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AHRQ Research Studies Date
Topics
- Arthritis (1)
- Asthma (1)
- Behavioral Health (2)
- Cancer: Colorectal Cancer (1)
- Caregiving (1)
- Children/Adolescents (5)
- (-) Chronic Conditions (14)
- Comparative Effectiveness (1)
- COVID-19 (2)
- Disparities (1)
- Elderly (1)
- Emergency Medical Services (EMS) (1)
- Healthcare Cost and Utilization Project (HCUP) (1)
- Healthcare Costs (3)
- Health Information Technology (HIT) (1)
- Hospitalization (1)
- Human Immunodeficiency Virus (HIV) (2)
- Medical Expenditure Panel Survey (MEPS) (1)
- Medication (3)
- Medication: Safety (1)
- Mortality (1)
- Outcomes (2)
- Pain (1)
- Patient-Centered Healthcare (1)
- Patient-Centered Outcomes Research (1)
- Patient Adherence/Compliance (1)
- Patient Self-Management (2)
- Quality of Care (2)
- Racial and Ethnic Minorities (1)
- Respiratory Conditions (2)
- Shared Decision Making (1)
- Telehealth (1)
- Transitions of Care (1)
- Women (1)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 14 of 14 Research Studies DisplayedStarnes LS, Starnes JR, Stopczynski T
Clinical prediction model: multisystem inflammatory syndrome in children versus Kawasaki disease.
This study aimed to develop a prediction model to differentiate between multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD). Using retrospective and prospective cohort data, a logistic regression model was developed, incorporating factors such as age, laboratory values, and clinical indicators. The model showed excellent discrimination (AUC 0.96) and calibration. It offers potential usefulness in aiding the diagnosis of MIS-C but requires further validation.
AHRQ-funded; HS026122.
Citation: Starnes LS, Starnes JR, Stopczynski T .
Clinical prediction model: multisystem inflammatory syndrome in children versus Kawasaki disease.
J Hosp Med 2024 Mar; 19(3):175-84. doi: 10.1002/jhm.13290.
Keywords: Children/Adolescents, Respiratory Conditions, COVID-19, Chronic Conditions
Melton K, Liu J, Sadeghi H
Predictors of transition outcomes in cystic fibrosis: analysis of National Patient Registry and CF RISE (Responsibility. Independence. Self-care. Education) data.
This retrospective cohort study’s goal was to identify predictors of transition outcomes in cystic fibrosis (CF) patients aged 16-25 years who transitioned to adult care from 2013 to 2019. The authors used data from the CF Foundation Patient Registry and the web-based transition program CF RISE (Responsibility. Independence. Self-care. Education). They modeled change in forced expiratory volume in 1 second % predicted and weight using linear regression fit with generalized estimating equations. Predictor variables included gap in care (time between last pediatric and first adult outpatient visit), transition program engagement, and sociodemographic and medical factors. Among 12,420 adolescents and young adults, 3876 transitioned to adult care with a median gap in care of 7.6 months. Patients from CF centers that have greater rates of CF RISE engagement had improved lung function and weight at their first adult outpatient visit. Patients with coverage on a parent's insurance plan and absence of CF complications predicted increased lung function. Sinus disease and history of a nonlung transplant predicted increased weight. Comorbid diabetes mellitus and gaps in care greater than 3 months predicted decreased lung function with longer gaps in care associated with greater decrease. Care gaps of 6 to 9 months predicted decreased weight. Other control variables including baseline forced expiratory volume in 1 second and weight, and exacerbation status were also statistically significant.
AHRQ-funded; HS000063.
Citation: Melton K, Liu J, Sadeghi H .
Predictors of transition outcomes in cystic fibrosis: analysis of National Patient Registry and CF RISE (Responsibility. Independence. Self-care. Education) data.
J Pediatr 2024 Feb; 265:113812. doi: 10.1016/j.jpeds.2023.113812.
