National Healthcare Quality and Disparities Report
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AHRQ Research Studies Date
Topics
- (-) Adverse Drug Events (ADE) (43)
- Adverse Events (7)
- Antimicrobial Stewardship (1)
- Blood Thinners (2)
- Cardiovascular Conditions (1)
- Caregiving (1)
- Care Management (1)
- Children/Adolescents (5)
- Clinical Decision Support (CDS) (2)
- Data (1)
- Diabetes (5)
- Dialysis (1)
- Disabilities (1)
- Disparities (1)
- Elderly (6)
- Electronic Health Records (EHRs) (6)
- Electronic Prescribing (E-Prescribing) (1)
- Emergency Department (1)
- Evidence-Based Practice (1)
- Guidelines (2)
- Healthcare-Associated Infections (HAIs) (1)
- Healthcare Cost and Utilization Project (HCUP) (1)
- Healthcare Costs (2)
- Healthcare Delivery (1)
- Health Information Technology (HIT) (4)
- Health Literacy (1)
- Health Systems (1)
- Heart Disease and Health (3)
- Hepatitis (1)
- Hospitalization (1)
- Hospitals (1)
- Human Immunodeficiency Virus (HIV) (1)
- Injuries and Wounds (1)
- Kidney Disease and Health (2)
- Medical Errors (6)
- Medicare (1)
- Medication (34)
- Medication: Safety (10)
- Mortality (2)
- Neurological Disorders (1)
- Newborns/Infants (1)
- Nursing Homes (2)
- Opioids (4)
- Orthopedics (1)
- Patient-Centered Healthcare (1)
- Patient-Centered Outcomes Research (3)
- Patient Adherence/Compliance (1)
- Patient Safety (17)
- Prevention (2)
- Provider: Pharmacist (2)
- Quality Improvement (1)
- Risk (6)
- Shared Decision Making (1)
- Skin Conditions (1)
- Substance Abuse (2)
- Surgery (3)
- Vulnerable Populations (1)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
26 to 43 of 43 Research Studies DisplayedBlumenthal KG, Lai KH, Huang M
Adverse and hypersensitivity reactions to prescription nonsteroidal anti-inflammatory agents in a large health care system.
The researchers aimed to use electronic health record data to determine the incidence and predictors of hypersentivity reaction (HSR) to prescription nonsteroidal anti-inflammatory drugs (NSAIDs). They concluded that NSAID therapeutic use can be limited by adverse drug reactions (ADRs); about 1 in 5 NSAID ADRs is an hypersentivity reaction.
AHRQ-funded; HS022728.
Citation: Blumenthal KG, Lai KH, Huang M .
Adverse and hypersensitivity reactions to prescription nonsteroidal anti-inflammatory agents in a large health care system.
J Allergy Clin Immunol Pract 2017 May-Jun;5(3):737-43. doi: 10.1016/j.jaip.2016.12.006.
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Keywords: Electronic Health Records (EHRs), Medication, Risk, Health Systems, Adverse Drug Events (ADE)
Schroeder SR, Salomon MM, Galanter WL
Cognitive tests predict real-world errors: the relationship between drug name confusion rates in laboratory-based memory and perception tests and corresponding error rates in large pharmacy chains.
The researchers conducted a study to assess the association between error rates in laboratory-based tests of drug name memory and perception and real-world drug name confusion error rates. They found that across two distinct pharmacy chains, there is a strong and significant association between drug name confusion error rates observed in the real world and those observed in laboratory-based tests of memory and perception.
AHRQ-funded; HS021093.
Citation: Schroeder SR, Salomon MM, Galanter WL .
Cognitive tests predict real-world errors: the relationship between drug name confusion rates in laboratory-based memory and perception tests and corresponding error rates in large pharmacy chains.
BMJ Qual Saf 2017 May;26(5):395-407. doi: 10.1136/bmjqs-2015-005099.
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Keywords: Adverse Drug Events (ADE), Medical Errors, Medication: Safety, Medication, Provider: Pharmacist
Gabriel MH, Powers C, Encinosa W
AHRQ Author: Encinosa W
E-prescribing and adverse drug events: an observational study of the Medicare part D population with diabetes.
The researchers examined the impact of e-prescribing on emergency visits or hospitalizations for diabetes-related adverse drug events (ADEs) including hypoglycemia. They concluded that at the e-prescribing threshold of 75 percent and above, there were significant reductions in ADE risk.
AHRQ-authored.
Citation: Gabriel MH, Powers C, Encinosa W .
