, Medicare
Fan T, Blitz J
AHRQ Author: Fan T
Screening for iron deficiency anemia and iron supplementation in pregnant women to improve maternal health and birth outcomes.
This case study involves a 28-year-old woman presents for a routine antepartum visit. She is 33 weeks pregnant and also has a four-year-old son. She has no particular problems, and the findings from your examination are unremarkable. She asks if her blood iron level should be tested. Based on the recommendations of the U.S. Preventive Services Task Force, the quiz asks 3 questions involving screening and treatment.
AHRQ-authored.
Citation: Fan T, Blitz J .
Screening for iron deficiency anemia and iron supplementation in pregnant women to improve maternal health and birth outcomes.
Am Fam Physician 2016 Jan 15;93(2):137-8..
Keywords: U.S. Preventive Services Task Force (USPSTF), Screening, Maternal Care, Women, Guidelines, Evidence-Based Practice
Hoopes MJ, Angier H, Gold R
Utilization of community health centers in Medicaid expansion and nonexpansion states, 2013-2014.
Using electronic health record data, the researchers examined longitudinal changes in community health center (CHC) visit rates from 2013 through 2014 in Medicaid expansion versus nonexpansion states. Rates increased in expansion state CHCs for new patient, preventive, and limited-service visits (14 percent, 41percent, and 23 percent, respectively), whereas these rates remained unchanged in nonexpansion states.
AHRQ-funded; HS024270.
Citation: Hoopes MJ, Angier H, Gold R .
Utilization of community health centers in Medicaid expansion and nonexpansion states, 2013-2014.
J Ambul Care Manage 2016 Jan 13;39(4):290-8. doi: 10.1097/jac.0000000000000123.
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Keywords: Electronic Health Records (EHRs), Community-Based Practice, Healthcare Utilization, Medicaid, Uninsured
Booth JN, 3rd, Redmond N, Sims M
The association of reduced lung function with blood pressure variability in African Americans: data from the Jackson Heart Study.
The reseaerchers evaluated the association between percent predicted lung-function and 24-hour blood pressure variability (BPV) in 1008 African Americans enrolled in the Jackson Heart Study who underwent ambulatory blood pressure (BP) monitoring. They found that lung-function was not associated with increased 24-hour BPV.
AHRQ-funded; HS023009.
Citation: Booth JN, 3rd, Redmond N, Sims M .
The association of reduced lung function with blood pressure variability in African Americans: data from the Jackson Heart Study.
BMC Cardiovasc Disord 2016 Jan 12;16:6. doi: 10.1186/s12872-015-0182-2.
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Keywords: Cardiovascular Conditions, Blood Pressure, Racial and Ethnic Minorities, Risk, Respiratory Conditions
Brown DW, Mangeot C, Anderson JB
Digoxin use is associated with reduced interstage mortality in patients with no history of arrhythmia after stage I palliation for single ventricle heart disease.
The researchers sought to determine whether digoxin use post-S1P is associated with reduced interstage mortality (IM), utilizing the multicenter database of the National Pediatric Cardiology Quality Improvement Collaborative (NPCQIC). They found that among infants with single vetricle defects in the NPCQIC database discharged post-S1P with no history of arrhythmia, use of digoxin at discharge was associated with reduced IM.
AHRQ-funded; HS021114.
Citation: Brown DW, Mangeot C, Anderson JB .
Digoxin use is associated with reduced interstage mortality in patients with no history of arrhythmia after stage I palliation for single ventricle heart disease.
J Am Heart Assoc 2016 Jan 11;5(1). doi: 10.1161/jaha.115.002376.
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Keywords: Medication, Mortality, Cardiovascular Conditions, Patient-Centered Outcomes Research
Cleynen I, Boucher G, Jostins L
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study.
The researchers undertook the largest genotype association study, to date, in widely used clinical subphenotypes of inflammatory bowel disease with the goal of further understanding the biological relations between between Crohn's disease and ulcerative colitis. Their data support a continuum of disorders within inflammatory bowel disease, much better explained by three groups (ileal Crohn's disease, colonic Crohn's disease, and ulcerative colitis) than by Crohn's disease and ulcerative colitis as currently defined.
AHRQ-funded; HS021747.
Citation: Cleynen I, Boucher G, Jostins L .
