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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 5 of 5 Research Studies DisplayedKhamash DF, Voskertchian A, Tamma PD
Increasing clindamycin and trimethoprim-sulfamethoxazole resistance in pediatric Staphylococcus aureus Infections.
This retrospective observational study looked at pediatric clinical cultures between 2005 and 2017 that grew Staphylococcus aureus culture and their trends in antibiotic resistance. Methicillin resistance declined but clindamycin and trimethoprim-sulfamethoxazole resistance increased significantly.
AHRQ-funded; HS022872.
Citation: Khamash DF, Voskertchian A, Tamma PD .
Increasing clindamycin and trimethoprim-sulfamethoxazole resistance in pediatric Staphylococcus aureus Infections.
J Pediatric Infect Dis Soc 2019 Sep 25;8(4):351-53. doi: 10.1093/jpids/piy062..
Keywords: Children/Adolescents, Antibiotics, Medication, Healthcare-Associated Infections (HAIs), Infectious Diseases, Methicillin-Resistant Staphylococcus aureus (MRSA)
Khamash DF, Voskertchian A, Tamma PD
Increasing clindamycin and trimethoprim-sulfamethoxazole resistance in pediatric Staphylococcus aureus Infections.
This retrospective observational study looked at pediatric clinical cultures between 2005 and 2017 that grew Staphylococcus aureus culture and their trends in antibiotic resistance. Methicillin resistance declined but clindamycin and trimethoprim-sulfamethoxazole resistance increased significantly.
AHRQ-funded; HS022872.
Citation: Khamash DF, Voskertchian A, Tamma PD .
Increasing clindamycin and trimethoprim-sulfamethoxazole resistance in pediatric Staphylococcus aureus Infections.
J Pediatric Infect Dis Soc 2019 Sep 25;8(4):351-53. doi: 10.1093/jpids/piy062..
Keywords: Children/Adolescents, Healthcare-Associated Infections (HAIs), Antibiotics, Medication
Murray MT, Johnson CL, Cohen B
Use of antibiotics in paediatric long-term care facilities.
The authors sought to describe antibiotic use in three pediatric long-term care (LTC) facilities and to describe the factors associated with use. They found that the use of antibiotics in pediatric LTC facilities is widespread. They recommended further assessment of antibiotic use in pediatric LTC facilities.
AHRQ-funded; HS021470.
Citation: Murray MT, Johnson CL, Cohen B .
Use of antibiotics in paediatric long-term care facilities.
J Hosp Infect 2018 Jun;99(2):139-44. doi: 10.1016/j.jhin.2017.10.019.
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Keywords: Antibiotics, Children/Adolescents, Healthcare-Associated Infections (HAIs), Long-Term Care, Practice Patterns
McBride S, Thurm C, Gouripeddi R
Comparison of empiric antibiotics for acute osteomyelitis in children.
Broad-spectrum antibiotics are commonly used for the empiric treatment of acute hematogenous osteomyelitis and often target methicillin-resistant Staphylococcus aureus (MRSA) with medication-associated risk and unknown treatment benefit. In this study, the investigators aimed to compare clinical outcomes among patients with osteomyelitis who did and did not receive initial antibiotics used to target MRSA. The investigators found that, early antibiotic treatment used to target MRSA was associated with a higher rate of repeat MRI.
AHRQ-funded; HS019862.
Citation: McBride S, Thurm C, Gouripeddi R .
Comparison of empiric antibiotics for acute osteomyelitis in children.
Hosp Pediatr 2018 May;8(5):280-87. doi: 10.1542/hpeds.2017-0079..
Keywords: Children/Adolescents, Antibiotics, Methicillin-Resistant Staphylococcus aureus (MRSA), Healthcare-Associated Infections (HAIs), Medication, Imaging, Patient Safety
Hogan PG, Rodriguez M, Spenner AM
Impact of systemic antibiotics on staphylococcus aureus colonization and recurrent skin infection.
This study found that systemic antibiotics, as part of acute skin and soft tissue infection (SSTI) management in conjunction with incision and drainage, impacted S. aureus colonization, thus contributing to a decreased incidence of recurrent SSTI. The mechanism by which clindamycin differentially affects colonization and recurrent SSTI compared to trimethoprim-sulfamethoxazole (TMP-SMX) warrants further study.
AHRQ-funded; HS021736; HS024269.
Citation: Hogan PG, Rodriguez M, Spenner AM .
Impact of systemic antibiotics on staphylococcus aureus colonization and recurrent skin infection.
Clin Infect Dis 2018 Jan 6;66(2):191-97. doi: 10.1093/cid/cix754.
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Keywords: Antibiotics, Children/Adolescents, Healthcare-Associated Infections (HAIs), Patient Safety, Skin Conditions