E-prescribing and adverse drug events: an observational study of the Medicare part D population with diabetes.
Med Care 2017 May;55(5):456-62. doi: 10.1097/mlr.0000000000000684.
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Keywords: Adverse Drug Events (ADE), Electronic Prescribing (E-Prescribing), Diabetes, Medicare, Medication
Banerji A, Blumenthal KG, Lai KH
Epidemiology of ACE inhibitor angioedema utilizing a large electronic health record.
The objective of this study was to identify the incidence of and risk factors for angioedema caused by angiotensin-converting enzyme inhibitors (ACEIs) using a large integrated electronic health record (EHR). It concluded that the incidence of ACEI angioedema within a large EHR is consistent with large clinical trial data. A history of nonsteroidal anti-inflammatory drug allergy was identified as a risk factor for patients with ACEI angioedema.
AHRQ-funded; HS022728.
Citation: Banerji A, Blumenthal KG, Lai KH .
Epidemiology of ACE inhibitor angioedema utilizing a large electronic health record.
J Allergy Clin Immunol Pract 2017 May - Jun;5(3):744-49. doi: 10.1016/j.jaip.2017.02.018.
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Keywords: Electronic Health Records (EHRs), Medication, Risk, Health Information Technology (HIT), Adverse Drug Events (ADE)
Waljee JF, Cron DC, Steiger RM
Effect of preoperative opioid exposure on healthcare utilization and expenditures following elective abdominal surgery.
The researchers examined the extent to which preoperative opioid use is correlated with healthcare utilization and costs following elective surgical procedures. They found that compared with non-users, patients using opioids preoperatively were more likely to have a longer hospital stay and were more likely to be discharged to a rehabilitation facility , adjusting for covariates.
AHRQ-funded; HS023313.
Citation: Waljee JF, Cron DC, Steiger RM .
Effect of preoperative opioid exposure on healthcare utilization and expenditures following elective abdominal surgery.
Ann Surg 2017 Apr;265(4):715-21. doi: 10.1097/sla.0000000000002117.
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Keywords: Opioids, Surgery, Healthcare Delivery, Healthcare Costs, Adverse Drug Events (ADE)
Walsh KE, Harik P, Mazor KM
Measuring harm in health care: optimizing adverse event review.
The objective of this study was to identify modifiable factors that improve the reliability of ratings of severity of health care-associated harm in clinical practice improvement and research. Using a generalizability theory framework to estimate the impact of number of raters, rater experience, and rater provider type on reliability, the researchers found that reliability was greatly improved with 2 reviewers.
AHRQ-funded; 290201000022I.
Citation: Walsh KE, Harik P, Mazor KM .
Measuring harm in health care: optimizing adverse event review.
Med Care 2017 Apr;55(4):436-41. doi: 10.1097/mlr.0000000000000679.
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Keywords: Medical Errors, Adverse Events, Quality Improvement, Adverse Drug Events (ADE), Patient Safety
Hanlon JT, Perera S, Newman AB
Potential drug-drug and drug-disease interactions in well-functioning community-dwelling older adults.
The objective of this study was to describe the prevalence of potential drug-drug and drug-disease interactions and associated factors in community-dwelling older adults. It found that drug interactions are common among community-dwelling older adults and are associated with the number of medications and hospitalization in the previous year.
AHRQ-funded; HS023779.
Citation: Hanlon JT, Perera S, Newman AB .
Potential drug-drug and drug-disease interactions in well-functioning community-dwelling older adults.
J Clin Pharm Ther 2017 Apr;42(2):228-33. doi: 10.1111/jcpt.12502.
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Keywords: Adverse Drug Events (ADE), Elderly, Medication, Patient Safety
Blumenthal KG, Acker WW, Li Y
Allergy entry and deletion in the electronic health record.
The researchers aimed to assess drug allergy entry, deletion, and accumulation, to identify health care professional types recording allergy data, and to assess the reaction types that lead to allergy entry and deletion. They found that of all allergies, 38.2 percent were immune mediated and 29.6 percent included only adverse effect reactions. Unavailable or unknown reactions comprised 32.2 percent of all allergies entered or deleted.
AHRQ-funded; HS022728.
Citation: Blumenthal KG, Acker WW, Li Y .
Allergy entry and deletion in the electronic health record.
Ann Allergy Asthma Immunol 2017 Mar;118(3):380-81. doi: 10.1016/j.anai.2016.12.020.
