National Healthcare Quality and Disparities Report
Latest available findings on quality of and access to health care
Data
- Data Infographics
- Data Visualizations
- Data Tools
- Data Innovations
- All-Payer Claims Database
- Healthcare Cost and Utilization Project (HCUP)
- Medical Expenditure Panel Survey (MEPS)
- AHRQ Quality Indicator Tools for Data Analytics
- State Snapshots
- United States Health Information Knowledgebase (USHIK)
- Data Sources Available from AHRQ
Search All Research Studies
AHRQ Research Studies Date
Topics
- Adverse Drug Events (ADE) (1)
- Adverse Events (1)
- Antibiotics (1)
- Antimicrobial Stewardship (1)
- Cardiovascular Conditions (1)
- Case Study (1)
- Chronic Conditions (3)
- Clinical Decision Support (CDS) (1)
- Clinician-Patient Communication (1)
- Comparative Effectiveness (4)
- Depression (1)
- Diagnostic Safety and Quality (3)
- (-) Digestive Disease and Health (24)
- Education: Continuing Medical Education (1)
- Education: Patient and Caregiver (2)
- Elderly (2)
- Electronic Health Records (EHRs) (1)
- Evidence-Based Practice (1)
- Genetics (2)
- Health Information Technology (HIT) (3)
- Health Literacy (2)
- Hospital Discharge (1)
- Intensive Care Unit (ICU) (1)
- Long-Term Care (1)
- Medication (5)
- Mortality (1)
- Newborns/Infants (1)
- Nursing Homes (2)
- Obesity (1)
- Outcomes (3)
- Patient-Centered Healthcare (1)
- Patient-Centered Outcomes Research (4)
- Patient Adherence/Compliance (1)
- Patient and Family Engagement (1)
- Patient Safety (1)
- Patient Self-Management (2)
- Practice Patterns (1)
- Quality Improvement (2)
- Quality Measures (1)
- Quality of Care (2)
- Quality of Life (2)
- Rehabilitation (1)
- Research Methodologies (1)
- Risk (2)
- Shared Decision Making (2)
- Surgery (3)
- Telehealth (4)
- Transitions of Care (1)
- Treatments (1)
AHRQ Research Studies
Sign up: AHRQ Research Studies Email updates
Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 24 of 24 Research Studies DisplayedChudy-Onwugaje K, Abutaleb A, Buchwald A
Age modifies the association between depressive symptoms and adherence to self-testing with telemedicine in patients with inflammatory bowel disease.
This study researched the association between age and increased depressive symptoms and adherence to self-testing with telemedicine in patients with inflammatory bowel disease (IBD). It was found that patients 40 and older had worse adherence than patients younger than 40 with depressive symptoms.
AHRQ-funded; HS018975.
Citation: Chudy-Onwugaje K, Abutaleb A, Buchwald A .
Age modifies the association between depressive symptoms and adherence to self-testing with telemedicine in patients with inflammatory bowel disease.
Inflamm Bowel Dis 2018 Nov 29;24(12):2648-54. doi: 10.1093/ibd/izy194..
Keywords: Chronic Conditions, Depression, Digestive Disease and Health, Patient Adherence/Compliance, Patient Self-Management, Telehealth
Balentine CJ, Kenzik K, Chu DI
Planning post-discharge destination for gastrointestinal surgery patients: room for improvement?
Investigators compared short-term recovery for patients discharged to inpatient rehabilitation versus skilled nursing facilities after gastrointestinal surgery. They found that there was no difference in 30-day readmission rates, but post-discharge mortality was higher for patients discharged to skilled nursing facilities compared to inpatient rehabilitation.
AHRQ-funded; HS023009.
Citation: Balentine CJ, Kenzik K, Chu DI .
Planning post-discharge destination for gastrointestinal surgery patients: room for improvement?
Am J Surg 2018 Nov;216(5):912-18. doi: 10.1016/j.amjsurg.2018.05.004..
