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AHRQ Research Studies Date
Topics
- Adverse Events (2)
- Ambulatory Care and Surgery (1)
- Antibiotics (1)
- Autism (1)
- Cancer (1)
- (-) Children/Adolescents (13)
- Clinician-Patient Communication (1)
- Comparative Effectiveness (2)
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- Evidence-Based Practice (2)
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- Patient-Centered Healthcare (1)
- (-) Patient-Centered Outcomes Research (13)
- Patient Safety (2)
- Respiratory Conditions (1)
- Shared Decision Making (1)
- Sleep Problems (1)
- Stroke (1)
- Surgery (4)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 13 of 13 Research Studies DisplayedRobinson M, Greenhawt M, Stukus DR
Factors associated with epinephrine administration for anaphylaxis in children before arrival to the emergency department.
Researchers evaluated factors associated with anaphylaxis management before arrival at the emergency department (ED) or urgent care center (UCC). Reactions occurring at home were less likely to be treated with epinephrine compared with reactions occurring at school. The odds of receiving epinephrine before arrival at the ED or UCC were significantly lower with a 2-organ system or 3-organ system presentation compared with 1-organ system involvement.
AHRQ-funded; HS024599.
Citation: Robinson M, Greenhawt M, Stukus DR .
Factors associated with epinephrine administration for anaphylaxis in children before arrival to the emergency department.
Ann Allergy Asthma Immunol 2017 Aug;119(2):164-69. doi: 10.1016/j.anai.2017.06.001.
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Keywords: Children/Adolescents, Emergency Medical Services (EMS), Healthcare Utilization, Medication, Patient-Centered Outcomes Research
Weitlauf AS, Sathe N, McPheeters ML
Interventions targeting sensory challenges in autism spectrum disorder: a systematic review.
This review evaluated the effectiveness and safety of interventions targeting sensory challenges in ASD. It concluded that some interventions may yield modest short-term (<6 months) improvements in sensory- and ASD symptom severity-related outcomes; the evidence base is small, and the durability of the effects is unclear. Although some therapies may hold promise, substantial needs exist for continuing improvements in methodologic rigor.
AHRQ-funded; 290201500003I.
Citation: Weitlauf AS, Sathe N, McPheeters ML .
Interventions targeting sensory challenges in autism spectrum disorder: a systematic review.
Pediatrics 2017 Jun;139(6):e20170347. doi: 10.1542/peds.2017-0347.
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Keywords: Patient-Centered Outcomes Research, Evidence-Based Practice, Comparative Effectiveness, Children/Adolescents, Autism
Couch C, Franxman T, Greenhawt M
Characteristics of tree nut challenges in tree nut allergic and tree nut sensitized individuals.
The purpose of this study was to determine the relation between tree nut (TN) sensitization levels and oral food challenges (OFC) outcomes. The investigators concluded that TN challenges were frequently passed in patients with TN sensitization with or without a history of TN reactivity despite a TN SPT wheal of at least 3 mm or a TN sIgE level of at least 2 kUA/L. Nearly all patients with peanut allergy and TN co-sensitization passed the TN challenge, questioning the clinical relevance of "co-allergy."
AHRQ-funded; HS024599.
Citation: Couch C, Franxman T, Greenhawt M .
Characteristics of tree nut challenges in tree nut allergic and tree nut sensitized individuals.
Ann Allergy Asthma Immunol 2017 May;118(5):591-96.e3. doi: 10.1016/j.anai.2017.02.010..
Keywords: Children/Adolescents, Nutrition, Outcomes, Patient-Centered Outcomes Research
Khan A, Baird J, Rogers JE
Parent and provider experience and shared understanding after a family-centered nighttime communication intervention.
This study assessed parent and provider experience and shared understanding after a family-centered, multidisciplinary nighttime communication intervention (nurse-physician brief, family huddle, family update sheet). It concluded that a family-centered, multidisciplinary nighttime communication intervention was associated with improvements in some, but not all, domains of parent/provider experience and shared understanding, particularly provider experience and nurse-family shared understanding.
AHRQ-funded; HS022986; HS000063.
Citation: Khan A, Baird J, Rogers JE .
Parent and provider experience and shared understanding after a family-centered nighttime communication intervention.
Acad Pediatr 2017 May - Jun;17(4):389-402. doi: 10.1016/j.acap.2017.01.012.
