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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 4 of 4 Research Studies DisplayedKlein IA, Rosenberg SM, Reynolds KL
Impact of cancer history on outcomes among hospitalized patients with COVID-19.
Researchers investigated whether a current cancer diagnosis or cancer history is an independent risk factor for death in hospitalized patients with COVID-19. They found that patients with a history of cancer hospitalized for COVID-19 had similar mortality to matched hospitalized patients with COVID-19 without cancer, and a lower risk of complications, while patients with active cancer or recent cancer treatment had a similar risk for adverse outcomes compared with survivors of cancer. They concluded that active cancer, systemic cancer therapy, and a cancer history are not independent risk factors for death from COVID-19 among hospitalized patients, and hospitalized patients without cancer are more likely to have severe COVID-19.
AHRQ-funded; HS023680.
Citation: Klein IA, Rosenberg SM, Reynolds KL .
Impact of cancer history on outcomes among hospitalized patients with COVID-19.
Oncologist 2021 Aug;26(8):685-93. doi: 10.1002/onco.13794..
Keywords: COVID-19, Cancer, Risk, Mortality, Hospitalization, Outcomes
Cooper AJ, Keller SP, Chan C
Improvements in sepsis-associated mortality in hospitalized patients with cancer versus those without cancer. a 12-year analysis using clinical data.
The goal of this study was to assess trends in sepsis-associated mortality in hospitalized patients with and without cancer using objective clinical criteria to identify sepsis and detailed clinical data to adjust for severity of illness. Findings showed that sepsis-associated mortality rates declined significantly over a 12-year period in patients with cancer, but not in patients without cancer. Potential explanations include advances in the management of cancer and/or better sepsis treatments specifically in patients with cancer.
AHRQ-funded; HS025008.
Citation: Cooper AJ, Keller SP, Chan C .
Improvements in sepsis-associated mortality in hospitalized patients with cancer versus those without cancer. a 12-year analysis using clinical data.
Ann Am Thorac Soc 2020 Apr;17(4):466-73. doi: 10.1513/AnnalsATS.201909-655OC..
Keywords: Sepsis, Mortality, Cancer, Hospitalization, Outcomes
Wilkes JJ, Hennessy S, Xiao R
Volume-outcome relationships in pediatric acute lymphoblastic leukemia: association between hospital pediatric and pediatric oncology volume with mortality and intensive care resources during initial therapy.
Researchers investigated if inpatient hospital volume influences outcomes. The objective of their study was to evaluate the relationship between inpatient pediatric and pediatric oncology volume and mortality and intensive care resources (ICU care). It concluded that induction mortality was low and that there was no inverse relationship between volume and mortality or ICU care.
AHRQ-funded; HS023419.
Citation: Wilkes JJ, Hennessy S, Xiao R .
Volume-outcome relationships in pediatric acute lymphoblastic leukemia: association between hospital pediatric and pediatric oncology volume with mortality and intensive care resources during initial therapy.
Clin Lymphoma Myeloma Leuk 2016 Jul;16(7):404-10.e1. doi: 10.1016/j.clml.2016.04.016.
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Keywords: Cancer, Children/Adolescents, Hospitalization, Mortality, Outcomes
Arvold ND, Wang Y, Zigler C
Hospitalization burden and survival among older glioblastoma patients.
The researchers performed a retrospective cohort study among patients aged 65 years and older with glioblastoma diagnosed between 1999 and 2007. They found that higher comorbidity score and black race were associated with an increased risk of being hospitalized for at least 25% of remaining life, whereas radiation, temozolomide, and extensive surgery were associated with a decreased risk.
AHRQ-funded; HS021991.
Citation: Arvold ND, Wang Y, Zigler C .
Hospitalization burden and survival among older glioblastoma patients.
Neuro Oncol 2014 Nov;16(11):1530-40. doi: 10.1093/neuonc/nou060.
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Keywords: Cancer, Elderly, Hospitalization, Mortality, Quality of Life