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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 11 of 11 Research Studies DisplayedCram P, Saag KG, Lou Y
Racial differences and disparities in osteoporosis-related bone health: results from the PAADRN randomized controlled trial.
The researchers examined whether providing dual-energy x-ray absorptiometry (DXA) test results directly to patients might reduce or eliminate racial differences in osteoporosis-related health care. They found that black women were still less likely to know their actual DXA result and less likely to be on guideline-concordant therapy, but black women had greater patient activation.
AHRQ-funded; HS023009.
Citation: Cram P, Saag KG, Lou Y .
Racial differences and disparities in osteoporosis-related bone health: results from the PAADRN randomized controlled trial.
Med Care 2017 Jun;55(6):561-68. doi: 10.1097/mlr.0000000000000718.
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Keywords: Racial and Ethnic Minorities, Disparities, Osteoporosis, Health Status
Wright NC, Delzell ES, Smith WK
Improving medical record retrieval for validation studies in Medicare data.
The purpose of the study is to describe medical record retrieval for a study validating claims-based algorithms used to identify seven adverse events of special interest (AESI) in a Medicare population. It concluded that the national medical record validation study of claims-based algorithms produced a modest retrieval rate. The medical record procedures outlined in this paper could have led to the improved retrieval from the researchers’ previous medical record retrieval study.
AHRQ-funded; HS023009.
Citation: Wright NC, Delzell ES, Smith WK .
Improving medical record retrieval for validation studies in Medicare data.
Pharmacoepidemiol Drug Saf 2017 Apr;26(4):393-401. doi: 10.1002/pds.4131.
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Keywords: Medicare, Electronic Health Records (EHRs), Osteoporosis, Elderly
Wright NC, Saag KG, Dawson-Hughes B
The impact of the new National Bone Health Alliance (NBHA) diagnostic criteria on the prevalence of osteoporosis in the USA.
This study evaluated the prevalence of osteoporosis using the osteoporosis diagnostic criteria developed by the National Bone Health Alliance (NBHA), which includes qualified fractures, FRAX score in addition to bone mineral density (BMD). The study found that 16% of men and 29.9% of women 50+ have osteoporosis based on the NBHA diagnostic criteria.
AHRQ-funded; HS023009.
Citation: Wright NC, Saag KG, Dawson-Hughes B .
The impact of the new National Bone Health Alliance (NBHA) diagnostic criteria on the prevalence of osteoporosis in the USA.
Osteoporos Int 2017 Apr;28(4):1225-32. doi: 10.1007/s00198-016-3865-3..
Keywords: Diagnostic Safety and Quality, Injuries and Wounds, Osteoporosis
Kathuria P, Gordon KB, Silverberg JI
Association of psoriasis and psoriatic arthritis with osteoporosis and pathological fractures.
This study investigated whether psoriasis (Pso) and psoriatic arthritis (PsA) are associated with osteoporosis and fractures in US adults. Using records of 183,725 persons with Pso and 28,765 with PsA from the 2006-2012 National Emergency Department Sample, including 20 percent of the emergency care visits throughout the United States, it found that Pso and PsA were associated with osteopenia, osteoporosis, ankylosing spondylitis, and pathologic fractures.
AHRQ-funded; HS023011.
Citation: Kathuria P, Gordon KB, Silverberg JI .
Association of psoriasis and psoriatic arthritis with osteoporosis and pathological fractures.
J Am Acad Dermatol 2017 Mar 14;76(6):1045-53.e3. doi: 10.1016/j.jaad.2016.11.046.
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Keywords: Healthcare Cost and Utilization Project (HCUP), Osteoporosis, Injuries and Wounds, Arthritis
Franklin PD, Miozzari H, Christofilopoulos P
Important patient characteristics differ prior to total knee arthroplasty and total hip arthroplasty between Switzerland and the United States.
The researchers compared preoperative patient and clinical characteristics from two large cohorts who underwent either total knee (TKA) or hip (THA) arthroplasty, one in Switzerland, the other in the US. They found substantial differences between US and Swiss cohorts in pre-operative patient characteristics and pain levels, which has potentially important implications for cross-cultural comparison of TKA/THA outcomes.
AHRQ-funded; HS018910.
Citation: Franklin PD, Miozzari H, Christofilopoulos P .
Important patient characteristics differ prior to total knee arthroplasty and total hip arthroplasty between Switzerland and the United States.
BMC Musculoskelet Disord 2017 Jan 11;18(1):14. doi: 10.1186/s12891-016-1372-5.
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Keywords: Surgery, Pain, Patient-Centered Outcomes Research, Osteoporosis, Arthritis
Goodwin JS, Zhou J, Kuo YF
Risk of jaw osteonecrosis after intravenous bisphosphonates in cancer patients and patients without cancer.
The researchers compared the risk of jaw osteonecrosis after intravenous (IV) bisphosphonate administered to patients with cancer vs patients without cancer. During follow-up, 40 (0.42 percent) out of 9,482 patients with cancer developed probable jaw osteonecrosis compared with 8 (0.05 percent) out of 16,046 patients without cancer.
