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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 14 of 14 Research Studies DisplayedWang Z, Whiteside SPH, Sim L
Comparative effectiveness and safety of cognitive behavioral therapy and pharmacotherapy for childhood anxiety disorders: a systematic review and meta-analysis.
This review evaluated the comparative effectiveness and adverse events of cognitive behavioral therapy (CBT) and pharmacotherapy for childhood anxiety disorders. Evidence supports the effectiveness of CBT and selective serotonin reuptake inhibitors (SSRIs) for reducing childhood anxiety symptoms. Serotonin-norepinephrine reuptake inhibitors also appear to be effective based on less consistent evidence.
AHRQ-funded; 290201500013I.
Citation: Wang Z, Whiteside SPH, Sim L .
Comparative effectiveness and safety of cognitive behavioral therapy and pharmacotherapy for childhood anxiety disorders: a systematic review and meta-analysis.
JAMA Pediatr 2017 Nov;171(11):1049-56. doi: 10.1001/jamapediatrics.2017.3036.
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Keywords: Anxiety, Behavioral Health, Children/Adolescents, Comparative Effectiveness, Medication
McKernan LC, Finn MTM, Carr ER
Personality and affect when the central nervous system is sensitized: an analysis of central sensitization syndromes in a substance use disorder population.
This article examined the impact of central sensitivity syndromes (CSS) on the clinical presentation of individuals presenting to treatment for a substance use disorder (SUD), with an emphasis on personality and emotional functioning. Exploratory analyses indicated which personality traits most strongly predicted the presence of CSS. The authors discuss these findings using descriptive psychopathology literature, with recommendations for future research.
AHRQ-funded; HS022990.
Citation: McKernan LC, Finn MTM, Carr ER .
Personality and affect when the central nervous system is sensitized: an analysis of central sensitization syndromes in a substance use disorder population.
Psychodyn Psychiatry 2017 Fall;45(3):385-409. doi: 10.1521/pdps.2017.45.3.385..
Keywords: Anxiety, Behavioral Health, Chronic Conditions, Substance Abuse
McBride NM, Johnco C, Salloum A
Prevalence and clinical differences of suicidal thoughts and behaviors in a community sample of youth receiving cognitive-behavioral therapy for anxiety.
This study examined the incidence of suicidal thoughts and behaviors in youth with anxiety before initiating cognitive behavioral therapy, as well as the emergence of suicidal thoughts and behaviors during treatment. Findings suggest that the assessment of suicidality at a single time-point and from one informant is not sufficient to identify at-risk youth. Ongoing assessment of suicidal risk during treatment is important in this population.
AHRQ-funded; HS018665.
Citation: McBride NM, Johnco C, Salloum A .
Prevalence and clinical differences of suicidal thoughts and behaviors in a community sample of youth receiving cognitive-behavioral therapy for anxiety.
Child Psychiatry Hum Dev 2017 Oct;48(5):705-13. doi: 10.1007/s10578-016-0696-6..
Keywords: Anxiety, Behavioral Health, Children/Adolescents, Depression
Albrecht JS, Peters ME, Smith GS
Anxiety and posttraumatic stress disorder among Medicare beneficiaries after traumatic brain injury.
This study estimated rates of anxiety and posttraumatic stress disorder (PTSD) diagnoses after traumatic brain injury (TBI) among Medicare beneficiaries. After TBI, 16,519 (17 percent) beneficiaries were diagnosed with anxiety and 269 (0.3 percent) were diagnosed with PTSD. Rates of anxiety and PTSD diagnoses were highest in the first 5 months post-TBI and decreased over time.
AHRQ-funded; HS024560.
Citation: Albrecht JS, Peters ME, Smith GS .
Anxiety and posttraumatic stress disorder among Medicare beneficiaries after traumatic brain injury.
J Head Trauma Rehabil 2017 May/Jun;32(3):178-84. doi: 10.1097/htr.0000000000000266.
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Keywords: Anxiety, Brain Injury, Medicare, Behavioral Health, Trauma
Sawchuk CN, Roy-Byrne P, Noonan C
Panic attacks and panic disorder in the American Indian community.
The purpose of this study is to describe the epidemiology, clinical features, and comorbidities of panic attacks and panic disorder in two large American Indian tribes. It found that the prevalence and clinical features of panic attacks and panic disorder in American Indians were similar to epidemiologic studies with majority populations. However, in contrast to earlier research, panic symptoms were similar in both males and females, and different patterns of comorbidity emerged.