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Keywords: Data, Electronic Health Records (EHRs), Medication: Safety, Medication, Adverse Drug Events (ADE)
Naidech AM, Toledo P, Prabhakaran S
Disparities in the use of seizure medications after intracerebral hemorrhage.
The researchers investigated potential disparities in the use of prophylactic seizure medications in patients with intracerebral hemorrhage. They concluded that although multicenter electronic health record data showed apparent racial/ethnic disparities in the use of prophylactic seizure medications, a more complete single-center cohort found the apparent disparity to be confounded by the clinical factors of hypertension and hematoma location.
AHRQ-funded; HS023437; HS000078.
Citation: Naidech AM, Toledo P, Prabhakaran S .
Disparities in the use of seizure medications after intracerebral hemorrhage.
Stroke 2017 Mar;48(3):802-04. doi: 10.1161/strokeaha.116.015779.
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Keywords: Disparities, Medication, Prevention, Adverse Drug Events (ADE), Risk
Snyder GM, McCoy C, D'Agata EM
Quantifying antimicrobial exposure: hazards in populations with end-stage renal disease.
Using a rigorously collected data set of antimicrobial use among patients receiving chronic hemodialysis, antimicrobial use was calculated using 3 different methodologies: daily defined dose, days of therapy, and start-stop days. Estimates of antimicrobial use varied by as much as 10-fold, depending on the type of antimicrobial.
AHRQ-funded; HS021666.
Citation: Snyder GM, McCoy C, D'Agata EM .
Quantifying antimicrobial exposure: hazards in populations with end-stage renal disease.
Infect Control Hosp Epidemiol 2017 Mar;38(3):360-63. doi: 10.1017/ice.2016.290.
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Keywords: Adverse Drug Events (ADE), Antimicrobial Stewardship, Dialysis, Kidney Disease and Health, Patient Safety
McDonald EM, Kennedy-Hendricks A, McGinty EE
Safe storage of opioid pain relievers among adults living in households with children.
The researchers sought to describe safe storage practices and beliefs among adults who have used a prescription opioid pain reliever (OPR) in the past year; to compare practices and beliefs among those living with younger (<7 years) versus older children (7-17 years). They concluded that OPRs are stored unsafely in many households with children.
AHRQ-funded; HS000029.
Citation: McDonald EM, Kennedy-Hendricks A, McGinty EE .
Safe storage of opioid pain relievers among adults living in households with children.
Pediatrics 2017 Mar;139(3). doi: 10.1542/peds.2016-2161.
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Keywords: Adverse Drug Events (ADE), Children/Adolescents, Medication: Safety, Medication, Opioids
Romagnoli KM, Nelson SD, Hines L
Information needs for making clinical recommendations about potential drug-drug interactions: a synthesis of literature review and interviews.
To better understand the information needs and work practices of specialists who search and synthesize potential drug-drug interactions (PDDIs) evidence for drug information resources, the researchers conducted an inquiry that combined a thematic analysis of published literature with unstructured interviews. Their review of 92 papers and 10 interviews identified 56 categories of information needs related to the interpretation of PDDI information including drug and interaction information, study design and evidence including clinical details.
AHRQ-funded; HS019461.
Citation: Romagnoli KM, Nelson SD, Hines L .
Information needs for making clinical recommendations about potential drug-drug interactions: a synthesis of literature review and interviews.
BMC Med Inform Decis Mak 2017 Feb 22;17(1):21. doi: 10.1186/s12911-017-0419-3.
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Keywords: Guidelines, Clinical Decision Support (CDS), Medication, Adverse Drug Events (ADE)
Steinman MA, Zullo AR, Lee Y
Association of β-blockers with functional outcomes, death, and rehospitalization in older nursing home residents after acute myocardial infarction.
The researchers studied the association of beta-blockers after AMI with functional decline, mortality, and rehospitalization among long-stay nursing home residents 65 years or older. Use of beta-blockers after AMI was associated with functional decline in older nursing home residents with substantial cognitive or functional impairment, but not in those with relatively preserved mental and functional abilities.
AHRQ-funded; HS022998.
Citation: Steinman MA, Zullo AR, Lee Y .
Association of β-blockers with functional outcomes, death, and rehospitalization in older nursing home residents after acute myocardial infarction.
JAMA Intern Med 2017 Feb;177(2):254-62. doi: 10.1001/jamainternmed.2016.7701.
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Keywords: Nursing Homes, Patient-Centered Outcomes Research, Medication, Adverse Drug Events (ADE), Heart Disease and Health
Lambert P, Chaisson K, Horton S, P, Chaisson K, Horton S
Reducing acute kidney injury due to contrast material: how nurses can improve patient safety.
