National Healthcare Quality and Disparities Report
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Search All Research Studies
AHRQ Research Studies Date
Topics
- Antibiotics (4)
- Children/Adolescents (3)
- Clostridium difficile Infections (1)
- (-) Community-Acquired Infections (11)
- Comparative Effectiveness (1)
- Elderly (1)
- Emergency Department (1)
- Family Health and History (1)
- Genetics (1)
- Health Information Technology (HIT) (1)
- Hospitalization (2)
- Infectious Diseases (2)
- Medication (2)
- Methicillin-Resistant Staphylococcus aureus (MRSA) (5)
- Mortality (1)
- Outcomes (1)
- Patient-Centered Outcomes Research (1)
- Patient Safety (3)
- Pneumonia (4)
- Prevention (1)
- Risk (2)
- Skin Conditions (1)
- Urinary Tract Infection (UTI) (1)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 11 of 11 Research Studies DisplayedAnesi JA, Lautenbach E, Nachamkin I
Poor clinical outcomes associated with community-onset urinary tract infections due to extended-spectrum cephalosporin-resistant Enterobacteriaceae.
In this retrospective cohort study, the investigators sought to determine the clinical outcomes associated with community-onset ESC-resistant (ESC-R) EB urinary tract infections (UTIs) in a US health system. The authors found that community-onset UTI due to an ESC-R EB organism was significantly associated with clinical failure, which may be due in part to inappropriate initial antibiotic therapy. They indicate that further studies are needed to determine which patients in the community are at high risk for drug-resistant infection to help inform prompt diagnosis and appropriate antibiotic prescribing for ESC-R EB.
AHRQ-funded; HS020002.
Citation: Anesi JA, Lautenbach E, Nachamkin I .
Poor clinical outcomes associated with community-onset urinary tract infections due to extended-spectrum cephalosporin-resistant Enterobacteriaceae.
Infect Control Hosp Epidemiol 2018 Dec;39(12):1431-35. doi: 10.1017/ice.2018.254..
Keywords: Antibiotics, Community-Acquired Infections, Medication, Outcomes, Patient Safety, Urinary Tract Infection (UTI)
Frush JM, Zhu Y, Edwards KM
Prevalence of staphylococcus aureus and use of antistaphylococcal therapy in children hospitalized with pneumonia.
In a studied group of children hospitalized with community-acquired pneumonia, staphylococcal pneumonia was rare but associated with adverse in-hospital outcomes. Despite this low prevalence, use of antistaphylococcal antibiotics was common. The authors recommended efforts to minimize overuse of antistaphylococcal antibiotics while also ensuring adequate treatment for pathogen-specific diseases.
AHRQ-funded; HS022342.
Citation: Frush JM, Zhu Y, Edwards KM .
Prevalence of staphylococcus aureus and use of antistaphylococcal therapy in children hospitalized with pneumonia.
J Hosp Med 2018 Dec;13(12):848-52. doi: 10.12788/jhm.3093..
Keywords: Children/Adolescents, Infectious Diseases, Pneumonia, Methicillin-Resistant Staphylococcus aureus (MRSA), Community-Acquired Infections, Hospitalization, Antibiotics, Medication
Mork RL, Hogan PG, Muenks CE
Comprehensive modeling reveals proximity, seasonality, and hygiene practices as key determinants of MRSA colonization in exposed households.
To develop interventions to prevent recurrent infections, household attributes and individual practices influencing S. aureus colonization must be discerned. In this paper, the investigators discuss key determinants of methicillin-resistant S. aureus (MRSA) colonization in exposed households. They suggest that the practices they identified in their study, that correlate with MRSA colonization, will inform physician counseling and multifaceted interventions among MRSA-affected households to mitigate MRSA in the community.
AHRQ-funded; HS021736; HS024269.
Citation: Mork RL, Hogan PG, Muenks CE .
Comprehensive modeling reveals proximity, seasonality, and hygiene practices as key determinants of MRSA colonization in exposed households.
