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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 2 of 2 Research Studies DisplayedWilkinson ST, Holtzheimer PE, Gao S
Leveraging neuroplasticity to enhance adaptive learning: the potential for synergistic somatic-behavioral treatment combinations to improve clinical outcomes in depression.
This article reviews the potential of synergistically combining plasticity-enhancing and behavioral therapies to develop translational treatment approaches for depression. After reviewing relevant neuroplasticity deficits in depression, the article surveys biological treatments that appear to reverse such deficits in humans; evidence that directly or indirectly supports the hypothesis that a robust enhancement of neuroplasticity through these methods might promote the uptake of cognitive and behavioral interventions to enhance longer-term treatment outcomes is then reviewed. The authors identify missing pieces of key evidence and discuss future directions that could enhance this line of research.
AHRQ-funded; HS023000.
Citation: Wilkinson ST, Holtzheimer PE, Gao S .
Leveraging neuroplasticity to enhance adaptive learning: the potential for synergistic somatic-behavioral treatment combinations to improve clinical outcomes in depression.
Biol Psychiatry 2019 Mar 15;85(6):454-65. doi: 10.1016/j.biopsych.2018.09.004..
Keywords: Behavioral Health, Depression, Patient-Centered Outcomes Research, Treatments
Antle BF, Owen JJ, Eells TD
Dissemination of computer-assisted cognitive-behavior therapy for depression in primary care.
Computer-assisted cognitive-behavior therapy (CCBT) for depression in primary care was evaluated in a trial with 240 patients randomly assigned to CCBT or treatment as usual (TAU). The study, described in this paper, disseminated a therapy method found to be effective in psychiatric settings into primary care - a setting in which there have been significant problems in the delivery of adequate, evidence-based treatment for depression.
AHRQ-funded; HS024047.
Citation: Antle BF, Owen JJ, Eells TD .
Dissemination of computer-assisted cognitive-behavior therapy for depression in primary care.
Contemp Clin Trials 2019 Mar;78:46-52. doi: 10.1016/j.cct.2018.11.001..
Keywords: Behavioral Health, Depression, Primary Care, Treatments