Acute kidney injury due to contrast material occurs in 3% to 15% of the 2 million cardiac catheterizations done in the United States each year. The purpose of this study was to reduce acute kidney injury due to contrast material after cardiovascular interventional procedures. The study concluded that standardization of evidence-based best practices in nursing care may reduce the incidence of acute kidney injury due to contrast material.
AHRQ-funded; HS018443.
Citation: Lambert P, Chaisson K, Horton S, P, Chaisson K, Horton S .
Reducing acute kidney injury due to contrast material: how nurses can improve patient safety.
Crit Care Nurse 2017 Feb;37(1):13-26. doi: 10.4037/ccn2017178..
Keywords: Adverse Drug Events (ADE), Adverse Events, Injuries and Wounds, Patient Safety, Heart Disease and Health
Pannucci CJ, Rondina MT
Should we be following anti-factor Xa levels in patients receiving prophylactic enoxaparin perioperatively?
The authors argue that existing data demonstrate that an individualized regimen of enoxaparin prophylaxis based on patient-level factors might provide an increased margin of effectiveness and safety for individual patients given enoxaparin prophylactically in the perioperative period.
AHRQ-funded; HS024326.
Citation: Pannucci CJ, Rondina MT .
Should we be following anti-factor Xa levels in patients receiving prophylactic enoxaparin perioperatively?
Surgery 2017 Feb;161(2):329-31. doi: 10.1016/j.surg.2016.07.038.
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Keywords: Adverse Drug Events (ADE), Medication, Medication: Safety, Patient Safety, Prevention
Horsky J, Aarts J, Verheul L
Clinical reasoning in the context of active decision support during medication prescribing.
The purpose of this study was to describe and analyze reasoning patterns of clinicians responding to drug-drug interaction alerts in order to understand the role of patient-specific information in the decision-making process about the risks and benefits of medication therapy. The investigators found that declining an alert suggestion was preceded by sometimes brief but often complex reasoning, prioritizing different aspects of care quality and safety, especially when the perceived risk was higher.
AHRQ-funded; HS021094.
Citation: Horsky J, Aarts J, Verheul L .
Clinical reasoning in the context of active decision support during medication prescribing.
Int J Med Inform 2017 Jan;97:1-11. doi: 10.1016/j.ijmedinf.2016.09.004..
Keywords: Adverse Drug Events (ADE), Adverse Events, Clinical Decision Support (CDS), Shared Decision Making, Electronic Health Records (EHRs), Health Information Technology (HIT), Medical Errors, Medication, Patient Safety
Cooper LB, Hammill BG, Peterson ED
Characterization of mineralocorticoid receptor antagonist therapy initiation in high-risk patients with heart failure.
Heart failure guidelines recommend routine monitoring of serum potassium, and renal function in patients treated with a mineralocorticoid receptor antagonist (MRA). This study found that patients initiated on MRA therapy as an outpatient had extremely poor rates of guideline indicated follow-up laboratory monitoring after drug initiation. In particular, patients with chronic kidney disease were at high risk for adverse events after MRA initiation.
AHRQ-funded; HS021092.
Citation: Cooper LB, Hammill BG, Peterson ED .
Characterization of mineralocorticoid receptor antagonist therapy initiation in high-risk patients with heart failure.
Circ Cardiovasc Qual Outcomes 2017 Jan;10(1):pii: e002946. doi: 10.1161/circoutcomes.116.002946.
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Keywords: Care Management, Heart Disease and Health, Kidney Disease and Health, Adverse Drug Events (ADE), Patient Adherence/Compliance
Bavishi AA, Grammer LC, Pongracic J
Diurnal variations in subcutaneous allergen immunotherapy reactions.
The investigators sought to assess whether the timing of subcutaneous immunotherapy (SCIT) affects the rate of adverse reactions. They found that afternoon and evening injections of SCIT are associated with increased cutaneous reaction rates when compared with morning injections, recommending the administration of SCIT in the morning in patients experiencing bothersome local reactions.
AHRQ-funded; HS023011.
Citation: Bavishi AA, Grammer LC, Pongracic J .
Diurnal variations in subcutaneous allergen immunotherapy reactions.
Ann Allergy Asthma Immunol 2017 Jan;118(1):103-07. doi: 10.1016/j.anai.2016.10.007.
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Keywords: Adverse Drug Events (ADE), Medication, Patient-Centered Healthcare, Patient-Centered Outcomes Research