Keywords: Chronic Conditions, Respiratory Conditions, Children/Adolescents, Transitions of Care
Kovacevic M, Montes M, Tirone V
Treating a common comorbidity: pain outcomes following a 3-week cognitive processing therapy-based intensive treatment for posttraumatic stress disorder address.
This study examined changes in pain, posttraumatic stress disorder (PTSD), and depressive symptoms among 125 veterans completing a 3-week cognitive processing therapy (CPT)-based intensive treatment program (ITP) for PTSD. The authors explored whether pretreatment pain interference predicted changes in PTSD and depressive symptom severity and whether larger changes in pain interference over the course of treatment were associated with larger changes in PTSD and depressive symptom severity. Higher levels of pretreatment pain interference were associated with higher PTSD, and depressive symptom severity, over time. Larger reductions in pain interference corresponded to more improvement in PTSD symptoms, but not depressive symptoms.
AHRQ-funded; HS028511.
Citation: Kovacevic M, Montes M, Tirone V .
Treating a common comorbidity: pain outcomes following a 3-week cognitive processing therapy-based intensive treatment for posttraumatic stress disorder address.
J Trauma Stress 2024 Feb; 37(1):47-56. doi: 10.1002/jts.22979.
Keywords: Pain, Behavioral Health, Outcomes, Chronic Conditions
Jolliff A, Coller RJ, Kearney H
An mHealth design to promote medication safety in children with medical complexity.
This study describes an effort to design a health information technology tool to improve medication safety for children with medical complexity (CMC). The study engaged family caregivers, secondary caregivers, and clinicians who work with CMC in a co-design process to identify: 1) medication safety challenges experienced by CMC caregivers and, 2) design requirements for a mobile health application to improve medication safety for CMC in the home. Family caregivers, secondary caregivers, and clinicians from a children's hospital-based pediatric complex care program participated in virtual co-design sessions. During these sessions, the facilitator guided 16 co-designers in generating and converging upon medication safety challenges and design requirements. These sessions were recorded and reviewed after conclusion to confirm that all designer comments had been captured. An analysis yielded 11 challenges to medication safety and 11 corresponding design requirements that fit into three broader challenges: giving the right medication at the right time; communicating with others about medications; and accommodating complex medical routines.
AHRQ-funded; HS028409.
Citation: Jolliff A, Coller RJ, Kearney H .
An mHealth design to promote medication safety in children with medical complexity.
Appl Clin Inform 2024 Jan; 15(1):45-54. doi: 10.1055/a-2214-8000..
Keywords: Children/Adolescents, Medication: Safety, Medication, Health Information Technology (HIT), Chronic Conditions, Telehealth, Caregiving
Cuca YP, Horvat C, Corless IB IB
The social, mental, and physical health impacts of the COVID-19 pandemic on people with HIV: protocol of an observational international multisite study.
The authors described the protocol for an international multisite observational study based on the SPIRIT guidelines to examine impact on the health and HIV outcomes for immunocompromised individuals such as people with HIV (PWH) from COVID-19 and from the strategies enacted to contain it. Investigators will recruit PWH to complete the study online or in-person. Study questions will address demographics, HIV continuum of care indicators, mental and social health, COVID-19 and vaccination knowledge, attitudes, behaviors, and fears; and overall outcomes. Results of this study can inform responses to future public health crises to minimize impacts on vulnerable populations such as PWH.
AHRQ-funded; HS028523.
Citation: Cuca YP, Horvat C, Corless IB IB .
The social, mental, and physical health impacts of the COVID-19 pandemic on people with HIV: protocol of an observational international multisite study.
J Assoc Nurses AIDS Care 2024 Jan-Feb; 35(1):60-74. doi: 10.1097/jnc.0000000000000444..
Keywords: COVID-19, Human Immunodeficiency Virus (HIV), Chronic Conditions
Minden SL, Ding L, Cleary PD
Improving the quality of mental health care in multiple sclerosis.
The researchers surveyed multiple sclerosis (MS) patients across the U.S. to determine how many experienced mental health problems and received treatment over the preceding year. Also studied were patient experiences with and ratings of care, type of treatment provider, and the location of care. The researchers found a high unmet need for mental health treatment among persons with MS.
