Setoguchi-Iwata, Soko

Institution: Brigham and Women's Hospital and Duke University
Grant Title: Improving Methods for Comparative Effectiveness Research in Cardiovascular Care
Grant Number: K08 HS017731
Duration: 5 years (2008-2012)
Total Award: $804,000

Project Description: The goal of the proposed study is to improve the validity of comparativeness effectiveness research for cardiovascular disease (CVD) using large databases by creating new databases combining claims data and clinical registries and developing/validating advanced analytic techniques to combat potential biases in claims data analyses. There are two main aims:

1. Develop new databases to study comparative effectiveness of therapies in patients with heart failure (HF) or coronary artery disease (CAD).
2. Develop and evaluate statistical models of advanced analytic techniques to control bias in claims data analyses assessing comparative effectiveness of therapies in patients with HF and CAD.

Career Goals: Dr. Setoguchi-Iwata is an Associate Professor in the School of Medicine at the Duke Clinical Research Institute. She received her MD from Miyazaki Medical College in Miyazaki, Japan and served a residency in General Medicine at the Kameda Medical Center in Chiba, Japan. The grantee then completed an internship in Internal Medicine at the University of Iowa Hospitals and Clinics in Iowa City. She went on to earn her MPH, ScM, and DrPH. from Harvard School of Public Health. Dr. Setoguchi-Iwata's long term career goal is to become an outstanding health services/outcomes researcher for CVD with strong methodological skills, especially studying comparative effectiveness/safety of therapies in patients with CVD.

Progress to Date: The grantee has obtained institutional review board (IRB) approval for the proposed study as well as the clinical registry data for CAD and HF. The data have been cleaned and linking efforts were successful. The cohort is being expanded to include Medicaid and Medicare/Caremark data to increase power. The candidate worked on a simulation study to assess the significance of collider stratification bias. Two abstracts have been accepted for presentation and one manuscript is under review.

Future Plans: The grantee will complete the work on multiple imputation and validation of claims-based definition. She will finish identifying the four cohorts from all proposed data sources and begin analytic work on developing and testing the statistical methods.

Highlights and Specific Accomplishments:

• Fist place poster at the International Conference for Pharmacoepidemiology in Lisbon, Portugal, 2006.
• Pharmacoepidemiology Training and Research Scholarship, Harvard, 2003.

K-Generated Publications: None thus far.

Return to Recently Funded Career Development Award Grants