Keywords: Hospital Discharge, Surgery, Digestive Disease and Health, Rehabilitation, Nursing Homes, Quality Improvement, Quality of Care, Transitions of Care
D'Agata EMC, Varu A, Geffert SF
Acquisition of multidrug-resistant organisms in the absence of antimicrobials.
This nested case-control study was conducted among 137 nursing home residents who did not receive antimicrobials, with 44 acquiring a multi-drug resistant organism. Risk factors identified included receiving gastrointestinal medication that affected the gut microbiome, the number of visits from healthcare workers, pressure ulcers, and not residing in a dementia unit.
AHRQ-funded; HS021666.
Citation: D'Agata EMC, Varu A, Geffert SF .
Acquisition of multidrug-resistant organisms in the absence of antimicrobials.
Clin Infect Dis 2018 Oct 15;67(9):1437-40. doi: 10.1093/cid/ciy358..
Keywords: Antimicrobial Stewardship, Antibiotics, Medication, Nursing Homes, Long-Term Care, Elderly, Digestive Disease and Health, Case Study
Li D, Haritunians T, Landers C
Late-onset Crohn's Disease is a subgroup distinct in genetic and behavioral risk factors with UC-like characteristics.
Age of onset is linked to variations in clinical phenotypes and natural history in Crohn's disease (CD). In this study, the investigators aimed to define etiologically more homogenous subgroups in CD based on ages of onset. The investigators concluded that late-onset CD was subgroup distinct in genetic and behavioral risk factors with UC-like characteristics.
AHRQ-funded; HS021747.
Citation: Li D, Haritunians T, Landers C .
Late-onset Crohn's Disease is a subgroup distinct in genetic and behavioral risk factors with UC-like characteristics.
Inflamm Bowel Dis 2018 Oct 12;24(11):2413-22. doi: 10.1093/ibd/izy148..
Keywords: Digestive Disease and Health, Risk, Genetics
Abutaleb A, Buchwald A, Chudy-Onwugaje K
Inflammatory bowel disease telemedicine clinical trial: impact of educational text messages on disease-specific knowledge over 1 year.
The authors aimed to determine if delivery of educational messages through a telemedicine system improves inflammatory bowel disease (IBD) knowledge. They found that, although telemedicine improves IBD-specific knowledge through text messaging, telemedicine is not superior to education given through standard visits at referral centers.
AHRQ-funded; HS018975.
Citation: Abutaleb A, Buchwald A, Chudy-Onwugaje K .
Inflammatory bowel disease telemedicine clinical trial: impact of educational text messages on disease-specific knowledge over 1 year.
Inflamm Bowel Dis 2018 Sep 15;24(10):2191-97. doi: 10.1093/ibd/izy149..
Keywords: Telehealth, Health Information Technology (HIT), Digestive Disease and Health, Education: Patient and Caregiver, Health Literacy, Quality of Life
Symer MM, Abelson JS, Sedrakyan A
Early operative management of complicated appendicitis is associated with improved surgical outcomes in adults.
In this study, the New York State Planning and Research Cooperative database was used to identify all patients admitted with complicated appendicitis and undergoing appendectomy within 1-year. Primary outcome was any complication. Secondary outcomes included length of stay (LOS), hospital charges, and laparoscopy use. Outcomes were compared in appendectomy before or after 48h from admission. The investigators found more complications, longer LOS, and higher charges in patients undergoing delayed surgery.
AHRQ-funded; HS000066.
Citation: Symer MM, Abelson JS, Sedrakyan A .
Early operative management of complicated appendicitis is associated with improved surgical outcomes in adults.
Am J Surg 2018 Sep;216(3):431-37. doi: 10.1016/j.amjsurg.2018.04.010..
Keywords: Surgery, Digestive Disease and Health, Outcomes
Clerc F, Novokmet M, Dotz V
Plasma N-glycan signatures are associated with features of inflammatory bowel diseases.