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Keywords: Children/Adolescents, Hospitalization, Patient-Centered Healthcare, Patient-Centered Outcomes Research, Clinician-Patient Communication
Berger BA, Cossio A, Saravia NG
Cost-effectiveness of meglumine antimoniate versus miltefosine caregiver DOT for the treatment of pediatric cutaneous leishmaniasis.
The researchers performed a cost-effectiveness analysis comparing Miltefosine administered via in-home caregiver Directly Observed Therapy (cDOT) versus injectable meglumine antimoniate (MA) for pediatric cutaneous leishmaniasis (CL) in southwest Colombia. Treatment of pediatric CL miltefosine via cDOT was found to be cost saving from patient and societal perspectives, and moderately more costly from the government payer perspective compared to treatment with MA.
AHRQ-funded; HS022433.
Citation: Berger BA, Cossio A, Saravia NG .
Cost-effectiveness of meglumine antimoniate versus miltefosine caregiver DOT for the treatment of pediatric cutaneous leishmaniasis.
PLoS Negl Trop Dis 2017 Apr 6;11(4):e0005459. doi: 10.1371/journal.pntd.0005459.
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Keywords: Patient-Centered Outcomes Research, Healthcare Costs, Medication, Healthcare Costs, Children/Adolescents
Wilson JL, Eriksson CO, Williams CN
Endovascular therapy in pediatric stroke: utilization, patient characteristics, and outcomes.
This study aimed to describe endovascular therapy utilization and explore outcomes in a national sample of pediatric arterial ischemic stroke patients. In this sample of children with a diagnosis of arterial ischemic stroke, endovascular therapy was infrequently utilized. Patients with a procedure code for endovascular therapy had significant stroke-related deficits, but outcomes were similar to those in children who did not receive endovascular therapy.
AHRQ-funded; HS022981.
Citation: Wilson JL, Eriksson CO, Williams CN .
Endovascular therapy in pediatric stroke: utilization, patient characteristics, and outcomes.
Pediatr Neurol 2017 Apr;69:87-92.e2. doi: 10.1016/j.pediatrneurol.2017.01.013.
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Keywords: Children/Adolescents, Healthcare Cost and Utilization Project (HCUP), Patient-Centered Outcomes Research, Stroke
Dorris K, Liu C, Li D
A comparison of safety and efficacy of cytotoxic versus molecularly targeted drugs in pediatric phase I solid tumor oncology trials.
A systematic review of pediatric phase I solid tumor trials published in 1990-2013 was performed. The published reports were evaluated for patient characteristics, toxicity information, and response numbers. The review concluded that in phase I pediatric solid tumor trials, objective response rates were significantly higher for cytotoxic versus targeted agents. Stable disease rates were similar in targeted and cytotoxic drug trials.
AHRQ-funded; HS022437.
Citation: Dorris K, Liu C, Li D .
A comparison of safety and efficacy of cytotoxic versus molecularly targeted drugs in pediatric phase I solid tumor oncology trials.
Pediatr Blood Cancer 2017 Mar;64(3). doi: 10.1002/pbc.26258.
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Keywords: Patient Safety, Patient-Centered Outcomes Research, Children/Adolescents, Cancer, Medication
Sathe N, Chinnadurai S, McPheeters M
Comparative effectiveness of partial versus total tonsillectomy in children.
This review assessed the effectiveness of partial versus total tonsillectomy in children. Data did not allow firm conclusions regarding the comparative benefit of partial versus total removal; however, neither surgical technique nor extent of surgery appeared to affect outcomes markedly. Partial tonsillectomy conferred moderate advantages in return to normal diet/activity but was also associated with tonsillar regrowth and symptom recurrence.
AHRQ-funded; 290201500003I.
Citation: Sathe N, Chinnadurai S, McPheeters M .
Comparative effectiveness of partial versus total tonsillectomy in children.
Otolaryngol Head Neck Surg 2017 Mar;156(3):456-63. doi: 10.1177/0194599816683916.
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Keywords: Comparative Effectiveness, Children/Adolescents, Surgery, Patient-Centered Outcomes Research, Children/Adolescents
Goldman JL, Richardson T, Newland JG
Outpatient parenteral antimicrobial therapy in pediatric Medicaid enrollees.
The study’s objective was to characterize outpatient parenteral antimicrobial therapy (OPAT) use and clinical outcomes for a large population of pediatric Medicaid enrollees treated with OPAT. It found that ceftriaxone and vancomycin were the most commonly prescribed antimicrobials. An emergency department visit or hospital admission occurred during 38 percent of OPAT episodes, among which 61 percent were OPAT-related.
