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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 4 of 4 Research Studies DisplayedFishbein AB, Lor J, Penedo FJ
Patient-reported outcomes for measuring sleep disturbance in pediatric atopic dermatitis: cross-sectional study of the patient reported outcomes measurement information system pediatric sleep measures and actigraphy.
The purposes of this cross-sectional study were to test the Patient-Reported Outcomes Measurement Information System (PROMIS) sleep measures in pediatric atopic dermatitis (AD) and to develop an algorithm to screen, evaluate, and intervene to reduce sleep disturbances. Participants were children with AD aged 5 to 17 and one parent who completed sleep, itch, and AD-specific questionnaires. Clinicians assessed disease severity. PROMIS sleep disturbance parent proxy reliability was high and was differentiated among Patient-Oriented Eczema Measure (POEM)-determined disease severity groups. The authors concluded that sleep disturbance in pediatric AD should be screened using the POEM sleep question, and further assessment using the PROMIS sleep disturbance measure or objective sleep monitoring if it is needed.
AHRQ-funded; HS023011.
Citation: Fishbein AB, Lor J, Penedo FJ .
Patient-reported outcomes for measuring sleep disturbance in pediatric atopic dermatitis: cross-sectional study of the patient reported outcomes measurement information system pediatric sleep measures and actigraphy.
J Am Acad Dermatol 2023 Feb; 88(2):348-56. doi: 10.1016/j.jaad.2020.05.138..
Keywords: Children/Adolescents, Sleep Problems, Skin Conditions, Patient-Centered Outcomes Research, Evidence-Based Practice
Silverberg JI, Lei D, Yousaf M
Measurement properties of the product of investigator's global assessment and body surface area in children and adults with atopic dermatitis.
This study’s goal was to determine the measurement properties of the product of validated Investigator’s Global Assessment for AD and body surface area (vIGA*BSA) for atopic dermatitis (AD) severity. The authors performed a prospective practice-based study using questionnaires and evaluation by a dermatologist (n = 653). The vIGA*BSA can also be divided into six categories (vIGA*cBSA: 0%/0.1, <10%/10, <30%/30, <50%/50, <70%/70 and <90%/90-100%)). The assessment was compared with other rating scales such as SCORAD, Patient-Oriented Eczema Measure, Dermatology Life Quality Index, ItchyOOL, PROMISE Sleep Disturbance, and sleep-related impairment. Scores showed good convergent and discriminant validity, reliability, responsiveness and interpretability in adults and children with AD.
AHRQ-funded; HS023011.
Citation: Silverberg JI, Lei D, Yousaf M .
Measurement properties of the product of investigator's global assessment and body surface area in children and adults with atopic dermatitis.
J Eur Acad Dermatol Venereol 2021 Jan;35(1):180-87. doi: 10.1111/jdv.16846..
Keywords: Children/Adolescents, Skin Conditions, Patient-Centered Outcomes Research, Evidence-Based Practice
Silverberg JI, Lei D, Yousaf M
Measurement properties of the Rajka-Langeland severity score in children and adults with atopic dermatitis.
This study looked at the measurement properties of the Rajka-Langeland severity score for atopic dermatitis (AD) in children and adults and compared it with other clinician-reported outcomes. The study used questionnaires and evaluation by a dermatologist (n = 427). Rajka-Langeland had good concurrent validity with the Eczema Area and Severity Index and body surface area; good convergent validity with the numeric rating scale average-itch and worst-itch, Patient-Oriented Eczema Measure, Dermatology Life Quality Index, Patient Reported Outcomes Measurement Information System Itch Questionnaire in adults and/or children; fair discriminant validity for patient- and physician reported global AD severity; good responsive to change of severity of AD and itch; and good reliability, internal consistency; with no floor or ceiling effects.
AHRQ-funded; HS023011.
Citation: Silverberg JI, Lei D, Yousaf M .
Measurement properties of the Rajka-Langeland severity score in children and adults with atopic dermatitis.
Br J Dermatol 2021 Jan;184(1):87-95. doi: 10.1111/bjd.19159..
Keywords: Children/Adolescents, Skin Conditions, Patient-Centered Outcomes Research, Evidence-Based Practice
Greenhawt M, Shaker M
Determining levers of cost-effectiveness for screening infants at high risk for peanut sensitization before early peanut introduction.
The authors sought to identify scenarios in which current early peanut introduction guidelines would be cost-effective. They found that the current screening approach to early peanut introduction could be cost-effective at a particular health utility for an in-clinic reaction, skin prick test sensitivity and specificity, and high baseline peanut allergy prevalence among high-risk infants. However, such conditions are unlikely to be plausible to achieve realistically. They recommend further research to define the health state utility associated with reaction location.
AHRQ-funded; HS024599.
Citation: Greenhawt M, Shaker M .
Determining levers of cost-effectiveness for screening infants at high risk for peanut sensitization before early peanut introduction.
JAMA Netw Open 2019 Dec 2;2(12):e1918041. doi: 10.1001/jamanetworkopen.2019.18041..
Keywords: Patient-Centered Outcomes Research, Newborns/Infants, Children/Adolescents, Respiratory Conditions, Skin Conditions, Screening, Healthcare Costs, Evidence-Based Practice, Guidelines