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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 1 of 1 Research Studies DisplayedOke I, Reshef ER, Elze T
Smoking is associated with a higher risk of surgical intervention for thyroid eye disease in the IRIS registry.
This study’s purpose was to describe the association of smoking status with surgical intervention for thyroid eye disease (TED) at the population-level. This retrospective cohort study included all adults (aged ≥18 years) with Graves disease (87,774 total) in the Intelligent Research in Sight (IRIS) Registry (January 1, 2013, to December 31, 2020). Primary outcomes were surgical intervention for TED, stratified into orbital decompression, strabismus surgery, and eyelid recession surgery. The median age was 59 years, and 81% were female. Current smokers had a greater 5-year cumulative probability of orbital decompression (3.7% vs 1.9%), strabismus surgery (4.6% vs 2.2%), and eyelid recession (4.1% vs 2.6%) compared to never smokers. After adjusting for demographic factors, current smokers were at greater risk for orbital decompression, strabismus surgery, and eyelid recession than never smokers. Former smokers were at higher risk for each type of surgery for TED, although at lower levels than current smokers.
AHRQ-funded; HS000063.
Citation: Oke I, Reshef ER, Elze T .
Smoking is associated with a higher risk of surgical intervention for thyroid eye disease in the IRIS registry.
Am J Ophthalmol 2023 May; 249:174-82. doi: 10.1016/j.ajo.2023.01.020..
Keywords: Tobacco Use, Eye Disease and Health