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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 5 of 5 Research Studies DisplayedYankova LC, Neuman MI, Wang ME
Febrile infants ≤60 days old with positive urinalysis results and invasive bacterial infections.
In this study, the investigators aimed to describe the clinical and laboratory characteristics of febrile infants ≤60 days old with positive urinalysis results and invasive bacterial infections (IBI). The investigators concluded that the sensitivity of high-risk PMH, ill appearance, and/or abnormal WBC count was suboptimal for identifying febrile infants with positive urinalysis results at low risk for IBI.
AHRQ-funded; HS026006.
Citation: Yankova LC, Neuman MI, Wang ME .
Febrile infants ≤60 days old with positive urinalysis results and invasive bacterial infections.
Hosp Pediatr 2020 Dec;10(12):1120-25. doi: 10.1542/hpeds.2020-000638..
Keywords: Newborns/Infants, Urinary Tract Infection (UTI), Diagnostic Safety and Quality
Feldman AG, Sokol RJ
Recent developments in diagnostics and treatment of neonatal cholestasis.
This review discusses recent advances in diagnosis and treatment of neonatal cholestatis, which is a sign common to over 100 hepatobiliary and/or metabolic disorders. Advances in genetic testing and bioinformatics have led to an expanding group of molecularly defined disorders involving bile formation, canalicular transporters, tight junction proteins and inborn errors of metabolism. This has enabled rapid and affordable molecular diagnosis for disorders that cannot be directly diagnosed from standard blood tests or liver biopsy.
AHRQ-funded; HS026510.
Citation: Feldman AG, Sokol RJ .
Recent developments in diagnostics and treatment of neonatal cholestasis.
Semin Pediatr Surg 2020 Aug;29(4):150945. doi: 10.1016/j.sempedsurg.2020.150945..
Keywords: Diagnostic Safety and Quality, Newborns/Infants
Brower LH, Wilson PM, Murtagh-Kurowski E
Evaluation for neonatal HSV in infants undergoing workup for serious bacterial infection: a 5-year retrospective review.
The purpose of this study was to describe the characteristics of infants evaluated for serious bacterial infection, focusing on empirical testing and treatment of herpes simplex virus (HSV) and describe the characteristics of HSV-positive patients. The investigators concluded that the absence of fever should not preclude a workup for HSV in neonates, and when a workup is initiated, emphasis should be placed on obtaining samples from serum, cerebrospinal fluid, and surface specimens.
AHRQ-funded; HS026763.
Citation: Brower LH, Wilson PM, Murtagh-Kurowski E .
Evaluation for neonatal HSV in infants undergoing workup for serious bacterial infection: a 5-year retrospective review.
Hosp Pediatr 2020 Jun;10(6):463-70. doi: 10.1542/hpeds.2020-0033..
Keywords: Newborns/Infants, Infectious Diseases, Diagnostic Safety and Quality
Henry MK, Feudtner C, Fortin K
Occult head injuries in infants evaluated for physical abuse.
Abusive head injuries in infants may be occult but clinically or forensically important. Data conflict regarding yield of neuroimaging in detecting occult head injuries in infants evaluated for physical abuse, with prior studies identifying yields of 4.3-37.3 %. The objectives of this study were (1) To quantify yield of computed tomography or magnetic resonance imaging in identification of occult head injuries in infants with concerns for physical abuse and (2) To evaluate risk factors for occult head injuries.
AHRQ-funded; HS024194.
Citation: Henry MK, Feudtner C, Fortin K .
Occult head injuries in infants evaluated for physical abuse.
Child Abuse Negl 2020 May;103:104431. doi: 10.1016/j.chiabu.2020.104431..
Keywords: Newborns/Infants, Brain Injury, Domestic Violence, Imaging, Diagnostic Safety and Quality, Injuries and Wounds
Beam K, Wojcik MH, Agrawal PB
Prenatal diagnosis of a ventral abdominal wall defect.
This paper is a case study describing an infant diagnosed prenatally with fetal ultrasonography with multiple abnormalities including a ventral abdominal wall defect and confirmed herniation of the liver with the portal vein extending outside the abdomen, stomach, small bowel, and majority of the large bowel without an overlying membrane. The kidneys were enlarged as well. Multiple surgeries were performed. Ultimately the infant died 38 days after birth.
AHRQ-funded; HS000063.
Citation: Beam K, Wojcik MH, Agrawal PB .
Prenatal diagnosis of a ventral abdominal wall defect.
Neoreviews 2020 Apr;21(4):e286-e92. doi: 10.1542/neo.21-4-e286..
Keywords: Newborns/Infants, Diagnostic Safety and Quality, Case Study