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AHRQ Research Studies Date
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- Antibiotics (1)
- Behavioral Health (1)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 7 of 7 Research Studies DisplayedHogan PG, Parrish KL, Mork RL
HOME2 study: household versus personalized decolonization in households of children with methicillin-resistant staphylococcus aureus skin and soft tissue infection-a randomized clinical trial.
This study’s goal was to compare the effectiveness of colonization measures to prevent skin and soft tissue infection (SSTI) from Methicillin-resistant Staphylococcus aureus (MRSA) with targeted household members with prior years SSTI to decolonizing all household members to prevent infections in children. The hypothesis was that the former method would be noninferior. Upon completion of the 12-month observational Household Observation of Methicillin-resistant Staphylococcus aureus in the Environment (HOME) study, 102 households were enrolled with the follow-up HOME2 study, a 12-month randomized noninferiority trial. Households were randomized 1:1 to the personalized (targeted members) or household (all members) approaches. Participants followed a 5-day regimen of hygiene education, twice-daily intranasal mupirocin, and daily bleach-water baths. At 5 follow-up visits at participants’ homes, swabs were taken to detect S. aureus. Noninferiority of the personalized approach was established, with little difference in SSTI rates in the two household approaches.
AHRQ-funded; HS021736; HS024269.
Citation: Hogan PG, Parrish KL, Mork RL .
HOME2 study: household versus personalized decolonization in households of children with methicillin-resistant staphylococcus aureus skin and soft tissue infection-a randomized clinical trial.
Clin Infect Dis 2021 Dec 6;73(11):e4568-e77. doi: 10.1093/cid/ciaa752..
Keywords: Children/Adolescents, Methicillin-Resistant Staphylococcus aureus (MRSA), Skin Conditions, Prevention
Cheng BT, Fishbein AB, Silverberg JI
Mental health symptoms and functional impairment in children with atopic dermatitis.
This study sought to determine the prevalence and predictors of social and behavioral symptoms and functional impairment among US children with atopic dermatitis (AD). Using MEPS data 1996-2015, findings showed that AD was associated with behavioral and functional impairment, similar to psoriasis and other common chronic conditions.
AHRQ-funded; HS023011.
Citation: Cheng BT, Fishbein AB, Silverberg JI .
Mental health symptoms and functional impairment in children with atopic dermatitis.
Dermatitis 2021 Sep-Oct;32(5):353-61. doi: 10.1097/der.0000000000000680..
Keywords: Children/Adolescents, Skin Conditions, Chronic Conditions, Behavioral Health
Fishbein AB, Lin B, Beaumont J
Nocturnal movements in children with atopic dermatitis have a timing pattern: a case-control study.
This case-control study compared nocturnal movements in children with atopic dermatitis (AD) with a control non-AD group. The study looked at nocturnal motor activity due to itch in children age 6 to 17 years with moderate-to-severe AD. The mean age of children with AD was 11.0 plus or minus 3.2 years, and without AD 11.5 plus or minute 3.3 years with the majority (65%) male. The AD scoring scale SCORAD was used to define moderate to severe AD. A home activity monitor, actigraphy and a sleep diary for 3 to 7 nights was used to monitor nocturnal movements and sleep. Activity counts were averaged across nights. Bouts of nocturnal activity increased in children with AD versus the controls between 1 and 6 hours after sleep onset. Nocturnal scratch activity peaks at 3 hours. Although AD patients were instructed to avoid oral antihistamine during the study, 5 patients took an antihistamine on some nights. Results showed no significant difference with respect to movement in the patients that took antihistamine some nights and not others. Timing of the nocturnal scratch behavior could potentially be targeted for treatment.
AHRQ-funded; HS023011.
Citation: Fishbein AB, Lin B, Beaumont J .
Nocturnal movements in children with atopic dermatitis have a timing pattern: a case-control study.
J Am Acad Dermatol 2021 Aug;85(2):474-76. doi: 10.1016/j.jaad.2018.04.020..
Keywords: Children/Adolescents, Skin Conditions, Chronic Conditions
Fishbein AB, Cheng BT, Tilley CC
Sleep disturbance in school-aged children with atopic dermatitis: prevalence and severity in a cross-sectional sample.