Biomarkers are needed for early detection of Crohn's disease (CD) and ulcerative colitis (UC) or to predict patient outcomes. This study compared plasma N-glycosylation profiles between patients with Crohn's disease (CD) or ulcerative colitis (UC) and healthy individuals (controls).
AHRQ-funded; HS021747.
Citation: Clerc F, Novokmet M, Dotz V .
Plasma N-glycan signatures are associated with features of inflammatory bowel diseases.
Gastroenterology 2018 Sep;155(3):829-43. doi: 10.1053/j.gastro.2018.05.030..
Keywords: Digestive Disease and Health, Outcomes
Egberg MD, Gulati AS, Gellad ZF
Improving quality in the care of patients with inflammatory bowel diseases.
In this article, the authors reviewed the history of quality initiatives in healthcare and identified ongoing gaps in inflammatory bowel disease (IBD) care with a review of current IBD improvement efforts taking place. Several targets for improving IBD care quality while moving forward into the 21st century were also identified.
AHRQ-funded; HS000063.
Citation: Egberg MD, Gulati AS, Gellad ZF .
Improving quality in the care of patients with inflammatory bowel diseases.
Inflamm Bowel Dis 2018 Jul 12;24(8):1660-69. doi: 10.1093/ibd/izy030..
Keywords: Digestive Disease and Health, Quality of Care, Quality Improvement
Gephart SM, Wyles C, Canvasser J
Expert consensus to weight an adherence score for audit and feedback of practices that prevent necrotizing enterocolitis in very low birth weight infants.
Necrotizing enterocolitis (NEC) is a catastrophic abdominal complication threatening the life of premature infants, but adoption of prevention and early recognition practices differs as do NEC rates in Neonatal Intensive Care Units (NICUs). The purpose of this research was to validate and weight an evidence-based adherence score (aka NEC-Zero Adherence Score) to prevent and foster timely recognition of NEC.
AHRQ-funded; HS022908.
Citation: Gephart SM, Wyles C, Canvasser J .
Expert consensus to weight an adherence score for audit and feedback of practices that prevent necrotizing enterocolitis in very low birth weight infants.
Appl Nurs Res 2018 Feb;39:182-88. doi: 10.1016/j.apnr.2017.11.021..
Keywords: Newborns/Infants, Digestive Disease and Health, Diagnostic Safety and Quality, Intensive Care Unit (ICU)
Dulai PS, Siegel CA
Optimization of drug safety profile in inflammatory bowel disease through a personalized approach.
Treatment strategies and treatment options have changed considerably over the past decade for Inflammatory Bowel Disease (IBD). In this review the authors discuss the potential risks of therapy in IBD, opportunities to mitigate those risks, and a personalized approach to consider when using these agents in clinical practice.
AHRQ-funded; HS021747.
Citation: Dulai PS, Siegel CA .
Optimization of drug safety profile in inflammatory bowel disease through a personalized approach.
Curr Drug Targets 2018;19(7):740-47. doi: 10.2174/1389450118666170525114939..
Keywords: Adverse Drug Events (ADE), Adverse Events, Shared Decision Making, Digestive Disease and Health, Medication, Patient-Centered Healthcare
Aggarwal R, Brown KM, de Groen PC
AHRQ Author: Henriksen K
Simulation research in gastrointestinal and urologic care-challenges and opportunities: summary of a National Institute of Diabetes and Digestive and Kidney Diseases and National Institute of Biomedical Imaging and Bioengineering workshop.
The purpose of the workshop was to examine the extent to which simulation approaches have been used by skilled proceduralists (not trainees) caring for patients with gastrointestinal and urologic diseases. The current status of research findings in the use and effectiveness of simulation applications was reviewed, and numerous knowledge gaps and research needs were identified by the faculty and the attendees.
AHRQ-authored.
Citation: Aggarwal R, Brown KM, de Groen PC .