Pediatr Res 2018 Nov;84(5):668-76. doi: 10.1038/s41390-018-0113-x..
Keywords: Community-Acquired Infections, Methicillin-Resistant Staphylococcus aureus (MRSA), Prevention, Patient Safety
Weir RE, Lyttle CS, Meltzer DO
The relative ability of comorbidity ascertainment methodologies to predict in-hospital mortality among hospitalized community-acquired pneumonia patients.
In this observational study, the investigators sought to compare the relative value of several methodologies by which comorbidities may be ascertained. The authors concluded that although comorbidities derived through administrative data did produce an area under the curve greater than chart review, their analyses suggested a coding bias in several comorbidities with a paradoxically protective effect. They assert that chart review, while labor and resource intensive, may be the ideal method for ascertainment of clinically relevant comorbidities.
AHRQ-funded; HS016948; HS010597.
Citation: Weir RE, Lyttle CS, Meltzer DO .
The relative ability of comorbidity ascertainment methodologies to predict in-hospital mortality among hospitalized community-acquired pneumonia patients.
Med Care 2018 Nov;56(11):950-55. doi: 10.1097/mlr.0000000000000989..
Keywords: Community-Acquired Infections, Hospitalization, Mortality, Pneumonia
Parrish KL, Hogan PG, Clemons AA
Spatial relationships among public places frequented by families plagued by methicillin-resistant Staphylococcus aureus.
In this study, the investigators mapped public places (including personal service establishments, fitness centers, pools, schools, and daycares) visited by members of households affected by community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) skin and soft tissue infection, in order to understand factors associated with CA-MRSA acquisition and infection.
AHRQ-funded; HS024269; HS021736.
Citation: Parrish KL, Hogan PG, Clemons AA .
Spatial relationships among public places frequented by families plagued by methicillin-resistant Staphylococcus aureus.
BMC Res Notes 2018 Oct 1;11(1):692. doi: 10.1186/s13104-018-3797-4..
Keywords: Community-Acquired Infections, Family Health and History, Methicillin-Resistant Staphylococcus aureus (MRSA)
Wardyn SE, Stegger M, Price LB
Whole-genome analysis of recurrent Staphylococcus aureus t571/ST398 infection in farmer, Iowa, USA.
Staphylococcus aureus strain sequence type (ST) 398 has emerged during the last decade, largely among persons who have contact with swine or other livestock. Although colonization with ST398 is common in livestock workers, infections are not frequently documented. The authors report recurrent ST398-IIa infection in an Iowa farmer in contact with swine and cattle.
AHRQ-funded; HS019966.
Citation: Wardyn SE, Stegger M, Price LB .
Whole-genome analysis of recurrent Staphylococcus aureus t571/ST398 infection in farmer, Iowa, USA.
Emerg Infect Dis 2018 Jan;24(1):153-54. doi: 10.3201/eid2401.161184.
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Keywords: Community-Acquired Infections, Genetics, Infectious Diseases, Methicillin-Resistant Staphylococcus aureus (MRSA)
Daum RS, Miller LG, Immergluck L
A placebo-controlled trial of antibiotics for smaller skin abscesses.
The authors evaluated the appropriate management of uncomplicated skin abscesses in the era of community-associated methicillin-resistant Staphylococcus aureus (MRSA). They concluded that, compared with incision and drainage alone, clindamycin or TMP-SMX in conjunction with incision and drainage improves short-term outcomes in patients who have a simple abscess. This benefit must be weighed against the known side-effect profile of these antimicrobials.
AHRQ-funded; HS024338.
Citation: Daum RS, Miller LG, Immergluck L .
A placebo-controlled trial of antibiotics for smaller skin abscesses.
N Engl J Med 2017 Jun 29;376(26):2545-55. doi: 10.1056/NEJMoa1607033.