AHRQ-funded; HS010854.
Citation: Sawchuk CN, Roy-Byrne P, Noonan C .
Panic attacks and panic disorder in the American Indian community.
J Anxiety Disord 2017 May;48:6-12. doi: 10.1016/j.janxdis.2016.10.004.
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Keywords: Anxiety, Behavioral Health, Racial and Ethnic Minorities, Racial and Ethnic Minorities, Stress
Musey PI, Jr., Kline JA
Emergency department cardiopulmonary evaluation of low-risk chest pain patients with self-reported stress and anxiety.
This study aimed to was to measure the frequency of self-identified stress or anxiety among chest pain patients, and compare their pretest probabilities, care processes, and outcomes. It concluded that without prompting, 8 percent of patients self-identified "stress" or "anxiety" as the etiology for their chest pain. Most had low pretest probability, were over-investigated for acute coronary syndrome and pulmonary embolism and not investigated for anxiety syndromes.
AHRQ-funded; HS018519.
Citation: Musey PI, Jr., Kline JA .
Emergency department cardiopulmonary evaluation of low-risk chest pain patients with self-reported stress and anxiety.
J Emerg Med 2017 Mar;52(3):273-79. doi: 10.1016/j.jemermed.2016.11.022.
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Keywords: Anxiety, Emergency Department, Health Services Research (HSR), Pain, Stress
Hamblin RJ, Lewin AB, Salloum A
Clinical characteristics and predictors of hoarding in children with anxiety disorders.
This investigation was conducted to describe the clinical characteristics of anxious children with significant hoarding behavior and to examine the contributions of anxiety, obsessive compulsive, and inattentive and hyperactive/impulsive symptoms in the prediction of hoarding. Its findings suggest a pattern of behavioral and emotional dysregulation for children who hoard and provide further insight into the relationships between anxiety, attention problems, and hoarding.
AHRQ-funded; HS018665.
Citation: Hamblin RJ, Lewin AB, Salloum A .
Clinical characteristics and predictors of hoarding in children with anxiety disorders.
J Anxiety Disord 2015 Dec;36:9-14. doi: 10.1016/j.janxdis.2015.07.006.
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Keywords: Children/Adolescents, Anxiety, Behavioral Health
Storch EA, Salloum A, King MA
A randomized controlled trial in community mental health centers of computer-assisted cognitive behavioral therapy versus treatment as usual for children with anxiety.
This study aimed to examine the real-world effectiveness of a computer-assisted cognitive behavioral therapy (CBT) protocol relative to treatment as usual (TAU) among anxious children presenting at community mental health centers. It found that relative to TAU, computer-assisted CBT was associated with greater reductions in parent-rated child impairment and internalizing symptoms, but not child-rated impairment and anxiety and depressive symptoms.
AHRQ-funded; HS018665.
Citation: Storch EA, Salloum A, King MA .
A randomized controlled trial in community mental health centers of computer-assisted cognitive behavioral therapy versus treatment as usual for children with anxiety.
Depress Anxiety 2015 Nov;32(11):843-52. doi: 10.1002/da.22399.
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Keywords: Anxiety, Children/Adolescents, Health Information Technology (HIT), Community-Based Practice, Patient-Centered Outcomes Research
Johnco CJ, Salloum A, Lewin AB
Refining clinical judgment of treatment response and symptom remission identification in childhood anxiety using a signal detection analysis on the pediatric anxiety rating scale.
The purpose of this study was to determine guidelines for delineating treatment response and symptom remission for children with anxiety disorder based on the five item Pediatric Anxiety Rating Scale (PARS5), and replicate guidelines using the six item PARS (PARS6). Optimal prediction of treatment response based on gold standard criteria was achieved at 15-20 percent reduction in symptoms on the PARS5 (with 20 percent reduction achieving marginally higher accuracy), and 20 percent reduction on the PARS6.
AHRQ-funded; HS018665.
Citation: Johnco CJ, Salloum A, Lewin AB .
Refining clinical judgment of treatment response and symptom remission identification in childhood anxiety using a signal detection analysis on the pediatric anxiety rating scale.
J Child Adolesc Psychopharmacol 2015 Nov;25(9):674-83. doi: 10.1089/cap.2015.0102.
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Keywords: Children/Adolescents, Anxiety, Diagnostic Safety and Quality, Guidelines
Storch EA, Salloum A, Johnco C
Phenomenology and clinical correlates of family accommodation in pediatric anxiety disorders.
