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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 2 of 2 Research Studies DisplayedDenstaedt SJ, Cano J, Wang XQ
Blood count derangements after sepsis and association with post-hospital outcomes.
Estimating long-term prognosis for sepsis survivors remains challenging. Prolonged inflammation following sepsis is linked to a higher likelihood of readmission and mortality. Complete blood count (CBC) parameters, as indicators of inflammation, might hold prognostic significance for sepsis survivors when measured at the time of hospital discharge. The purpose of this study was to assess the additional value of CBC parameters in predicting 90-day outcomes in sepsis survivors, beyond clinical features alone. Electronic health records were utilized to identify sepsis-related hospitalizations at US Veterans Affairs hospitals involving live discharge and relevant laboratory data (2013-2018). The researchers examined the relationship between eight CBC parameters and 90-day outcomes (mortality, readmission, cause-specific readmissions) using multivariable logistic regression models. The study found 155,988 eligible sepsis hospitalizations. Anemia and lymphopenia were the most prevalent blood count abnormalities at discharge. In multivariable models, all parameters correlated with the primary outcome of 90-day mortality or readmission and enhanced model discrimination beyond clinical features alone. Hemoglobin exhibited the highest prognostic distinction, with a 1.5-fold increase in the incidence of the primary outcome in the lowest quintile compared to the highest quintile Hemoglobin and neutrophil-lymphocyte ratio contributed the most added value in predicting the primary outcome and 90-day mortality independently. Absolute lymphocyte count offered minimal value in forecasting 90-day outcomes.
AHRQ-funded; HS026725
Citation: Denstaedt SJ, Cano J, Wang XQ .
Blood count derangements after sepsis and association with post-hospital outcomes.
Front Immunol 2023 Feb 28;14:1133351. doi: 10.3389/fimmu.2023.1133351.
Keywords: Sepsis, Outcomes
Mohr NM, Okoro U, Harland KK
Outcomes associated with rural emergency department provider-to-provider telehealth for sepsis care: a multicenter cohort study.
The objective of this multicenter cohort study was to test the hypothesis that provider-to-provider tele-emergency department (tele-ED) care is associated with more 28-day hospital-free days and improved Surviving Sepsis Campaign (SSC) guideline adherence in rural emergency departments. Medical records of patients with sepsis were taken from rural hospitals in an established, on-demand, video tele-ED Midwestern network. Findings suggest that tele-ED cases did not have more 28-day hospital-free days or 28-day in-hospital mortality. A subgroup of patients treated by advanced practice providers suggest that mortality was lower in the cohort with tele-ED use in spite of no significant difference in complete SSC adherence. The researchers concluded that rural emergency department patients treated with provider-to-provider tele-ED care in a developed network showed similar clinical outcomes to those treated without.
AHRQ-funded; HS025753.
Citation: Mohr NM, Okoro U, Harland KK .
Outcomes associated with rural emergency department provider-to-provider telehealth for sepsis care: a multicenter cohort study.
Ann Emerg Med 2023 Jan;81(1):1-13. doi: 10.1016/j.annemergmed.2022.07.024..
Keywords: Rural Health, Emergency Department, Telehealth, Health Information Technology (HIT), Sepsis, Outcomes