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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 12 of 12 Research Studies DisplayedLake ET, Staiger D, Smith JG
The association of missed nursing care with very low birthweight infant outcomes.
This study examined the association of missed nursing care and health outcomes of very low birthweight (VLBW) infants in neonatal intensive care units (NICUs). The authors used 2016 hospital administrative discharge abstracts for VLBW newborns (n = 7,595) and NICU registered nurse survey responses (n = 6,963) from the National Database of Nursing Quality Indicators. Mortality, morbidity, and length of stay (LOS) was examined in 190 sample hospitals from 19 states in all regions. There was a significant association between higher odds of bloodstream infection and longer LOS, but not mortality or severe intraventricular hemorrhage and missed nursing care.
AHRQ-funded; HS024918.
Citation: Lake ET, Staiger D, Smith JG .
The association of missed nursing care with very low birthweight infant outcomes.
Med Care Res Rev 2023 Jun; 80(3):293-302. doi: 10.1177/10775587221150950..
Keywords: Healthcare Cost and Utilization Project (HCUP), Quality Indicators (QIs), Nursing, Newborns/Infants, Outcomes, Healthcare Utilization, Quality of Care
Wu AJ, Du N, Chen TY
Sociodemographic differences of hospitalization and associations of resource utilization for failure to thrive.
The objective of this study was to examine sociodemographic differences between elective and nonelective admissions for failure to thrive. Researchers investigated associations between admission type and hospital resource utilization, including length of stay and feeding tube placement. The study included data on children less than 2 years old with failure to thrive in the Kids' Inpatient Database. The findings showed differences by race and ethnicity, income, and insurance type, among other factors. Nonelective admissions had higher proportions of infants who were Black, Hispanic, and of lower-income, and were associated with longer lengths of stay. The researchers concluded that future research is needed to elucidate drivers of these differences, particularly those related to racial and ethnic disparities and structural racism.
AHRQ-funded; HS000063.
Citation: Wu AJ, Du N, Chen TY .
Sociodemographic differences of hospitalization and associations of resource utilization for failure to thrive.
J Pediatr Gastroenterol Nutr 2023 Mar;76(3):385-89. doi: 10.1097/mpg.0000000000003694.
Keywords: Newborns/Infants, Healthcare Cost and Utilization Project (HCUP), Hospitalization, Healthcare Utilization, Children/Adolescents, Racial and Ethnic Minorities, Low-Income
Ko JY, Hirai AH, Owens PL
AHRQ Author: Owens PL
Neonatal abstinence syndrome and maternal opioid-related diagnoses: analysis of ICD-10-CM transition, 2013-2017.
Researchers sought to evaluate whether the transition from ICD-9-CM to ICD-10-CM may have affected surveillance on rates of neonatal abstinence syndrome (NAS), maternal opioid use disorder (OUD), and opioid-related diagnoses. Using HCUP data, they found that the ICD-10-CM transition did not appear to affect NAS. However, coding of maternal OUD alone may not capture the same population across the transition, potentially confounding the interpretation of trend data spanning this time period.
AHRQ-authored.
Citation: Ko JY, Hirai AH, Owens PL .
Neonatal abstinence syndrome and maternal opioid-related diagnoses: analysis of ICD-10-CM transition, 2013-2017.
Hosp Pediatr 2021 Aug;11(8):902-08. doi: 10.1542/hpeds.2021-005845..
Keywords: Healthcare Cost and Utilization Project (HCUP), Newborns/Infants, Opioids, Medication, Pregnancy, Substance Abuse
Hirai AH, Ko JY, Owens PL
AHRQ Author: Owens PL, Stocks C
Neonatal abstinence syndrome and maternal opioid-Related diagnoses in the US, 2010-2017.
This study analyzed trends in neonatal abstinence syndrome (NAS) and maternal opioid-Related diagnosis (MOD) in the United States from 2010 to 2017. A cross-sectional analysis was done of the HCUP National Inpatient Sample and State Inpatient Database from 2010 through 2017. Diagnoses of NAS and MOD were found using the ICD-10, CM codes. Significant increases occurred in rates of NAS, from 4.0 to 7.3 per birth hospitalizations and MOD, from 3.5 to 8.2 per 1000 delivery hospitalizations. A census of 47 state databases in 2017 found a large range of NAS rates – from 1.3 per 1000 birth hospitalizations in Nebraska to 53.5 per 1000 hospitalizations in West Virginia with the same ranges found for MOD rates. In all states except Nebraska and Vermont which only had significant MOD increases, NAS and MOD rates rose significantly from 2010 to 2017.