Simulation research in gastrointestinal and urologic care-challenges and opportunities: summary of a National Institute of Diabetes and Digestive and Kidney Diseases and National Institute of Biomedical Imaging and Bioengineering workshop.
Ann Surg 2018 Jan;267(1):26-34. doi: 10.1097/sla.0000000000002228.
.
.
Keywords: Digestive Disease and Health, Education: Continuing Medical Education, Evidence-Based Practice, Research Methodologies
Almario CV, Chey WD, Iriana S
Computer versus physician identification of gastrointestinal alarm features.
This study's objective was to compare the number of alarms documented by physicians during usual care vs. that collected by a computer algorithm called Automated Evaluation of Gastrointestinal Symptoms (AEGIS). AEGIS identified more patients with positive alarm features compared to physicians and also documented more positive alarms. Moreover, clinicians documented only 30% of the positive alarms self-reported by patients through AEGIS.
AHRQ-funded; HS000046.
Citation: Almario CV, Chey WD, Iriana S .
Computer versus physician identification of gastrointestinal alarm features.
Int J Med Inform 2015 Dec;84(12):1111-7. doi: 10.1016/j.ijmedinf.2015.07.006.
.
.
Keywords: Clinical Decision Support (CDS), Diagnostic Safety and Quality, Digestive Disease and Health, Electronic Health Records (EHRs), Patient Safety
Krouse RS, You YN
Prospective comparative effectiveness trial for malignant bowel obstruction: SWOG S1316.
This paper is an update on the status of the Prospective Comparative Effectiveness Trial for Malignant Bowel Obstruction trial (S1316), the aim of which is to assess the quality of life outcome of “good days” for patients with malignant bowel obstruction (MBO) who receive surgical intervention in comparison with patients who undergo nonsurgical intervention.
AHRQ-funded; HS021491.
Citation: Krouse RS, You YN .
Prospective comparative effectiveness trial for malignant bowel obstruction: SWOG S1316.
Bull Am Coll Surg 2015 Dec;100(12):49-50.
.
.
Keywords: Comparative Effectiveness, Digestive Disease and Health, Patient-Centered Outcomes Research, Quality of Life
Johnson SL, Bartels CM, Palta M
Biological and steroid use in relationship to quality measures in older patients with inflammatory bowel disease: a US Medicare cohort study.
The researchers examined the frequency and predictors of antitumour necrosis factor (TNF) use, among US patients with inflammatory bowel disease (IBD) aged 65 years and older prior to the publication of a new Medicare quality measure calling for the use of anti-TNFs and other steroid-sparing agents. They found that anti-TNF use was very low in this population of older patients with IBD.
AHRQ-funded; HS022786.
Citation: Johnson SL, Bartels CM, Palta M .
Biological and steroid use in relationship to quality measures in older patients with inflammatory bowel disease: a US Medicare cohort study.
BMJ Open 2015 Sep 07;5(9):e008597. doi: 10.1136/bmjopen-2015-008597.
.
.
Keywords: Elderly, Digestive Disease and Health, Medication, Quality Measures
Siegel CA, Lofland JH, Naim A
Gastroenterologists' views of shared decision making for patients with inflammatory bowel disease.
The researchers examined gastroenterologists' perspectives about shared decision making (SDM) with patients with inflammatory bowel disease (IBD). They found three key barriers to practicing SDM were lack of time, reimbursement, and tools. They concluded that gastroenterologists lack the systematic approaches and tools for implementing SDM within their IBD practices.
AHRQ-funded; HS021747.
Citation: Siegel CA, Lofland JH, Naim A .
Gastroenterologists' views of shared decision making for patients with inflammatory bowel disease.
Dig Dis Sci 2015 Sep;60(9):2636-45. doi: 10.1007/s10620-015-3675-z.
.
.
Keywords: Shared Decision Making, Digestive Disease and Health, Patient and Family Engagement, Practice Patterns
Chung CF, Cook K, Bales E
More than telemonitoring: Health provider use and nonuse of life-log data in irritable bowel syndrome and weight management.
