National Healthcare Quality and Disparities Report
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AHRQ Research Studies Date
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- Adverse Drug Events (ADE) (1)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 7 of 7 Research Studies DisplayedKelly JP, DeVore AD, Wu J
Rhythm control versus rate control in patients with atrial fibrillation and heart failure with preserved ejection fraction: insights from get with the guidelines-heart failure.
Researchers analyzed the Get With The Guidelines - Heart Failure (GWTG-HF) registry linked to Medicare claims data to describe current treatments for rate versus rhythm control and subsequent outcomes in patients with heart failure with preserved ejection fraction and atrial fibrillation. They found that rhythm control in patients aged 65 and older with heart failure with preserved ejection fraction and AF was associated with a lower risk of one-year all-cause mortality. They recommended future prospective randomized studies to explore this potential benefit.
AHRQ-funded; HS021092.
Citation: Kelly JP, DeVore AD, Wu J .
Rhythm control versus rate control in patients with atrial fibrillation and heart failure with preserved ejection fraction: insights from get with the guidelines-heart failure.
J Am Heart Assoc 2019 Dec 17;8(24):e011560. doi: 10.1161/jaha.118.011560.
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Keywords: Heart Disease and Health, Cardiovascular Conditions, Guidelines, Evidence-Based Practice, Registries, Patient-Centered Outcomes Research
Fanaroff AC, Vora AN, Chen AY
Hospital participation in clinical trials for patients with acute myocardial infarction: results from the National Cardiovascular Data Registry.
Using the nationwide Chest Pain-MI registry, the authors described the proportion of hospitals that enrolled patients with acute myocardial infarction (MI) in clinical trials from 2009 to 2014. They concluded that hospitals are becoming less likely to engage in clinical trials for patients with MI, and that patients admitted to hospitals that participated in clinical trials more often received guideline-adherent care and had better long-term outcomes.
AHRQ-funded; HS021092.
Citation: Fanaroff AC, Vora AN, Chen AY .
Hospital participation in clinical trials for patients with acute myocardial infarction: results from the National Cardiovascular Data Registry.
Am Heart J 2019 Aug;214:184-93. doi: 10.1016/j.ahj.2019.05.011..
Keywords: Cardiovascular Conditions, Heart Disease and Health, Registries, Research Methodologies
Mentias A, Briasoulis A, Shantha G
Impact of heart failure type on thromboembolic and bleeding risk in patients with atrial fibrillation on oral anticoagulation.
Differential impact of heart failure (HF) category on thromboembolic and bleeding risk in atrial fibrillation (AF) patients on oral anticoagulation (OAC) is unknown. In this study, the investigators used Medicare data for beneficiaries with new AF diagnosed between 2011 and 2013 to identify patients with HF with reduced ejection fraction (HFrEF), HF with preserved ejection fraction (HFpEF), and no HF. The investigators concluded that in AF patients, HFrEF and HFpEF are both associated with higher risk of ischemic stroke, HF and AMI admissions, even after adjusting for OAC use, compared with patients without HF.
AHRQ-funded; HS023104.
Citation: Mentias A, Briasoulis A, Shantha G .
Impact of heart failure type on thromboembolic and bleeding risk in patients with atrial fibrillation on oral anticoagulation.
Am J Cardiol 2019 May 15;123(10):1649-53. doi: 10.1016/j.amjcard.2019.02.027..
Keywords: Heart Disease and Health, Cardiovascular Conditions, Blood Thinners, Medication, Adverse Drug Events (ADE), Adverse Events, Risk, Elderly, Patient-Centered Healthcare, Registries
Inohara T, Kim S, Pieper K
B-type natriuretic peptide, disease progression and clinical outcomes in atrial fibrillation.
In this study, the investigators evaluated the association between B-type natriuretic peptide (BNP) levels and outcomes, including atrial fibrillation (AF) progression, composite outcome of major adverse cardiovascular or neurological events (MACNE) and major bleeding, via pooled logistic regression and Cox frailty models in Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II registry.
AHRQ-funded; HS021092.
Citation: Inohara T, Kim S, Pieper K .
B-type natriuretic peptide, disease progression and clinical outcomes in atrial fibrillation.
Heart 2019 Mar;105(5):370-77. doi: 10.1136/heartjnl-2018-313642..
Keywords: Heart Disease and Health, Cardiovascular Conditions, Patient-Centered Outcomes Research, Outcomes, Registries
Alapati V, Tang F, Charlap E
Discharge heart rate after hospitalization for myocardial infarction and long-term mortality in 2 US registries.
In this study, researchers evaluated the association of discharge and admission heart rates with 3-year mortality. They concluded that a higher discharge heart rate after AMI was more strongly associated with 3-year mortality than a high heart rate at admissions.
AHRQ-funded; HS011282.
Citation: Alapati V, Tang F, Charlap E .
Discharge heart rate after hospitalization for myocardial infarction and long-term mortality in 2 US registries.
J Am Heart Assoc 2019 Feb 5;8(3):e010855. doi: 10.1161/jaha.118.010855..
Keywords: Cardiovascular Conditions, Hospital Discharge, Mortality, Heart Disease and Health, Registries
Calkins H, Gliklich RE, Leavy MB
Harmonized outcome measures for use in atrial fibrillation patient registries and clinical practice: endorsed by the Heart Rhythm Society Board of Trustees.
This study used AHRQ’s Outcome Measures Framework (OMF) to create standards so that different registries for atrial fibrillation (AF) can be linked and their data compared. One-hundred outcome measures from 13 different registries were curated and then harmonized according to OMF standards. Twenty measures were created to represent a minimum set of outcomes for research and clinical practice.
AHRQ-funded; 290201400004C.
Citation: Calkins H, Gliklich RE, Leavy MB .
Harmonized outcome measures for use in atrial fibrillation patient registries and clinical practice: endorsed by the Heart Rhythm Society Board of Trustees.
Heart Rhythm 2019 Jan;16(1):e3 - e16. doi: 10.1016/j.hrthm.2018.09.021..
Keywords: Heart Disease and Health, Cardiovascular Conditions, Outcomes, Patient-Centered Outcomes Research, Registries
Anderson JB, Brown DW, Lihn S
Power of a learning network in congenital heart disease.
This paper discusses the efforts of the National Pediatric Cardiology Quality Improvement Collaborative (NPC-QIC). The collaborative formed to improve outcomes in infants with hypoplastic left heart syndrome. It sought to (1) decrease mortality, (2) reduce growth failure, and (3) reduce hospital readmissions due to major medical problems during the interstage period between discharge following stage 1 palliation (S1P) and admission for stage 2 palliation (S2P).
AHRQ-funded; HS016957.
Citation: Anderson JB, Brown DW, Lihn S .
Power of a learning network in congenital heart disease.
World J Pediatr Congenit Heart Surg 2019 Jan;10(1):66-71. doi: 10.1177/2150135118815023..
Keywords: Cardiovascular Conditions, Children/Adolescents, Education: Continuing Medical Education, Palliative Care, Quality Improvement, Registries