AHRQ-authored; AHRQ-funded; 290201800001C.
Citation: Hirai AH, Ko JY, Owens PL .
Neonatal abstinence syndrome and maternal opioid-Related diagnoses in the US, 2010-2017.
Neonatal abstinence syndrome and maternal opioid-Related diagnoses in the US, 2010-2017..
Keywords: Healthcare Cost and Utilization Project (HCUP), Newborns/Infants, Opioids, Medication, Substance Abuse, Hospitalization, Pregnancy
Rosenbloom J, Lewkowitz A, Sondgeroth K
Antenatal corticosteroid administration in late-preterm gestations: a cost-effectiveness analysis.
The purpose of this study was to evaluate whether administration of antenatal late-preterm betamethasone was cost-effective in the immediate neonatal period. Cost-effectiveness analysis of late-preterm betamethasone administration with a time horizon of 7.5 days was conducted using a health-system perspective The investigators concluded that administration of betamethasone in the late-preterm period was likely not cost-effective in the short-term.
AHRQ-funded; HS022330.
Citation: Rosenbloom J, Lewkowitz A, Sondgeroth K .
Antenatal corticosteroid administration in late-preterm gestations: a cost-effectiveness analysis.
J Matern Fetal Neonatal Med 2020 Jun;33(12):2109-15. doi: 10.1080/14767058.2018.1540582..
Keywords: Healthcare Cost and Utilization Project (HCUP), Newborns/Infants, Pregnancy, Respiratory Conditions, Medication, Healthcare Costs, Healthcare Utilization
Nguyen DK, Friedlander S, Fleischman RJ
Length of stay and complications associated with febrile infants <90 days of age hospitalized in the United States, 2000-2012.
This study tracked length of stay (LOS) and complications associated with febrile infants younger than 90 days hospitalized in the United States from 2000-2012. Data from the HCUP Kids’ Inpatient Database and other state-specific data was used to identify infants hospitalized in 2000, 2003, 2006, 2009, and 2012. Multivariate analysis was used to determine LOS, risk factors for prolonged LOS, and complications of care among infants with isolated fever or viral respiratory disease. 44,875 infants were identified with approximately two-thirds staying for 2 days or less, and 11% for 4 days or more. Factors associated with longer LOS included younger age, critical clinical status, concomitant chronic disease, and presence of complications.
AHRQ-funded; HS024146.
Citation: Nguyen DK, Friedlander S, Fleischman RJ .
Length of stay and complications associated with febrile infants <90 days of age hospitalized in the United States, 2000-2012.
Hosp Pediatr 2018 Dec;8(12):746-52. doi: 10.1542/hpeds.2018-0132..
Keywords: Healthcare Cost and Utilization Project (HCUP), Hospitalization, Newborns/Infants, Children/Adolescents
Han RH, McKinnon A, CreveCoeur TS
Predictors of mortality for preterm infants with intraventricular hemorrhage: a population-based study.
This study examined the risk factors for mortality in preterm infants with intraventricular hemorrhage (IVH). An overall inpatient mortality occurred in 10% of the cohort of 7437 preterm infants born between 2005 and 2014. Mortality risk was independently associated with a variety of factors including male sex, Asian race, lower gestational age, higher IVH grade, gastrotomy, tracheostomy, and shunt infection.
AHRQ-funded; HS019455.
Citation: Han RH, McKinnon A, CreveCoeur TS .
Predictors of mortality for preterm infants with intraventricular hemorrhage: a population-based study.
Childs Nerv Syst 2018 Nov;34(11):2203-13. Epub ahead of print. doi: 10.1007/s00381-018-3897-4..
Keywords: Healthcare Cost and Utilization Project (HCUP), Mortality, Newborns/Infants, Outcomes
Weinberger DM, Warren JL, Steiner CA
AHRQ Author: Steiner CA
Reduced-dose schedule of prophylaxis based on local data provides near-optimal protection against respiratory syncytial virus.
The researchers considered whether a reduced- dose schedule tailored to the local RSV season in the continental United States would provide adequate protection. They found that a 4-dose schedule of prophylactic injections timed with local RSV epidemics could provide protection comparable to 5 doses and could be considered as a way to improve the cost-effectiveness of prophylaxis.
AHRQ-authored.
Citation: Weinberger DM, Warren JL, Steiner CA .