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study.
Lancet 2016 Jan 9;387(10014):156-67. doi: 10.1016/s0140-6736(15)00465-1.
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Keywords: Genetics, Digestive Disease and Health, Chronic Conditions
Sorkin DH, Amin A, Weimer DL
Rationale and study protocol for the Nursing Home Compare Plus (NHCPlus) randomized controlled trial: A personalized decision aid for patients transitioning from the hospital to a skilled-nursing facility.
This paper describes the design and rationale of a two-arm randomized controlled trial designed to test the effectiveness of Nursing Home Compare Plus (NHCPlus) compared to usual care only, in a sample of patients being discharged from the hospital to an SNF (N=229). Assessments were conducted within 24h prior to patient discharge and 30-days post discharge. A primary outcome to be examined was the use of NHC.
AHRQ-funded; HS021844.
Citation: Sorkin DH, Amin A, Weimer DL .
Rationale and study protocol for the Nursing Home Compare Plus (NHCPlus) randomized controlled trial: A personalized decision aid for patients transitioning from the hospital to a skilled-nursing facility.
Contemp Clin Trials 2016 Jan 7;47:139-45. doi: 10.1016/j.cct.2015.12.018.
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Keywords: Nursing Homes, Web-Based, Patient Experience, Hospitalization, Health Information Technology (HIT)
Roth JA, Ramsey SD
Computed tomography screening for lung cancer: A high-value proposition?
This study assessed the cost-effectiveness of low-dose computed tomographic scan screening for lung cancer within the Canadian health care system. It found that compared with no screening, the reference scenario saved 51,000 quality-adjusted life-years (QALY) and had an incremental cost-effectiveness ratio of CaD $52,000/QALY.
HS022982.
Citation: Roth JA, Ramsey SD .
Computed tomography screening for lung cancer: A high-value proposition?
JAMA 2016 Jan 5;315(1):77-8. doi: 10.1001/jama.2015.17877..
Keywords: Cancer: Lung Cancer, Imaging, Screening, Healthcare Costs, Quality of Life
Amin AP, Wang TY, McCoy L
Impact of bleeding on quality of life in patients on DAPT: insights from TRANSLATE-ACS.
This study sought to determine the incidence of post-percutaneous coronary intervention (PCI) bleeding that occurs on contemporary prolonged dual antiplatelet therapy (DAPT) and its impact on quality of life (QOL). Among patients undergoing PCI for acute myocardial infarction, bleeding during follow-up was associated with worse 6-month utility and QOL
AHRQ-funded; HS022481.
Citation: Amin AP, Wang TY, McCoy L .
Impact of bleeding on quality of life in patients on DAPT: insights from TRANSLATE-ACS.
J Am Coll Cardiol 2016 Jan 5;67(1):59-65. doi: 10.1016/j.jacc.2015.10.034.
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Keywords: Quality of Life, Heart Disease and Health, Adverse Drug Events (ADE), Adverse Events
Sheridan SL, Sutkowi-Hemstreet A, Barclay C
A comparative effectiveness trial of alternate formats for presenting benefits and harms information for low-value screening services: a randomized clinical trial.
The researchers examined the effect of different benefits and harms presentations on patients' intentions to accept low-value or potentially low-value screening services (prostate cancer screening in men ages 50-69 years; osteoporosis screening in low-risk women ages 50-64 years) They concluded that single, brief, written decision support interventions, such as the ones in this study, are unlikely to be sufficient to change intentions for screening.
AHRQ-funded; HS021133.
Citation: Sheridan SL, Sutkowi-Hemstreet A, Barclay C .
A comparative effectiveness trial of alternate formats for presenting benefits and harms information for low-value screening services: a randomized clinical trial.
JAMA Intern Med 2016 Jan;176(1):31-41. doi: 10.1001/jamainternmed.2015.7339.
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Keywords: Screening, Decision Making, Health Services Research (HSR), Prevention, Healthcare Utilization
Mirsky JB, Tieu L, Lyles C
A mixed-methods study of patient-provider e-mail content in a safety-net setting.
The researchers explored the content of patient-provider e-mails in a safety-net primary care clinic, by conducting a content analysis using inductive and deductive coding of e-mail exchanges. Their results showed that patients in safety-net clinics are capable of safely and effectively using electronic messaging for between-visit communication with providers.