AHRQ-funded; HS016978
Citation: Minden SL, Ding L, Cleary PD .
Improving the quality of mental health care in multiple sclerosis.
J Neurol Sci. 2013 Dec 15;335(1-2):42-7. doi: 10.1016/j.jns.2013.08.021..
Keywords: Behavioral Health, Quality of Care, Chronic Conditions
Nkoy FL, Stone BL, Fassl BA
Longitudinal validation of a tool for asthma self-monitoring.
The purpose of this study was to show longitudinal validation of a new tool, the Asthma Symptom Tracker (AST). The study established longitudinal validation of the AST, a novel tool designed for use by children or their parents to facilitate ongoing monitoring of patients’ asthma symptoms and proactive medical decision-making to prevent acute exacerbations.
AHRQ-funded; HS018166; HS018678.
Citation: Nkoy FL, Stone BL, Fassl BA .
Longitudinal validation of a tool for asthma self-monitoring.
Pediatrics 2013 Dec;132(6):e1554-61. doi: 10.1542/peds.2013-1389..
Keywords: Asthma, Children/Adolescents, Chronic Conditions, Shared Decision Making, Patient Self-Management
Navarro-Millán I, Sattui SE, Curtis JR
Systematic review of tumor necrosis factor inhibitor discontinuation studies in rheumatoid arthritis.
The objective of this article is to conduct a systematic review of the available literature on discontinuation of anti-tumor necrosis factor (anti-TNF) agents in rheumatoid arthritis (RA) patients and the associated features of study designs, including eligibility criteria, outcome definitions, and outcomes of discontinuation. The authors concluded that discontinuation of anti-TNF therapy is achievable for many RA patients who start in clinical remission or low disease activity.
AHRQ-funded; HS018517
Citation: Navarro-Millán I, Sattui SE, Curtis JR .
Systematic review of tumor necrosis factor inhibitor discontinuation studies in rheumatoid arthritis.
Clin Ther. 2013 Nov;35(11):1850-61.e1. doi: 10.1016/j.clinthera.2013.09.015..
Keywords: Comparative Effectiveness, Outcomes, Arthritis, Medication, Chronic Conditions
Johnson TJ, Weaver MD, Borrero S
Association of race and ethnicity with management of abdominal pain in the emergency department.
This study, examining racial/ethnic differences in analgesic administration and prolonged length of stay (LOS) in the emergency department (ED) found that among children 21 years of age and younger presenting to EDs with abdominal pain, those who were non-Hispanic black patients were less likely than non-Hispanic white patients to receive any analgesics for pain. They were also more likely to have a prolonged LOS.
AHRQ-funded; HS017587
Citation: Johnson TJ, Weaver MD, Borrero S .
Association of race and ethnicity with management of abdominal pain in the emergency department.
Pediatrics. 2013 Oct;132(4):e851-8. doi: 10.1542/peds.2012-3127..
Keywords: Children/Adolescents, Emergency Medical Services (EMS), Racial and Ethnic Minorities, Disparities, Chronic Conditions
Liss DT, Fishman PA, Rutter CM
Outcomes among chronically ill adults in a medical home prototype.
The researchers compared quality, utilization, and cost outcomes for patients with selected chronic illnesses at a patient-centered medical home (PCMH) prototype site with outcomes for patients with the same chronic illnesses at 19 nonintervention control sites. They concluded that a clinic-level population-based PCMH redesign can decrease downstream utilization and reduce total healthcare costs in a subpopulation of patients with common chronic illnesses.
AHRQ-funded; HS019129.
Citation: Liss DT, Fishman PA, Rutter CM .
Outcomes among chronically ill adults in a medical home prototype.
Am J Manag Care 2013 Oct;19(10):e348-58.
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Keywords: Chronic Conditions, Healthcare Costs, Quality of Care, Patient-Centered Healthcare, Patient-Centered Outcomes Research
Galarraga O, Genberg BL, Martin RA
Conditional economic incentives to improve HIV treatment adherence: literature review and theoretical considerations.