Reduced-dose schedule of prophylaxis based on local data provides near-optimal protection against respiratory syncytial virus.
Clin Infect Dis 2015 Aug 15;61(4):506-14. doi: 10.1093/cid/civ331..
Keywords: Healthcare Cost and Utilization Project (HCUP), Newborns/Infants, Newborns/Infants, Medication
Weinberger DM, Klugman KP, Steiner CA
AHRQ Author: Steiner CA
Association between respiratory syncytial virus activity and pneumococcal disease in infants: a time series analysis of US hospitalization data.
The researchers evaluated whether variations in respiratory syncytial virus (RSV) epidemic timing and magnitude are associated with variations in pneumococcal disease epidemics and whether changes in pneumococcal disease following the introduction of a pneumococcal conjugate vaccine (PCV7) were associated with changes in the rate of RSV hospitalizations. Their findings indicate that RSV is associated with increases in the incidence of pneumococcal pneumonia.
AHRQ-authored.
Citation: Weinberger DM, Klugman KP, Steiner CA .
Association between respiratory syncytial virus activity and pneumococcal disease in infants: a time series analysis of US hospitalization data.
PLoS Med 2015 Jan 6;12(1):e1001776. doi: 10.1371/journal.pmed.1001776..
Keywords: Healthcare Cost and Utilization Project (HCUP), Newborns/Infants, Respiratory Conditions, Hospitalization
Pitzer VE, Viboud C, Alonso WJ
AHRQ Author: Steiner CA
Environmental drivers of the spatiotemporal dynamics of respiratory syncytial virus in the United States.
The authors examined the association between environmental variables and state-specific measures of respiratory syncytial virus (RSV) seasonality. They found that states with low mean vapor pressure and the largest seasonal variation in potential evapotranspiration tended to experience biennial patterns of RSV activity, with alternating years of "early-big" and "late-small" epidemics. Their results successfully connected environmental drivers to the epidemic dynamics of RSV; however, the results do not fully explain why RSV activity begins in Florida, one of the warmest states, when RSV is a winter-seasonal pathogen.
AHRQ-authored.
Citation: Pitzer VE, Viboud C, Alonso WJ .
Environmental drivers of the spatiotemporal dynamics of respiratory syncytial virus in the United States.
PLoS Pathog 2015 Jan;11(1):e1004591. doi: 10.1371/journal.ppat.1004591.
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Keywords: Children/Adolescents, Healthcare Cost and Utilization Project (HCUP), Newborns/Infants, Infectious Diseases, Respiratory Conditions
Trudnak Fowler T, Fairbrother G, Owens P
AHRQ Author: Owens P
Trends in complicated newborn hospital stays & costs, 2002-2009: implications for the future.
The researchers used HCUP data to examine trends from 2002 through 2009 in complicated newborn hospital stays, and to explore the relationship between expected sources of payment and reasons for hospitalizations. They concluded that state Medicaid programs are paying for an increasing proportion of births and costly complicated births, and they suggested that policies to prevent common birth complications have the potential to reduce costs for public programs and improve birth outcomes.
AHRQ-authored.
Citation: Trudnak Fowler T, Fairbrother G, Owens P .
Trends in complicated newborn hospital stays & costs, 2002-2009: implications for the future.
Medicare Medicaid Res Rev 2014;4(4). doi: 10.5600/mmrr.004.04.a03.
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Keywords: Healthcare Costs, Healthcare Cost and Utilization Project (HCUP), Hospitalization, Newborns/Infants
Schiltz NK, Finkelstein Rosenthal B, Crowley MA
Rehospitalization during the first year of life by insurance status.
The authors assessed the association of insurance status on infant rehospitalization in a population-based setting. They found that Medicaid coverage and being uninsured were strong predictors of rehospitalizations, with Medicaid bearing a disproportionate share of the economic burden. Normal birth weight infants had the lowest risk. They further found that jaundice and acute bronchiolitis were the leading causes of rehospitalization within 30 days and 1 year, respectively.
AHRQ-funded; HS000059.
Citation: Schiltz NK, Finkelstein Rosenthal B, Crowley MA .
Rehospitalization during the first year of life by insurance status.
Clin Pediatr 2014 Aug;53(9):845-53. doi: 10.1177/0009922814536924.
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Keywords: Health Insurance, Healthcare Cost and Utilization Project (HCUP), Hospital Readmissions, Newborns/Infants, Medicaid, Newborns/Infants