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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 1 of 1 Research Studies DisplayedBajaj JS, Peña-Rodriguez M, La Reau A
Longitudinal transkingdom gut microbial approach towards decompensation in outpatients with cirrhosis.
The purpose of this study was to ascertain the crucial role of predicting the onset of initial decompensation development. It emphasizes the significance of transkingdom gut microbial interactions, including archaeal methanogens, as potential markers and predictors, and the need for a longitudinal approach to do so. The study included cirrhosis outpatients who were categorized into three groups: those with compensated cirrhosis in Group 1, those with one incidence of decompensation in Group 2, and those with more than one incidence of decompensation in Group 3. Group 3 was further divided based on stability or further decompensation. The presence of bacteria, viruses, and archaea, along with α/β diversity and temporal taxa fluctuations adjusted for clinical variables were analyzed. The study tracked 157 outpatients and found that between 28% and 47% of those patients developed outcomes. Baseline between those who remained stable/developed outcome: While no differences were seen in α/β diversity, commensals were lower and pathobionts were higher in those who decompensated. After decompensation: those experiencing their first decompensation showed a larger decrease in α/β-diversity, bacterial change and viral change vs those with further decompensation. Archaea: 19% had Methanobacter brevii, which was similar between/within groups. The study concluded that the largest changes in transkingdom gut microbial were observed in those reaching the first decompensation, compared with subsequent decompensating events.
AHRQ-funded; HS025412.
Citation: Bajaj JS, Peña-Rodriguez M, La Reau A .
Longitudinal transkingdom gut microbial approach towards decompensation in outpatients with cirrhosis.
Gut 2023 Apr; 72(4):759-71. doi: 10.1136/gutjnl-2022-328403.
AHRQ-funded; HS025412.
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AHRQ-funded; HS025412.
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Keywords: Chronic Conditions, Ambulatory Care and Surgery, Outcomes