AHRQ-funded; HS022134.
Citation: Goodwin JS, Zhou J, Kuo YF .
Risk of jaw osteonecrosis after intravenous bisphosphonates in cancer patients and patients without cancer.
Mayo Clin Proc 2017 Jan;92(1):106-13. doi: 10.1016/j.mayocp.2016.09.015.
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Keywords: Cancer, Osteoporosis, Risk, Medication, Patient-Centered Outcomes Research
Garcia I, Chiodo V, Ma Y
Evidence of altered matrix composition in iliac crest biopsies from patients with idiopathic juvenile osteoporosis.
The goal of this study is to describe idiopathic juvenile osteoporosis (IJO)bone composition. It concluded that IJO bone, similar to post-menopausal osteoporosis (PMO) bone, had elevated collagen maturity relative to its age-matched controls. This emphasizes the importance of the collagen matrix for bone health. IJO bone differed from PMO bone as IJO bone contains more recently formed mineral than age-matched controls.
AHRQ-funded; HS021734.
Citation: Garcia I, Chiodo V, Ma Y .
Evidence of altered matrix composition in iliac crest biopsies from patients with idiopathic juvenile osteoporosis.
Connect Tissue Res 2016;57(1):28-37. doi: 10.3109/03008207.2015.1088531.
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Keywords: Osteoporosis, Children/Adolescents, Children/Adolescents
Cram P, Wolinsky FD, Lou Y
Patient-activation and guideline-concordant pharmacological treatment after bone density testing: the PAADRN randomized controlled trial.
In a clinical trial of 7749 patients, the researchers tested whether usual care augmented by a tailored patient-activation DXA result letter accompanied by an educational brochure would improve guideline-concordant pharmacological treatment compared to usual care only. They found that treatment rates did not improve.
AHRQ-funded; HS023009.
Citation: Cram P, Wolinsky FD, Lou Y .
Patient-activation and guideline-concordant pharmacological treatment after bone density testing: the PAADRN randomized controlled trial.
Osteoporos Int 2016 Dec;27(12):3513-24. doi: 10.1007/s00198-016-3681-9.
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Keywords: Education: Patient and Caregiver, Guidelines, Medication, Osteoporosis, Patient and Family Engagement
Edmonds SW, Cram P, Lou Y
Effects of a DXA result letter on satisfaction, quality of life, and osteoporosis knowledge: a randomized controlled trial.
This study tested whether a tailored dual energy x-ray absorptiometry (DXA) test result letter and an accompanying educational bone-health brochure affected patient satisfaction, quality of life (QOL), or osteoporosis (OP) knowledge. It found that a tailored DXA result letter and bone-health educational brochure sent to patients improved patient satisfaction with bone-related health care. There were no differences between the intervention and usual care groups in QOL or OP knowledge.
AHRQ-funded; HS023009.
Citation: Edmonds SW, Cram P, Lou Y .
Effects of a DXA result letter on satisfaction, quality of life, and osteoporosis knowledge: a randomized controlled trial.
BMC Musculoskelet Disord 2016 Aug 26;17(1):369. doi: 10.1186/s12891-016-1227-0.
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Keywords: Education: Patient and Caregiver, Osteoporosis, Patient Experience, Quality of Life
Fenton JJ, Robbins JA, Amarnath AL
Osteoporosis overtreatment in a regional health care system.
The researchers estimated the frequency of osteoporosis overtreatment in a regional health care system where DXA reports routinely include T scores for anatomic sites (e.g., lateral lumbar spine) that the International Society for Clinical Densitometry does not recommend for osteoporosis diagnosis. They found that two-thirds of new osteoporosis drug prescriptions were potentially inappropriate.
AHRQ-funded; HS022236.
Citation: Fenton JJ, Robbins JA, Amarnath AL .
Osteoporosis overtreatment in a regional health care system.
JAMA Intern Med 2016 Mar;176(3):391-3. doi: 10.1001/jamainternmed.2015.6020.
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Keywords: Shared Decision Making, Diagnostic Safety and Quality, Medication, Osteoporosis
LaFleur J, Rillamas-Sun E, Colon-Emeric CS
Fracture rates and bone density among postmenopausal veteran and non-veteran women from the Women's Health Initiative.
The authors compared fracture rates and bone mineral density for veterans and non-veterans using Women's Health Initiative data. They found that veterans had higher 10-year probabilities for any major fracture and hip fracture compared with non-veterans, but that risk of fracture at other anatomic sites did not differ by veteran status. They concluded that female veterans had an increased hip fracture rate not explained by differences in well-recognized fracture risk factors.
AHRQ-funded; HS018582.
Citation: LaFleur J, Rillamas-Sun E, Colon-Emeric CS .
Fracture rates and bone density among postmenopausal veteran and non-veteran women from the Women's Health Initiative.
Gerontologist 2016 Feb;56 Suppl 1:S78-90. doi: 10.1093/geront/gnv677.
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Keywords: Elderly, Injuries and Wounds, Osteoporosis, Women