AHRQ-funded; HS023320.
Citation: Goldman JL, Richardson T, Newland JG .
Outpatient parenteral antimicrobial therapy in pediatric Medicaid enrollees.
J Pediatric Infect Dis Soc 2017 Mar 1;6(1):65-71. doi: 10.1093/jpids/piv106.
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Keywords: Antibiotics, Children/Adolescents, Medicaid, Ambulatory Care and Surgery, Patient-Centered Outcomes Research
Francis DO, Fonnesbeck C, Sathe N
Postoperative bleeding and associated utilization following tonsillectomy in children.
This review assessed posttonsillectomy hemorrhage (PTH), associated nonoperative readmissions/revisits, and reoperations in children. It concluded that PTH occurred in roughly 4 percent of tonsillectomies. Although studies typically did not report bleeding severity or amount, relatively few episodes of PTH necessitated reoperation for hemostasis. Frequency of PTH across techniques was similar; thus, it cannot be concluded that a given technique is superior.
AHRQ-funded; 290201500003I.
Citation: Francis DO, Fonnesbeck C, Sathe N .
Postoperative bleeding and associated utilization following tonsillectomy in children.
Otolaryngol Head Neck Surg 2017 Mar;156(3):442-55. doi: 10.1177/0194599816683915.
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Keywords: Children/Adolescents, Surgery, Adverse Events, Hospital Readmissions, Patient-Centered Outcomes Research
Lindly OJ, Zuckerman KE, Mistry KB
AHRQ Author: Mistry KB
Clarifying the predictive value of family-centered care and shared decision making for pediatric healthcare outcomes using the Medical Expenditure Panel Survey.
The researchers estimated (1) family-centered care (FCC) and shared decision-making (SDM) prevalence, and (2) associations of FCC and SDM (FCC/SDM) with health care outcomes among U.S. children. FCC/SDM prevalence in year 1 varied from 38.6 to 93.7 percent, and it was lower for composites with more stringent scoring approaches. FCC/SDM composites with stringent scoring approaches in year 1 were associated with reduced unmet needs in year 2.
AHRQ-authored.
Citation: Lindly OJ, Zuckerman KE, Mistry KB .
Clarifying the predictive value of family-centered care and shared decision making for pediatric healthcare outcomes using the Medical Expenditure Panel Survey.
Health Serv Res 2017 Feb;52(1):313-45. doi: 10.1111/1475-6773.12488.
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Keywords: Medical Expenditure Panel Survey (MEPS), Shared Decision Making, Patient-Centered Outcomes Research, Children/Adolescents, Healthcare Costs
Roxbury CR, Jatana KR, Shah RK
Safety and postoperative adverse events in pediatric airway reconstruction: analysis of ACS-NSQIP-P 30-day outcomes.
The researchers describe postoperative sequelae of pediatric airway reconstructive procedures and identify predictive factors for adverse events. They conclude that the 30-day adverse event rate in pediatric airway surgery is high, with no identifiable predictors noted in the analysis of these data. Findings imply that systematic collection of variables and outcomes will be essential to truly effect quality improvement in these high-risk procedures..
AHRQ-funded; HS022932.
Citation: Roxbury CR, Jatana KR, Shah RK .
Safety and postoperative adverse events in pediatric airway reconstruction: analysis of ACS-NSQIP-P 30-day outcomes.
Laryngoscope 2017 Feb;127(2):504-08. doi: 10.1002/lary.26165.
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Keywords: Children/Adolescents, Patient Safety, Adverse Events, Patient-Centered Outcomes Research, Surgery
Chinnadurai S, Jordan AK, Sathe NA
Tonsillectomy for obstructive sleep-disordered breathing: a meta-analysis.
This meta-analysis compared sleep, cognitive or behavioral, and health outcomes of tonsillectomy versus watchful waiting with supportive care in children with sleep-disordered breathing. It determined that, relative to watchful waiting, most studies reported better sleep-related outcomes in children who had a tonsillectomy.
AHRQ-funded; 290201500003I.
Citation: Chinnadurai S, Jordan AK, Sathe NA .
Tonsillectomy for obstructive sleep-disordered breathing: a meta-analysis.
Pediatrics 2017 Feb;139(2). doi: 10.1542/peds.2016-3491.
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Keywords: Children/Adolescents, Sleep Problems, Surgery, Evidence-Based Practice, Respiratory Conditions, Patient-Centered Outcomes Research, Evidence-Based Practice, Outcomes