AHRQ-funded; HS022408; HS023558.
Citation: Mirsky JB, Tieu L, Lyles C .
A mixed-methods study of patient-provider e-mail content in a safety-net setting.
J Health Commun 2016;21(1):85-91. doi: 10.1080/10810730.2015.1033118..
Keywords: Communication, Health Information Technology (HIT), Patient and Family Engagement, Primary Care, Web-Based
Siegel CA, Horton H, Siegel LS
A validated web-based tool to display individualised Crohn's disease predicted outcomes based on clinical, serologic and genetic variables.
The researchers developed a validated, individualised, web-based tool for patients and clinicians to visualise individualised risks for developing Crohn's disease complications. Their web-based tool displays an individualised predicted outcome for adult patients with Crohn's disease based on clinical, serologic and genetic variables. This tool can be used to help providers and patients make personalised decisions about treatment options.
AHRQ-funded; HS021747.
Citation: Siegel CA, Horton H, Siegel LS .
A validated web-based tool to display individualised Crohn's disease predicted outcomes based on clinical, serologic and genetic variables.
Aliment Pharmacol Ther 2016 Jan;43(2):262-71. doi: 10.1111/apt.13460.
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Keywords: Web-Based, Tools & Toolkits, Risk, Outcomes
Dalal AK, Dykes PC, Collins S
A web-based, patient-centered toolkit to engage patients and caregivers in the acute care setting: a preliminary evaluation.
The researchers implemented a web-based, patient-centered toolkit that engages patients/caregivers in the hospital plan of care by facilitating education and patient-provider communication. Of the 585 eligible patients approached on medical intensive care and oncology units, 239 were enrolled (119 patients, 120 caregivers). They found that the average system usability scores and satisfaction ratings of a sample of surveyed enrollees were favorable.
AHRQ-funded; HS023535.
Citation: Dalal AK, Dykes PC, Collins S .
A web-based, patient-centered toolkit to engage patients and caregivers in the acute care setting: a preliminary evaluation.
J Am Med Inform Assoc 2016 Jan;23(1):80-7. doi: 10.1093/jamia/ocv093.
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Keywords: Critical Care, Patient and Family Engagement, Clinician-Patient Communication, Tools & Toolkits, Web-Based
Finnerty M, Neese-Todd S, Pritam R
Access to psychosocial services prior to starting antipsychotic treatment among Medicaid-insured youth.
The researchers sought to examine rates and predictors of receiving a psychosocial service before initiating antipsychotic treatment among young people in the Medicaid program. They found that less than one-half of youth received a psychosocial service before initiating antipsychotic treatment, and youth diagnosed with stress disorders were significantly more likely than those diagnosed with psychotic or bipolar disorders to have received a psychosocial service before starting an antipsychotic. They concluded that this service pattern highlights a critical gap in access to psychosocial services.
AHRQ-funded; HS019937; HS020503; HS021112.
Citation: Finnerty M, Neese-Todd S, Pritam R .
Access to psychosocial services prior to starting antipsychotic treatment among Medicaid-insured youth.
J Am Acad Child Adolesc Psychiatry 2016 Jan;55(1):69-76.e3. doi: 10.1016/j.jaac.2015.09.020.
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Keywords: Access to Care, Children/Adolescents, Medication, Behavioral Health
Dresden SM, Feinglass JM, Kang R
Ambulatory care sensitive hospitalizations through the emergency department by payer: comparing 2003 and 2009.
This study compared rates of ED ambulatory care sensitive hospitalizations (ACSHs) for 2003 and 2009 among patients 18 to 64 years of age with private insurance, Medicaid, or no insurance.It found that an increase in the uninsured population was associated with an increase in the rate of ED ACSH for uninsured patients.
AHRQ-funded; HS000078.
Citation: Dresden SM, Feinglass JM, Kang R .
Ambulatory care sensitive hospitalizations through the emergency department by payer: comparing 2003 and 2009.
J Emerg Med 2016 Jan;50(1):135-42. doi: 10.1016/j.jemermed.2015.02.047.
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Keywords: Healthcare Cost and Utilization Project (HCUP), Quality Indicators (QIs), Hospitalization, Emergency Medical Services (EMS)