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Keywords: Antibiotics, Community-Acquired Infections, Skin Conditions
Anderson DJ, Rojas LF, Watson S
Identification of novel risk factors for community-acquired Clostridium difficile infection using spatial statistics and geographic information system analyses.
The rate of community-acquired Clostridium difficile infection (CA-CDI) is increasing. While receipt of antibiotics remains an important risk factor for CDI, studies related to acquisition of C. difficile outside of hospitals are lacking. This study found that proximity to a livestock farm (0.01), proximity to farming raw materials services (0.02), and proximity to a nursing home (0.04) were independently associated with increased rates of CA-CDI.
AHRQ-funded; HS023866.
Citation: Anderson DJ, Rojas LF, Watson S .
Identification of novel risk factors for community-acquired Clostridium difficile infection using spatial statistics and geographic information system analyses.
PLoS One 2017 May 16;12(5):e0176285. doi: 10.1371/journal.pone.0176285.
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Keywords: Clostridium difficile Infections, Community-Acquired Infections, Risk, Patient Safety
Meystre S, Gouripeddi R, Tieder J
Enhancing comparative effectiveness research with automated pediatric pneumonia detection in a multi-institutional clinical repository: a PHIS+ pilot study.
The aim of this study was to develop an automated, scalable, and accurate method to determine the presence or absence of pneumonia in children using chest imaging reports. It found that, when compared with each of the domain experts manually annotating these reports, the new Natural Language Processing (NLP) application developed by the researchers allowed for significantly higher sensitivity (.71 vs .527) and similar positive predictive value and specificity.
AHRQ-funded; HS019862.
Citation: Meystre S, Gouripeddi R, Tieder J .
Enhancing comparative effectiveness research with automated pediatric pneumonia detection in a multi-institutional clinical repository: a PHIS+ pilot study.
J Med Internet Res 2017 May 15;19(5):e162. doi: 10.2196/jmir.6887.
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Keywords: Children/Adolescents, Community-Acquired Infections, Comparative Effectiveness, Health Information Technology (HIT), Pneumonia
Frei CR, Rehani S, Lee GC
Application of a risk score to identify older adults with community-onset pneumonia most likely to benefit from empiric pseudomonas therapy.
The researchers assessed the impact of empiric Pseudomonas pharmacotherapy on 30-day mortality in hospitalized patients with community-onset pneumonia stratified according to their risk (low, medium, or high) of drug-resistant pathogens. By using a risk score, they found that empiric Pseudomonas therapy was associated with lower 30-day mortality in the high-risk group but not the low- or medium-risk groups.
AHRQ-funded; HS022418.
Citation: Frei CR, Rehani S, Lee GC .
Application of a risk score to identify older adults with community-onset pneumonia most likely to benefit from empiric pseudomonas therapy.
Pharmacotherapy 2017 Feb;37(2):195-203. doi: 10.1002/phar.1891.
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Keywords: Elderly, Community-Acquired Infections, Pneumonia, Patient-Centered Outcomes Research, Risk
Immergluck LC, Jain S, Ray SM
Risk of skin and soft tissue infections among children found to be staphylococcus aureus MRSA USA300 carriers.
The purpose of this study conducted in a pediatric emergency department was to examine community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) carriage and infections and determine risk factors associated specifically with MRSA USA300. It found that children younger than two years were at highest risk for MRSA USA300 carriage. Lower income, recent antibiotic use, and previous or family history of skin and soft tissue infections were risk factors for MRSA USA300 carriage.
AHRQ-funded; HS024338.
Citation: Immergluck LC, Jain S, Ray SM .
Risk of skin and soft tissue infections among children found to be staphylococcus aureus MRSA USA300 carriers.
West J Emerg Med 2017 Feb;18(2):201-12. doi: 10.5811/westjem.2016.10.30483.
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Keywords: Antibiotics, Children/Adolescents, Community-Acquired Infections, Emergency Department, Methicillin-Resistant Staphylococcus aureus (MRSA)