The authors sought to estimate the US prevalence of sleep disturbance and its impact on psychological and neurocognitive function in patients with atopic dermatitis (AD). Using PROMIS (Patient Reported Outcome Measurement Information System), they found that sleep disturbance was a common symptom of AD affecting approximately 3 million US children and was associated with neuropsychiatric impairment, including depression, anxiety, and inattention. They recommended that clinicians screen for these symptoms in school-aged children, particularly with moderate-to-severe AD.
AHRQ-funded; HS023011.
Citation: Fishbein AB, Cheng BT, Tilley CC .
Sleep disturbance in school-aged children with atopic dermatitis: prevalence and severity in a cross-sectional sample.
J Allergy Clin Immunol Pract 2021 Aug;8(8):3120-29.e3. doi: 10.1016/j.jaip.2021.04.064..
Keywords: Children/Adolescents, Sleep Problems, Skin Conditions
Neubauer HC, Hall M, Lopez MA
Antibiotic regimens and associated outcomes in children hospitalized with staphylococcal scalded skin syndrome.
Controversy exists regarding the optimal antibiotic regimen for use in hospitalized children with staphylococcal scalded skin syndrome (SSSS). Various regimens may confer toxin suppression and/or additional coverage for methicillin-susceptible Staphylococcus aureus (MSSA) or methicillin-resistant S aureus (MRSA). The purpose of this study was to describe antibiotic regimens in hospitalized children with SSSS and examine the association between antistaphylococcal antibiotic regimens and patient outcomes.
AHRQ-funded; HS026006.
Citation: Neubauer HC, Hall M, Lopez MA .
Antibiotic regimens and associated outcomes in children hospitalized with staphylococcal scalded skin syndrome.
J Hosp Med 2021 Mar;16(3):149-55. doi: 10.12788/jhm.3529..
Keywords: Children/Adolescents, Antibiotics, Medication, Methicillin-Resistant Staphylococcus aureus (MRSA), Skin Conditions, Infectious Diseases
Silverberg JI, Lei D, Yousaf M
Measurement properties of the product of investigator's global assessment and body surface area in children and adults with atopic dermatitis.
This study’s goal was to determine the measurement properties of the product of validated Investigator’s Global Assessment for AD and body surface area (vIGA*BSA) for atopic dermatitis (AD) severity. The authors performed a prospective practice-based study using questionnaires and evaluation by a dermatologist (n = 653). The vIGA*BSA can also be divided into six categories (vIGA*cBSA: 0%/0.1, <10%/10, <30%/30, <50%/50, <70%/70 and <90%/90-100%)). The assessment was compared with other rating scales such as SCORAD, Patient-Oriented Eczema Measure, Dermatology Life Quality Index, ItchyOOL, PROMISE Sleep Disturbance, and sleep-related impairment. Scores showed good convergent and discriminant validity, reliability, responsiveness and interpretability in adults and children with AD.
AHRQ-funded; HS023011.
Citation: Silverberg JI, Lei D, Yousaf M .
Measurement properties of the product of investigator's global assessment and body surface area in children and adults with atopic dermatitis.
J Eur Acad Dermatol Venereol 2021 Jan;35(1):180-87. doi: 10.1111/jdv.16846..
Keywords: Children/Adolescents, Skin Conditions, Patient-Centered Outcomes Research, Evidence-Based Practice
Silverberg JI, Lei D, Yousaf M
Measurement properties of the Rajka-Langeland severity score in children and adults with atopic dermatitis.
This study looked at the measurement properties of the Rajka-Langeland severity score for atopic dermatitis (AD) in children and adults and compared it with other clinician-reported outcomes. The study used questionnaires and evaluation by a dermatologist (n = 427). Rajka-Langeland had good concurrent validity with the Eczema Area and Severity Index and body surface area; good convergent validity with the numeric rating scale average-itch and worst-itch, Patient-Oriented Eczema Measure, Dermatology Life Quality Index, Patient Reported Outcomes Measurement Information System Itch Questionnaire in adults and/or children; fair discriminant validity for patient- and physician reported global AD severity; good responsive to change of severity of AD and itch; and good reliability, internal consistency; with no floor or ceiling effects.
AHRQ-funded; HS023011.
Citation: Silverberg JI, Lei D, Yousaf M .
Measurement properties of the Rajka-Langeland severity score in children and adults with atopic dermatitis.
Br J Dermatol 2021 Jan;184(1):87-95. doi: 10.1111/bjd.19159..
Keywords: Children/Adolescents, Skin Conditions, Patient-Centered Outcomes Research, Evidence-Based Practice