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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 1 of 1 Research Studies DisplayedKumar AJ, Parthasarathy C, Prescott HC
Pneumosepsis survival in the setting of obesity leads to persistent steatohepatitis and metabolic dysfunction.
The purpose of this study was to explore the long-term effect of sepsis on pre-existing NAFLD and hyperglycemia. The researchers randomized male mice to either a high-fat diet or a control diet (CD). After 24 weeks on the diet, mice were inoculated with Klebsiella pneumoniae (Kpa). To assess whether persistent inflammation could be reproduced in other abnormal liver environments, mice were also challenged with Kpa after exposure to a methionine-choline-deficient high-fat diet. Finally, a retrospective cohort of 65,139 patients was analyzed to evaluate whether obesity was related with liver injury after sepsis. The study found that after Kpa inoculation, high-fat diet mice had normalized fasting blood glucose without a change in insulin sensitivity but with a notable decrease in pyruvate utilization. Liver examination revealed focal macrophage collections and a unique inflammatory gene signature on RNA analysis. In the clinical cohort, preobesity, and class 1 and class 2 obesity were related with higher odds of elevated aminotransferase levels 1-2 years after sepsis.
Citation: Kumar AJ, Parthasarathy C, Prescott HC .
Pneumosepsis survival in the setting of obesity leads to persistent steatohepatitis and metabolic dysfunction.
Hepatol Commun 2023 Sep; 7(9). doi: 10.1097/hc9.0000000000000210..
Keywords: Sepsis, Obesity