This study assessed the nature and clinical correlates of family accommodation in pediatric anxiety, as well as validating a mechanistic model. It concluded that family accommodation was associated with increased anxiety severity and externalizing behaviors, having a diagnosis of separation anxiety, and increased functional impairment. Family accommodation partially mediated the relationship between anxiety severity and functional impairment.
AHRQ-funded; HS018665.
Citation: Storch EA, Salloum A, Johnco C .
Phenomenology and clinical correlates of family accommodation in pediatric anxiety disorders.
J Anxiety Disord 2015 Oct;35:75-81. doi: 10.1016/j.janxdis.2015.09.001.
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Keywords: Children/Adolescents, Anxiety, Behavioral Health, Children/Adolescents, Family Health and History
Johnco CJ, Salloum A, De Nadai AS
Incidence, clinical correlates and treatment effect of rage in anxious children.
This study examined the incidence and clinical correlates of rage in children with anxiety disorders. Change in rage during treatment for anxiety was also examined. It found that rage was associated with a more severe clinical profile, including increased anxiety severity, functional impairment, family accommodation and caregiver strain, as well as poorer relationships with parents, siblings, extended family and peers.
AHRQ-funded; HS018665.
Citation: Johnco CJ, Salloum A, De Nadai AS .
Incidence, clinical correlates and treatment effect of rage in anxious children.
Psychiatry Res 2015 Sep 30;229(1-2):63-9. doi: 10.1016/j.psychres.2015.07.071..
Keywords: Anxiety, Behavioral Health, Children/Adolescents, Family Health and History
Johnco CJ, Salloum A, Lewin AB
The impact of comorbidity profiles on clinical and psychosocial functioning in childhood anxiety disorders.
This study compared the profile of children with a primary anxiety disorder without comorbidity to those with different comorbidity profiles in a treatment-seeking sample of 111 children recruited from community mental health settings. It found that anxiety severity and depressive symptomatology did not vary by comorbidity profile. Anxious children without comorbidity had lower levels of aggressive and externalizing behaviors compared to the comorbid ADHD group.
AHRQ-funded; HS018665.
Citation: Johnco CJ, Salloum A, Lewin AB .
The impact of comorbidity profiles on clinical and psychosocial functioning in childhood anxiety disorders.
Psychiatry Res 2015 Sep 30;229(1-2):237-44. doi: 10.1016/j.psychres.2015.07.027..
Keywords: Children/Adolescents, Anxiety, Behavioral Health
Fernandes-Taylor S, Adesoye T, Bloom JR
Managing psychosocial issues faced by young women with breast cancer at the time of diagnosis and during active treatment.
This review examines recent literature on the psychosocial needs of and interventions for young women. It focuses on the active treatment period given the toxicity of treatment, the incidence of anxiety, and depressive symptoms in these women during treatment. It concluded that shared decision-making, balancing body image, fear of recurrence, and recommended treatment, and palliative care for metastasis are essential research priorities for the clinical setting.
AHRQ-funded; HS023395.
Citation: Fernandes-Taylor S, Adesoye T, Bloom JR .
Managing psychosocial issues faced by young women with breast cancer at the time of diagnosis and during active treatment.
Curr Opin Support Palliat Care 2015 Sep;9(3):279-84. doi: 10.1097/spc.0000000000000161..
Keywords: Anxiety, Cancer: Breast Cancer, Shared Decision Making, Depression, Quality of Life
Salloum A, Crawford EA, Lewin AB
Consumers' and providers' perceptions of utilizing a computer-assisted cognitive behavioral therapy for childhood anxiety.
The purpose of this study was to explore consumers’ and providers’ perceptions of utilizing a Computer-Assisted Cognitive Behavioral Therapy (CCBT) for childhood anxiety in community mental health centers (CMHC) in an effort to identify factors that may impact implementation of CCBT in CMHC. Results suggest that both consumers and providers were highly receptive to participation in and implementation of CCBT in CMHC.
AHRQ-funded; HS018665.
Citation: Salloum A, Crawford EA, Lewin AB .
Consumers' and providers' perceptions of utilizing a computer-assisted cognitive behavioral therapy for childhood anxiety.
Behav Cogn Psychother 2015 Jan;43(1):31-41. doi: 10.1017/s1352465813000647..
Keywords: Anxiety, Children/Adolescents, Community-Based Practice, Health Information Technology (HIT), Patient Experience