The researchers sought to develop an in-depth understanding of providers’ facilitators and barriers to successfully integrating life-log data into their practices and creating better experiences. Providers reported using self-monitoring data to enhance provider-patient communication, develop personalized treatment plans, and to motivate and educate patients, in addition to using them as diagnostic and adherence tools. Barriers included a lack of time to review detailed records and questions about providers' expertise to review it.
AHRQ-funded; HS023654.
Citation: Chung CF, Cook K, Bales E .
More than telemonitoring: Health provider use and nonuse of life-log data in irritable bowel syndrome and weight management.
J Med Internet Res 2015 Aug 21;17(8):e203. doi: 10.2196/jmir.4364..
Keywords: Digestive Disease and Health, Health Information Technology (HIT), Telehealth, Obesity, Clinician-Patient Communication
Bewtra M, Newcomb CW, Wu Q
Mortality associated with medical therapy versus elective colectomy in ulcerative colitis: a cohort study.
This study sought to determine whether patients with advanced ulcerative colitis (UC) treated with elective colectomy have improved survival compared with those treated with medical therapy. It found that elective colectomy was associated with improved survival compared with long-term medical therapy, although this result did not remain statistically significant in all sensitivity analyses.
AHRQ-funded; HS018517.
Citation: Bewtra M, Newcomb CW, Wu Q .
Mortality associated with medical therapy versus elective colectomy in ulcerative colitis: a cohort study.
Ann Intern Med 2015 Aug 18;163(4):262-70. doi: 10.7326/m14-0960..
Keywords: Comparative Effectiveness, Mortality, Outcomes, Surgery, Digestive Disease and Health
Lo Re V, Carbonari DM, Forde KA
Validity of diagnostic codes and laboratory tests of liver dysfunction to identify acute liver failure events.
The researchers examined positive predictive values (PPVs) of hospital ICD-9 diagnoses and laboratory tests of liver dysfunction for identifying acute liver failure (ALF) within a large, community-based integrated care organization. They found that algorithms comprising relevant hospital diagnoses, laboratory evidence of liver dysfunction, and prescriptions for hepatic encephalopathy treatment had low PPVs for confirmed (ALF) events. Studies of ALF will need to rely on medical records to confirm this outcome.
AHRQ-funded; HS018372.
Citation: Lo Re V, Carbonari DM, Forde KA .
Validity of diagnostic codes and laboratory tests of liver dysfunction to identify acute liver failure events.
Pharmacoepidemiol Drug Saf 2015 Jul;24(7):676-83. doi: 10.1002/pds.3774..
Keywords: Diagnostic Safety and Quality, Digestive Disease and Health
Khalil D, Boktor M, Mortensen EM
Comparison of frequency of inflammatory bowel disease and noninfectious gastroenteritis among statin users versus nonusers.
The objective of this study was to examine the association of statin use on the prevalence of IBD and noninfectious gastroenteritis (NI-GE) in a cohort of patients who were followed longitudinally in a military health care system, where patients had similar access and availability of health care. It found that statin use was not associated with either an increased or decreased risk of IBD or NI-GE diagnoses.
AHRQ-funded; HS022418.
Citation: Khalil D, Boktor M, Mortensen EM .
Comparison of frequency of inflammatory bowel disease and noninfectious gastroenteritis among statin users versus nonusers.
Am J Cardiol 2015 May 15;115(10):1396-401. doi: 10.1016/j.amjcard.2015.02.035..
Keywords: Digestive Disease and Health, Patient-Centered Outcomes Research, Risk, Medication, Cardiovascular Conditions
Cross RK, Jambaulikar G, Langenberg P
TELEmedicine for Patients with Inflammatory Bowel Disease (TELE-IBD): design and implementation of randomized clinical trial.
This study compares disease activity and quality of life over 1 year in a randomized trial of IBD patients receiving standard care versus telemedicine. If effective, telemedicine should decrease symptoms, improve quality of life, and decrease health care utilization. The burden associated with use of telemedicine for patients and providers needs to be assessed. This trial is ongoing and will be completed in July 2016.