This review summarizes various theories from micro- and behavioral-economics to social and clinical psychology that may help to understand how conditional economic incentives (CEI) work, and how they may be integrated with theories of health behavior that focus more on internal motivation. It concluded that appropriate CEI can help patients adhere to HIV treatment in the short-term, while incentives are in place.
AHRQ-funded; HS019657
Citation: Galarraga O, Genberg BL, Martin RA .
Conditional economic incentives to improve HIV treatment adherence: literature review and theoretical considerations.
AIDS Behav. 2013 Sep;17(7):2283-92. doi: 10.1007/s10461-013-0415-2..
Keywords: Human Immunodeficiency Virus (HIV), Patient Self-Management, Chronic Conditions, Medication, Patient Adherence/Compliance
Matthews CA, Whitehead WE, Townsend MK
Risk factors for urinary, fecal, or dual incontinence in the Nurses' Health Study.
This study estimating the prevalence of urinary incontinence, fecal incontinence, and dual incontinence in a group of 64,396 women aged 62-87 years found that 38 percent had urinary incontinence alone, 4 percent had fecal incontinence alone, and 7 percent had dual incontinence. Dual incontinence was primarily associated with advanced age, decompensating medical conditions, depression, and multiparity.
AHRQ-funded; HS018695.
Citation: Matthews CA, Whitehead WE, Townsend MK .
Risk factors for urinary, fecal, or dual incontinence in the Nurses' Health Study.
Obstet Gynecol. 2013 Sep;122(3):539-45. doi: 10.1097/AOG.0b013e31829efbff..
Keywords: Chronic Conditions, Elderly, Women
Machlin SR, Soni A
AHRQ Author: Machlin SR, Soni A
Health care expenditures for adults with multiple treated chronic conditions: estimates from the Medical Expenditure Panel Survey, 2009.
The authors illustrated the usefulness of MEPS data for examining variations in medical expenditures for people with multiple chronic conditions (MCC). They found that the proportion of adults treated for MCC increased with age, with white non-Hispanic adults most likely and Hispanic and Asian adults least likely to be treated for MCC. Regardless of age or sex, hypertension and hyperlipidemia was the most common dyad among adults treated for MCC, and diabetes in conjunction with these 2 conditions was a common triad. They concluded that MEPS has the capacity to produce national estimates of health care expenditures associated with MCC.
AHRQ-authored.
Citation: Machlin SR, Soni A .
Health care expenditures for adults with multiple treated chronic conditions: estimates from the Medical Expenditure Panel Survey, 2009.
Prev Chronic Dis 2013 Apr 25;10:E63. doi: 10.5888/pcd10.120172.
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Keywords: Cancer: Colorectal Cancer, Chronic Conditions, Healthcare Costs, Medical Expenditure Panel Survey (MEPS)
Steiner CA, Friedman B
AHRQ Author: Steiner CA, Friedman B
Hospital utilization, costs, and mortality for adults with multiple chronic conditions, Nationwide Inpatient Sample, 2009.
The investigators provided a national estimate across all payers of the distribution and cost of selected chronic conditions for hospitalized adults in 2009, stratified by demographic characteristics. They found that there were approximately 28 million adult discharges from US hospitals other than those related to pregnancy and maternity; 39% had 2 to 3 multiple chronic conditions (MCC), and 33% had 4 or more. They concluded that their descriptive analysis of multipayer inpatient data provides a robust national view of the substantial use and costs among adults hospitalized with MCC.
AHRQ-authored.
Citation: Steiner CA, Friedman B .
Hospital utilization, costs, and mortality for adults with multiple chronic conditions, Nationwide Inpatient Sample, 2009.
Prev Chronic Dis 2013 Apr 25;10:E62. doi: 10.5888/pcd10.120292.
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Keywords: Chronic Conditions, Healthcare Costs, Healthcare Cost and Utilization Project (HCUP), Hospitalization, Mortality