AHRQ-funded; HS018975.
Citation: Cross RK, Jambaulikar G, Langenberg P .
TELEmedicine for Patients with Inflammatory Bowel Disease (TELE-IBD): design and implementation of randomized clinical trial.
Contemp Clin Trials 2015 May;42:132-44. doi: 10.1016/j.cct.2015.03.006..
Keywords: Comparative Effectiveness, Digestive Disease and Health, Health Information Technology (HIT), Patient-Centered Outcomes Research, Telehealth
Hazelwood GS, Rezaie A, Borman M
Comparative effectiveness of immunosuppressants and biologics for inducing and maintaining remission in Crohn's disease: a network meta-analysis.
The authors compared therapies for induction and maintenance of remission in patients with Crohn's disease. They found that adalimumab and infliximab + azathioprine are the most effective therapies for induction and maintenance of remission of Crohn's disease.
AHRQ-funded; HS021747.
Citation: Hazelwood GS, Rezaie A, Borman M .
Comparative effectiveness of immunosuppressants and biologics for inducing and maintaining remission in Crohn's disease: a network meta-analysis.
Gastroenterology 2015 Feb;148(2):344-54.e5; quiz e14-5. doi: 10.1053/j.gastro.2014.10.011.
.
.
Keywords: Comparative Effectiveness, Digestive Disease and Health, Medication, Patient-Centered Outcomes Research, Treatments
Goyette P, Boucher G, Mallon D
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.
Studies in inflammatory bowel diseases (IBD) have indicated that multiple independent associations exist at human leukocyte antigen (HLA) and non-HLA genes, but they have lacked the statistical power to define the architecture of association and causal alleles. To address this, the researchers performed high-density single nucleotide polymorphism (SNP) typing of the major histocompatibility complex in >32,000 individuals with IBD.
AHRQ-funded; HS021747.
Citation: Goyette P, Boucher G, Mallon D .
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.
Nat Genet 2015 Feb;47(2):172-9. doi: 10.1038/ng.3176..
Keywords: Chronic Conditions, Genetics, Digestive Disease and Health
Norman JM, Handley SA, Baldridge MT
Disease-specific alterations in the enteric virome in inflammatory bowel disease.
The researchers show that the enteric virome is abnormal in Crohn's disease (CD) and ulcerative colitis (UC) patients. Their data support a model in which changes in the virome may contribute to intestinal inflammation and bacterial dysbiosis. They conclude that the virome is a candidate for contributing to, or being a biomarker for, human inflammatory bowel disease and speculate that the enteric virome may play a role in other diseases.
AHRQ-funded; HS021747.
Citation: Norman JM, Handley SA, Baldridge MT .
Disease-specific alterations in the enteric virome in inflammatory bowel disease.
Cell 2015 Jan 29;160(3):447-60. doi: 10.1016/j.cell.2015.01.002.
.
.
Keywords: Digestive Disease and Health, Chronic Conditions
Dorn SD, Palsson OS, Woldeghebriel M
Development and pilot testing of an integrated, web-based self-management program for irritable bowel syndrome (IBS).
The researchers developed, assessed, and refined an integrated IBS self-management program (IBS Self-care) and then conducted a 12-week pilot test. They found that the IBS Self-Care program was well received by users who after 12 weeks reported improved knowledge about IBS, but no significant changes in self-efficacy or quality of life.
AHRQ-funded; HS019468.
Citation: Dorn SD, Palsson OS, Woldeghebriel M .
Development and pilot testing of an integrated, web-based self-management program for irritable bowel syndrome (IBS).
Neurogastroenterol Motil 2015 Jan;27(1):128-34. doi: 10.1111/nmo.12487..
Keywords: Patient Self-Management, Health Literacy, Education: Patient and Caregiver, Digestive Disease and Health